Randomized Evaluation of Anagliptin vs Sitagliptin On low-density lipoproteiN cholesterol in diabetes (REASON) Trial: A 52-week, open-label, randomized clinical trial View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-06-12

AUTHORS

Takeshi Morimoto, Ichiro Sakuma, Mio Sakuma, Akihiro Tokushige, Masahiro Natsuaki, Tomohiro Asahi, Michio Shimabukuro, Takashi Nomiyama, Osamu Arasaki, Koichi Node, Shinichiro Ueda

ABSTRACT

Additional reductions in low-density lipoprotein-cholesterol (LDL-C) via antidiabetic therapies should be considered in statin-using patients with sub-optimal LDL-C levels. We compared the efficacy of anagliptin and sitagliptin, two antidiabetic therapies, in reducing LDL-C in type 2 diabetic patients. A randomized, open-label, parallel-group trial was conducted at 17 centres in Japan between April 2015 and January 2018. Adults (age ≥20 years) with type 2 diabetes, any atherosclerotic vascular lesions, and statin prescriptions were included. Anagliptin or sitagliptin were administered for 52 weeks. Primary and secondary endpoints were changes in LDL-C and haemoglobin A1C (HbA1c) levels, respectively. We assessed the superiority (primary endpoint) and non-inferiority (secondary endpoint) of anagliptin over sitagliptin. This study was registered at Clinicaltrials.gov (NCT02330406). Of 380 participants, 353 were eligible and randomized. Mean participant age was 68 years, and 61% were males. Baseline median LDL-C and HbA1c were 108 mg/dL and 6.9%, respectively. Changes in LDL-C were −3.7 mg/dL with anagliptin and +2.1 mg/dL with sitagliptin at 52 weeks, and the estimated treatment difference was a significant −4.5 mg/dL (P = 0.01 for superiority). Changes in HbA1c were +0.02% with anagliptin and +0.12% with sitagliptin (P < 0.0001 for non-inferiority). Overall, anagliptin was superior to sitagliptin in lowering LDL-C without deteriorating HbA1c. More... »

PAGES

8537

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-44885-x

DOI

http://dx.doi.org/10.1038/s41598-019-44885-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1117069698

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31189978


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cholesterol, LDL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diabetes Mellitus, Type 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glycated Hemoglobin A", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pyrimidines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sitagliptin Phosphate", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Clinical Epidemiology, Hyogo College of Medicine, 1-1 Mukogawa, 663-8501, Nishinomiya, Hyogo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272264.7", 
          "name": [
            "Department of Clinical Epidemiology, Hyogo College of Medicine, 1-1 Mukogawa, 663-8501, Nishinomiya, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morimoto", 
        "givenName": "Takeshi", 
        "id": "sg:person.011273662612.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011273662612.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Caress Sapporo Hokko Memorial Clinic N-27, E-8, 1-15, Higashi, 065-0027, Sapporo, Hokkaido, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Caress Sapporo Hokko Memorial Clinic N-27, E-8, 1-15, Higashi, 065-0027, Sapporo, Hokkaido, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sakuma", 
        "givenName": "Ichiro", 
        "id": "sg:person.01353136535.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353136535.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Epidemiology, Hyogo College of Medicine, 1-1 Mukogawa, 663-8501, Nishinomiya, Hyogo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.272264.7", 
          "name": [
            "Department of Clinical Epidemiology, Hyogo College of Medicine, 1-1 Mukogawa, 663-8501, Nishinomiya, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sakuma", 
        "givenName": "Mio", 
        "id": "sg:person.01041233531.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041233531.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacology and Therapeutics, University of the Ryukyus, 207 Uehara, 903-0215, Nishihara, Okinawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.267625.2", 
          "name": [
            "Department of Pharmacology and Therapeutics, University of the Ryukyus, 207 Uehara, 903-0215, Nishihara, Okinawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tokushige", 
        "givenName": "Akihiro", 
        "id": "sg:person.0654476125.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654476125.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiovascular Medicine, Saga University, 5-1-1 Nabeshima, 849-8501, Saga, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412339.e", 
          "name": [
            "Department of Cardiovascular Medicine, Saga University, 5-1-1 Nabeshima, 849-8501, Saga, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Natsuaki", 
        "givenName": "Masahiro", 
        "id": "sg:person.0777223020.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777223020.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Naha City Hospital, 2-31-1 Furujima, 902-8511, Naha, Okinawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.474837.b", 
          "name": [
            "Department of Cardiology, Naha City Hospital, 2-31-1 Furujima, 902-8511, Naha, Okinawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Asahi", 
        "givenName": "Tomohiro", 
        "id": "sg:person.01143676322.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143676322.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Diabetes, Endocrinology and Metabolism, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411582.b", 
          "name": [
            "Department of Diabetes, Endocrinology and Metabolism, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shimabukuro", 
        "givenName": "Michio", 
        "id": "sg:person.01233731752.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233731752.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Endocrinology and Diabetes Mellitus, Fukuoka University, 7-45-1 Nanakuma, 814-0180, Jyonan, Fukuoka, Japan", 
          "id": "http://www.grid.ac/institutes/grid.411497.e", 
          "name": [
            "Department of Endocrinology and Diabetes Mellitus, Fukuoka University, 7-45-1 Nanakuma, 814-0180, Jyonan, Fukuoka, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nomiyama", 
        "givenName": "Takashi", 
        "id": "sg:person.01255040512.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255040512.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiology, Tomishiro Central Hospital, 25 Ueda, 901-0243, Tomigusuku, Okinawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.460111.3", 
          "name": [
            "Department of Cardiology, Tomishiro Central Hospital, 25 Ueda, 901-0243, Tomigusuku, Okinawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arasaki", 
        "givenName": "Osamu", 
        "id": "sg:person.0611455170.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611455170.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiovascular Medicine, Saga University, 5-1-1 Nabeshima, 849-8501, Saga, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412339.e", 
          "name": [
            "Department of Cardiovascular Medicine, Saga University, 5-1-1 Nabeshima, 849-8501, Saga, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Node", 
        "givenName": "Koichi", 
        "id": "sg:person.01100453460.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100453460.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pharmacology and Therapeutics, University of the Ryukyus, 207 Uehara, 903-0215, Nishihara, Okinawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.267625.2", 
          "name": [
            "Department of Pharmacology and Therapeutics, University of the Ryukyus, 207 Uehara, 903-0215, Nishihara, Okinawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ueda", 
        "givenName": "Shinichiro", 
        "id": "sg:person.012353001702.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012353001702.96"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s40256-013-0043-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022431347", 
          "https://doi.org/10.1007/s40256-013-0043-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s12944-017-0443-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084251334", 
          "https://doi.org/10.1186/s12944-017-0443-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10557-018-6776-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100981423", 
          "https://doi.org/10.1007/s10557-018-6776-z"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-06-12", 
    "datePublishedReg": "2019-06-12", 
    "description": "Additional reductions in low-density lipoprotein-cholesterol (LDL-C) via antidiabetic therapies should be considered in statin-using patients with sub-optimal LDL-C levels. We compared the efficacy of anagliptin and sitagliptin, two antidiabetic therapies, in reducing LDL-C in type 2 diabetic patients. A randomized, open-label, parallel-group trial was conducted at 17 centres in Japan between April 2015 and January 2018. Adults (age \u226520 years) with type 2 diabetes, any atherosclerotic vascular lesions, and statin prescriptions were included. Anagliptin or sitagliptin were administered for 52 weeks. Primary and secondary endpoints were changes in LDL-C and haemoglobin A1C (HbA1c) levels, respectively. We assessed the superiority (primary endpoint) and non-inferiority (secondary endpoint) of anagliptin over sitagliptin. This study was registered at Clinicaltrials.gov (NCT02330406). Of 380 participants, 353 were eligible and randomized. Mean participant age was 68 years, and 61% were males. Baseline median LDL-C and HbA1c were 108\u2009mg/dL and 6.9%, respectively. Changes in LDL-C were \u22123.7\u2009mg/dL with anagliptin and +2.1\u2009mg/dL with sitagliptin at 52 weeks, and the estimated treatment difference was a significant \u22124.5\u2009mg/dL (P\u2009=\u20090.01 for superiority). Changes in HbA1c were +0.02% with anagliptin and +0.12% with sitagliptin (P\u2009<\u20090.0001 for non-inferiority). Overall, anagliptin was superior to sitagliptin in lowering LDL-C without deteriorating HbA1c.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41598-019-44885-x", 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "keywords": [
      "antidiabetic therapy", 
      "type 2 diabetic patients", 
      "low-density lipoprotein cholesterol", 
      "parallel-group trial", 
      "hemoglobin A1c levels", 
      "LDL-C levels", 
      "type 2 diabetes", 
      "atherosclerotic vascular lesions", 
      "secondary endpoints", 
      "statin prescription", 
      "lipoprotein cholesterol", 
      "Diabetes (ACCORD) trial", 
      "diabetic patients", 
      "A1c levels", 
      "median LDL", 
      "vascular lesions", 
      "clinical trials", 
      "LDL", 
      "sitagliptin", 
      "anagliptin", 
      "Randomized Evaluation", 
      "participant age", 
      "treatment differences", 
      "trials", 
      "patients", 
      "therapy", 
      "dl", 
      "weeks", 
      "additional reduction", 
      "statins", 
      "diabetes", 
      "lesions", 
      "cholesterol", 
      "endpoint", 
      "efficacy", 
      "adults", 
      "age", 
      "prescription", 
      "levels", 
      "males", 
      "changes", 
      "participants", 
      "years", 
      "differences", 
      "evaluation", 
      "center", 
      "study", 
      "reduction", 
      "Japan", 
      "superiority"
    ], 
    "name": "Randomized Evaluation of Anagliptin vs Sitagliptin On low-density lipoproteiN cholesterol in diabetes (REASON) Trial: A 52-week, open-label, randomized clinical trial", 
    "pagination": "8537", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1117069698"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-019-44885-x"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "31189978"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-019-44885-x", 
      "https://app.dimensions.ai/details/publication/pub.1117069698"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:45", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_806.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41598-019-44885-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-44885-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-44885-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-44885-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-44885-x'


 

This table displays all metadata directly associated to this object as RDF triples.

253 TRIPLES      21 PREDICATES      88 URIs      77 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-019-44885-x schema:about N2f5502d5e5354dff80c6bf3cf16fe6ba
2 N6897ee95f1d14a3f8bf27d70f6d9774e
3 N7978e4e48a1348eaa88c487ec5290297
4 N8430796f7b524a12ab1bba7bc3b2cd39
5 N86d53d5c359c40f2a810e5da93859e00
6 N8a9757be973242b5bc69500f33ecde70
7 N8da28264f398414e87d45a4feb7078ca
8 Nb42bf8e168304e6e9ed3bee6bcab533e
9 Nc5c63922b9eb43a48936492f1cd812be
10 Nfb155d5ba917496cb2345084cbf9d352
11 anzsrc-for:11
12 anzsrc-for:1103
13 schema:author N2eeb418feac744b3813de82a48c5b1c9
14 schema:citation sg:pub.10.1007/s10557-018-6776-z
15 sg:pub.10.1007/s40256-013-0043-2
16 sg:pub.10.1186/s12944-017-0443-4
17 schema:datePublished 2019-06-12
18 schema:datePublishedReg 2019-06-12
19 schema:description Additional reductions in low-density lipoprotein-cholesterol (LDL-C) via antidiabetic therapies should be considered in statin-using patients with sub-optimal LDL-C levels. We compared the efficacy of anagliptin and sitagliptin, two antidiabetic therapies, in reducing LDL-C in type 2 diabetic patients. A randomized, open-label, parallel-group trial was conducted at 17 centres in Japan between April 2015 and January 2018. Adults (age ≥20 years) with type 2 diabetes, any atherosclerotic vascular lesions, and statin prescriptions were included. Anagliptin or sitagliptin were administered for 52 weeks. Primary and secondary endpoints were changes in LDL-C and haemoglobin A1C (HbA1c) levels, respectively. We assessed the superiority (primary endpoint) and non-inferiority (secondary endpoint) of anagliptin over sitagliptin. This study was registered at Clinicaltrials.gov (NCT02330406). Of 380 participants, 353 were eligible and randomized. Mean participant age was 68 years, and 61% were males. Baseline median LDL-C and HbA1c were 108 mg/dL and 6.9%, respectively. Changes in LDL-C were −3.7 mg/dL with anagliptin and +2.1 mg/dL with sitagliptin at 52 weeks, and the estimated treatment difference was a significant −4.5 mg/dL (P = 0.01 for superiority). Changes in HbA1c were +0.02% with anagliptin and +0.12% with sitagliptin (P < 0.0001 for non-inferiority). Overall, anagliptin was superior to sitagliptin in lowering LDL-C without deteriorating HbA1c.
20 schema:genre article
21 schema:isAccessibleForFree true
22 schema:isPartOf N209ce7ffa473479eb5187b46102a21a8
23 Na613e5afc38e481a89142ae76c2cb0d2
24 sg:journal.1045337
25 schema:keywords A1c levels
26 Diabetes (ACCORD) trial
27 Japan
28 LDL
29 LDL-C levels
30 Randomized Evaluation
31 additional reduction
32 adults
33 age
34 anagliptin
35 antidiabetic therapy
36 atherosclerotic vascular lesions
37 center
38 changes
39 cholesterol
40 clinical trials
41 diabetes
42 diabetic patients
43 differences
44 dl
45 efficacy
46 endpoint
47 evaluation
48 hemoglobin A1c levels
49 lesions
50 levels
51 lipoprotein cholesterol
52 low-density lipoprotein cholesterol
53 males
54 median LDL
55 parallel-group trial
56 participant age
57 participants
58 patients
59 prescription
60 reduction
61 secondary endpoints
62 sitagliptin
63 statin prescription
64 statins
65 study
66 superiority
67 therapy
68 treatment differences
69 trials
70 type 2 diabetes
71 type 2 diabetic patients
72 vascular lesions
73 weeks
74 years
75 schema:name Randomized Evaluation of Anagliptin vs Sitagliptin On low-density lipoproteiN cholesterol in diabetes (REASON) Trial: A 52-week, open-label, randomized clinical trial
76 schema:pagination 8537
77 schema:productId N436d71d25bd5478fb04fa21c13aae4ce
78 N84bffbac09ce4c63836febdbf6d11b6b
79 Nd903be963d6f48dbbc8bfee27050509a
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1117069698
81 https://doi.org/10.1038/s41598-019-44885-x
82 schema:sdDatePublished 2022-10-01T06:45
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher Nbd4de4f93e6d4fce81f73c322d73ac07
85 schema:url https://doi.org/10.1038/s41598-019-44885-x
86 sgo:license sg:explorer/license/
87 sgo:sdDataset articles
88 rdf:type schema:ScholarlyArticle
89 N13e32d0a2a854aa0b9542b0384f872b7 rdf:first sg:person.01143676322.28
90 rdf:rest N7eafc26c1d6648e691686d5e3bf6f711
91 N209ce7ffa473479eb5187b46102a21a8 schema:issueNumber 1
92 rdf:type schema:PublicationIssue
93 N2eeb418feac744b3813de82a48c5b1c9 rdf:first sg:person.011273662612.03
94 rdf:rest N5a19ec383e904696900ffecb08fbc686
95 N2f5502d5e5354dff80c6bf3cf16fe6ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Female
97 rdf:type schema:DefinedTerm
98 N436d71d25bd5478fb04fa21c13aae4ce schema:name dimensions_id
99 schema:value pub.1117069698
100 rdf:type schema:PropertyValue
101 N5a19ec383e904696900ffecb08fbc686 rdf:first sg:person.01353136535.75
102 rdf:rest Nae57711a1058426d925e1fe036707f8d
103 N6897ee95f1d14a3f8bf27d70f6d9774e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Aged
105 rdf:type schema:DefinedTerm
106 N7134b6edcb82411eb75029fa86255d06 rdf:first sg:person.012353001702.96
107 rdf:rest rdf:nil
108 N7978e4e48a1348eaa88c487ec5290297 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Pyrimidines
110 rdf:type schema:DefinedTerm
111 N7eafc26c1d6648e691686d5e3bf6f711 rdf:first sg:person.01233731752.49
112 rdf:rest N90504de766ee47e9a412485a17980397
113 N8430796f7b524a12ab1bba7bc3b2cd39 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Middle Aged
115 rdf:type schema:DefinedTerm
116 N84bffbac09ce4c63836febdbf6d11b6b schema:name pubmed_id
117 schema:value 31189978
118 rdf:type schema:PropertyValue
119 N86d53d5c359c40f2a810e5da93859e00 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Cholesterol, LDL
121 rdf:type schema:DefinedTerm
122 N8a9757be973242b5bc69500f33ecde70 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Sitagliptin Phosphate
124 rdf:type schema:DefinedTerm
125 N8da28264f398414e87d45a4feb7078ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Humans
127 rdf:type schema:DefinedTerm
128 N90504de766ee47e9a412485a17980397 rdf:first sg:person.01255040512.80
129 rdf:rest Naf2ced4ba5284a59b17b682e3b28fdcd
130 Na613e5afc38e481a89142ae76c2cb0d2 schema:volumeNumber 9
131 rdf:type schema:PublicationVolume
132 Nae57711a1058426d925e1fe036707f8d rdf:first sg:person.01041233531.06
133 rdf:rest Nd067c2b84c6f4c2c946a4e5a34de4205
134 Naf2ced4ba5284a59b17b682e3b28fdcd rdf:first sg:person.0611455170.93
135 rdf:rest Nee1f5bc8c5c740bbb2277f9ce3b12adb
136 Nb42bf8e168304e6e9ed3bee6bcab533e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Glycated Hemoglobin A
138 rdf:type schema:DefinedTerm
139 Nb93a4d6b5d3847a699345853f322af36 rdf:first sg:person.0777223020.83
140 rdf:rest N13e32d0a2a854aa0b9542b0384f872b7
141 Nbd4de4f93e6d4fce81f73c322d73ac07 schema:name Springer Nature - SN SciGraph project
142 rdf:type schema:Organization
143 Nc5c63922b9eb43a48936492f1cd812be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Diabetes Mellitus, Type 2
145 rdf:type schema:DefinedTerm
146 Nd067c2b84c6f4c2c946a4e5a34de4205 rdf:first sg:person.0654476125.52
147 rdf:rest Nb93a4d6b5d3847a699345853f322af36
148 Nd903be963d6f48dbbc8bfee27050509a schema:name doi
149 schema:value 10.1038/s41598-019-44885-x
150 rdf:type schema:PropertyValue
151 Nee1f5bc8c5c740bbb2277f9ce3b12adb rdf:first sg:person.01100453460.13
152 rdf:rest N7134b6edcb82411eb75029fa86255d06
153 Nfb155d5ba917496cb2345084cbf9d352 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Male
155 rdf:type schema:DefinedTerm
156 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
157 schema:name Medical and Health Sciences
158 rdf:type schema:DefinedTerm
159 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
160 schema:name Clinical Sciences
161 rdf:type schema:DefinedTerm
162 sg:journal.1045337 schema:issn 2045-2322
163 schema:name Scientific Reports
164 schema:publisher Springer Nature
165 rdf:type schema:Periodical
166 sg:person.01041233531.06 schema:affiliation grid-institutes:grid.272264.7
167 schema:familyName Sakuma
168 schema:givenName Mio
169 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01041233531.06
170 rdf:type schema:Person
171 sg:person.01100453460.13 schema:affiliation grid-institutes:grid.412339.e
172 schema:familyName Node
173 schema:givenName Koichi
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100453460.13
175 rdf:type schema:Person
176 sg:person.011273662612.03 schema:affiliation grid-institutes:grid.272264.7
177 schema:familyName Morimoto
178 schema:givenName Takeshi
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011273662612.03
180 rdf:type schema:Person
181 sg:person.01143676322.28 schema:affiliation grid-institutes:grid.474837.b
182 schema:familyName Asahi
183 schema:givenName Tomohiro
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143676322.28
185 rdf:type schema:Person
186 sg:person.01233731752.49 schema:affiliation grid-institutes:grid.411582.b
187 schema:familyName Shimabukuro
188 schema:givenName Michio
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233731752.49
190 rdf:type schema:Person
191 sg:person.012353001702.96 schema:affiliation grid-institutes:grid.267625.2
192 schema:familyName Ueda
193 schema:givenName Shinichiro
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012353001702.96
195 rdf:type schema:Person
196 sg:person.01255040512.80 schema:affiliation grid-institutes:grid.411497.e
197 schema:familyName Nomiyama
198 schema:givenName Takashi
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255040512.80
200 rdf:type schema:Person
201 sg:person.01353136535.75 schema:affiliation grid-institutes:None
202 schema:familyName Sakuma
203 schema:givenName Ichiro
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353136535.75
205 rdf:type schema:Person
206 sg:person.0611455170.93 schema:affiliation grid-institutes:grid.460111.3
207 schema:familyName Arasaki
208 schema:givenName Osamu
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611455170.93
210 rdf:type schema:Person
211 sg:person.0654476125.52 schema:affiliation grid-institutes:grid.267625.2
212 schema:familyName Tokushige
213 schema:givenName Akihiro
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0654476125.52
215 rdf:type schema:Person
216 sg:person.0777223020.83 schema:affiliation grid-institutes:grid.412339.e
217 schema:familyName Natsuaki
218 schema:givenName Masahiro
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777223020.83
220 rdf:type schema:Person
221 sg:pub.10.1007/s10557-018-6776-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1100981423
222 https://doi.org/10.1007/s10557-018-6776-z
223 rdf:type schema:CreativeWork
224 sg:pub.10.1007/s40256-013-0043-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022431347
225 https://doi.org/10.1007/s40256-013-0043-2
226 rdf:type schema:CreativeWork
227 sg:pub.10.1186/s12944-017-0443-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084251334
228 https://doi.org/10.1186/s12944-017-0443-4
229 rdf:type schema:CreativeWork
230 grid-institutes:None schema:alternateName Caress Sapporo Hokko Memorial Clinic N-27, E-8, 1-15, Higashi, 065-0027, Sapporo, Hokkaido, Japan
231 schema:name Caress Sapporo Hokko Memorial Clinic N-27, E-8, 1-15, Higashi, 065-0027, Sapporo, Hokkaido, Japan
232 rdf:type schema:Organization
233 grid-institutes:grid.267625.2 schema:alternateName Department of Pharmacology and Therapeutics, University of the Ryukyus, 207 Uehara, 903-0215, Nishihara, Okinawa, Japan
234 schema:name Department of Pharmacology and Therapeutics, University of the Ryukyus, 207 Uehara, 903-0215, Nishihara, Okinawa, Japan
235 rdf:type schema:Organization
236 grid-institutes:grid.272264.7 schema:alternateName Department of Clinical Epidemiology, Hyogo College of Medicine, 1-1 Mukogawa, 663-8501, Nishinomiya, Hyogo, Japan
237 schema:name Department of Clinical Epidemiology, Hyogo College of Medicine, 1-1 Mukogawa, 663-8501, Nishinomiya, Hyogo, Japan
238 rdf:type schema:Organization
239 grid-institutes:grid.411497.e schema:alternateName Department of Endocrinology and Diabetes Mellitus, Fukuoka University, 7-45-1 Nanakuma, 814-0180, Jyonan, Fukuoka, Japan
240 schema:name Department of Endocrinology and Diabetes Mellitus, Fukuoka University, 7-45-1 Nanakuma, 814-0180, Jyonan, Fukuoka, Japan
241 rdf:type schema:Organization
242 grid-institutes:grid.411582.b schema:alternateName Department of Diabetes, Endocrinology and Metabolism, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan
243 schema:name Department of Diabetes, Endocrinology and Metabolism, Fukushima Medical University, 1 Hikarigaoka, 960-1295, Fukushima, Japan
244 rdf:type schema:Organization
245 grid-institutes:grid.412339.e schema:alternateName Department of Cardiovascular Medicine, Saga University, 5-1-1 Nabeshima, 849-8501, Saga, Japan
246 schema:name Department of Cardiovascular Medicine, Saga University, 5-1-1 Nabeshima, 849-8501, Saga, Japan
247 rdf:type schema:Organization
248 grid-institutes:grid.460111.3 schema:alternateName Department of Cardiology, Tomishiro Central Hospital, 25 Ueda, 901-0243, Tomigusuku, Okinawa, Japan
249 schema:name Department of Cardiology, Tomishiro Central Hospital, 25 Ueda, 901-0243, Tomigusuku, Okinawa, Japan
250 rdf:type schema:Organization
251 grid-institutes:grid.474837.b schema:alternateName Department of Cardiology, Naha City Hospital, 2-31-1 Furujima, 902-8511, Naha, Okinawa, Japan
252 schema:name Department of Cardiology, Naha City Hospital, 2-31-1 Furujima, 902-8511, Naha, Okinawa, Japan
253 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...