Possible role of complement factor H in podocytes in clearing glomerular subendothelial immune complex deposits View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-05-27

AUTHORS

Takeshi Zoshima, Satoshi Hara, Masakazu Yamagishi, Ira Pastan, Taiji Matsusaka, Mitsuhiro Kawano, Michio Nagata

ABSTRACT

Podocytes are known to express various complement factors including complement factor H (CFH) and to promote the removal of both subendothelial and subepithelial immune complex (IC) deposits. Using podocyte-selective injury model NEP25 mice and an IgG3-producing hybridoma clone 2B11.3 established by MRL/lpr mice, the present study investigated the role of podocyte complement regulation in only subendothelial IC deposition. In immunotoxin (LMB2) induced fatal podocyte injury (NEP25/LMB2) at day 12, glomerular CFH and C3a receptor (C3aR) expression was decreased as compared with NEP25/vehicle mice. In contrast, in sublytic podocyte injury 5 days after LMB2, glomerular CFH and C3aR expression was increased as compared with NEP25/vehicle mice. Intra-abdominal injection of 2B11.3 hybridoma to NEP25 mice (NEP25/hybridoma) caused IC deposition limited to the subendothelial area associated with unaltered CFH expression. NEP25/hybridoma mice with sublytic podocyte injury (NEP25/hybridoma/LMB2) resulted in increased glomerular CFH expression (1.7-fold) accompanied by decreased subendothelial IC deposition, as compared with NEP25/hybridoma. Immunostaining revealed that CFH was dominantly expressed in podocytes of NEP25/hybridoma/LMB2. In addition, puromycin-induced sublytic podocyte injury promoted CFH expression in immortalized mouse podocytes in vitro. These results suggest that in response to sublytic levels of injury, podocyte induced CFH expression locally and clearance of subendothelial IC deposits. More... »

PAGES

7857

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-44380-3

DOI

http://dx.doi.org/10.1038/s41598-019-44380-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1115897998

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31133737


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigen-Antibody Complex", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Complement Factor H", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Complement System Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Glomerulus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Podocytes", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Kidney and Vascular Pathology, Faculty of Medicine, University of Tsukuba, 1-1-1, Ten-nodai, 305-8577, Tsukuba, Ibaraki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Division of Rheumatology, Department of Internal Medicine, Kanazawa University Graduate School of Medicine, Takara-machi 13-1, 920-8640, Kanazawa, Ishikawa, Japan", 
            "Kidney and Vascular Pathology, Faculty of Medicine, University of Tsukuba, 1-1-1, Ten-nodai, 305-8577, Tsukuba, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zoshima", 
        "givenName": "Takeshi", 
        "id": "sg:person.01356402621.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356402621.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Rheumatology, Department of Internal Medicine, Kanazawa University Graduate School of Medicine, Takara-machi 13-1, 920-8640, Kanazawa, Ishikawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.9707.9", 
          "name": [
            "Division of Rheumatology, Department of Internal Medicine, Kanazawa University Graduate School of Medicine, Takara-machi 13-1, 920-8640, Kanazawa, Ishikawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hara", 
        "givenName": "Satoshi", 
        "id": "sg:person.01230221331.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230221331.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, Takara-machi 13-1, 920-8640, Kanazawa, Ishikawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.9707.9", 
          "name": [
            "Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, Takara-machi 13-1, 920-8640, Kanazawa, Ishikawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamagishi", 
        "givenName": "Masakazu", 
        "id": "sg:person.01111610241.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111610241.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, 37 Convent Dr, Room 5106, 20892-4264, Bethesda, Maryland, USA", 
          "id": "http://www.grid.ac/institutes/grid.417768.b", 
          "name": [
            "Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, 37 Convent Dr, Room 5106, 20892-4264, Bethesda, Maryland, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pastan", 
        "givenName": "Ira", 
        "id": "sg:person.0657571167.43", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657571167.43"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Life Sciences, Tokai University School of Medicine, Shimokasuya 143, 259-1193, Isehara, Kanagawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.265061.6", 
          "name": [
            "Department of Molecular Life Sciences, Tokai University School of Medicine, Shimokasuya 143, 259-1193, Isehara, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsusaka", 
        "givenName": "Taiji", 
        "id": "sg:person.01215730763.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215730763.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Rheumatology, Department of Internal Medicine, Kanazawa University Graduate School of Medicine, Takara-machi 13-1, 920-8640, Kanazawa, Ishikawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.9707.9", 
          "name": [
            "Division of Rheumatology, Department of Internal Medicine, Kanazawa University Graduate School of Medicine, Takara-machi 13-1, 920-8640, Kanazawa, Ishikawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawano", 
        "givenName": "Mitsuhiro", 
        "id": "sg:person.01033615457.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033615457.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kidney and Vascular Pathology, Faculty of Medicine, University of Tsukuba, 1-1-1, Ten-nodai, 305-8577, Tsukuba, Ibaraki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Kidney and Vascular Pathology, Faculty of Medicine, University of Tsukuba, 1-1-1, Ten-nodai, 305-8577, Tsukuba, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagata", 
        "givenName": "Michio", 
        "id": "sg:person.01022702772.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022702772.51"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s004280050069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050331509", 
          "https://doi.org/10.1007/s004280050069"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-05-27", 
    "datePublishedReg": "2019-05-27", 
    "description": "Podocytes are known to express various complement factors including complement factor H (CFH) and to promote the removal of both subendothelial and subepithelial immune complex (IC) deposits. Using podocyte-selective injury model NEP25 mice and an IgG3-producing hybridoma clone 2B11.3 established by MRL/lpr mice, the present study investigated the role of podocyte complement regulation in only subendothelial IC deposition. In immunotoxin (LMB2) induced fatal podocyte injury (NEP25/LMB2) at day 12, glomerular CFH and C3a receptor (C3aR) expression was decreased as compared with NEP25/vehicle mice. In contrast, in sublytic podocyte injury 5 days after LMB2, glomerular CFH and C3aR expression was increased as compared with NEP25/vehicle mice. Intra-abdominal injection of 2B11.3 hybridoma to NEP25 mice (NEP25/hybridoma) caused IC deposition limited to the subendothelial area associated with unaltered CFH expression. NEP25/hybridoma mice with sublytic podocyte injury (NEP25/hybridoma/LMB2) resulted in increased glomerular CFH expression (1.7-fold) accompanied by decreased subendothelial IC deposition, as compared with NEP25/hybridoma. Immunostaining revealed that CFH was dominantly expressed in podocytes of NEP25/hybridoma/LMB2. In addition, puromycin-induced sublytic podocyte injury promoted CFH expression in immortalized mouse podocytes in vitro. These results suggest that in response to sublytic levels of injury, podocyte induced CFH expression locally and clearance of subendothelial IC deposits.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/s41598-019-44380-3", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2723638", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.8534227", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7522376", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "keywords": [
      "complement factor H", 
      "immune complex deposits", 
      "CFH expression", 
      "podocyte injury", 
      "IC deposition", 
      "NEP25 mice", 
      "vehicle mice", 
      "subepithelial immune complex deposits", 
      "MRL/lpr mice", 
      "C3a receptor (C3aR) expression", 
      "factor H", 
      "intra-abdominal injection", 
      "complex deposits", 
      "immortalized mouse podocytes", 
      "C3aR expression", 
      "lpr mice", 
      "receptor expression", 
      "complement factors", 
      "IC deposits", 
      "subendothelial area", 
      "day 12", 
      "injury", 
      "mice", 
      "mouse podocytes", 
      "complement regulation", 
      "podocytes", 
      "possible role", 
      "LMB2", 
      "present study", 
      "hybridomas", 
      "expression", 
      "IgG3", 
      "sublytic levels", 
      "immunostaining", 
      "immunotoxin", 
      "clearance", 
      "injection", 
      "role", 
      "days", 
      "response", 
      "factors", 
      "levels", 
      "study", 
      "regulation", 
      "contrast", 
      "addition", 
      "removal", 
      "area", 
      "results", 
      "deposition", 
      "deposits"
    ], 
    "name": "Possible role of complement factor H in podocytes in clearing glomerular subendothelial immune complex deposits", 
    "pagination": "7857", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1115897998"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-019-44380-3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "31133737"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-019-44380-3", 
      "https://app.dimensions.ai/details/publication/pub.1115897998"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:46", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_818.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/s41598-019-44380-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-44380-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-44380-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-44380-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-44380-3'


 

This table displays all metadata directly associated to this object as RDF triples.

207 TRIPLES      21 PREDICATES      85 URIs      76 LITERALS      15 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-019-44380-3 schema:about N07a383f6bd024e20a102ccbd80352794
2 N3604271b8cc9492bbcbc3eae2d888ed1
3 N4f234e828f344a74a33763e9f6b8c7f1
4 N627685751600409d9388989827a3f1cd
5 N847303a42f5e4b0d955c100695751a2b
6 N97e01197b89a4dd3833f075df782e72d
7 Nc3ee23b51dc64a5ea21b6a5f2864dff8
8 Nd7bcc803dad7447ea61ca0c6523de9f7
9 anzsrc-for:11
10 anzsrc-for:1103
11 schema:author N4c73ce075d1145649fa118ead457d942
12 schema:citation sg:pub.10.1007/s004280050069
13 schema:datePublished 2019-05-27
14 schema:datePublishedReg 2019-05-27
15 schema:description Podocytes are known to express various complement factors including complement factor H (CFH) and to promote the removal of both subendothelial and subepithelial immune complex (IC) deposits. Using podocyte-selective injury model NEP25 mice and an IgG3-producing hybridoma clone 2B11.3 established by MRL/lpr mice, the present study investigated the role of podocyte complement regulation in only subendothelial IC deposition. In immunotoxin (LMB2) induced fatal podocyte injury (NEP25/LMB2) at day 12, glomerular CFH and C3a receptor (C3aR) expression was decreased as compared with NEP25/vehicle mice. In contrast, in sublytic podocyte injury 5 days after LMB2, glomerular CFH and C3aR expression was increased as compared with NEP25/vehicle mice. Intra-abdominal injection of 2B11.3 hybridoma to NEP25 mice (NEP25/hybridoma) caused IC deposition limited to the subendothelial area associated with unaltered CFH expression. NEP25/hybridoma mice with sublytic podocyte injury (NEP25/hybridoma/LMB2) resulted in increased glomerular CFH expression (1.7-fold) accompanied by decreased subendothelial IC deposition, as compared with NEP25/hybridoma. Immunostaining revealed that CFH was dominantly expressed in podocytes of NEP25/hybridoma/LMB2. In addition, puromycin-induced sublytic podocyte injury promoted CFH expression in immortalized mouse podocytes in vitro. These results suggest that in response to sublytic levels of injury, podocyte induced CFH expression locally and clearance of subendothelial IC deposits.
16 schema:genre article
17 schema:isAccessibleForFree true
18 schema:isPartOf N24735d70a97b4f3a9f495ab4eb3d1ccf
19 Nd77e6bd0803c4eb98afa37c7f2b6d531
20 sg:journal.1045337
21 schema:keywords C3a receptor (C3aR) expression
22 C3aR expression
23 CFH expression
24 IC deposition
25 IC deposits
26 IgG3
27 LMB2
28 MRL/lpr mice
29 NEP25 mice
30 addition
31 area
32 clearance
33 complement factor H
34 complement factors
35 complement regulation
36 complex deposits
37 contrast
38 day 12
39 days
40 deposition
41 deposits
42 expression
43 factor H
44 factors
45 hybridomas
46 immortalized mouse podocytes
47 immune complex deposits
48 immunostaining
49 immunotoxin
50 injection
51 injury
52 intra-abdominal injection
53 levels
54 lpr mice
55 mice
56 mouse podocytes
57 podocyte injury
58 podocytes
59 possible role
60 present study
61 receptor expression
62 regulation
63 removal
64 response
65 results
66 role
67 study
68 subendothelial area
69 subepithelial immune complex deposits
70 sublytic levels
71 vehicle mice
72 schema:name Possible role of complement factor H in podocytes in clearing glomerular subendothelial immune complex deposits
73 schema:pagination 7857
74 schema:productId N017e4b3194f64e998ba0571090b6905d
75 N2646595f00a347a688e2ce2f3e132e0a
76 Nfe7a6b9894cf4ed8b9c93d9acb8f0019
77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1115897998
78 https://doi.org/10.1038/s41598-019-44380-3
79 schema:sdDatePublished 2022-10-01T06:46
80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
81 schema:sdPublisher N8d918f85ff0b42568bc9197bb1a99bbf
82 schema:url https://doi.org/10.1038/s41598-019-44380-3
83 sgo:license sg:explorer/license/
84 sgo:sdDataset articles
85 rdf:type schema:ScholarlyArticle
86 N017e4b3194f64e998ba0571090b6905d schema:name pubmed_id
87 schema:value 31133737
88 rdf:type schema:PropertyValue
89 N07a383f6bd024e20a102ccbd80352794 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Complement System Proteins
91 rdf:type schema:DefinedTerm
92 N0886eb8290bb4384b982af640b4fa863 rdf:first sg:person.01022702772.51
93 rdf:rest rdf:nil
94 N16368b4fa1534fe0a73593f783e7be81 rdf:first sg:person.01215730763.41
95 rdf:rest N7aea62c9fbdb43609811c14030744ba2
96 N1da04db6782d4ab3b178e926032e0885 rdf:first sg:person.01111610241.58
97 rdf:rest Na1670308a6594e3eb5f51ea00e451b85
98 N24735d70a97b4f3a9f495ab4eb3d1ccf schema:issueNumber 1
99 rdf:type schema:PublicationIssue
100 N2646595f00a347a688e2ce2f3e132e0a schema:name doi
101 schema:value 10.1038/s41598-019-44380-3
102 rdf:type schema:PropertyValue
103 N3604271b8cc9492bbcbc3eae2d888ed1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Animals
105 rdf:type schema:DefinedTerm
106 N4c73ce075d1145649fa118ead457d942 rdf:first sg:person.01356402621.04
107 rdf:rest Nf1a07263b7d24e62b3faedd887b066c6
108 N4f234e828f344a74a33763e9f6b8c7f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Mice
110 rdf:type schema:DefinedTerm
111 N627685751600409d9388989827a3f1cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Antigen-Antibody Complex
113 rdf:type schema:DefinedTerm
114 N7aea62c9fbdb43609811c14030744ba2 rdf:first sg:person.01033615457.45
115 rdf:rest N0886eb8290bb4384b982af640b4fa863
116 N847303a42f5e4b0d955c100695751a2b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Kidney Glomerulus
118 rdf:type schema:DefinedTerm
119 N8d918f85ff0b42568bc9197bb1a99bbf schema:name Springer Nature - SN SciGraph project
120 rdf:type schema:Organization
121 N97e01197b89a4dd3833f075df782e72d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
122 schema:name Cell Line
123 rdf:type schema:DefinedTerm
124 Na1670308a6594e3eb5f51ea00e451b85 rdf:first sg:person.0657571167.43
125 rdf:rest N16368b4fa1534fe0a73593f783e7be81
126 Nc3ee23b51dc64a5ea21b6a5f2864dff8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Podocytes
128 rdf:type schema:DefinedTerm
129 Nd77e6bd0803c4eb98afa37c7f2b6d531 schema:volumeNumber 9
130 rdf:type schema:PublicationVolume
131 Nd7bcc803dad7447ea61ca0c6523de9f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Complement Factor H
133 rdf:type schema:DefinedTerm
134 Nf1a07263b7d24e62b3faedd887b066c6 rdf:first sg:person.01230221331.92
135 rdf:rest N1da04db6782d4ab3b178e926032e0885
136 Nfe7a6b9894cf4ed8b9c93d9acb8f0019 schema:name dimensions_id
137 schema:value pub.1115897998
138 rdf:type schema:PropertyValue
139 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
140 schema:name Medical and Health Sciences
141 rdf:type schema:DefinedTerm
142 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
143 schema:name Clinical Sciences
144 rdf:type schema:DefinedTerm
145 sg:grant.2723638 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-44380-3
146 rdf:type schema:MonetaryGrant
147 sg:grant.7522376 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-44380-3
148 rdf:type schema:MonetaryGrant
149 sg:grant.8534227 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-44380-3
150 rdf:type schema:MonetaryGrant
151 sg:journal.1045337 schema:issn 2045-2322
152 schema:name Scientific Reports
153 schema:publisher Springer Nature
154 rdf:type schema:Periodical
155 sg:person.01022702772.51 schema:affiliation grid-institutes:grid.20515.33
156 schema:familyName Nagata
157 schema:givenName Michio
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022702772.51
159 rdf:type schema:Person
160 sg:person.01033615457.45 schema:affiliation grid-institutes:grid.9707.9
161 schema:familyName Kawano
162 schema:givenName Mitsuhiro
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01033615457.45
164 rdf:type schema:Person
165 sg:person.01111610241.58 schema:affiliation grid-institutes:grid.9707.9
166 schema:familyName Yamagishi
167 schema:givenName Masakazu
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01111610241.58
169 rdf:type schema:Person
170 sg:person.01215730763.41 schema:affiliation grid-institutes:grid.265061.6
171 schema:familyName Matsusaka
172 schema:givenName Taiji
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215730763.41
174 rdf:type schema:Person
175 sg:person.01230221331.92 schema:affiliation grid-institutes:grid.9707.9
176 schema:familyName Hara
177 schema:givenName Satoshi
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230221331.92
179 rdf:type schema:Person
180 sg:person.01356402621.04 schema:affiliation grid-institutes:grid.20515.33
181 schema:familyName Zoshima
182 schema:givenName Takeshi
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01356402621.04
184 rdf:type schema:Person
185 sg:person.0657571167.43 schema:affiliation grid-institutes:grid.417768.b
186 schema:familyName Pastan
187 schema:givenName Ira
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657571167.43
189 rdf:type schema:Person
190 sg:pub.10.1007/s004280050069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050331509
191 https://doi.org/10.1007/s004280050069
192 rdf:type schema:CreativeWork
193 grid-institutes:grid.20515.33 schema:alternateName Kidney and Vascular Pathology, Faculty of Medicine, University of Tsukuba, 1-1-1, Ten-nodai, 305-8577, Tsukuba, Ibaraki, Japan
194 schema:name Division of Rheumatology, Department of Internal Medicine, Kanazawa University Graduate School of Medicine, Takara-machi 13-1, 920-8640, Kanazawa, Ishikawa, Japan
195 Kidney and Vascular Pathology, Faculty of Medicine, University of Tsukuba, 1-1-1, Ten-nodai, 305-8577, Tsukuba, Ibaraki, Japan
196 rdf:type schema:Organization
197 grid-institutes:grid.265061.6 schema:alternateName Department of Molecular Life Sciences, Tokai University School of Medicine, Shimokasuya 143, 259-1193, Isehara, Kanagawa, Japan
198 schema:name Department of Molecular Life Sciences, Tokai University School of Medicine, Shimokasuya 143, 259-1193, Isehara, Kanagawa, Japan
199 rdf:type schema:Organization
200 grid-institutes:grid.417768.b schema:alternateName Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, 37 Convent Dr, Room 5106, 20892-4264, Bethesda, Maryland, USA
201 schema:name Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, NIH, 37 Convent Dr, Room 5106, 20892-4264, Bethesda, Maryland, USA
202 rdf:type schema:Organization
203 grid-institutes:grid.9707.9 schema:alternateName Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, Takara-machi 13-1, 920-8640, Kanazawa, Ishikawa, Japan
204 Division of Rheumatology, Department of Internal Medicine, Kanazawa University Graduate School of Medicine, Takara-machi 13-1, 920-8640, Kanazawa, Ishikawa, Japan
205 schema:name Department of Cardiovascular and Internal Medicine, Kanazawa University Graduate School of Medicine, Takara-machi 13-1, 920-8640, Kanazawa, Ishikawa, Japan
206 Division of Rheumatology, Department of Internal Medicine, Kanazawa University Graduate School of Medicine, Takara-machi 13-1, 920-8640, Kanazawa, Ishikawa, Japan
207 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...