Comparative RNA sequencing reveals that HPV16 E6 abrogates the effect of E6*I on ROS metabolism. View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Philippe Paget-Bailly, Koceila Meznad, Diane Bruyère, Jérôme Perrard, Michael Herfs, Alain C Jung, Christiane Mougin, Jean-Luc Prétet, Aurélie Baguet

ABSTRACT

High-risk Human Papillomavirus infections are responsible for anogenital and oropharyngeal cancers. Alternative splicing is an important mechanism controlling HPV16 gene expression. Modulation in the splice pattern leads to polycistronic HPV16 early transcripts encoding a full length E6 oncoprotein or truncated E6 proteins, commonly named E6*. Spliced E6*I transcripts are the most abundant RNAs produced in HPV-related cancers. To date, the biological function of the E6*I isoform remains controversial. In this study, we identified, by RNA sequencing, cellular targets deregulated by E6*I, among which genes related to ROS metabolism. Concomitantly, E6*I-overexpressing cells display high levels of ROS. However, co-overexpression of both E6 and E6*I has no effect on ROS production. In HPV16-infected cells expressing different E6/E6*I levels, we show that the newly identified targets CCL2 and RAC2 are increased by E6*I but decreased by E6 expression, suggesting that E6 abrogates the effect of E6*I. Taken together, these data support the idea that E6*I acts independently of E6 to increase ROS production and that E6 has the ability to counteract the effects of E6*I. This asks the question of how E6*I can be considered separately of E6 in the natural history of HPV16 infection. More... »

PAGES

5938

References to SciGraph publications

  • 2013-04. Regulation of human papillomavirus gene expression by splicing and polyadenylation in NATURE REVIEWS MICROBIOLOGY
  • 2005-07. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability in NATURE
  • 2010-12. The HPV-16 E7 oncoprotein is expressed mainly from the unspliced E6/E7 transcript in cervical carcinoma C33-A cells in ARCHIVES OF VIROLOGY
  • 2017-04. Implications of oxidative stress on viral pathogenesis in ARCHIVES OF VIROLOGY
  • 2008-07. Mapping and quantifying mammalian transcriptomes by RNA-Seq in NATURE METHODS
  • 2014-12. Effect of hypoxia on the expression of αB-crystallin in head and neck squamous cell carcinoma in BMC CANCER
  • 2013-12. Oxidative stress and hepatitis C virus in VIROLOGY JOURNAL
  • 2010-08. Human papillomavirus oncoproteins: pathways to transformation in NATURE REVIEWS CANCER
  • 2011-01. Small RNA sorting: matchmaking for Argonautes in NATURE REVIEWS GENETICS
  • 2011-12. Identification and validation of genes involved in cervical tumourigenesis in BMC CANCER
  • 2004-05. Regulation of alternative RNA splicing by exon definition and exon sequences in viral and mammalian gene expression in JOURNAL OF BIOMEDICAL SCIENCE
  • 1997-07. Alternatively spliced HPV-18 E6* protein inhibits E6 mediated degradation of p53 and suppresses transformed cell growth in ONCOGENE
  • 2009-02. A single-codon mutation converts HPV16 E6 oncoprotein into a potential tumor suppressor, which induces p53-dependent senescence of HPV-positive HeLa cervical cancer cells in ONCOGENE
  • 2015-12. The transcription map of HPV11 in U2OS cells adequately reflects the initial and stable replication phases of the viral genome in VIROLOGY JOURNAL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-019-42393-6

    DOI

    http://dx.doi.org/10.1038/s41598-019-42393-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113378330

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30976051


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Bourgogne Franche-Comt\u00e9", 
              "id": "https://www.grid.ac/institutes/grid.493090.7", 
              "name": [
                "EA3181, LabEx LipSTIC ANR-11-LABX-0021, UFR Sant\u00e9, 19 rue Ambroise Par\u00e9, Besan\u00e7on, France.", 
                "Universit\u00e9 Bourgogne Franche Comt\u00e9, Besan\u00e7on, France."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Paget-Bailly", 
            "givenName": "Philippe", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Bourgogne Franche-Comt\u00e9", 
              "id": "https://www.grid.ac/institutes/grid.493090.7", 
              "name": [
                "EA3181, LabEx LipSTIC ANR-11-LABX-0021, UFR Sant\u00e9, 19 rue Ambroise Par\u00e9, Besan\u00e7on, France.", 
                "Universit\u00e9 Bourgogne Franche Comt\u00e9, Besan\u00e7on, France."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Meznad", 
            "givenName": "Koceila", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Li\u00e8ge", 
              "id": "https://www.grid.ac/institutes/grid.4861.b", 
              "name": [
                "Laboratory of Experimental Pathology, GIGA-Cancer, University of Liege, Liege, Belgium."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bruy\u00e8re", 
            "givenName": "Diane", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Bourgogne Franche-Comt\u00e9", 
              "id": "https://www.grid.ac/institutes/grid.493090.7", 
              "name": [
                "EA3181, LabEx LipSTIC ANR-11-LABX-0021, UFR Sant\u00e9, 19 rue Ambroise Par\u00e9, Besan\u00e7on, France.", 
                "Universit\u00e9 Bourgogne Franche Comt\u00e9, Besan\u00e7on, France."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Perrard", 
            "givenName": "J\u00e9r\u00f4me", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Li\u00e8ge", 
              "id": "https://www.grid.ac/institutes/grid.4861.b", 
              "name": [
                "Laboratory of Experimental Pathology, GIGA-Cancer, University of Liege, Liege, Belgium."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Herfs", 
            "givenName": "Michael", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Strasbourg", 
              "id": "https://www.grid.ac/institutes/grid.11843.3f", 
              "name": [
                "Universit\u00e9 de Strasbourg, Inserm, UMR_S1113, Centre de lutte contre le cancer Paul STRAUSS, Strasbourg, France."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Jung", 
            "givenName": "Alain C", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centre Hospitalier Universitaire de Grenoble", 
              "id": "https://www.grid.ac/institutes/grid.410529.b", 
              "name": [
                "EA3181, LabEx LipSTIC ANR-11-LABX-0021, UFR Sant\u00e9, 19 rue Ambroise Par\u00e9, Besan\u00e7on, France.", 
                "Universit\u00e9 Bourgogne Franche Comt\u00e9, Besan\u00e7on, France.", 
                "Centre Hospitalier R\u00e9gional Universitaire, CNR HPV, 3 Bvd Alexandre Fleming, Besan\u00e7on, France."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mougin", 
            "givenName": "Christiane", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Centre Hospitalier Universitaire de Grenoble", 
              "id": "https://www.grid.ac/institutes/grid.410529.b", 
              "name": [
                "EA3181, LabEx LipSTIC ANR-11-LABX-0021, UFR Sant\u00e9, 19 rue Ambroise Par\u00e9, Besan\u00e7on, France.", 
                "Universit\u00e9 Bourgogne Franche Comt\u00e9, Besan\u00e7on, France.", 
                "Centre Hospitalier R\u00e9gional Universitaire, CNR HPV, 3 Bvd Alexandre Fleming, Besan\u00e7on, France."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pr\u00e9tet", 
            "givenName": "Jean-Luc", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Bourgogne Franche-Comt\u00e9", 
              "id": "https://www.grid.ac/institutes/grid.493090.7", 
              "name": [
                "EA3181, LabEx LipSTIC ANR-11-LABX-0021, UFR Sant\u00e9, 19 rue Ambroise Par\u00e9, Besan\u00e7on, France. aurelie.baguet@univ-fcomte.fr.", 
                "Universit\u00e9 Bourgogne Franche Comt\u00e9, Besan\u00e7on, France. aurelie.baguet@univ-fcomte.fr."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Baguet", 
            "givenName": "Aur\u00e9lie", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1074/jbc.274.35.24819", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001377913"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/27.1.29", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001521131"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-14-252", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003537689", 
              "https://doi.org/10.1186/1471-2407-14-252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.80.9.4249-4263.2006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003735893"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00705-016-3187-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004544782", 
              "https://doi.org/10.1007/s00705-016-3187-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00705-016-3187-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004544782", 
              "https://doi.org/10.1007/s00705-016-3187-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/onc.2008.422", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005135875", 
              "https://doi.org/10.1038/onc.2008.422"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2303.2007.00481.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005917972"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.freeradbiomed.2007.01.035", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005974705"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2011-10-385658", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009662139"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1509322112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011374843"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btp120", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012425816"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkw937", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015021383"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.01365-08", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015450654"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3109/09553002.2010.484477", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015996969"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.freeradbiomed.2010.09.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017850976"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/09031936.00029109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017950205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1183/09031936.00029109", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017950205"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/fvl.10.73", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018615252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/cas.12809", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019129351"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.0906-6705.2005.00296.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020059384"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.0906-6705.2005.00296.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020059384"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.virol.2013.12.011", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020109637"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.90.9.3988", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021004257"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jmv.21496", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023311302"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jmv.21496", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023311302"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrmicro2984", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024601608", 
              "https://doi.org/10.1038/nrmicro2984"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/bgu046", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024748248"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.00539-09", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025149771"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1017213108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025192373"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2886", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026952779", 
              "https://doi.org/10.1038/nrc2886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc2886", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026952779", 
              "https://doi.org/10.1038/nrc2886"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1201202", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028126531", 
              "https://doi.org/10.1038/sj.onc.1201202"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1201202", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028126531", 
              "https://doi.org/10.1038/sj.onc.1201202"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2916", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029813835", 
              "https://doi.org/10.1038/nrg2916"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrg2916", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029813835", 
              "https://doi.org/10.1038/nrg2916"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1155/2014/467452", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030769278"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.121494298", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032824350"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkw1138", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033346264"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.virol.2014.05.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034478730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.virol.2014.05.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034478730"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00705-010-0787-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035435046", 
              "https://doi.org/10.1007/s00705-010-0787-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00705-010-0787-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035435046", 
              "https://doi.org/10.1007/s00705-010-0787-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/path.4358", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035876432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.03355-13", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036784713"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hep.20719", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037557618"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hep.20719", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037557618"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0092-8674(90)90409-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040120250"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.02545-06", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040508177"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajpheart.00716.2003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040956568"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02254432", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040983908", 
              "https://doi.org/10.1007/bf02254432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf02254432", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040983908", 
              "https://doi.org/10.1007/bf02254432"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03688", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041676119", 
              "https://doi.org/10.1038/nature03688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03688", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041676119", 
              "https://doi.org/10.1038/nature03688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature03688", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041676119", 
              "https://doi.org/10.1038/nature03688"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.virol.2008.10.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043378517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2015.06.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043526178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.celrep.2015.06.024", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043526178"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1743-422x-10-251", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043690779", 
              "https://doi.org/10.1186/1743-422x-10-251"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-11-80", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044198217", 
              "https://doi.org/10.1186/1471-2407-11-80"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nmeth.1226", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045381177", 
              "https://doi.org/10.1038/nmeth.1226"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12985-015-0292-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046030204", 
              "https://doi.org/10.1186/s12985-015-0292-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12985-015-0292-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046030204", 
              "https://doi.org/10.1186/s12985-015-0292-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-06-3619", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046192964"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.24911", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046838016"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.74.16.7284-7297.2000", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048292810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0115954", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048493199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ol.2014.2698", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051723249"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3892/ol.2014.2698", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051723249"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1055-9965.epi-14-1353", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053518590"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/15384047.2015.1108489", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058401614"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/15384101.2016.1259039", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1058402453"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1099/0022-1317-71-5-1243", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060357563"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1099/vir.0.038265-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060398936"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.2157286", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062524630"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.2537532", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062542761"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077196679", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077392514", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078998064", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079271720", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082473902", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.30716", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084509414"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.virol.2017.04.022", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085119446"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/v9090245", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1091387683"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.01001-17", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092172980"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1128/jvi.01001-17", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092172980"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jdiacomp.2017.11.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099607700"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jdiacomp.2017.11.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099607700"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jdiacomp.2017.11.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099607700"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jdiacomp.2017.11.012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099607700"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.7150/ijbs.21547", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099791517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3390/ijms19020465", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100837153"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-12", 
        "datePublishedReg": "2019-12-01", 
        "description": "High-risk Human Papillomavirus infections are responsible for anogenital and oropharyngeal cancers. Alternative splicing is an important mechanism controlling HPV16 gene expression. Modulation in the splice pattern leads to polycistronic HPV16 early transcripts encoding a full length E6 oncoprotein or truncated E6 proteins, commonly named E6*. Spliced E6*I transcripts are the most abundant RNAs produced in HPV-related cancers. To date, the biological function of the E6*I isoform remains controversial. In this study, we identified, by RNA sequencing, cellular targets deregulated by E6*I, among which genes related to ROS metabolism. Concomitantly, E6*I-overexpressing cells display high levels of ROS. However, co-overexpression of both E6 and E6*I has no effect on ROS production. In HPV16-infected cells expressing different E6/E6*I levels, we show that the newly identified targets CCL2 and RAC2 are increased by E6*I but decreased by E6 expression, suggesting that E6 abrogates the effect of E6*I. Taken together, these data support the idea that E6*I acts independently of E6 to increase ROS production and that E6 has the ability to counteract the effects of E6*I. This asks the question of how E6*I can be considered separately of E6 in the natural history of HPV16 infection.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41598-019-42393-6", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "name": "Comparative RNA sequencing reveals that HPV16 E6 abrogates the effect of E6*I on ROS metabolism.", 
        "pagination": "5938", 
        "productId": [
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-019-42393-6"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1113378330"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101563288"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30976051"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-019-42393-6", 
          "https://app.dimensions.ai/details/publication/pub.1113378330"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-16T06:25", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000377_0000000377/records_106837_00000003.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/articles/s41598-019-42393-6"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-42393-6'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-42393-6'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-42393-6'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-42393-6'


     

    This table displays all metadata directly associated to this object as RDF triples.

    350 TRIPLES      21 PREDICATES      100 URIs      20 LITERALS      8 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-019-42393-6 schema:about anzsrc-for:06
    2 anzsrc-for:0604
    3 schema:author N17711729345e4058812e36e28aff1928
    4 schema:citation sg:pub.10.1007/bf02254432
    5 sg:pub.10.1007/s00705-010-0787-9
    6 sg:pub.10.1007/s00705-016-3187-y
    7 sg:pub.10.1038/nature03688
    8 sg:pub.10.1038/nmeth.1226
    9 sg:pub.10.1038/nrc2886
    10 sg:pub.10.1038/nrg2916
    11 sg:pub.10.1038/nrmicro2984
    12 sg:pub.10.1038/onc.2008.422
    13 sg:pub.10.1038/sj.onc.1201202
    14 sg:pub.10.1186/1471-2407-11-80
    15 sg:pub.10.1186/1471-2407-14-252
    16 sg:pub.10.1186/1743-422x-10-251
    17 sg:pub.10.1186/s12985-015-0292-6
    18 https://app.dimensions.ai/details/publication/pub.1077196679
    19 https://app.dimensions.ai/details/publication/pub.1077392514
    20 https://app.dimensions.ai/details/publication/pub.1078998064
    21 https://app.dimensions.ai/details/publication/pub.1079271720
    22 https://app.dimensions.ai/details/publication/pub.1082473902
    23 https://doi.org/10.1002/hep.20719
    24 https://doi.org/10.1002/ijc.24911
    25 https://doi.org/10.1002/ijc.30716
    26 https://doi.org/10.1002/jmv.21496
    27 https://doi.org/10.1002/path.4358
    28 https://doi.org/10.1016/0092-8674(90)90409-8
    29 https://doi.org/10.1016/j.celrep.2015.06.024
    30 https://doi.org/10.1016/j.freeradbiomed.2007.01.035
    31 https://doi.org/10.1016/j.freeradbiomed.2010.09.006
    32 https://doi.org/10.1016/j.jdiacomp.2017.11.012
    33 https://doi.org/10.1016/j.virol.2008.10.006
    34 https://doi.org/10.1016/j.virol.2013.12.011
    35 https://doi.org/10.1016/j.virol.2014.05.026
    36 https://doi.org/10.1016/j.virol.2017.04.022
    37 https://doi.org/10.1073/pnas.1017213108
    38 https://doi.org/10.1073/pnas.121494298
    39 https://doi.org/10.1073/pnas.1509322112
    40 https://doi.org/10.1073/pnas.90.9.3988
    41 https://doi.org/10.1074/jbc.274.35.24819
    42 https://doi.org/10.1080/15384047.2015.1108489
    43 https://doi.org/10.1080/15384101.2016.1259039
    44 https://doi.org/10.1093/bioinformatics/btp120
    45 https://doi.org/10.1093/carcin/bgu046
    46 https://doi.org/10.1093/nar/27.1.29
    47 https://doi.org/10.1093/nar/gkw1138
    48 https://doi.org/10.1093/nar/gkw937
    49 https://doi.org/10.1099/0022-1317-71-5-1243
    50 https://doi.org/10.1099/vir.0.038265-0
    51 https://doi.org/10.1111/cas.12809
    52 https://doi.org/10.1111/j.0906-6705.2005.00296.x
    53 https://doi.org/10.1111/j.1365-2303.2007.00481.x
    54 https://doi.org/10.1126/science.2157286
    55 https://doi.org/10.1126/science.2537532
    56 https://doi.org/10.1128/jvi.00539-09
    57 https://doi.org/10.1128/jvi.01001-17
    58 https://doi.org/10.1128/jvi.01365-08
    59 https://doi.org/10.1128/jvi.02545-06
    60 https://doi.org/10.1128/jvi.03355-13
    61 https://doi.org/10.1128/jvi.74.16.7284-7297.2000
    62 https://doi.org/10.1128/jvi.80.9.4249-4263.2006
    63 https://doi.org/10.1152/ajpheart.00716.2003
    64 https://doi.org/10.1155/2014/467452
    65 https://doi.org/10.1158/0008-5472.can-06-3619
    66 https://doi.org/10.1158/1055-9965.epi-14-1353
    67 https://doi.org/10.1182/blood-2011-10-385658
    68 https://doi.org/10.1183/09031936.00029109
    69 https://doi.org/10.1371/journal.pone.0115954
    70 https://doi.org/10.2217/fvl.10.73
    71 https://doi.org/10.3109/09553002.2010.484477
    72 https://doi.org/10.3390/ijms19020465
    73 https://doi.org/10.3390/v9090245
    74 https://doi.org/10.3892/ol.2014.2698
    75 https://doi.org/10.7150/ijbs.21547
    76 schema:datePublished 2019-12
    77 schema:datePublishedReg 2019-12-01
    78 schema:description High-risk Human Papillomavirus infections are responsible for anogenital and oropharyngeal cancers. Alternative splicing is an important mechanism controlling HPV16 gene expression. Modulation in the splice pattern leads to polycistronic HPV16 early transcripts encoding a full length E6 oncoprotein or truncated E6 proteins, commonly named E6*. Spliced E6*I transcripts are the most abundant RNAs produced in HPV-related cancers. To date, the biological function of the E6*I isoform remains controversial. In this study, we identified, by RNA sequencing, cellular targets deregulated by E6*I, among which genes related to ROS metabolism. Concomitantly, E6*I-overexpressing cells display high levels of ROS. However, co-overexpression of both E6 and E6*I has no effect on ROS production. In HPV16-infected cells expressing different E6/E6*I levels, we show that the newly identified targets CCL2 and RAC2 are increased by E6*I but decreased by E6 expression, suggesting that E6 abrogates the effect of E6*I. Taken together, these data support the idea that E6*I acts independently of E6 to increase ROS production and that E6 has the ability to counteract the effects of E6*I. This asks the question of how E6*I can be considered separately of E6 in the natural history of HPV16 infection.
    79 schema:genre research_article
    80 schema:inLanguage en
    81 schema:isAccessibleForFree true
    82 schema:isPartOf N7422fa76f2844d509cc8e08e0748b864
    83 Nc320c00680ac4a1bbd68cde826e63854
    84 sg:journal.1045337
    85 schema:name Comparative RNA sequencing reveals that HPV16 E6 abrogates the effect of E6*I on ROS metabolism.
    86 schema:pagination 5938
    87 schema:productId N1cd02a24baca465991bae3a77395d3dd
    88 N4a9bf2e59f704cd58ded7e675903efaa
    89 N89ffa0a5be0843c986ada6367855e6ed
    90 Ncf2434a156e0416c93c1a3bf530db868
    91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113378330
    92 https://doi.org/10.1038/s41598-019-42393-6
    93 schema:sdDatePublished 2019-04-16T06:25
    94 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    95 schema:sdPublisher N6c021f1765bc47f4a62b9512208f0fc5
    96 schema:url http://www.nature.com/articles/s41598-019-42393-6
    97 sgo:license sg:explorer/license/
    98 sgo:sdDataset articles
    99 rdf:type schema:ScholarlyArticle
    100 N17711729345e4058812e36e28aff1928 rdf:first Nabbe0b2cc4954d34be7871bedfa28c49
    101 rdf:rest N9662375d86e9402aa21720e500d56a05
    102 N1cd02a24baca465991bae3a77395d3dd schema:name dimensions_id
    103 schema:value pub.1113378330
    104 rdf:type schema:PropertyValue
    105 N274b70f8217a471892cad2437f07b352 rdf:first Na42076bde9304603909c783ddc6d14c2
    106 rdf:rest N4ab0efab1dab4102a918464fad4fdd48
    107 N3726e50940b4490193981a3b93901f11 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
    108 schema:familyName Herfs
    109 schema:givenName Michael
    110 rdf:type schema:Person
    111 N4a9bf2e59f704cd58ded7e675903efaa schema:name pubmed_id
    112 schema:value 30976051
    113 rdf:type schema:PropertyValue
    114 N4aabb3b7004c4dffb4a4156eb0a74456 rdf:first N8446de4a85ff4a18ae555348566b4a7b
    115 rdf:rest Nd1cb001522524a1ab327df87f9ba9033
    116 N4ab0efab1dab4102a918464fad4fdd48 rdf:first N3726e50940b4490193981a3b93901f11
    117 rdf:rest Nf93f9a1a3c1a41c9996b02f9244eeb2c
    118 N5267d3a540084f91ab3f4e16bb888179 schema:affiliation https://www.grid.ac/institutes/grid.493090.7
    119 schema:familyName Meznad
    120 schema:givenName Koceila
    121 rdf:type schema:Person
    122 N6c021f1765bc47f4a62b9512208f0fc5 schema:name Springer Nature - SN SciGraph project
    123 rdf:type schema:Organization
    124 N7422fa76f2844d509cc8e08e0748b864 schema:volumeNumber 9
    125 rdf:type schema:PublicationVolume
    126 N795d3cd1dbce49bbb4c190eac8afa6cf rdf:first Na512d363f425404695a6e9ace9ca12e2
    127 rdf:rest N274b70f8217a471892cad2437f07b352
    128 N8446de4a85ff4a18ae555348566b4a7b schema:affiliation https://www.grid.ac/institutes/grid.410529.b
    129 schema:familyName Mougin
    130 schema:givenName Christiane
    131 rdf:type schema:Person
    132 N89ffa0a5be0843c986ada6367855e6ed schema:name doi
    133 schema:value 10.1038/s41598-019-42393-6
    134 rdf:type schema:PropertyValue
    135 N9662375d86e9402aa21720e500d56a05 rdf:first N5267d3a540084f91ab3f4e16bb888179
    136 rdf:rest N795d3cd1dbce49bbb4c190eac8afa6cf
    137 Na42076bde9304603909c783ddc6d14c2 schema:affiliation https://www.grid.ac/institutes/grid.493090.7
    138 schema:familyName Perrard
    139 schema:givenName Jérôme
    140 rdf:type schema:Person
    141 Na512d363f425404695a6e9ace9ca12e2 schema:affiliation https://www.grid.ac/institutes/grid.4861.b
    142 schema:familyName Bruyère
    143 schema:givenName Diane
    144 rdf:type schema:Person
    145 Nabbe0b2cc4954d34be7871bedfa28c49 schema:affiliation https://www.grid.ac/institutes/grid.493090.7
    146 schema:familyName Paget-Bailly
    147 schema:givenName Philippe
    148 rdf:type schema:Person
    149 Nbd28dd8de4ca4f509e708f7b1f601806 rdf:first Nf342c168127c4cd0a6d0c909a85eab80
    150 rdf:rest rdf:nil
    151 Nc320c00680ac4a1bbd68cde826e63854 schema:issueNumber 1
    152 rdf:type schema:PublicationIssue
    153 Ncf2434a156e0416c93c1a3bf530db868 schema:name nlm_unique_id
    154 schema:value 101563288
    155 rdf:type schema:PropertyValue
    156 Nd1cb001522524a1ab327df87f9ba9033 rdf:first Ndceb946777e44fd09a56a6bb35bf6de2
    157 rdf:rest Nbd28dd8de4ca4f509e708f7b1f601806
    158 Ndceb946777e44fd09a56a6bb35bf6de2 schema:affiliation https://www.grid.ac/institutes/grid.410529.b
    159 schema:familyName Prétet
    160 schema:givenName Jean-Luc
    161 rdf:type schema:Person
    162 Nf342c168127c4cd0a6d0c909a85eab80 schema:affiliation https://www.grid.ac/institutes/grid.493090.7
    163 schema:familyName Baguet
    164 schema:givenName Aurélie
    165 rdf:type schema:Person
    166 Nf6b5944d4e4d4533a56b507c82bd93eb schema:affiliation https://www.grid.ac/institutes/grid.11843.3f
    167 schema:familyName Jung
    168 schema:givenName Alain C
    169 rdf:type schema:Person
    170 Nf93f9a1a3c1a41c9996b02f9244eeb2c rdf:first Nf6b5944d4e4d4533a56b507c82bd93eb
    171 rdf:rest N4aabb3b7004c4dffb4a4156eb0a74456
    172 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    173 schema:name Biological Sciences
    174 rdf:type schema:DefinedTerm
    175 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    176 schema:name Genetics
    177 rdf:type schema:DefinedTerm
    178 sg:journal.1045337 schema:issn 2045-2322
    179 schema:name Scientific Reports
    180 rdf:type schema:Periodical
    181 sg:pub.10.1007/bf02254432 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040983908
    182 https://doi.org/10.1007/bf02254432
    183 rdf:type schema:CreativeWork
    184 sg:pub.10.1007/s00705-010-0787-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035435046
    185 https://doi.org/10.1007/s00705-010-0787-9
    186 rdf:type schema:CreativeWork
    187 sg:pub.10.1007/s00705-016-3187-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1004544782
    188 https://doi.org/10.1007/s00705-016-3187-y
    189 rdf:type schema:CreativeWork
    190 sg:pub.10.1038/nature03688 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041676119
    191 https://doi.org/10.1038/nature03688
    192 rdf:type schema:CreativeWork
    193 sg:pub.10.1038/nmeth.1226 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045381177
    194 https://doi.org/10.1038/nmeth.1226
    195 rdf:type schema:CreativeWork
    196 sg:pub.10.1038/nrc2886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026952779
    197 https://doi.org/10.1038/nrc2886
    198 rdf:type schema:CreativeWork
    199 sg:pub.10.1038/nrg2916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029813835
    200 https://doi.org/10.1038/nrg2916
    201 rdf:type schema:CreativeWork
    202 sg:pub.10.1038/nrmicro2984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024601608
    203 https://doi.org/10.1038/nrmicro2984
    204 rdf:type schema:CreativeWork
    205 sg:pub.10.1038/onc.2008.422 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005135875
    206 https://doi.org/10.1038/onc.2008.422
    207 rdf:type schema:CreativeWork
    208 sg:pub.10.1038/sj.onc.1201202 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028126531
    209 https://doi.org/10.1038/sj.onc.1201202
    210 rdf:type schema:CreativeWork
    211 sg:pub.10.1186/1471-2407-11-80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044198217
    212 https://doi.org/10.1186/1471-2407-11-80
    213 rdf:type schema:CreativeWork
    214 sg:pub.10.1186/1471-2407-14-252 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003537689
    215 https://doi.org/10.1186/1471-2407-14-252
    216 rdf:type schema:CreativeWork
    217 sg:pub.10.1186/1743-422x-10-251 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043690779
    218 https://doi.org/10.1186/1743-422x-10-251
    219 rdf:type schema:CreativeWork
    220 sg:pub.10.1186/s12985-015-0292-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046030204
    221 https://doi.org/10.1186/s12985-015-0292-6
    222 rdf:type schema:CreativeWork
    223 https://app.dimensions.ai/details/publication/pub.1077196679 schema:CreativeWork
    224 https://app.dimensions.ai/details/publication/pub.1077392514 schema:CreativeWork
    225 https://app.dimensions.ai/details/publication/pub.1078998064 schema:CreativeWork
    226 https://app.dimensions.ai/details/publication/pub.1079271720 schema:CreativeWork
    227 https://app.dimensions.ai/details/publication/pub.1082473902 schema:CreativeWork
    228 https://doi.org/10.1002/hep.20719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037557618
    229 rdf:type schema:CreativeWork
    230 https://doi.org/10.1002/ijc.24911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046838016
    231 rdf:type schema:CreativeWork
    232 https://doi.org/10.1002/ijc.30716 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084509414
    233 rdf:type schema:CreativeWork
    234 https://doi.org/10.1002/jmv.21496 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023311302
    235 rdf:type schema:CreativeWork
    236 https://doi.org/10.1002/path.4358 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035876432
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1016/0092-8674(90)90409-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040120250
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1016/j.celrep.2015.06.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043526178
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1016/j.freeradbiomed.2007.01.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005974705
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1016/j.freeradbiomed.2010.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017850976
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1016/j.jdiacomp.2017.11.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099607700
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1016/j.virol.2008.10.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043378517
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1016/j.virol.2013.12.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020109637
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1016/j.virol.2014.05.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034478730
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1016/j.virol.2017.04.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085119446
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1073/pnas.1017213108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025192373
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1073/pnas.121494298 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032824350
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1073/pnas.1509322112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011374843
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1073/pnas.90.9.3988 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021004257
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1074/jbc.274.35.24819 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001377913
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1080/15384047.2015.1108489 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058401614
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1080/15384101.2016.1259039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058402453
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1093/bioinformatics/btp120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012425816
    271 rdf:type schema:CreativeWork
    272 https://doi.org/10.1093/carcin/bgu046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024748248
    273 rdf:type schema:CreativeWork
    274 https://doi.org/10.1093/nar/27.1.29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001521131
    275 rdf:type schema:CreativeWork
    276 https://doi.org/10.1093/nar/gkw1138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033346264
    277 rdf:type schema:CreativeWork
    278 https://doi.org/10.1093/nar/gkw937 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015021383
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1099/0022-1317-71-5-1243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060357563
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1099/vir.0.038265-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060398936
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1111/cas.12809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019129351
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1111/j.0906-6705.2005.00296.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020059384
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1111/j.1365-2303.2007.00481.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005917972
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1126/science.2157286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062524630
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1126/science.2537532 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062542761
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1128/jvi.00539-09 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025149771
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1128/jvi.01001-17 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092172980
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1128/jvi.01365-08 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015450654
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1128/jvi.02545-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040508177
    301 rdf:type schema:CreativeWork
    302 https://doi.org/10.1128/jvi.03355-13 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036784713
    303 rdf:type schema:CreativeWork
    304 https://doi.org/10.1128/jvi.74.16.7284-7297.2000 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048292810
    305 rdf:type schema:CreativeWork
    306 https://doi.org/10.1128/jvi.80.9.4249-4263.2006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003735893
    307 rdf:type schema:CreativeWork
    308 https://doi.org/10.1152/ajpheart.00716.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040956568
    309 rdf:type schema:CreativeWork
    310 https://doi.org/10.1155/2014/467452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030769278
    311 rdf:type schema:CreativeWork
    312 https://doi.org/10.1158/0008-5472.can-06-3619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046192964
    313 rdf:type schema:CreativeWork
    314 https://doi.org/10.1158/1055-9965.epi-14-1353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053518590
    315 rdf:type schema:CreativeWork
    316 https://doi.org/10.1182/blood-2011-10-385658 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009662139
    317 rdf:type schema:CreativeWork
    318 https://doi.org/10.1183/09031936.00029109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017950205
    319 rdf:type schema:CreativeWork
    320 https://doi.org/10.1371/journal.pone.0115954 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048493199
    321 rdf:type schema:CreativeWork
    322 https://doi.org/10.2217/fvl.10.73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018615252
    323 rdf:type schema:CreativeWork
    324 https://doi.org/10.3109/09553002.2010.484477 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015996969
    325 rdf:type schema:CreativeWork
    326 https://doi.org/10.3390/ijms19020465 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100837153
    327 rdf:type schema:CreativeWork
    328 https://doi.org/10.3390/v9090245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091387683
    329 rdf:type schema:CreativeWork
    330 https://doi.org/10.3892/ol.2014.2698 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051723249
    331 rdf:type schema:CreativeWork
    332 https://doi.org/10.7150/ijbs.21547 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099791517
    333 rdf:type schema:CreativeWork
    334 https://www.grid.ac/institutes/grid.11843.3f schema:alternateName University of Strasbourg
    335 schema:name Université de Strasbourg, Inserm, UMR_S1113, Centre de lutte contre le cancer Paul STRAUSS, Strasbourg, France.
    336 rdf:type schema:Organization
    337 https://www.grid.ac/institutes/grid.410529.b schema:alternateName Centre Hospitalier Universitaire de Grenoble
    338 schema:name Centre Hospitalier Régional Universitaire, CNR HPV, 3 Bvd Alexandre Fleming, Besançon, France.
    339 EA3181, LabEx LipSTIC ANR-11-LABX-0021, UFR Santé, 19 rue Ambroise Paré, Besançon, France.
    340 Université Bourgogne Franche Comté, Besançon, France.
    341 rdf:type schema:Organization
    342 https://www.grid.ac/institutes/grid.4861.b schema:alternateName University of Liège
    343 schema:name Laboratory of Experimental Pathology, GIGA-Cancer, University of Liege, Liege, Belgium.
    344 rdf:type schema:Organization
    345 https://www.grid.ac/institutes/grid.493090.7 schema:alternateName Université Bourgogne Franche-Comté
    346 schema:name EA3181, LabEx LipSTIC ANR-11-LABX-0021, UFR Santé, 19 rue Ambroise Paré, Besançon, France.
    347 EA3181, LabEx LipSTIC ANR-11-LABX-0021, UFR Santé, 19 rue Ambroise Paré, Besançon, France. aurelie.baguet@univ-fcomte.fr.
    348 Université Bourgogne Franche Comté, Besançon, France.
    349 Université Bourgogne Franche Comté, Besançon, France. aurelie.baguet@univ-fcomte.fr.
    350 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...