Helicobacter pylori Vacuolating Cytotoxin A Causes Anorexia and Anxiety via Hypothalamic Urocortin 1 in Mice. View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Hajime Suzuki, Koji Ataka, Akihiro Asakawa, Kai-Chun Cheng, Miharu Ushikai, Haruki Iwai, Takakazu Yagi, Takeshi Arai, Kinnosuke Yahiro, Katsuhiro Yamamoto, Yoshito Yokoyama, Masayasu Kojima, Toshihiko Yada, Toshiya Hirayama, Norifumi Nakamura, Akio Inui

ABSTRACT

Helicobacter pylori (Hp) infection is related to the pathogenesis of chronic gastric disorders and extragastric diseases. Here, we examined the anorexigenic and anxiogenic effects of Hp vacuolating cytotoxin A (VacA) through activation of hypothalamic urocortin1 (Ucn1). VacA was detected in the hypothalamus after peripheral administration and increased Ucn1 mRNA expression and c-Fos-positive cells in the hypothalamus but not in the nucleus tractus solitarius. c-Fos and Ucn1-double positive cells were detected. CRF1 and CRF2 receptor antagonists suppressed VacA-induced anxiety and anorexia, respectively. VacA activated single paraventricular nucleus neurons and A7r5 cells; this activation was inhibited by phospholipase C (PLC) and protein kinase C (PKC) inhibitors. VacA causes anorexia and anxiety through the intracellular PLC-PKC pathway, migrates across the blood-brain barrier, and activates the Ucn1-CRF receptor axis. More... »

PAGES

6011

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-42163-4

DOI

http://dx.doi.org/10.1038/s41598-019-42163-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113380263

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30979915


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Neurosciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Kagoshima University", 
          "id": "https://www.grid.ac/institutes/grid.258333.c", 
          "name": [
            "Department of Oral and Maxillofacial Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. hajime@dent.kagoshima-u.ac.jp.", 
            "Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. hajime@dent.kagoshima-u.ac.jp."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suzuki", 
        "givenName": "Hajime", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kagoshima University", 
          "id": "https://www.grid.ac/institutes/grid.258333.c", 
          "name": [
            "Department of Pharmacological Sciences of Herbal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ataka", 
        "givenName": "Koji", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kagoshima University", 
          "id": "https://www.grid.ac/institutes/grid.258333.c", 
          "name": [
            "Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Asakawa", 
        "givenName": "Akihiro", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kagoshima University", 
          "id": "https://www.grid.ac/institutes/grid.258333.c", 
          "name": [
            "Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cheng", 
        "givenName": "Kai-Chun", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kagoshima University", 
          "id": "https://www.grid.ac/institutes/grid.258333.c", 
          "name": [
            "Department of Hygiene and Health Promotion Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ushikai", 
        "givenName": "Miharu", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kagoshima University", 
          "id": "https://www.grid.ac/institutes/grid.258333.c", 
          "name": [
            "Department of Oral Anatomy and Cell Biology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iwai", 
        "givenName": "Haruki", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kagoshima University", 
          "id": "https://www.grid.ac/institutes/grid.258333.c", 
          "name": [
            "Department of Orthodontics and Dentofacial Orthopedics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yagi", 
        "givenName": "Takakazu", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jichi Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Department of Physiology, Jichi Medical University School of Medicine, Tochigi, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Arai", 
        "givenName": "Takeshi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chiba University", 
          "id": "https://www.grid.ac/institutes/grid.136304.3", 
          "name": [
            "Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, Chiba, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yahiro", 
        "givenName": "Kinnosuke", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Quality Control Department, Yoshitomi Plant, Mitsubishi Tanabe Pharma Factory Ltd., Fukuoka, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamamoto", 
        "givenName": "Katsuhiro", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mitsubishi Chemical Holdings (Japan)", 
          "id": "https://www.grid.ac/institutes/grid.418306.8", 
          "name": [
            "Discovery Technology Laboratories, Sohyaku. Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Saitama, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yokoyama", 
        "givenName": "Yoshito", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kurume University", 
          "id": "https://www.grid.ac/institutes/grid.410781.b", 
          "name": [
            "Molecular Genetics, Institute of Life Science, Kurume University, Fukuoka, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kojima", 
        "givenName": "Masayasu", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Jichi Medical University", 
          "id": "https://www.grid.ac/institutes/grid.410804.9", 
          "name": [
            "Department of Physiology, Jichi Medical University School of Medicine, Tochigi, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yada", 
        "givenName": "Toshihiko", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nagasaki University", 
          "id": "https://www.grid.ac/institutes/grid.174567.6", 
          "name": [
            "Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hirayama", 
        "givenName": "Toshiya", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kagoshima University", 
          "id": "https://www.grid.ac/institutes/grid.258333.c", 
          "name": [
            "Department of Oral and Maxillofacial Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakamura", 
        "givenName": "Norifumi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kagoshima University", 
          "id": "https://www.grid.ac/institutes/grid.258333.c", 
          "name": [
            "Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Inui", 
        "givenName": "Akio", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.psyneuen.2010.02.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000044101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.psyneuen.2010.02.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000044101"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.270.41.23937", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001874674"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/hel.12159", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003395218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.micpath.2016.08.030", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003724182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.physbeh.2015.04.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004557631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1440-1746.2008.05415.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007563814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2007.03.048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008462374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(99)70491-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008559354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/jgh.13256", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009227364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0306-4522(98)00732-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010305894"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/meg.0000000000000774", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010617385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/meg.0000000000000774", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010617385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/meg.0000000000000774", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010617385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/mpat.1998.0256", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012040060"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2009.10.069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012281201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2007.44", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012369107", 
          "https://doi.org/10.1038/nprot.2007.44"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/toxins8050152", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012612093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2005.11.057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013417666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/j.1572-0241.2008.01980.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013854535", 
          "https://doi.org/10.1111/j.1572-0241.2008.01980.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/apt.12790", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015157638"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrmicro1095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015362103", 
          "https://doi.org/10.1038/nrmicro1095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrmicro1095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015362103", 
          "https://doi.org/10.1038/nrmicro1095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrmicro1095", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015362103", 
          "https://doi.org/10.1038/nrmicro1095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01211183", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017159867", 
          "https://doi.org/10.1007/bf01211183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01211183", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017159867", 
          "https://doi.org/10.1007/bf01211183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1515/bmc.2011.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017588052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2036.2003.01669.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020407700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.peptides.2011.05.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020581987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-7967(93)90028-s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022044364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-7967(93)90028-s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022044364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0304-3940(99)00185-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023488330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-230x-11-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024063353", 
          "https://doi.org/10.1186/1471-230x-11-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.plipres.2010.06.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025395271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m308898200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030346924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yhbeh.2011.06.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031294228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2016.02.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036055701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/obr.12320", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042363216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.peptides.2004.05.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043177549"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1997.7345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044905005"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2036.2011.04610.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045107670"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(98)70540-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045447648"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0016-5085(98)70540-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045447648"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05562", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047846730", 
          "https://doi.org/10.1038/nature05562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2004.12.047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048222004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep08731", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048953411", 
          "https://doi.org/10.1038/srep08731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/2277-9175.190938", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049669705"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.regpep.2007.09.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049672548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pbio.1000575", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050460095"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/gast.2001.22158", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051016864"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci19212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063416392"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2010-1143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064250791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/gmic.27001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072304003"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075127201", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077177090", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077690399", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v22.i12.3486", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079249090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuropharm.2017.03.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084098908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2017.04.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085070620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2017.04.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085070620"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3748/wjg.v23.i30.5486", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091254926"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/hel.12445", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092232998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/j.gastro.2017.11.279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099915849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00429-018-1652-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101696352", 
          "https://doi.org/10.1007/s00429-018-1652-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00429-018-1652-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101696352", 
          "https://doi.org/10.1007/s00429-018-1652-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00429-018-1652-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101696352", 
          "https://doi.org/10.1007/s00429-018-1652-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcmgh.2018.04.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103211124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcmgh.2018.04.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103211124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcmgh.2018.04.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103211124"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Helicobacter pylori (Hp) infection is related to the pathogenesis of chronic gastric disorders and extragastric diseases. Here, we examined the anorexigenic and anxiogenic effects of Hp vacuolating cytotoxin A (VacA) through activation of hypothalamic urocortin1 (Ucn1). VacA was detected in the hypothalamus after peripheral administration and increased Ucn1 mRNA expression and c-Fos-positive cells in the hypothalamus but not in the nucleus tractus solitarius. c-Fos and Ucn1-double positive cells were detected. CRF1 and CRF2 receptor antagonists suppressed VacA-induced anxiety and anorexia, respectively. VacA activated single paraventricular nucleus neurons and A7r5 cells; this activation was inhibited by phospholipase C (PLC) and protein kinase C (PKC) inhibitors. VacA causes anorexia and anxiety through the intracellular PLC-PKC pathway, migrates across the blood-brain barrier, and activates the Ucn1-CRF receptor axis.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-019-42163-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.5878999", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6532998", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Helicobacter pylori Vacuolating Cytotoxin A Causes Anorexia and Anxiety via Hypothalamic Urocortin 1 in Mice.", 
    "pagination": "6011", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-019-42163-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1113380263"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30979915"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-019-42163-4", 
      "https://app.dimensions.ai/details/publication/pub.1113380263"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-16T06:24", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000377_0000000377/records_106828_00000003.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/s41598-019-42163-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-42163-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-42163-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-42163-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-42163-4'


 

This table displays all metadata directly associated to this object as RDF triples.

354 TRIPLES      21 PREDICATES      84 URIs      20 LITERALS      8 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-019-42163-4 schema:about anzsrc-for:11
2 anzsrc-for:1109
3 schema:author N732fd41788e1435cad8bb2ed77e0e5ab
4 schema:citation sg:pub.10.1007/bf01211183
5 sg:pub.10.1007/s00429-018-1652-y
6 sg:pub.10.1038/nature05562
7 sg:pub.10.1038/nprot.2007.44
8 sg:pub.10.1038/nrmicro1095
9 sg:pub.10.1038/srep08731
10 sg:pub.10.1111/j.1572-0241.2008.01980.x
11 sg:pub.10.1186/1471-230x-11-7
12 https://app.dimensions.ai/details/publication/pub.1075127201
13 https://app.dimensions.ai/details/publication/pub.1077177090
14 https://app.dimensions.ai/details/publication/pub.1077690399
15 https://doi.org/10.1006/bbrc.1997.7345
16 https://doi.org/10.1006/mpat.1998.0256
17 https://doi.org/10.1016/0005-7967(93)90028-s
18 https://doi.org/10.1016/j.bbrc.2009.10.069
19 https://doi.org/10.1016/j.jcmgh.2018.04.003
20 https://doi.org/10.1016/j.micpath.2016.08.030
21 https://doi.org/10.1016/j.neuropharm.2017.03.002
22 https://doi.org/10.1016/j.neuroscience.2004.12.047
23 https://doi.org/10.1016/j.peptides.2004.05.025
24 https://doi.org/10.1016/j.peptides.2011.05.014
25 https://doi.org/10.1016/j.physbeh.2015.04.007
26 https://doi.org/10.1016/j.plipres.2010.06.001
27 https://doi.org/10.1016/j.psyneuen.2010.02.003
28 https://doi.org/10.1016/j.regpep.2007.09.010
29 https://doi.org/10.1016/j.yhbeh.2011.06.004
30 https://doi.org/10.1016/s0016-5085(98)70540-2
31 https://doi.org/10.1016/s0016-5085(99)70491-9
32 https://doi.org/10.1016/s0304-3940(99)00185-8
33 https://doi.org/10.1016/s0306-4522(98)00732-5
34 https://doi.org/10.1046/j.1365-2036.2003.01669.x
35 https://doi.org/10.1053/gast.2001.22158
36 https://doi.org/10.1053/j.gastro.2005.11.057
37 https://doi.org/10.1053/j.gastro.2007.03.048
38 https://doi.org/10.1053/j.gastro.2016.02.011
39 https://doi.org/10.1053/j.gastro.2017.04.022
40 https://doi.org/10.1053/j.gastro.2017.11.279
41 https://doi.org/10.1074/jbc.270.41.23937
42 https://doi.org/10.1074/jbc.m308898200
43 https://doi.org/10.1097/meg.0000000000000774
44 https://doi.org/10.1111/apt.12790
45 https://doi.org/10.1111/hel.12159
46 https://doi.org/10.1111/hel.12445
47 https://doi.org/10.1111/j.1365-2036.2011.04610.x
48 https://doi.org/10.1111/j.1440-1746.2008.05415.x
49 https://doi.org/10.1111/jgh.13256
50 https://doi.org/10.1111/obr.12320
51 https://doi.org/10.1172/jci19212
52 https://doi.org/10.1210/en.2010-1143
53 https://doi.org/10.1371/journal.pbio.1000575
54 https://doi.org/10.1515/bmc.2011.022
55 https://doi.org/10.3390/toxins8050152
56 https://doi.org/10.3748/wjg.v22.i12.3486
57 https://doi.org/10.3748/wjg.v23.i30.5486
58 https://doi.org/10.4103/2277-9175.190938
59 https://doi.org/10.4161/gmic.27001
60 schema:datePublished 2019-12
61 schema:datePublishedReg 2019-12-01
62 schema:description Helicobacter pylori (Hp) infection is related to the pathogenesis of chronic gastric disorders and extragastric diseases. Here, we examined the anorexigenic and anxiogenic effects of Hp vacuolating cytotoxin A (VacA) through activation of hypothalamic urocortin1 (Ucn1). VacA was detected in the hypothalamus after peripheral administration and increased Ucn1 mRNA expression and c-Fos-positive cells in the hypothalamus but not in the nucleus tractus solitarius. c-Fos and Ucn1-double positive cells were detected. CRF1 and CRF2 receptor antagonists suppressed VacA-induced anxiety and anorexia, respectively. VacA activated single paraventricular nucleus neurons and A7r5 cells; this activation was inhibited by phospholipase C (PLC) and protein kinase C (PKC) inhibitors. VacA causes anorexia and anxiety through the intracellular PLC-PKC pathway, migrates across the blood-brain barrier, and activates the Ucn1-CRF receptor axis.
63 schema:genre research_article
64 schema:inLanguage en
65 schema:isAccessibleForFree true
66 schema:isPartOf Nbecb1505be8844dcb52a70fcc870b5ca
67 Nf8514b2fa3e74900a3a680620d9f32c5
68 sg:journal.1045337
69 schema:name Helicobacter pylori Vacuolating Cytotoxin A Causes Anorexia and Anxiety via Hypothalamic Urocortin 1 in Mice.
70 schema:pagination 6011
71 schema:productId N05d60fc4aa054f33b2ef6f3950c2d7ad
72 N4a411b7e1b724490b24e1fe26d27e43e
73 N9935455ffa81419eae732dcf9b1326e7
74 Nfa664acce3f541f8b313186c42119426
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113380263
76 https://doi.org/10.1038/s41598-019-42163-4
77 schema:sdDatePublished 2019-04-16T06:24
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher N133a98f9fb1145a991bf2c72753a3e49
80 schema:url http://www.nature.com/articles/s41598-019-42163-4
81 sgo:license sg:explorer/license/
82 sgo:sdDataset articles
83 rdf:type schema:ScholarlyArticle
84 N01f071c4ea6746a2bee41576f794dcb6 rdf:first N595dca6a7b3849939b6f7ba5f04e63f2
85 rdf:rest N3d5a2662c275428ba6edc215d30c1a09
86 N05d60fc4aa054f33b2ef6f3950c2d7ad schema:name nlm_unique_id
87 schema:value 101563288
88 rdf:type schema:PropertyValue
89 N0821facfd7904d668f11f9255a0349bf schema:affiliation https://www.grid.ac/institutes/grid.258333.c
90 schema:familyName Inui
91 schema:givenName Akio
92 rdf:type schema:Person
93 N0acb0c0739384f7d9313c6bb68dccbbc rdf:first N7b8db25328024071b12af0541b2009e1
94 rdf:rest Nb2ca21d37ffe4d948bda4c7656e62162
95 N0d4b7675476545cba6b757780e3b69b0 schema:affiliation https://www.grid.ac/institutes/grid.136304.3
96 schema:familyName Yahiro
97 schema:givenName Kinnosuke
98 rdf:type schema:Person
99 N12000d7ab01240b3b464ed43766d8801 schema:affiliation N1e20f43c22f44700a5143f1d79b6eecf
100 schema:familyName Yamamoto
101 schema:givenName Katsuhiro
102 rdf:type schema:Person
103 N133a98f9fb1145a991bf2c72753a3e49 schema:name Springer Nature - SN SciGraph project
104 rdf:type schema:Organization
105 N16976a6e9a5441dabc6abde586ab84ed schema:affiliation https://www.grid.ac/institutes/grid.258333.c
106 schema:familyName Suzuki
107 schema:givenName Hajime
108 rdf:type schema:Person
109 N1e20f43c22f44700a5143f1d79b6eecf schema:name Quality Control Department, Yoshitomi Plant, Mitsubishi Tanabe Pharma Factory Ltd., Fukuoka, Japan.
110 rdf:type schema:Organization
111 N23a1cbbc38fe4016aeec447801d982ce schema:affiliation https://www.grid.ac/institutes/grid.410804.9
112 schema:familyName Yada
113 schema:givenName Toshihiko
114 rdf:type schema:Person
115 N387593cf828a4ad6b0cabc6dab0bd16e rdf:first Nd1469d9320154f1981adf6d5ea319ca2
116 rdf:rest N8ece8e641bed4e44a217275880c5ca8a
117 N3d5a2662c275428ba6edc215d30c1a09 rdf:first N5abdeb62fa204e7b9fe7ca03c325b43b
118 rdf:rest N934c1f77bd1d42ada739d28d75e59c2c
119 N4a411b7e1b724490b24e1fe26d27e43e schema:name doi
120 schema:value 10.1038/s41598-019-42163-4
121 rdf:type schema:PropertyValue
122 N4eb7456286fa469f8a142b894c68cdd3 rdf:first Na173dadd34db4446a1665fa43d487441
123 rdf:rest N387593cf828a4ad6b0cabc6dab0bd16e
124 N52ce9e4fa91a49cf9cbd70a1b3b79b1e schema:affiliation https://www.grid.ac/institutes/grid.418306.8
125 schema:familyName Yokoyama
126 schema:givenName Yoshito
127 rdf:type schema:Person
128 N595dca6a7b3849939b6f7ba5f04e63f2 schema:affiliation https://www.grid.ac/institutes/grid.174567.6
129 schema:familyName Hirayama
130 schema:givenName Toshiya
131 rdf:type schema:Person
132 N5abdeb62fa204e7b9fe7ca03c325b43b schema:affiliation https://www.grid.ac/institutes/grid.258333.c
133 schema:familyName Nakamura
134 schema:givenName Norifumi
135 rdf:type schema:Person
136 N6440eba15e8e46989996f7ea5e452fb4 rdf:first Nac68da8ac9504598b3e950d9e850c946
137 rdf:rest N0acb0c0739384f7d9313c6bb68dccbbc
138 N732fd41788e1435cad8bb2ed77e0e5ab rdf:first N16976a6e9a5441dabc6abde586ab84ed
139 rdf:rest N6440eba15e8e46989996f7ea5e452fb4
140 N78df649501fd47e0a57e1a53a53559dd rdf:first N8c3e5fe1a6b6489e938621861944af70
141 rdf:rest Na9db3e853b3747ba92cca7022e88442d
142 N7b8db25328024071b12af0541b2009e1 schema:affiliation https://www.grid.ac/institutes/grid.258333.c
143 schema:familyName Asakawa
144 schema:givenName Akihiro
145 rdf:type schema:Person
146 N850d5db01bd544adb8e739970802c679 schema:affiliation https://www.grid.ac/institutes/grid.258333.c
147 schema:familyName Cheng
148 schema:givenName Kai-Chun
149 rdf:type schema:Person
150 N8c3e5fe1a6b6489e938621861944af70 schema:affiliation https://www.grid.ac/institutes/grid.410781.b
151 schema:familyName Kojima
152 schema:givenName Masayasu
153 rdf:type schema:Person
154 N8ece8e641bed4e44a217275880c5ca8a rdf:first Nbec63f04bb2649819cfcc5e9459267f0
155 rdf:rest Nd7112f78e684427a9526987534d72fb1
156 N934c1f77bd1d42ada739d28d75e59c2c rdf:first N0821facfd7904d668f11f9255a0349bf
157 rdf:rest rdf:nil
158 N9935455ffa81419eae732dcf9b1326e7 schema:name pubmed_id
159 schema:value 30979915
160 rdf:type schema:PropertyValue
161 N9d5c4752fc1744e1b760bd73538f7b81 rdf:first N12000d7ab01240b3b464ed43766d8801
162 rdf:rest Nb6593dbff56a463ca534c916469add87
163 Na173dadd34db4446a1665fa43d487441 schema:affiliation https://www.grid.ac/institutes/grid.258333.c
164 schema:familyName Iwai
165 schema:givenName Haruki
166 rdf:type schema:Person
167 Na9db3e853b3747ba92cca7022e88442d rdf:first N23a1cbbc38fe4016aeec447801d982ce
168 rdf:rest N01f071c4ea6746a2bee41576f794dcb6
169 Nac68da8ac9504598b3e950d9e850c946 schema:affiliation https://www.grid.ac/institutes/grid.258333.c
170 schema:familyName Ataka
171 schema:givenName Koji
172 rdf:type schema:Person
173 Nb2ca21d37ffe4d948bda4c7656e62162 rdf:first N850d5db01bd544adb8e739970802c679
174 rdf:rest Nf224425a37b54b4195db07ceeb442397
175 Nb6593dbff56a463ca534c916469add87 rdf:first N52ce9e4fa91a49cf9cbd70a1b3b79b1e
176 rdf:rest N78df649501fd47e0a57e1a53a53559dd
177 Nb7301f96a42e42d19b338e2ac1abb9a9 schema:affiliation https://www.grid.ac/institutes/grid.258333.c
178 schema:familyName Ushikai
179 schema:givenName Miharu
180 rdf:type schema:Person
181 Nbec63f04bb2649819cfcc5e9459267f0 schema:affiliation https://www.grid.ac/institutes/grid.410804.9
182 schema:familyName Arai
183 schema:givenName Takeshi
184 rdf:type schema:Person
185 Nbecb1505be8844dcb52a70fcc870b5ca schema:volumeNumber 9
186 rdf:type schema:PublicationVolume
187 Nd1469d9320154f1981adf6d5ea319ca2 schema:affiliation https://www.grid.ac/institutes/grid.258333.c
188 schema:familyName Yagi
189 schema:givenName Takakazu
190 rdf:type schema:Person
191 Nd7112f78e684427a9526987534d72fb1 rdf:first N0d4b7675476545cba6b757780e3b69b0
192 rdf:rest N9d5c4752fc1744e1b760bd73538f7b81
193 Nf224425a37b54b4195db07ceeb442397 rdf:first Nb7301f96a42e42d19b338e2ac1abb9a9
194 rdf:rest N4eb7456286fa469f8a142b894c68cdd3
195 Nf8514b2fa3e74900a3a680620d9f32c5 schema:issueNumber 1
196 rdf:type schema:PublicationIssue
197 Nfa664acce3f541f8b313186c42119426 schema:name dimensions_id
198 schema:value pub.1113380263
199 rdf:type schema:PropertyValue
200 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
201 schema:name Medical and Health Sciences
202 rdf:type schema:DefinedTerm
203 anzsrc-for:1109 schema:inDefinedTermSet anzsrc-for:
204 schema:name Neurosciences
205 rdf:type schema:DefinedTerm
206 sg:grant.5878999 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-42163-4
207 rdf:type schema:MonetaryGrant
208 sg:grant.6532998 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-42163-4
209 rdf:type schema:MonetaryGrant
210 sg:journal.1045337 schema:issn 2045-2322
211 schema:name Scientific Reports
212 rdf:type schema:Periodical
213 sg:pub.10.1007/bf01211183 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017159867
214 https://doi.org/10.1007/bf01211183
215 rdf:type schema:CreativeWork
216 sg:pub.10.1007/s00429-018-1652-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1101696352
217 https://doi.org/10.1007/s00429-018-1652-y
218 rdf:type schema:CreativeWork
219 sg:pub.10.1038/nature05562 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047846730
220 https://doi.org/10.1038/nature05562
221 rdf:type schema:CreativeWork
222 sg:pub.10.1038/nprot.2007.44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012369107
223 https://doi.org/10.1038/nprot.2007.44
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/nrmicro1095 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015362103
226 https://doi.org/10.1038/nrmicro1095
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/srep08731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048953411
229 https://doi.org/10.1038/srep08731
230 rdf:type schema:CreativeWork
231 sg:pub.10.1111/j.1572-0241.2008.01980.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1013854535
232 https://doi.org/10.1111/j.1572-0241.2008.01980.x
233 rdf:type schema:CreativeWork
234 sg:pub.10.1186/1471-230x-11-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024063353
235 https://doi.org/10.1186/1471-230x-11-7
236 rdf:type schema:CreativeWork
237 https://app.dimensions.ai/details/publication/pub.1075127201 schema:CreativeWork
238 https://app.dimensions.ai/details/publication/pub.1077177090 schema:CreativeWork
239 https://app.dimensions.ai/details/publication/pub.1077690399 schema:CreativeWork
240 https://doi.org/10.1006/bbrc.1997.7345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044905005
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1006/mpat.1998.0256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012040060
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/0005-7967(93)90028-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1022044364
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1016/j.bbrc.2009.10.069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012281201
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1016/j.jcmgh.2018.04.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103211124
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1016/j.micpath.2016.08.030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003724182
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1016/j.neuropharm.2017.03.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084098908
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/j.neuroscience.2004.12.047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048222004
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/j.peptides.2004.05.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043177549
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/j.peptides.2011.05.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020581987
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/j.physbeh.2015.04.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004557631
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/j.plipres.2010.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025395271
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/j.psyneuen.2010.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000044101
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/j.regpep.2007.09.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049672548
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/j.yhbeh.2011.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031294228
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/s0016-5085(98)70540-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045447648
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/s0016-5085(99)70491-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008559354
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/s0304-3940(99)00185-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023488330
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/s0306-4522(98)00732-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010305894
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1046/j.1365-2036.2003.01669.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020407700
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1053/gast.2001.22158 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051016864
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1053/j.gastro.2005.11.057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013417666
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1053/j.gastro.2007.03.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008462374
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1053/j.gastro.2016.02.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036055701
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1053/j.gastro.2017.04.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085070620
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1053/j.gastro.2017.11.279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099915849
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1074/jbc.270.41.23937 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001874674
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1074/jbc.m308898200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030346924
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1097/meg.0000000000000774 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010617385
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1111/apt.12790 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015157638
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1111/hel.12159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003395218
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1111/hel.12445 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092232998
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1111/j.1365-2036.2011.04610.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045107670
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1111/j.1440-1746.2008.05415.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007563814
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1111/jgh.13256 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009227364
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1111/obr.12320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042363216
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1172/jci19212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063416392
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1210/en.2010-1143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064250791
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1371/journal.pbio.1000575 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050460095
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1515/bmc.2011.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017588052
319 rdf:type schema:CreativeWork
320 https://doi.org/10.3390/toxins8050152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012612093
321 rdf:type schema:CreativeWork
322 https://doi.org/10.3748/wjg.v22.i12.3486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079249090
323 rdf:type schema:CreativeWork
324 https://doi.org/10.3748/wjg.v23.i30.5486 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091254926
325 rdf:type schema:CreativeWork
326 https://doi.org/10.4103/2277-9175.190938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049669705
327 rdf:type schema:CreativeWork
328 https://doi.org/10.4161/gmic.27001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072304003
329 rdf:type schema:CreativeWork
330 https://www.grid.ac/institutes/grid.136304.3 schema:alternateName Chiba University
331 schema:name Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, Chiba, Japan.
332 rdf:type schema:Organization
333 https://www.grid.ac/institutes/grid.174567.6 schema:alternateName Nagasaki University
334 schema:name Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.
335 rdf:type schema:Organization
336 https://www.grid.ac/institutes/grid.258333.c schema:alternateName Kagoshima University
337 schema:name Department of Hygiene and Health Promotion Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
338 Department of Oral Anatomy and Cell Biology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
339 Department of Oral and Maxillofacial Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
340 Department of Oral and Maxillofacial Surgery, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. hajime@dent.kagoshima-u.ac.jp.
341 Department of Orthodontics and Dentofacial Orthopedics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
342 Department of Pharmacological Sciences of Herbal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
343 Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
344 Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. hajime@dent.kagoshima-u.ac.jp.
345 rdf:type schema:Organization
346 https://www.grid.ac/institutes/grid.410781.b schema:alternateName Kurume University
347 schema:name Molecular Genetics, Institute of Life Science, Kurume University, Fukuoka, Japan.
348 rdf:type schema:Organization
349 https://www.grid.ac/institutes/grid.410804.9 schema:alternateName Jichi Medical University
350 schema:name Department of Physiology, Jichi Medical University School of Medicine, Tochigi, Japan.
351 rdf:type schema:Organization
352 https://www.grid.ac/institutes/grid.418306.8 schema:alternateName Mitsubishi Chemical Holdings (Japan)
353 schema:name Discovery Technology Laboratories, Sohyaku. Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, Saitama, Japan.
354 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...