Serum of patients with acute myocardial infarction prevents inflammation in iPSC-cardiomyocytes. View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Katherine Sattler, Ibrahim El-Battrawy, Zhihan Zhao, Christoph Schrottenberg, Gökhan Yücel, Huan Lan, Xin Li, Siegfried Lang, Wolfram-Hubertus Zimmermann, Lukas Cyganek, Jochen Utikal, Thomas Wieland, Ursula Ravens, Karen Bieback, Martin Borggrefe, Xiaobo Zhou, Ibrahim Akin

ABSTRACT

Acute myocardial infarction (MI) evokes a systemic inflammatory response and locally the degradation of the necrotic tissue, followed by scar formation. The mechanisms for containment of the infarct zone are not studied well. The study aimed to examine the response of healthy cardiomyocytes to serum of patients with myocardial infarction. Human iPSC-cardiomyocytes (iPSC-CM) generated from two healthy donors were incubated with serum of patients with MI with and without ventricular fibrillation (VF) or of healthy controls. Different cell adhesion molecules were studied by flow cytometry and immunostaining. Cellular electrophysiology was studied by patch clamp. The cell adhesion molecules CD54/ICAM-1, CD58/LFA-3 and CD321/JAM-A were expressed on iPSC-CM within the plasma membrane. Incubation with serum of MI patients reduced the levels of expression of CD54/ICAM-1 and CD321/JAM-A by 15-20%. VF serum was less effective than serum of MI patients without VF. MI serum or VF serum did not affect resting potential, action potential duration or maximum depolarization velocity. Myocardial infarction serum exerts anti-inflammatory effects on healthy cardiomyocytes without affecting their electrical activity, thus helping to contain the infarct zone and to protect healthy tissue. Ventricular fibrillation during MI drives healthy cardiomyocytes towards a pro-inflammatory phenotype. More... »

PAGES

5651

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-42079-z

DOI

http://dx.doi.org/10.1038/s41598-019-42079-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113185021

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30948775


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1116", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Physiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University Medical Centre Mannheim", 
          "id": "https://www.grid.ac/institutes/grid.411778.c", 
          "name": [
            "First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sattler", 
        "givenName": "Katherine", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Centre for Cardiovascular Research", 
          "id": "https://www.grid.ac/institutes/grid.452396.f", 
          "name": [
            "First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany. Ibrahim.El-Battrawy@umm.de.", 
            "DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg-Mannheim and G\u00f6ttingen, G\u00f6ttingen, Germany. Ibrahim.El-Battrawy@umm.de."
          ], 
          "type": "Organization"
        }, 
        "familyName": "El-Battrawy", 
        "givenName": "Ibrahim", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Centre for Cardiovascular Research", 
          "id": "https://www.grid.ac/institutes/grid.452396.f", 
          "name": [
            "First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.", 
            "DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg-Mannheim and G\u00f6ttingen, G\u00f6ttingen, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhao", 
        "givenName": "Zhihan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Centre Mannheim", 
          "id": "https://www.grid.ac/institutes/grid.411778.c", 
          "name": [
            "First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schrottenberg", 
        "givenName": "Christoph", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Centre for Cardiovascular Research", 
          "id": "https://www.grid.ac/institutes/grid.452396.f", 
          "name": [
            "First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.", 
            "DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg-Mannheim and G\u00f6ttingen, G\u00f6ttingen, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Y\u00fccel", 
        "givenName": "G\u00f6khan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Centre for Cardiovascular Research", 
          "id": "https://www.grid.ac/institutes/grid.452396.f", 
          "name": [
            "First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.", 
            "DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg-Mannheim and G\u00f6ttingen, G\u00f6ttingen, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lan", 
        "givenName": "Huan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Centre Mannheim", 
          "id": "https://www.grid.ac/institutes/grid.411778.c", 
          "name": [
            "First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Xin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Centre for Cardiovascular Research", 
          "id": "https://www.grid.ac/institutes/grid.452396.f", 
          "name": [
            "First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.", 
            "DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg-Mannheim and G\u00f6ttingen, G\u00f6ttingen, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lang", 
        "givenName": "Siegfried", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of G\u00f6ttingen", 
          "id": "https://www.grid.ac/institutes/grid.7450.6", 
          "name": [
            "DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg-Mannheim and G\u00f6ttingen, G\u00f6ttingen, Germany.", 
            "Institute of Pharmacology and Toxicology, University of G\u00f6ttingen, G\u00f6ttingen, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zimmermann", 
        "givenName": "Wolfram-Hubertus", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsmedizin G\u00f6ttingen", 
          "id": "https://www.grid.ac/institutes/grid.411984.1", 
          "name": [
            "DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg-Mannheim and G\u00f6ttingen, G\u00f6ttingen, Germany.", 
            "Stem Cell Unit, Clinic for Cardiology and Pneumology, University Medical Center G\u00f6ttingen, G\u00f6ttingen, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cyganek", 
        "givenName": "Lukas", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Centre Mannheim", 
          "id": "https://www.grid.ac/institutes/grid.411778.c", 
          "name": [
            "Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg and Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Utikal", 
        "givenName": "Jochen", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heidelberg University", 
          "id": "https://www.grid.ac/institutes/grid.7700.0", 
          "name": [
            "DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg-Mannheim and G\u00f6ttingen, G\u00f6ttingen, Germany.", 
            "Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wieland", 
        "givenName": "Thomas", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4ts-Herzzentrum Freiburg-Bad Krozingen", 
          "id": "https://www.grid.ac/institutes/grid.418466.9", 
          "name": [
            "Institue of Experimental Cardiovascular Medicine, University Heart Centre Freiburg, Bad Krozingen, Freiburg, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ravens", 
        "givenName": "Ursula", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Institute for Transfusion Medicine and Immunology, Mannheim, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bieback", 
        "givenName": "Karen", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Centre for Cardiovascular Research", 
          "id": "https://www.grid.ac/institutes/grid.452396.f", 
          "name": [
            "First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.", 
            "DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg-Mannheim and G\u00f6ttingen, G\u00f6ttingen, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Borggrefe", 
        "givenName": "Martin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Luzhou Medical College", 
          "id": "https://www.grid.ac/institutes/grid.410578.f", 
          "name": [
            "First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.", 
            "DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg-Mannheim and G\u00f6ttingen, G\u00f6ttingen, Germany.", 
            "Key Laboratory of Medical Electrophysiology of the Ministry of Education, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Xiaobo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Centre for Cardiovascular Research", 
          "id": "https://www.grid.ac/institutes/grid.452396.f", 
          "name": [
            "First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.", 
            "DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg-Mannheim and G\u00f6ttingen, G\u00f6ttingen, Germany."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Akin", 
        "givenName": "Ibrahim", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1172/jci115626", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004090870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2008.08.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004948652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2008.08.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004948652"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.99.11.1492", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005348632"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/jhg.2009.96", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009645259", 
          "https://doi.org/10.1038/jhg.2009.96"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/jhg.2009.96", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009645259", 
          "https://doi.org/10.1038/jhg.2009.96"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrcardio.2014.28", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010191575", 
          "https://doi.org/10.1038/nrcardio.2014.28"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/jcmm.12356", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013415026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000051363.86009.3c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014827229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2014.95", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020349648", 
          "https://doi.org/10.1038/onc.2014.95"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.lfs.2014.01.060", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020717503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.89.6.2736", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021531764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/jaha.114.001101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024778797"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0002886", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025881115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/jaha.114.001399", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026330532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurheartj/ehv320", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031315483"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1189/jlb.1105645", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031505469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jcp.43.11.893", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032333102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2015.12.048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032645708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/shk.0000000000000740", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035096738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/shk.0000000000000740", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035096738"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.11909/j.issn.1671-5411.2015.03.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035796105"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circimaging.113.001093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038171531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circimaging.113.001093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038171531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.imbio.2013.03.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038769426"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/eci.12118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042403434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0166143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042725238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci116333", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042949388"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1515/jbcpp-2013-0117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043536882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/pcmr.12369", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047283799"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/moh.0000000000000103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048442147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/moh.0000000000000103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048442147"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archsurg.1985.01390250024004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049959692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2015/698368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051531826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1553-2712.2008.00237.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052743587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.8343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053650635"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s40560-017-0208-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054055336", 
          "https://doi.org/10.1186/s40560-017-0208-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s40560-017-0208-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054055336", 
          "https://doi.org/10.1186/s40560-017-0208-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s40560-017-0208-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054055336", 
          "https://doi.org/10.1186/s40560-017-0208-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cvr/27.5.703", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059487775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.116.303577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063343800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circresaha.116.303577", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063343800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.5604/17322693.1194612", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073046102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physrev.1999.79.3.917", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074485457"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077850772", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079261058", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.11909/j.issn.1671-5411.2016.09.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079361121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-03147-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085793388", 
          "https://doi.org/10.1038/s41598-017-03147-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circgen.117.001893", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101565567"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circgen.117.001893", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101565567"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Acute myocardial infarction (MI) evokes a systemic inflammatory response and locally the degradation of the necrotic tissue, followed by scar formation. The mechanisms for containment of the infarct zone are not studied well. The study aimed to examine the response of healthy cardiomyocytes to serum of patients with myocardial infarction. Human iPSC-cardiomyocytes (iPSC-CM) generated from two healthy donors were incubated with serum of patients with MI with and without ventricular fibrillation (VF) or of healthy controls. Different cell adhesion molecules were studied by flow cytometry and immunostaining. Cellular electrophysiology was studied by patch clamp. The cell adhesion molecules CD54/ICAM-1, CD58/LFA-3 and CD321/JAM-A were expressed on iPSC-CM within the plasma membrane. Incubation with serum of MI patients reduced the levels of expression of CD54/ICAM-1 and CD321/JAM-A by 15-20%. VF serum was less effective than serum of MI patients without VF. MI serum or VF serum did not affect resting potential, action potential duration or maximum depolarization velocity. Myocardial infarction serum exerts anti-inflammatory effects on healthy cardiomyocytes without affecting their electrical activity, thus helping to contain the infarct zone and to protect healthy tissue. Ventricular fibrillation during MI drives healthy cardiomyocytes towards a pro-inflammatory phenotype.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-019-42079-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Serum of patients with acute myocardial infarction prevents inflammation in iPSC-cardiomyocytes.", 
    "pagination": "5651", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-019-42079-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1113185021"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30948775"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-019-42079-z", 
      "https://app.dimensions.ai/details/publication/pub.1113185021"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-15T09:10", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000376_0000000376/records_56155_00000006.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/articles/s41598-019-42079-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-42079-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-42079-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-42079-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-42079-z'


 

This table displays all metadata directly associated to this object as RDF triples.

314 TRIPLES      21 PREDICATES      69 URIs      20 LITERALS      8 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-019-42079-z schema:about anzsrc-for:11
2 anzsrc-for:1116
3 schema:author Nf32dc5cd37074311a7f890875125f17d
4 schema:citation sg:pub.10.1038/jhg.2009.96
5 sg:pub.10.1038/nrcardio.2014.28
6 sg:pub.10.1038/onc.2014.95
7 sg:pub.10.1038/s41598-017-03147-4
8 sg:pub.10.1186/s40560-017-0208-1
9 https://app.dimensions.ai/details/publication/pub.1077850772
10 https://app.dimensions.ai/details/publication/pub.1079261058
11 https://doi.org/10.1001/archsurg.1985.01390250024004
12 https://doi.org/10.1016/j.imbio.2013.03.006
13 https://doi.org/10.1016/j.jacc.2015.12.048
14 https://doi.org/10.1016/j.lfs.2014.01.060
15 https://doi.org/10.1016/j.stem.2008.08.003
16 https://doi.org/10.1093/cvr/27.5.703
17 https://doi.org/10.1093/eurheartj/ehv320
18 https://doi.org/10.1097/moh.0000000000000103
19 https://doi.org/10.1097/shk.0000000000000740
20 https://doi.org/10.1111/eci.12118
21 https://doi.org/10.1111/j.1553-2712.2008.00237.x
22 https://doi.org/10.1111/jcmm.12356
23 https://doi.org/10.1111/pcmr.12369
24 https://doi.org/10.1136/jcp.43.11.893
25 https://doi.org/10.1152/physrev.1999.79.3.917
26 https://doi.org/10.1155/2015/698368
27 https://doi.org/10.1161/01.cir.0000051363.86009.3c
28 https://doi.org/10.1161/01.cir.89.6.2736
29 https://doi.org/10.1161/01.cir.99.11.1492
30 https://doi.org/10.1161/circgen.117.001893
31 https://doi.org/10.1161/circimaging.113.001093
32 https://doi.org/10.1161/circresaha.116.303577
33 https://doi.org/10.1161/jaha.114.001101
34 https://doi.org/10.1161/jaha.114.001399
35 https://doi.org/10.1172/jci115626
36 https://doi.org/10.1172/jci116333
37 https://doi.org/10.1189/jlb.1105645
38 https://doi.org/10.11909/j.issn.1671-5411.2015.03.020
39 https://doi.org/10.11909/j.issn.1671-5411.2016.09.006
40 https://doi.org/10.1371/journal.pone.0002886
41 https://doi.org/10.1371/journal.pone.0166143
42 https://doi.org/10.1515/jbcpp-2013-0117
43 https://doi.org/10.18632/oncotarget.8343
44 https://doi.org/10.5604/17322693.1194612
45 schema:datePublished 2019-12
46 schema:datePublishedReg 2019-12-01
47 schema:description Acute myocardial infarction (MI) evokes a systemic inflammatory response and locally the degradation of the necrotic tissue, followed by scar formation. The mechanisms for containment of the infarct zone are not studied well. The study aimed to examine the response of healthy cardiomyocytes to serum of patients with myocardial infarction. Human iPSC-cardiomyocytes (iPSC-CM) generated from two healthy donors were incubated with serum of patients with MI with and without ventricular fibrillation (VF) or of healthy controls. Different cell adhesion molecules were studied by flow cytometry and immunostaining. Cellular electrophysiology was studied by patch clamp. The cell adhesion molecules CD54/ICAM-1, CD58/LFA-3 and CD321/JAM-A were expressed on iPSC-CM within the plasma membrane. Incubation with serum of MI patients reduced the levels of expression of CD54/ICAM-1 and CD321/JAM-A by 15-20%. VF serum was less effective than serum of MI patients without VF. MI serum or VF serum did not affect resting potential, action potential duration or maximum depolarization velocity. Myocardial infarction serum exerts anti-inflammatory effects on healthy cardiomyocytes without affecting their electrical activity, thus helping to contain the infarct zone and to protect healthy tissue. Ventricular fibrillation during MI drives healthy cardiomyocytes towards a pro-inflammatory phenotype.
48 schema:genre research_article
49 schema:inLanguage en
50 schema:isAccessibleForFree true
51 schema:isPartOf N028bd2e07f5a4441aad664c645be86ab
52 N626d513ee30244a4b867627407bae3b1
53 sg:journal.1045337
54 schema:name Serum of patients with acute myocardial infarction prevents inflammation in iPSC-cardiomyocytes.
55 schema:pagination 5651
56 schema:productId N099de804a03240f1ab2497db51237a52
57 N188356e85f8041aeb8d53fb9c9b3a273
58 N701d7174c5df4db0a9d0e5f6bfa43c23
59 Ncbcc167de5ce433db076b9bafe1baa43
60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113185021
61 https://doi.org/10.1038/s41598-019-42079-z
62 schema:sdDatePublished 2019-04-15T09:10
63 schema:sdLicense https://scigraph.springernature.com/explorer/license/
64 schema:sdPublisher N1a3e4a0b03784637ba8e25fc1b941d84
65 schema:url http://www.nature.com/articles/s41598-019-42079-z
66 sgo:license sg:explorer/license/
67 sgo:sdDataset articles
68 rdf:type schema:ScholarlyArticle
69 N028bd2e07f5a4441aad664c645be86ab schema:issueNumber 1
70 rdf:type schema:PublicationIssue
71 N04de636c4e55429c83c2f97da84ff699 schema:affiliation https://www.grid.ac/institutes/grid.452396.f
72 schema:familyName El-Battrawy
73 schema:givenName Ibrahim
74 rdf:type schema:Person
75 N079a5c99393d4bc0afd807341aee134a schema:name Institute for Transfusion Medicine and Immunology, Mannheim, Germany.
76 rdf:type schema:Organization
77 N0920df04231d4643b46c7e8bf9338fa9 rdf:first Nb88a8285a6f240b69884f9c649e89dab
78 rdf:rest N46fc5114afef42dfab3434fa55797967
79 N099de804a03240f1ab2497db51237a52 schema:name pubmed_id
80 schema:value 30948775
81 rdf:type schema:PropertyValue
82 N0a774b3ef5344a4da420580e3190214e schema:affiliation https://www.grid.ac/institutes/grid.7450.6
83 schema:familyName Zimmermann
84 schema:givenName Wolfram-Hubertus
85 rdf:type schema:Person
86 N0c49855aaf8d4307b211d28bd1a5c9ed rdf:first N80d6b9b5935c4ecfb0f0ec605287ebc0
87 rdf:rest N0f950bf50fa04884adb04c96b33ec250
88 N0d4d051eee784c589956783c339701ba schema:affiliation https://www.grid.ac/institutes/grid.411778.c
89 schema:familyName Utikal
90 schema:givenName Jochen
91 rdf:type schema:Person
92 N0f950bf50fa04884adb04c96b33ec250 rdf:first Nd4ee2edc39d24d41941a7b579e62e66b
93 rdf:rest Nf0f4e275c7ba460197d117b5dd214b5d
94 N188356e85f8041aeb8d53fb9c9b3a273 schema:name nlm_unique_id
95 schema:value 101563288
96 rdf:type schema:PropertyValue
97 N18b21f1c727b4aa5b3e224f7dbf8c93a rdf:first N7a68923f452b4661b6e81eff14d19965
98 rdf:rest Na283275413114914880c23eb0c3dac5e
99 N1a3e4a0b03784637ba8e25fc1b941d84 schema:name Springer Nature - SN SciGraph project
100 rdf:type schema:Organization
101 N2b517097909d420a877dfdf19597101a rdf:first N0d4d051eee784c589956783c339701ba
102 rdf:rest N0c49855aaf8d4307b211d28bd1a5c9ed
103 N2dd66d3d99414617a0fe550dcee4b30f rdf:first N744c709797234450b2b5638025ddb0cb
104 rdf:rest N72ebee1f4a8743ebbc5e25e7df4ad3b5
105 N2f169f56b1c84b74aef34235436e9dee schema:affiliation https://www.grid.ac/institutes/grid.452396.f
106 schema:familyName Akin
107 schema:givenName Ibrahim
108 rdf:type schema:Person
109 N32de2bcf25854905b12d3f9990aa5c00 rdf:first N0a774b3ef5344a4da420580e3190214e
110 rdf:rest Nf3c21c6915a64e318d6a4c8463d2345b
111 N38f7bc13544245b28d358ff38511ef32 schema:affiliation https://www.grid.ac/institutes/grid.411984.1
112 schema:familyName Cyganek
113 schema:givenName Lukas
114 rdf:type schema:Person
115 N3bdac3f3f27e44e8bb39a27d7b7e04fe schema:affiliation https://www.grid.ac/institutes/grid.411778.c
116 schema:familyName Sattler
117 schema:givenName Katherine
118 rdf:type schema:Person
119 N46fc5114afef42dfab3434fa55797967 rdf:first Nbf13fa65b2aa48af8c4ad450e2c0b71a
120 rdf:rest Ndca652c07d464f469cd65e700422ee86
121 N6233045621a749afa55be3d3cbf52079 schema:affiliation https://www.grid.ac/institutes/grid.452396.f
122 schema:familyName Zhao
123 schema:givenName Zhihan
124 rdf:type schema:Person
125 N626d513ee30244a4b867627407bae3b1 schema:volumeNumber 9
126 rdf:type schema:PublicationVolume
127 N701d7174c5df4db0a9d0e5f6bfa43c23 schema:name doi
128 schema:value 10.1038/s41598-019-42079-z
129 rdf:type schema:PropertyValue
130 N72ebee1f4a8743ebbc5e25e7df4ad3b5 rdf:first Nbebf68bfb8764552b1cce81a0a6a5561
131 rdf:rest N32de2bcf25854905b12d3f9990aa5c00
132 N736f9b347bd64e088ec9f1c4c0754cc0 rdf:first N6233045621a749afa55be3d3cbf52079
133 rdf:rest Neeaf4216234e4cf6b70fb5a63f914340
134 N744c709797234450b2b5638025ddb0cb schema:affiliation https://www.grid.ac/institutes/grid.411778.c
135 schema:familyName Li
136 schema:givenName Xin
137 rdf:type schema:Person
138 N7a68923f452b4661b6e81eff14d19965 schema:affiliation https://www.grid.ac/institutes/grid.452396.f
139 schema:familyName Yücel
140 schema:givenName Gökhan
141 rdf:type schema:Person
142 N7bf809d300df442fab1782e1fb9dcc48 rdf:first N04de636c4e55429c83c2f97da84ff699
143 rdf:rest N736f9b347bd64e088ec9f1c4c0754cc0
144 N80d6b9b5935c4ecfb0f0ec605287ebc0 schema:affiliation https://www.grid.ac/institutes/grid.7700.0
145 schema:familyName Wieland
146 schema:givenName Thomas
147 rdf:type schema:Person
148 Na283275413114914880c23eb0c3dac5e rdf:first Na319691a8c5b44e5b2f513ee06ef2f36
149 rdf:rest N2dd66d3d99414617a0fe550dcee4b30f
150 Na2f2936342ab42c39b261bbda3235c83 schema:affiliation https://www.grid.ac/institutes/grid.411778.c
151 schema:familyName Schrottenberg
152 schema:givenName Christoph
153 rdf:type schema:Person
154 Na319691a8c5b44e5b2f513ee06ef2f36 schema:affiliation https://www.grid.ac/institutes/grid.452396.f
155 schema:familyName Lan
156 schema:givenName Huan
157 rdf:type schema:Person
158 Nb88a8285a6f240b69884f9c649e89dab schema:affiliation https://www.grid.ac/institutes/grid.452396.f
159 schema:familyName Borggrefe
160 schema:givenName Martin
161 rdf:type schema:Person
162 Nbebf68bfb8764552b1cce81a0a6a5561 schema:affiliation https://www.grid.ac/institutes/grid.452396.f
163 schema:familyName Lang
164 schema:givenName Siegfried
165 rdf:type schema:Person
166 Nbf13fa65b2aa48af8c4ad450e2c0b71a schema:affiliation https://www.grid.ac/institutes/grid.410578.f
167 schema:familyName Zhou
168 schema:givenName Xiaobo
169 rdf:type schema:Person
170 Ncbcc167de5ce433db076b9bafe1baa43 schema:name dimensions_id
171 schema:value pub.1113185021
172 rdf:type schema:PropertyValue
173 Nd33f3c1bb53048348221d626d2115ce2 schema:affiliation N079a5c99393d4bc0afd807341aee134a
174 schema:familyName Bieback
175 schema:givenName Karen
176 rdf:type schema:Person
177 Nd4ee2edc39d24d41941a7b579e62e66b schema:affiliation https://www.grid.ac/institutes/grid.418466.9
178 schema:familyName Ravens
179 schema:givenName Ursula
180 rdf:type schema:Person
181 Ndca652c07d464f469cd65e700422ee86 rdf:first N2f169f56b1c84b74aef34235436e9dee
182 rdf:rest rdf:nil
183 Neeaf4216234e4cf6b70fb5a63f914340 rdf:first Na2f2936342ab42c39b261bbda3235c83
184 rdf:rest N18b21f1c727b4aa5b3e224f7dbf8c93a
185 Nf0f4e275c7ba460197d117b5dd214b5d rdf:first Nd33f3c1bb53048348221d626d2115ce2
186 rdf:rest N0920df04231d4643b46c7e8bf9338fa9
187 Nf32dc5cd37074311a7f890875125f17d rdf:first N3bdac3f3f27e44e8bb39a27d7b7e04fe
188 rdf:rest N7bf809d300df442fab1782e1fb9dcc48
189 Nf3c21c6915a64e318d6a4c8463d2345b rdf:first N38f7bc13544245b28d358ff38511ef32
190 rdf:rest N2b517097909d420a877dfdf19597101a
191 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
192 schema:name Medical and Health Sciences
193 rdf:type schema:DefinedTerm
194 anzsrc-for:1116 schema:inDefinedTermSet anzsrc-for:
195 schema:name Medical Physiology
196 rdf:type schema:DefinedTerm
197 sg:journal.1045337 schema:issn 2045-2322
198 schema:name Scientific Reports
199 rdf:type schema:Periodical
200 sg:pub.10.1038/jhg.2009.96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009645259
201 https://doi.org/10.1038/jhg.2009.96
202 rdf:type schema:CreativeWork
203 sg:pub.10.1038/nrcardio.2014.28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010191575
204 https://doi.org/10.1038/nrcardio.2014.28
205 rdf:type schema:CreativeWork
206 sg:pub.10.1038/onc.2014.95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020349648
207 https://doi.org/10.1038/onc.2014.95
208 rdf:type schema:CreativeWork
209 sg:pub.10.1038/s41598-017-03147-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085793388
210 https://doi.org/10.1038/s41598-017-03147-4
211 rdf:type schema:CreativeWork
212 sg:pub.10.1186/s40560-017-0208-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054055336
213 https://doi.org/10.1186/s40560-017-0208-1
214 rdf:type schema:CreativeWork
215 https://app.dimensions.ai/details/publication/pub.1077850772 schema:CreativeWork
216 https://app.dimensions.ai/details/publication/pub.1079261058 schema:CreativeWork
217 https://doi.org/10.1001/archsurg.1985.01390250024004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049959692
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/j.imbio.2013.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038769426
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/j.jacc.2015.12.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032645708
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/j.lfs.2014.01.060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020717503
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/j.stem.2008.08.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004948652
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1093/cvr/27.5.703 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059487775
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1093/eurheartj/ehv320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031315483
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1097/moh.0000000000000103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048442147
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1097/shk.0000000000000740 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035096738
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1111/eci.12118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042403434
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1111/j.1553-2712.2008.00237.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052743587
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1111/jcmm.12356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013415026
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1111/pcmr.12369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047283799
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1136/jcp.43.11.893 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032333102
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1152/physrev.1999.79.3.917 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074485457
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1155/2015/698368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051531826
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1161/01.cir.0000051363.86009.3c schema:sameAs https://app.dimensions.ai/details/publication/pub.1014827229
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1161/01.cir.89.6.2736 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021531764
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1161/01.cir.99.11.1492 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005348632
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1161/circgen.117.001893 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101565567
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1161/circimaging.113.001093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038171531
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1161/circresaha.116.303577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063343800
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1161/jaha.114.001101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024778797
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1161/jaha.114.001399 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026330532
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1172/jci115626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004090870
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1172/jci116333 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042949388
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1189/jlb.1105645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031505469
270 rdf:type schema:CreativeWork
271 https://doi.org/10.11909/j.issn.1671-5411.2015.03.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035796105
272 rdf:type schema:CreativeWork
273 https://doi.org/10.11909/j.issn.1671-5411.2016.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079361121
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1371/journal.pone.0002886 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025881115
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1371/journal.pone.0166143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042725238
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1515/jbcpp-2013-0117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043536882
280 rdf:type schema:CreativeWork
281 https://doi.org/10.18632/oncotarget.8343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053650635
282 rdf:type schema:CreativeWork
283 https://doi.org/10.5604/17322693.1194612 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073046102
284 rdf:type schema:CreativeWork
285 https://www.grid.ac/institutes/grid.410578.f schema:alternateName Luzhou Medical College
286 schema:name DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg-Mannheim and Göttingen, Göttingen, Germany.
287 First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.
288 Key Laboratory of Medical Electrophysiology of the Ministry of Education, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, China.
289 rdf:type schema:Organization
290 https://www.grid.ac/institutes/grid.411778.c schema:alternateName University Medical Centre Mannheim
291 schema:name First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.
292 Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg and Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
293 rdf:type schema:Organization
294 https://www.grid.ac/institutes/grid.411984.1 schema:alternateName Universitätsmedizin Göttingen
295 schema:name DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg-Mannheim and Göttingen, Göttingen, Germany.
296 Stem Cell Unit, Clinic for Cardiology and Pneumology, University Medical Center Göttingen, Göttingen, Germany.
297 rdf:type schema:Organization
298 https://www.grid.ac/institutes/grid.418466.9 schema:alternateName Universitäts-Herzzentrum Freiburg-Bad Krozingen
299 schema:name Institue of Experimental Cardiovascular Medicine, University Heart Centre Freiburg, Bad Krozingen, Freiburg, Germany.
300 rdf:type schema:Organization
301 https://www.grid.ac/institutes/grid.452396.f schema:alternateName German Centre for Cardiovascular Research
302 schema:name DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg-Mannheim and Göttingen, Göttingen, Germany.
303 DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg-Mannheim and Göttingen, Göttingen, Germany. Ibrahim.El-Battrawy@umm.de.
304 First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany.
305 First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Mannheim, Germany. Ibrahim.El-Battrawy@umm.de.
306 rdf:type schema:Organization
307 https://www.grid.ac/institutes/grid.7450.6 schema:alternateName University of Göttingen
308 schema:name DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg-Mannheim and Göttingen, Göttingen, Germany.
309 Institute of Pharmacology and Toxicology, University of Göttingen, Göttingen, Germany.
310 rdf:type schema:Organization
311 https://www.grid.ac/institutes/grid.7700.0 schema:alternateName Heidelberg University
312 schema:name DZHK (German Center for Cardiovascular Research), Partner Site Heidelberg-Mannheim and Göttingen, Göttingen, Germany.
313 Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
314 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...