TGFβ2-induced senescence during early inner ear development. View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Alejandro Gibaja, María R Aburto, Sara Pulido, Manuel Collado, Juan M Hurle, Isabel Varela-Nieto, Marta Magariños

ABSTRACT

Embryonic development requires the coordinated regulation of apoptosis, survival, autophagy, proliferation and differentiation programs. Senescence has recently joined the cellular processes required to master development, in addition to its well-described roles in cancer and ageing. Here, we show that senescent cells are present in a highly regulated temporal pattern in the developing vertebrate inner ear, first, surrounding the otic pore and, later, in the otocyst at the endolymphatic duct. Cellular senescence is associated with areas of increased apoptosis and reduced proliferation consistent with the induction of the process when the endolymphatic duct is being formed. Modulation of senescence disrupts otic vesicle morphology. Transforming growth factor beta (TGFβ) signaling interacts with signaling pathways elicited by insulin-like growth factor type 1 (IGF-1) to jointly coordinate cellular dynamics required for morphogenesis and differentiation. Taken together, these results show that senescence is a natural occurring process essential for early inner ear development. More... »

PAGES

5912

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-42040-0

DOI

http://dx.doi.org/10.1038/s41598-019-42040-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113378294

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30976015


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