Ontology type: schema:ScholarlyArticle Open Access: True
2019-12
AUTHORSYvette J. E. Sloot, Marcel J. R. Janssen, Antonius E. van Herwaarden, Robin P. Peeters, Romana T. Netea-Maier, Johannes W. A. Smit
ABSTRACTSufficient thyroid iodine uptake is needed to ensure effective radioactive iodine (RAI) treatment, which is mediated by the sodium-iodide symporter (NIS). Activation of AMP-activated-protein-kinase (AMPK), leads to decreased NIS expression and thyroid iodine uptake in in vitro and animal models. Clinically relevant conditions that lead to AMPK activation include metformin use and hypocaloric conditions. Here, we aim to assess the effects of metformin and hypocaloric diet on thyroid iodine uptake in healthy volunteers. Healthy male volunteers were included and randomized. Group 1 (n = 8) received metformin, group 2 (n = 7) followed a hypocaloric diet (1500 kcal/day), superposed on a moderate iodine restriction diet; Baseline measurements included thyroid iodine-123 (I-123) uptake and TSH, fT4, T3 and rT3 levels. After two weeks, thyroid function and I-123 uptake measurements were repeated. Baseline characteristics were similar between groups. Levels of TSH and fT4 were similar after each intervention. T3 decreased after hypocaloric diet and metformin (-0.2 ± 0.19 nmol/L, p = 0.0327; respectively -0.13 ± 0.13 nmol/L, p = 0.0282), resulting in decreased T3/rT3 ratios. There was no significant difference in thyroid I-123 uptake after each intervention. In conclusion, metformin treatment and hypocaloric diet resulted in a significant decrease in T3 levels and T3/rT3 ratios in healthy volunteers, without significant effects on thyroid iodine uptake. We found no indications that metformin or hypocaloric diet will have clinically relevant effects on RAI uptake. More... »
PAGES5396
http://scigraph.springernature.com/pub.10.1038/s41598-019-41997-2
DOIhttp://dx.doi.org/10.1038/s41598-019-41997-2
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1113160316
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30932012
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Pharmacology and Pharmaceutical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Radboud University Nijmegen Medical Centre",
"id": "https://www.grid.ac/institutes/grid.10417.33",
"name": [
"Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Geert Grooteplein Zuid 8, 6525 GA, Nijmegen, The Netherlands"
],
"type": "Organization"
},
"familyName": "Sloot",
"givenName": "Yvette J. E.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Radboud University Nijmegen Medical Centre",
"id": "https://www.grid.ac/institutes/grid.10417.33",
"name": [
"Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Geert Grooteplein Zuid 8, 6525 GA, Nijmegen, The Netherlands"
],
"type": "Organization"
},
"familyName": "Janssen",
"givenName": "Marcel J. R.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Radboud University Nijmegen Medical Centre",
"id": "https://www.grid.ac/institutes/grid.10417.33",
"name": [
"Department of Laboratory Medicine, Radboud University Medical Center, Geert Grooteplein Zuid 8, 6525, Nijmegen, GA, The Netherlands"
],
"type": "Organization"
},
"familyName": "van Herwaarden",
"givenName": "Antonius E.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Erasmus University Medical Center",
"id": "https://www.grid.ac/institutes/grid.5645.2",
"name": [
"Department of Internal Medicine, Academic centre for Thyroid Diseases, Erasmus University Medical Center, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands"
],
"type": "Organization"
},
"familyName": "Peeters",
"givenName": "Robin P.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Radboud University Nijmegen Medical Centre",
"id": "https://www.grid.ac/institutes/grid.10417.33",
"name": [
"Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Geert Grooteplein Zuid 8, 6525 GA, Nijmegen, The Netherlands"
],
"type": "Organization"
},
"familyName": "Netea-Maier",
"givenName": "Romana T.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Radboud University Nijmegen Medical Centre",
"id": "https://www.grid.ac/institutes/grid.10417.33",
"name": [
"Department of Internal Medicine, Division of Endocrinology, Radboud University Medical Center, Geert Grooteplein Zuid 8, 6525 GA, Nijmegen, The Netherlands"
],
"type": "Organization"
},
"familyName": "Smit",
"givenName": "Johannes W. A.",
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1159/000437365",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000192128"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s13277-015-3315-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003381944",
"https://doi.org/10.1007/s13277-015-3315-4"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/diabetes.51.7.2074",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003444821"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1089/thy.2015.0020",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007626247"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1530/eje-13-0284",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009238467"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1530/eje-13-0284",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009238467"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1677/joe.0.0730395",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010134819"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/379458a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016268461",
"https://doi.org/10.1038/379458a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.mlg.0000240287.57704.01",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018542924"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.mlg.0000240287.57704.01",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018542924"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/jcp.19.4.389",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023265532"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.pharmthera.2012.06.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024944028"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gad.17420111",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025759639"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1152/ajpcell.00136.2010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027804300"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1159/000346248",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029215092"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1530/eje-12-0447",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030121354"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1159/000371512",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030463032"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jc.2005-0535",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031775080"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci109590",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037180588"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4162/nrp.2016.10.2.167",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040406219"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/jamainternmed.2014.5294",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042554262"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci13505",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043705336"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci13505",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043705336"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1365-2265.2005.02247.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044875862"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1089/thy.2010.0417",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047217636"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1530/eje-13-0589",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050008626"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1055/s-0032-1312656",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1057262658"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1055/s-0034-1371803",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1057310048"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1089/thy.2007.0253",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059320120"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1089/thy.2013.0041",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059321669"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1089/thy.2013.0041",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059321669"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/er.2012-1036",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064286032"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jc.2002-022013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064286636"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jc.2008-2520",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064291108"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jc.2012-3799",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064293994"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jcem-42-1-197",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064309158"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jcem-65-5-829",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064314918"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/ajcn/71.6.1421",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074648260"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/ajcn/40.1.168",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1081933664"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082448608",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3389/fendo.2017.00163",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1090826415"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1055/s-0043-122224",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1092955288"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-12",
"datePublishedReg": "2019-12-01",
"description": "Sufficient thyroid iodine uptake is needed to ensure effective radioactive iodine (RAI) treatment, which is mediated by the sodium-iodide symporter (NIS). Activation of AMP-activated-protein-kinase (AMPK), leads to decreased NIS expression and thyroid iodine uptake in in vitro and animal models. Clinically relevant conditions that lead to AMPK activation include metformin use\u00a0and hypocaloric conditions. Here, we aim to assess the effects of metformin and hypocaloric diet on thyroid iodine uptake in healthy volunteers. Healthy male volunteers were included and randomized. Group 1 (n\u2009=\u20098) received metformin, group 2 (n\u2009=\u20097) followed a hypocaloric diet (1500\u2009kcal/day), superposed on a moderate iodine restriction diet; Baseline measurements included thyroid iodine-123 (I-123) uptake and TSH, fT4, T3 and rT3 levels. After two weeks, thyroid function and I-123 uptake measurements were repeated. Baseline characteristics were similar between groups. Levels of TSH and fT4 were similar after each intervention. T3 decreased after hypocaloric diet and metformin (-0.2\u2009\u00b1\u20090.19 nmol/L, p\u2009=\u20090.0327; respectively -0.13\u2009\u00b1\u20090.13 nmol/L, p\u2009=\u20090.0282), resulting in decreased T3/rT3 ratios. There was no significant difference in thyroid I-123 uptake after each intervention. In conclusion, metformin treatment and hypocaloric diet resulted in a significant decrease in T3 levels and T3/rT3 ratios in healthy volunteers, without significant effects on thyroid iodine uptake. We found no indications that metformin or hypocaloric diet will have clinically relevant effects on RAI uptake.",
"genre": "research_article",
"id": "sg:pub.10.1038/s41598-019-41997-2",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1045337",
"issn": [
"2045-2322"
],
"name": "Scientific Reports",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "9"
}
],
"name": "The Influence of Energy Depletion by Metformin or Hypocaloric Diet on Thyroid Iodine Uptake in Healthy Volunteers: a Randomized Trial",
"pagination": "5396",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"9ff229dccd247d87ff0f0d1a74d05fd649be0442c0d57f81c06e7a291728f9d5"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30932012"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101563288"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41598-019-41997-2"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1113160316"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41598-019-41997-2",
"https://app.dimensions.ai/details/publication/pub.1113160316"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T14:16",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000372_0000000372/records_117088_00000003.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/s41598-019-41997-2"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-41997-2'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-41997-2'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-41997-2'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-41997-2'
This table displays all metadata directly associated to this object as RDF triples.
217 TRIPLES
21 PREDICATES
67 URIs
21 LITERALS
9 BLANK NODES