Gestation age-associated dynamics of mitochondrial calcium uniporter subunits expression in feto-maternal complex at term and preterm delivery View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Polina A. Vishnyakova, Nadezhda V. Tarasova, Maria A. Volodina, Daria V. Tsvirkun, Iuliia A. Sukhanova, Tatiana A. Kurchakova, Nataliya E. Kan, Marzanat K. Medzidova, Gennadiy T. Sukhikh, Mikhail Yu. Vysokikh

ABSTRACT

Calcium plays a role of universal cellular regulator in the living cell and one of the crucial regulators of proper fetal development during gestation. Mitochondria are important for intracellular calcium handling and signaling. Mitochondrial calcium uniporter (mtCU) is a multiprotein complex of the mitochondrial inner membrane responsible for the transport of calcium to the mitochondrial matrix. In the present study, we analyzed the expression level of mtCU components in two parts of the feto-maternal system - placenta and myometrium at full-term delivery and at preterm birth (PTB) on different stages: 22-27, 28-32, 33-36 weeks of gestation (n = 50). A gradual increase of mRNA expression and changes in protein content of MCU and MICU1 subunits were revealed in the placenta during gestation. We also observed slower depolarization rate of isolated placental mitochondria induced by Ca2+ titration at PTB. In myometrium at PTB relative gene expression level of MCU, MCUb and SMDT1 increased as compared to full-term pregnancy, but the tendency to gradual increase of MCU protein simultaneous with MCUb increase and MICU1 decline was shown in gestational dynamics. Changes observed in the present study might be considered both natural dynamics as well as possible pathological mechanisms underlying preterm birth. More... »

PAGES

5501

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-41996-3

DOI

http://dx.doi.org/10.1038/s41598-019-41996-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113174496

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30940880


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