Ontology type: schema:ScholarlyArticle Open Access: True
2019-12
AUTHORSSara A. Zahran, Marwa Ali-Tammam, Abdelgawad M. Hashem, Ramy K. Aziz, Amal E. Ali
ABSTRACTThe gut microbiota enriches the human gene pool and contributes to xenobiotic metabolism. Microbial azoreductases modulate the reduction of azo-bonds, activating produgs and azo polymer-coated dosage forms, or degrading food additives. Here, we aimed to screen the healthy human gut microbiota for food colorant-reducing activity and to characterize factors modulating it. Four representative isolates from screened fecal samples were identified as E. coli (AZO-Ec), E. faecalis (AZO-Ef), E. avium (AZO-Ev) and B. cereus (AZO-Bc). Both AZO-Ef and AZO-Ev decolorized amaranth aerobically and microaerophilically while AZO-Ec and AZO-Bc had higher aerobic reduction rates. The isolates varied in their activities against different dyes, and the azo-reduction activity mostly followed zero-order reaction kinetics, with a few exceptions. Additionally, the isolates had different pH dependence, e.g., AZO-Ec was not affected by pH variation while AZO-Bc exhibited variable degradation kinetics at different pH levels. Cell-free extracts showed NADH-dependent enzymatic activities 14-19 times higher than extracellular fractions. FMN did not affect the reducing activity of AZO-Ef cell-free extract, whereas AZO-Ec, AZO-Ev and AZO-Bc had significantly higher reduction rates in its presence (P values = 0.02, 0.0001 and 0.02, respectively). Using Degenerate primers allowed the amplification of azoreductase genes, whose sequences were 98-99% similar to genes encoding FMN-dependent-NADH azoreductases. More... »
PAGES5508
http://scigraph.springernature.com/pub.10.1038/s41598-019-41894-8
DOIhttp://dx.doi.org/10.1038/s41598-019-41894-8
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30940826
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"type": "PropertyValue",
"value": [
"4abaea51a3c1b0c387763306722e6fa3b9eac57755c77f5e084f68f03af93235"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1113172350"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101563288"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30940826"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41598-019-41894-8",
"https://app.dimensions.ai/details/publication/pub.1113172350"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-15T09:10",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000376_0000000376/records_56155_00000006.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/s41598-019-41894-8"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-41894-8'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-41894-8'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-41894-8'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-41894-8'
This table displays all metadata directly associated to this object as RDF triples.
308 TRIPLES
21 PREDICATES
97 URIs
21 LITERALS
9 BLANK NODES