No signal of deleterious mutation accumulation in conserved gene sequences of extant asexual hexapods View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Alexander Brandt, Jens Bast, Stefan Scheu, Karen Meusemann, Alexander Donath, Kai Schütte, Ryuichiro Machida, Ken Kraaijeveld

ABSTRACT

Loss of sex and recombination is generally assumed to impede the effectiveness of purifying selection and to result in the accumulation of slightly deleterious mutations. Empirical evidence for this has come from several studies investigating mutational load in a small number of individual genes. However, recent whole transcriptome based studies have yielded inconsistent results, hence questioning the validity of the assumption of mutational meltdown in asexual populations. Here, we study the effectiveness of purifying selection in eight asexual hexapod lineages and their sexual relatives, as present in the 1 K Insect Transcriptome Evolution (1KITE) project, covering eight hexapod groups. We analyse the accumulation of slightly deleterious nonsynonymous and synonymous point mutations in 99 single copy orthologue protein-coding loci shared among the investigated taxa. While accumulation rates of nonsynonymous mutations differed between genes and hexapod groups, we found no effect of reproductive mode on the effectiveness of purifying selection acting at nonsynonymous and synonymous sites. Although the setup of this study does not fully rule out nondetection of subtle effects, our data does not support the established consensus of asexual lineages undergoing 'mutational meltdown'. More... »

PAGES

5338

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-41821-x

DOI

http://dx.doi.org/10.1038/s41598-019-41821-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113054396

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30926861


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