HCV-coinfection is related to an increased HIV-1 reservoir size in cART-treated HIV patients: a cross-sectional study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Maria Rosa López-Huertas, Claudia Palladino, Marta Garrido-Arquero, Beatriz Esteban-Cartelle, Marta Sánchez-Carrillo, Paula Martínez-Román, Luz Martín-Carbonero, Pablo Ryan, Lourdes Domínguez-Domínguez, Ignacio De Los Santos, Sara De La Fuente Moral, José Miguel Benito, Norma Rallón, José Alcamí, Salvador Resino, Amanda Fernández-Rodríguez, Mayte Coiras, Verónica Briz,

ABSTRACT

In HIV-1/HCV-coinfected patients, chronic HCV infection leads to an increased T-lymphocyte immune activation compared to HIV-monoinfected patients, thereby likely contributing to increase HIV-1 reservoir that is the major barrier for its eradication. Our objective was to evaluate the influence of HCV coinfection in HIV-1 viral reservoir size in resting (r) CD4+ T-cells (CD25-CD69-HLADR-). Multicenter cross-sectional study of 97 cART-treated HIV-1 patients, including 36 patients with HIV and HCV-chronic co-infection without anti-HCV treatment, 32 HIV patients with HCV spontaneous clearance and 29 HIV-monoinfected patients. rCD4+ T-cells were isolated and total DNA was extracted. HIV viral reservoir was measured by Alu-LTR qPCR. Differences between groups were calculated with a generalized linear model. Overall, 63.9% were men, median age of 41 years and Caucasian. Median CD4+ and CD8+ T-lymphocytes were 725 and 858 cells/mm3, respectively. CD4+ T nadir cells was 305 cells/mm3. Proviral HIV-1 DNA size was significantly increased in chronic HIV/HCV-coinfected compared to HIV-monoinfected patients (206.21 ± 47.38 vs. 87.34 ± 22.46, respectively; P = 0.009), as well as in spontaneously clarified HCV co-infected patients when compared to HIV-monoinfected individuals (136.20 ± 33.20; P = 0.009). HIV-1/HCV co-infected patients showed a larger HIV-1 reservoir size in comparison to HIV-monoinfected individuals. This increase could lead to a greater complexity in the elimination of HIV-1 reservoir in HIV-1/HCV-coinfected individuals, which should be considered in the current strategies for the elimination of HIV-1 reservoir. More... »

PAGES

5606

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-41788-9

DOI

http://dx.doi.org/10.1038/s41598-019-41788-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113182148

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30944340


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