The potential probiotic Lactobacillus rhamnosus CNCM I-3690 strain protects the intestinal barrier by stimulating both mucus production and cytoprotective response View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Rebeca Martín, Celia Chamignon, Nadia Mhedbi-Hajri, Florian Chain, Muriel Derrien, Unai Escribano-Vázquez, Peggy Garault, Aurélie Cotillard, Hang Phuong Pham, Christian Chervaux, Luis G. Bermúdez-Humarán, Tamara Smokvina, Philippe Langella

ABSTRACT

The gut barrier plays an important role in human health. When barrier function is impaired, altered permeability and barrier dysfunction can occur, leading to inflammatory bowel diseases, irritable bowel syndrome or obesity. Several bacteria, including pathogens and commensals, have been found to directly or indirectly modulate intestinal barrier function. The use of probiotic strains could be an important landmark in the management of gut dysfunction with a clear impact on the general population. Previously, we found that Lactobacillus rhamnosus CNCM I-3690 can protect intestinal barrier functions in mice inflammation model. Here, we investigated its mechanism of action. Our results show that CNCM I-3690 can (i) physically maintain modulated goblet cells and the mucus layer and (ii) counteract changes in local and systemic lymphocytes. Furthermore, mice colonic transcriptome analysis revealed that CNCM I-3690 enhances the expression of genes related to healthy gut permeability: motility and absorption, cell proliferation; and protective functions by inhibiting endogenous proteases. Finally, SpaFED pili are clearly important effectors since an L. rhamnosus ΔspaF mutant failed to provide the same benefits as the wild type strain. Taken together, our data suggest that CNCM I-3690 restores impaired intestinal barrier functions via anti-inflammatory and cytoprotective responses. More... »

PAGES

5398

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-019-41738-5

    DOI

    http://dx.doi.org/10.1038/s41598-019-41738-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113157180

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30931953


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