SuPAR correlates with mortality and clinical severity in patients with necrotizing soft-tissue infections: results from a prospective, observational cohort study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Peter Polzik, Olav Grøndal, Juliette Tavenier, Martin B. Madsen, Ove Andersen, Morten Hedetoft, Ole Hyldegaard

ABSTRACT

Necrotizing soft tissue infections (NSTI) have a 90-day mortality rate of 18-22%. Tools are needed for estimating the prognosis and severity of NSTI upon admission. We evaluated soluble urokinase-type plasminogen activator receptor (suPAR) levels at admission as a prognostic marker of NSTI severity and mortality. In a prospective, observational cohort study, suPAR was measured in 200 NSTI patients. We compared admission suPAR levels in survivors and non-survivors, patients with septic shock and non-shock, amputation and non-amputation, correlations with Simplified Acute Physiology Score II (SAPS II) and the Sequential Organ Failure Assessment (SOFA) score. Admission suPAR levels were higher in septic shock vs. non-septic shock patients (9.2 vs. 5.8 ng/mL, p-value < 0.001) and non-survivors vs. survivors (11 vs. 6.1 ng/mL, p-value < 0.001) and correlated with SAPS II (r = 0.52, p < 0.001) and SOFA score (r = 0.64, p < 0.001). Elevated suPAR upon admission was associated with 90-day mortality (log-rank test p < 0.001), however not after adjustment for age, sex, and SOFA score. The AUC for suPAR and 90-day mortality was 0.77. We found that suPAR is a promising candidate for prognosis and severity in patients with NSTI. More... »

PAGES

5098

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-41688-y

DOI

http://dx.doi.org/10.1038/s41598-019-41688-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112968769

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30911053


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Department of Anesthesiology, Center of Head and Orthopedics, Copenhagen University Hospital (Rigshospitalet), Copenhagen \u00d8, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Polzik", 
        "givenName": "Peter", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Anesthesiology, Center of Head and Orthopedics, Copenhagen University Hospital (Rigshospitalet), Copenhagen \u00d8, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gr\u00f8ndal", 
        "givenName": "Olav", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hvidovre Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411905.8", 
          "name": [
            "Clinical Research Center, Copenhagen University Hospital (Hvidovre), Hvidovre, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tavenier", 
        "givenName": "Juliette", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Rigshospitalet", 
          "id": "https://www.grid.ac/institutes/grid.475435.4", 
          "name": [
            "Department of Intensive Care, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Madsen", 
        "givenName": "Martin B.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hvidovre Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411905.8", 
          "name": [
            "Clinical Research Center, Copenhagen University Hospital (Hvidovre), Hvidovre, Denmark", 
            "The Emergency Department, Copenhagen University Hospital (Hvidovre), Hvidovre, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Andersen", 
        "givenName": "Ove", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Copenhagen University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.4973.9", 
          "name": [
            "Hyperbaric Medicine Center, Department of Anesthesiology, Center of Head and Orthopedics, University Hospital of Copenhagen (Rigshospitalet), Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hedetoft", 
        "givenName": "Morten", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Anesthesiology, Center of Head and Orthopedics, Copenhagen University Hospital (Rigshospitalet), Copenhagen \u00d8, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hyldegaard", 
        "givenName": "Ole", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1186/cc11463", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003453647", 
          "https://doi.org/10.1186/cc11463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13054-016-1210-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004788628", 
          "https://doi.org/10.1186/s13054-016-1210-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11739-015-1268-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004851916", 
          "https://doi.org/10.1007/s11739-015-1268-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2796.2011.02363.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010736781"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10096-011-1236-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013946116", 
          "https://doi.org/10.1007/s10096-011-1236-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10096-011-1236-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013946116", 
          "https://doi.org/10.1007/s10096-011-1236-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1757-7241-23-s1-a31", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014869503", 
          "https://doi.org/10.1186/1757-7241-23-s1-a31"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10096-016-2704-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015997720", 
          "https://doi.org/10.1007/s10096-016-2704-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10096-016-2704-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015997720", 
          "https://doi.org/10.1007/s10096-016-2704-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jclinepi.2007.11.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016528221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2796.2010.02252.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021627514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2796.2010.02252.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021627514"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jinf.2011.07.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023635245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijantimicag.2015.10.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024453386"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.168.7.3507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024818751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijcard.2012.07.018", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027029880"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jcrc.2013.08.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028695544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/cc10037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029080892", 
          "https://doi.org/10.1186/cc10037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/1354750x.2016.1171911", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030062827"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.it.2004.06.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030101857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2147/copd.s77654", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030759052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2796.2012.02569.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031483195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2004-06-2424", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032245353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00134-012-2613-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035973869", 
          "https://doi.org/10.1007/s00134-012-2613-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1993.03510240069035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037698576"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1067/j.cpsurg.2014.06.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038570037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000239120.32490.ab", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038807633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.ccm.0000239120.32490.ab", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038807633"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2008-12-193524", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044063538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2008-12-193524", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044063538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1469-0691.2004.00850.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045256866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2016.0287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045696843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.0901008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046979028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00365540310017366", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047785172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10096-007-0447-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050810209", 
          "https://doi.org/10.1007/s10096-007-0447-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10096-007-0447-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050810209", 
          "https://doi.org/10.1007/s10096-007-0447-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2009/504294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063203008"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/srep42179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083733712", 
          "https://doi.org/10.1038/srep42179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmjopen-2017-017805", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092116062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmjopen-2017-017805", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092116062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/tsaco-2017-000157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100395711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/tsaco-2017-000157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100395711"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Necrotizing soft tissue infections (NSTI) have a 90-day mortality rate of 18-22%. Tools are needed for estimating the prognosis and severity of NSTI upon admission. We evaluated soluble urokinase-type plasminogen activator receptor (suPAR) levels at admission as a prognostic marker of NSTI severity and mortality. In a prospective, observational cohort study, suPAR was measured in 200 NSTI patients. We compared admission suPAR levels in survivors and non-survivors, patients with septic shock and non-shock, amputation and non-amputation, correlations with Simplified Acute Physiology Score II (SAPS II) and the Sequential Organ Failure Assessment (SOFA) score. Admission suPAR levels were higher in septic shock vs. non-septic shock patients (9.2 vs. 5.8\u2009ng/mL, p-value\u2009<\u20090.001) and non-survivors vs. survivors (11 vs. 6.1\u2009ng/mL, p-value\u2009<\u20090.001) and correlated with SAPS II (r\u2009=\u20090.52, p\u2009<\u20090.001) and SOFA score (r\u2009=\u20090.64, p\u2009<\u20090.001). Elevated suPAR upon admission was associated with 90-day mortality (log-rank test p\u2009<\u20090.001), however not after adjustment for age, sex, and SOFA score. The AUC for suPAR and 90-day mortality was 0.77. We found that suPAR is a promising candidate for prognosis and severity in patients with NSTI.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-019-41688-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.3796335", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "SuPAR correlates with mortality and clinical severity in patients with necrotizing soft-tissue infections: results from a prospective, observational cohort study", 
    "pagination": "5098", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6e3e7951dd8849edfd148d2fb00e0dd0a6a80509c6dfa6f97cca3b9f68662c77"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30911053"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-019-41688-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112968769"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-019-41688-y", 
      "https://app.dimensions.ai/details/publication/pub.1112968769"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:57", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130817_00000006.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-019-41688-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-41688-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-41688-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-41688-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-41688-y'


 

This table displays all metadata directly associated to this object as RDF triples.

230 TRIPLES      21 PREDICATES      63 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-019-41688-y schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N7a9e93398f4e4e3eaece86d140872559
4 schema:citation sg:pub.10.1007/s00134-012-2613-1
5 sg:pub.10.1007/s10096-007-0447-5
6 sg:pub.10.1007/s10096-011-1236-8
7 sg:pub.10.1007/s10096-016-2704-y
8 sg:pub.10.1007/s11739-015-1268-7
9 sg:pub.10.1038/srep42179
10 sg:pub.10.1186/1757-7241-23-s1-a31
11 sg:pub.10.1186/cc10037
12 sg:pub.10.1186/cc11463
13 sg:pub.10.1186/s13054-016-1210-z
14 https://doi.org/10.1001/jama.1993.03510240069035
15 https://doi.org/10.1001/jama.2016.0287
16 https://doi.org/10.1016/j.ijantimicag.2015.10.011
17 https://doi.org/10.1016/j.ijcard.2012.07.018
18 https://doi.org/10.1016/j.it.2004.06.004
19 https://doi.org/10.1016/j.jclinepi.2007.11.008
20 https://doi.org/10.1016/j.jcrc.2013.08.005
21 https://doi.org/10.1016/j.jinf.2011.07.019
22 https://doi.org/10.1067/j.cpsurg.2014.06.001
23 https://doi.org/10.1080/00365540310017366
24 https://doi.org/10.1097/01.ccm.0000239120.32490.ab
25 https://doi.org/10.1111/j.1365-2796.2010.02252.x
26 https://doi.org/10.1111/j.1365-2796.2011.02363.x
27 https://doi.org/10.1111/j.1365-2796.2012.02569.x
28 https://doi.org/10.1111/j.1469-0691.2004.00850.x
29 https://doi.org/10.1136/bmjopen-2017-017805
30 https://doi.org/10.1136/tsaco-2017-000157
31 https://doi.org/10.1155/2009/504294
32 https://doi.org/10.1182/blood-2004-06-2424
33 https://doi.org/10.1182/blood-2008-12-193524
34 https://doi.org/10.2147/copd.s77654
35 https://doi.org/10.3109/1354750x.2016.1171911
36 https://doi.org/10.4049/jimmunol.0901008
37 https://doi.org/10.4049/jimmunol.168.7.3507
38 schema:datePublished 2019-12
39 schema:datePublishedReg 2019-12-01
40 schema:description Necrotizing soft tissue infections (NSTI) have a 90-day mortality rate of 18-22%. Tools are needed for estimating the prognosis and severity of NSTI upon admission. We evaluated soluble urokinase-type plasminogen activator receptor (suPAR) levels at admission as a prognostic marker of NSTI severity and mortality. In a prospective, observational cohort study, suPAR was measured in 200 NSTI patients. We compared admission suPAR levels in survivors and non-survivors, patients with septic shock and non-shock, amputation and non-amputation, correlations with Simplified Acute Physiology Score II (SAPS II) and the Sequential Organ Failure Assessment (SOFA) score. Admission suPAR levels were higher in septic shock vs. non-septic shock patients (9.2 vs. 5.8 ng/mL, p-value < 0.001) and non-survivors vs. survivors (11 vs. 6.1 ng/mL, p-value < 0.001) and correlated with SAPS II (r = 0.52, p < 0.001) and SOFA score (r = 0.64, p < 0.001). Elevated suPAR upon admission was associated with 90-day mortality (log-rank test p < 0.001), however not after adjustment for age, sex, and SOFA score. The AUC for suPAR and 90-day mortality was 0.77. We found that suPAR is a promising candidate for prognosis and severity in patients with NSTI.
41 schema:genre research_article
42 schema:inLanguage en
43 schema:isAccessibleForFree true
44 schema:isPartOf N23cb566e67214739b38785a54209229a
45 N28f6e86b9f9841b8a1f232d8242f8c9f
46 sg:journal.1045337
47 schema:name SuPAR correlates with mortality and clinical severity in patients with necrotizing soft-tissue infections: results from a prospective, observational cohort study
48 schema:pagination 5098
49 schema:productId N17a8832ba48a4b33b2d5462f13cd8737
50 N5a474e6d3a614c38a4c9c37d5fbe483f
51 N951483d24ecd47a7a35969463c26be86
52 Nbc7d023338d340c8866496be89be0bb6
53 Nd6b995af4dc1494e85f05f5ab22c7225
54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112968769
55 https://doi.org/10.1038/s41598-019-41688-y
56 schema:sdDatePublished 2019-04-11T13:57
57 schema:sdLicense https://scigraph.springernature.com/explorer/license/
58 schema:sdPublisher N76b4024e1f0e4b82960daf5d56affd8b
59 schema:url https://www.nature.com/articles/s41598-019-41688-y
60 sgo:license sg:explorer/license/
61 sgo:sdDataset articles
62 rdf:type schema:ScholarlyArticle
63 N17a8832ba48a4b33b2d5462f13cd8737 schema:name pubmed_id
64 schema:value 30911053
65 rdf:type schema:PropertyValue
66 N2168511b3650408daed16c5c8250ba48 schema:affiliation Nbf830a8ed2b74161b8baee1fd0f76d98
67 schema:familyName Grøndal
68 schema:givenName Olav
69 rdf:type schema:Person
70 N23cb566e67214739b38785a54209229a schema:issueNumber 1
71 rdf:type schema:PublicationIssue
72 N27c9887f29d04ce6a35a1d0b43cf4303 schema:affiliation https://www.grid.ac/institutes/grid.4973.9
73 schema:familyName Hedetoft
74 schema:givenName Morten
75 rdf:type schema:Person
76 N28f6e86b9f9841b8a1f232d8242f8c9f schema:volumeNumber 9
77 rdf:type schema:PublicationVolume
78 N3dba8eb014404dbaaeecb9e4970f2003 schema:affiliation https://www.grid.ac/institutes/grid.411905.8
79 schema:familyName Tavenier
80 schema:givenName Juliette
81 rdf:type schema:Person
82 N418e67377c7a4c88a3cd93bcaf3e3856 schema:affiliation Nacf00ac3e65344a0a9e8642a020a230c
83 schema:familyName Hyldegaard
84 schema:givenName Ole
85 rdf:type schema:Person
86 N5a474e6d3a614c38a4c9c37d5fbe483f schema:name doi
87 schema:value 10.1038/s41598-019-41688-y
88 rdf:type schema:PropertyValue
89 N7366a951b6d6491eb8fadf1de7078b5a rdf:first Nf500ad4e089845a9a2637c1f1ecd887c
90 rdf:rest N879edbcdb1a141feb682a240ffb85d42
91 N76b4024e1f0e4b82960daf5d56affd8b schema:name Springer Nature - SN SciGraph project
92 rdf:type schema:Organization
93 N7a9e93398f4e4e3eaece86d140872559 rdf:first N86db6a6a8cf94773814b43fbdd54942c
94 rdf:rest N8f9319f52f274e039773588f598cdfc4
95 N86db6a6a8cf94773814b43fbdd54942c schema:affiliation Nc98391a2926142279018a23e53607be3
96 schema:familyName Polzik
97 schema:givenName Peter
98 rdf:type schema:Person
99 N879edbcdb1a141feb682a240ffb85d42 rdf:first N27c9887f29d04ce6a35a1d0b43cf4303
100 rdf:rest Nee1a598751a741e0a03b9adc799f0bc2
101 N8f9319f52f274e039773588f598cdfc4 rdf:first N2168511b3650408daed16c5c8250ba48
102 rdf:rest Nb3c3bbcfb9af4e47a2f2df510551ab81
103 N951483d24ecd47a7a35969463c26be86 schema:name readcube_id
104 schema:value 6e3e7951dd8849edfd148d2fb00e0dd0a6a80509c6dfa6f97cca3b9f68662c77
105 rdf:type schema:PropertyValue
106 Nacc16fbe1b154f2081af1e09f2ee5c63 rdf:first Nde08a549157e4cebb79496371507b363
107 rdf:rest N7366a951b6d6491eb8fadf1de7078b5a
108 Nacf00ac3e65344a0a9e8642a020a230c schema:name Department of Anesthesiology, Center of Head and Orthopedics, Copenhagen University Hospital (Rigshospitalet), Copenhagen Ø, Denmark
109 rdf:type schema:Organization
110 Nb3c3bbcfb9af4e47a2f2df510551ab81 rdf:first N3dba8eb014404dbaaeecb9e4970f2003
111 rdf:rest Nacc16fbe1b154f2081af1e09f2ee5c63
112 Nbc7d023338d340c8866496be89be0bb6 schema:name nlm_unique_id
113 schema:value 101563288
114 rdf:type schema:PropertyValue
115 Nbf830a8ed2b74161b8baee1fd0f76d98 schema:name Department of Anesthesiology, Center of Head and Orthopedics, Copenhagen University Hospital (Rigshospitalet), Copenhagen Ø, Denmark
116 rdf:type schema:Organization
117 Nc98391a2926142279018a23e53607be3 schema:name Department of Anesthesiology, Center of Head and Orthopedics, Copenhagen University Hospital (Rigshospitalet), Copenhagen Ø, Denmark
118 rdf:type schema:Organization
119 Nd6b995af4dc1494e85f05f5ab22c7225 schema:name dimensions_id
120 schema:value pub.1112968769
121 rdf:type schema:PropertyValue
122 Nde08a549157e4cebb79496371507b363 schema:affiliation https://www.grid.ac/institutes/grid.475435.4
123 schema:familyName Madsen
124 schema:givenName Martin B.
125 rdf:type schema:Person
126 Nee1a598751a741e0a03b9adc799f0bc2 rdf:first N418e67377c7a4c88a3cd93bcaf3e3856
127 rdf:rest rdf:nil
128 Nf500ad4e089845a9a2637c1f1ecd887c schema:affiliation https://www.grid.ac/institutes/grid.411905.8
129 schema:familyName Andersen
130 schema:givenName Ove
131 rdf:type schema:Person
132 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
133 schema:name Medical and Health Sciences
134 rdf:type schema:DefinedTerm
135 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
136 schema:name Clinical Sciences
137 rdf:type schema:DefinedTerm
138 sg:grant.3796335 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-41688-y
139 rdf:type schema:MonetaryGrant
140 sg:journal.1045337 schema:issn 2045-2322
141 schema:name Scientific Reports
142 rdf:type schema:Periodical
143 sg:pub.10.1007/s00134-012-2613-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035973869
144 https://doi.org/10.1007/s00134-012-2613-1
145 rdf:type schema:CreativeWork
146 sg:pub.10.1007/s10096-007-0447-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050810209
147 https://doi.org/10.1007/s10096-007-0447-5
148 rdf:type schema:CreativeWork
149 sg:pub.10.1007/s10096-011-1236-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013946116
150 https://doi.org/10.1007/s10096-011-1236-8
151 rdf:type schema:CreativeWork
152 sg:pub.10.1007/s10096-016-2704-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1015997720
153 https://doi.org/10.1007/s10096-016-2704-y
154 rdf:type schema:CreativeWork
155 sg:pub.10.1007/s11739-015-1268-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004851916
156 https://doi.org/10.1007/s11739-015-1268-7
157 rdf:type schema:CreativeWork
158 sg:pub.10.1038/srep42179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083733712
159 https://doi.org/10.1038/srep42179
160 rdf:type schema:CreativeWork
161 sg:pub.10.1186/1757-7241-23-s1-a31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014869503
162 https://doi.org/10.1186/1757-7241-23-s1-a31
163 rdf:type schema:CreativeWork
164 sg:pub.10.1186/cc10037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029080892
165 https://doi.org/10.1186/cc10037
166 rdf:type schema:CreativeWork
167 sg:pub.10.1186/cc11463 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003453647
168 https://doi.org/10.1186/cc11463
169 rdf:type schema:CreativeWork
170 sg:pub.10.1186/s13054-016-1210-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1004788628
171 https://doi.org/10.1186/s13054-016-1210-z
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1001/jama.1993.03510240069035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037698576
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1001/jama.2016.0287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045696843
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1016/j.ijantimicag.2015.10.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024453386
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1016/j.ijcard.2012.07.018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027029880
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1016/j.it.2004.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030101857
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1016/j.jclinepi.2007.11.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016528221
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1016/j.jcrc.2013.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028695544
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1016/j.jinf.2011.07.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023635245
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1067/j.cpsurg.2014.06.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038570037
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1080/00365540310017366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047785172
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1097/01.ccm.0000239120.32490.ab schema:sameAs https://app.dimensions.ai/details/publication/pub.1038807633
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1111/j.1365-2796.2010.02252.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021627514
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1111/j.1365-2796.2011.02363.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010736781
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1111/j.1365-2796.2012.02569.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1031483195
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1111/j.1469-0691.2004.00850.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045256866
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1136/bmjopen-2017-017805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092116062
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1136/tsaco-2017-000157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100395711
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1155/2009/504294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063203008
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1182/blood-2004-06-2424 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032245353
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1182/blood-2008-12-193524 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044063538
212 rdf:type schema:CreativeWork
213 https://doi.org/10.2147/copd.s77654 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030759052
214 rdf:type schema:CreativeWork
215 https://doi.org/10.3109/1354750x.2016.1171911 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030062827
216 rdf:type schema:CreativeWork
217 https://doi.org/10.4049/jimmunol.0901008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046979028
218 rdf:type schema:CreativeWork
219 https://doi.org/10.4049/jimmunol.168.7.3507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024818751
220 rdf:type schema:CreativeWork
221 https://www.grid.ac/institutes/grid.411905.8 schema:alternateName Hvidovre Hospital
222 schema:name Clinical Research Center, Copenhagen University Hospital (Hvidovre), Hvidovre, Denmark
223 The Emergency Department, Copenhagen University Hospital (Hvidovre), Hvidovre, Denmark
224 rdf:type schema:Organization
225 https://www.grid.ac/institutes/grid.475435.4 schema:alternateName Rigshospitalet
226 schema:name Department of Intensive Care, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark
227 rdf:type schema:Organization
228 https://www.grid.ac/institutes/grid.4973.9 schema:alternateName Copenhagen University Hospital
229 schema:name Hyperbaric Medicine Center, Department of Anesthesiology, Center of Head and Orthopedics, University Hospital of Copenhagen (Rigshospitalet), Copenhagen, Denmark
230 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...