Pancreatic stone protein/regenerating protein is a potential biomarker for endoplasmic reticulum stress in beta cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Stephen Stone, Damien Abreu, Jana Mahadevan, Rie Asada, Kelly Kries, Rolf Graf, Bess A. Marshall, Tamara Hershey, Fumihiko Urano

ABSTRACT

Endoplasmic reticulum (ER) stress in beta cells is an important pathogenic component of both type 1 and type 2 diabetes mellitus, as well as genetic forms of diabetes, especially Wolfram syndrome. However, there are currently no convenient ways to assess ER stress in beta cells, raising the need for circulating ER stress markers indicative of beta cell health. Here we show that pancreatic stone protein/regenerating protein (PSP/reg) is a potential biomarker for ER stressed beta cells. PSP/reg levels are elevated in cell culture and mouse models of Wolfram syndrome, a prototype of ER stress-induced diabetes. Moreover, PSP/reg expression is induced by the canonical chemical inducers of ER stress, tunicamycin and thapsigargin. Circulating PSP/reg levels are also increased in some patients with Wolfram syndrome. Our results therefore reveal PSP/reg as a potential biomarker for beta cells under chronic ER stress, as is the case in Wolfram syndrome. More... »

PAGES

5199

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-019-41604-4

    DOI

    http://dx.doi.org/10.1038/s41598-019-41604-4

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112989699

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30914711


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