IL-27 promotes NK cell effector functions via Maf-Nrf2 pathway during influenza infection View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Pawan Kumar, Kamalakannan Rajasekaran, Arash Nanbakhsh, Jack Gorski, Monica S. Thakar, Subramaniam Malarkannan

ABSTRACT

Influenza virus targets epithelial cells in the upper respiratory tract. Natural Killer (NK) cell-mediated early innate defense responses to influenza infection include the killing of infected epithelial cells and generation of anti-viral cytokines including interferon gamma (IFN-γ). To date, it is unclear how the underlying cytokine milieu during infection regulates NK cell effector functions. Our data show during influenza infection myeloid cell-derived IL-27 regulates the early-phase effector functions of NK cells in the bronchioalveolar and lung tissue. Lack of IL-27R (Il27ra-/-) or IL-27 (Ebi3-/-) resulted in impaired NK cell effector functions including the generation of anti-viral IFN-γ responses. We identify CD27+CD11b+ NK cells as the primary subset that expresses IL-27R, which predominantly produces IFN-γ within the upper respiratory tract of the infected mice. IL-27 alone was incapable of altering the effector functions of NK cells. However, IL-27 sensitizes NK cells to augment both in vitro and in vivo responses mediated via the NKG2D receptor. This 'priming' function of IL-27 is mediated partly via transcriptional pathways regulated by Mafs and Nrf2 transcriptionally regulating TFAM and CPT1. Our data for the first time establishes a novel role for IL-27 in regulating early-phase effector functions of NK cells during influenza infection. More... »

PAGES

4984

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-41478-6

DOI

http://dx.doi.org/10.1038/s41598-019-41478-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112897108

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30899058


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