The miRNA-449 family mediates doxorubicin resistance in triple-negative breast cancer by regulating cell cycle factors View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Eduardo Tormo, Sandra Ballester, Anna Adam-Artigues, Octavio Burgués, Elisa Alonso, Begoña Bermejo, Silvia Menéndez, Sandra Zazo, Juan Madoz-Gúrpide, Ana Rovira, Joan Albanell, Federico Rojo, Ana Lluch, Pilar Eroles

ABSTRACT

The mechanisms of chemotherapy resistance in triple negative breast cancer remain unclear, and so, new molecules which might mediate this resistance could optimize treatment response. Here we analyzed the involvement of the miRNA-449 family in the response to doxorubicin. The cell viability, cell-cycle phases, and the expression of in silico target genes and proteins of sensitive/resistant triple negative breast cancer cell lines were evaluated in response to doxorubicin treatment and after gain/loss of miRNAs-449 function achieved by transient transfection. Triple negative breast cancer patients were selected for ex vivo experiments and to evaluate gene and miRNAs expression changes after treatment, as well as survival analysis by Kaplan-Meier. Doxorubicin treatment upregulated miRNAs-449 and DNA-damage responder factors E2F1 and E2F3 in triple negative breast cancer sensitive breast cancer cells, while expression remained unaltered in resistant ones. In vitro overexpression of miRNAs-449 sensitized cells to the treatment and significantly reduced the resistance to doxorubicin. These changes showed also a strong effect on cell cycle regulation. Finally, elevated levels of miRNA-449a associated significantly with better survival in chemotherapy-treated triple negative breast cancer patients. These results reveal for the first time the involvement of the miRNA-449 family in doxorubicin resistance and their predictive and prognostic value in triple negative breast cancer patients. More... »

PAGES

5316

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-41472-y

DOI

http://dx.doi.org/10.1038/s41598-019-41472-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113058312

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30926829


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-41472-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-41472-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-41472-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-41472-y'


 

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307 https://www.grid.ac/institutes/grid.5612.0 schema:alternateName Pompeu Fabra University
308 schema:name Cancer Research Program, IMIM (Hospital del Mar Research Institute), Barcelona, Spain
309 Medical Oncology Department, Hospital del Mar-CIBERONC, Barcelona, Spain
310 Universitat Pompeu Fabra, Barcelona, Spain
311 rdf:type schema:Organization
 




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