Biological Cardiac Tissue Effects of High-Energy Heavy Ions – Investigation for Myocardial Ablation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Felicitas Rapp, Palma Simoniello, Julia Wiedemann, Karola Bahrami, Valeria Grünebaum, Svetlana Ktitareva, Marco Durante, P. Lugenbiel, D. Thomas, H. Immo Lehmann, Douglas L. Packer, Christian Graeff, Claudia Fournier

ABSTRACT

Noninvasive X-ray stereotactic treatment is considered a promising alternative to catheter ablation in patients affected by severe heart arrhythmia. High-energy heavy ions can deliver high radiation doses in small targets with reduced damage to the normal tissue compared to conventional X-rays. For this reason, charged particle therapy, widely used in oncology, can be a powerful tool for radiosurgery in cardiac diseases. We have recently performed a feasibility study in a swine model using high doses of high-energy C-ions to target specific cardiac structures. Interruption of cardiac conduction was observed in some animals. Here we report the biological effects measured in the pig heart tissue of the same animals six months after the treatment. Immunohistological analysis of the target tissue showed (1.) long-lasting vascular damage, i.e. persistent hemorrhage, loss of microvessels, and occurrence of siderophages, (2.) fibrosis and (3.) loss of polarity of targeted cardiomyocytes and wavy fibers with vacuolization. We conclude that the observed physiological changes in heart function are produced by radiation-induced fibrosis and cardiomyocyte functional inactivation. No effects were observed in the normal tissue traversed by the particle beam, suggesting that charged particles have the potential to produce ablation of specific heart targets with minimal side effects. More... »

PAGES

5000

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-41314-x

DOI

http://dx.doi.org/10.1038/s41598-019-41314-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112902377

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30899027


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