The acidic protein rich in leucines Anp32b is an immunomodulator of inflammation in mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Jan Chemnitz, Dorothea Pieper, Lena Stich, Udo Schumacher, Stefan Balabanov, Michael Spohn, Adam Grundhoff, Alexander Steinkasserer, Joachim Hauber, Elisabeth Zinser

ABSTRACT

ANP32B belongs to a family of evolutionary conserved acidic nuclear phosphoproteins (ANP32A-H). Family members have been described as multifunctional regulatory proteins and proto-oncogenic factors affecting embryonic development, cell proliferation, apoptosis, and gene expression at various levels. Involvement of ANP32B in multiple processes of cellular life is reflected by the previous finding that systemic gene knockout (KO) of Anp32b leads to embryonic lethality in mice. Here, we demonstrate that a conditional KO of Anp32b is well tolerated in adult animals. However, after immune activation splenocytes isolated from Anp32b KO mice showed a strong commitment towards Th17 immune responses. Therefore, we further analyzed the respective animals in vivo using an experimental autoimmune encephalomyelitis (EAE) model. Interestingly, an exacerbated clinical score was observed in the Anp32b KO mice. This was accompanied by the finding that animal-derived T lymphocytes were in a more activated state, and RNA sequencing analyses revealed hyperactivation of several T lymphocyte-associated immune modulatory pathways, attended by significant upregulation of Tfh cell numbers that altogether might explain the observed strong autoreactive processes. Therefore, Anp32b appears to fulfill a role in regulating adequate adaptive immune responses and, hence, may be involved in dysregulation of pathways leading to autoimmune disorders and/or immune deficiencies. More... »

PAGES

4853

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-41269-z

DOI

http://dx.doi.org/10.1038/s41598-019-41269-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112850665

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30890743


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Heinrich-Pette-Institute", 
          "id": "https://www.grid.ac/institutes/grid.418481.0", 
          "name": [
            "Heinrich Pette Institute \u2013 Leibniz Institute for Experimental Virology, Martinistrasse 52, 20251, Hamburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chemnitz", 
        "givenName": "Jan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heinrich-Pette-Institute", 
          "id": "https://www.grid.ac/institutes/grid.418481.0", 
          "name": [
            "Heinrich Pette Institute \u2013 Leibniz Institute for Experimental Virology, Martinistrasse 52, 20251, Hamburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pieper", 
        "givenName": "Dorothea", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsklinikum Erlangen", 
          "id": "https://www.grid.ac/institutes/grid.411668.c", 
          "name": [
            "Department of Immune Modulation, University Hospital Erlangen, Hartmannstrasse 14, 91052, Erlangen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stich", 
        "givenName": "Lena", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Medical Center Hamburg-Eppendorf", 
          "id": "https://www.grid.ac/institutes/grid.13648.38", 
          "name": [
            "Center for Experimental Medicine, Department of Anatomy and Experimental Morphology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schumacher", 
        "givenName": "Udo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital of Zurich", 
          "id": "https://www.grid.ac/institutes/grid.412004.3", 
          "name": [
            "Division of Hematology, University Hospital Zurich, R\u00e4mistrasse 100, CH-8091, Zurich, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Balabanov", 
        "givenName": "Stefan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heinrich-Pette-Institute", 
          "id": "https://www.grid.ac/institutes/grid.418481.0", 
          "name": [
            "Heinrich Pette Institute \u2013 Leibniz Institute for Experimental Virology, Martinistrasse 52, 20251, Hamburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Spohn", 
        "givenName": "Michael", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Heinrich-Pette-Institute", 
          "id": "https://www.grid.ac/institutes/grid.418481.0", 
          "name": [
            "Heinrich Pette Institute \u2013 Leibniz Institute for Experimental Virology, Martinistrasse 52, 20251, Hamburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grundhoff", 
        "givenName": "Adam", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsklinikum Erlangen", 
          "id": "https://www.grid.ac/institutes/grid.411668.c", 
          "name": [
            "Department of Immune Modulation, University Hospital Erlangen, Hartmannstrasse 14, 91052, Erlangen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Steinkasserer", 
        "givenName": "Alexander", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "German Center for Infection Research", 
          "id": "https://www.grid.ac/institutes/grid.452463.2", 
          "name": [
            "Heinrich Pette Institute \u2013 Leibniz Institute for Experimental Virology, Martinistrasse 52, 20251, Hamburg, Germany", 
            "German Center for Infection Research (DZIF), Partner site Hamburg, Hamburg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hauber", 
        "givenName": "Joachim", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universit\u00e4tsklinikum Erlangen", 
          "id": "https://www.grid.ac/institutes/grid.411668.c", 
          "name": [
            "Department of Immune Modulation, University Hospital Erlangen, Hartmannstrasse 14, 91052, Erlangen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zinser", 
        "givenName": "Elisabeth", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1074/jbc.m115.664490", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000368814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.ppat.1003587", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000396688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1204294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001572839", 
          "https://doi.org/10.1038/sj.onc.1204294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1204294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001572839", 
          "https://doi.org/10.1038/sj.onc.1204294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.2000.3133", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003627520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/cddis.2016.8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004246401", 
          "https://doi.org/10.1038/cddis.2016.8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.274.29.20053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005780665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1538/expanim.15-0062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006931807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coi.2016.08.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007111578"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m608849200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007534902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.2000.4244", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007701243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.89.22.10915", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010234644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.00383-06", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011323121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m510306200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011709900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20030973", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011833589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/dbio.2002.0597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014465698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13059-014-0550-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015222646", 
          "https://doi.org/10.1186/s13059-014-0550-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13059-014-0550-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015222646", 
          "https://doi.org/10.1186/s13059-014-0550-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000064058", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016389711"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2012.06.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020946919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-8993(01)02351-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027145823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbrc.2006.02.026", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027345333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgp320", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028143276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/carcin/bgp320", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028143276"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m400017200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029518280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0057820", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030729810"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0097233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030816533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature16474", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031148592", 
          "https://doi.org/10.1038/nature16474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/40159", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032260577", 
          "https://doi.org/10.1038/40159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/40159", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032260577", 
          "https://doi.org/10.1038/40159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1080/14734220310017212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032601961", 
          "https://doi.org/10.1080/14734220310017212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0022-1759(98)00204-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033648033"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jmb.2010.06.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034472890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(03)00150-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034517449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4401825", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035627220", 
          "https://doi.org/10.1038/sj.cdd.4401825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.cdd.4401825", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035627220", 
          "https://doi.org/10.1038/sj.cdd.4401825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7554/elife.08939", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036380246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(96)00010-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036396905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0167-4781(97)00165-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038032988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.200838619", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039311087"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7600210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039762656"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(01)00196-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041000766"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0904-925", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041181708", 
          "https://doi.org/10.1038/ng0904-925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0904-925", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041181708", 
          "https://doi.org/10.1038/ng0904-925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1080/14734220410019020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041808894", 
          "https://doi.org/10.1080/14734220410019020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1091/mbc.7.12.2045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041832872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/22.22.4673", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042438223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dmm.014449", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043771199"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01734359", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044065382", 
          "https://doi.org/10.1007/bf01734359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01734359", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044065382", 
          "https://doi.org/10.1007/bf01734359"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-5793(00)01218-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046329716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)80371-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046740254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.01396-07", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047260154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1106211108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047522538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0013597", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047994482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.21.9670", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049153586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1460-9568.2005.04555.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050567177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1460-9568.2005.04555.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050567177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/jvi.01518-10", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051449139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.24.8.3140-3149.2004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052471185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2011.07.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053060803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/bts635", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053365587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00006a020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055156849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1064693", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062445438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1076807", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062446982"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/me.2005-0248", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064327541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/nxi.0000000000000272", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064351891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/nxi.0000000000000272", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064351891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/nxi.0000000000000272", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064351891"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078709041", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079104928", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "ANP32B belongs to a family of evolutionary conserved acidic nuclear phosphoproteins (ANP32A-H). Family members have been described as multifunctional regulatory proteins and proto-oncogenic factors affecting embryonic development, cell proliferation, apoptosis, and gene expression at various levels. Involvement of ANP32B in multiple processes of cellular life is reflected by the previous finding that systemic gene knockout (KO) of Anp32b leads to embryonic lethality in mice. Here, we demonstrate that a conditional KO of Anp32b is well tolerated in adult animals. However, after immune activation splenocytes isolated from Anp32b KO mice showed a strong commitment towards Th17 immune responses. Therefore, we further analyzed the respective animals in vivo using an experimental autoimmune encephalomyelitis (EAE) model. Interestingly, an exacerbated clinical score was observed in the Anp32b KO mice. This was accompanied by the finding that animal-derived T lymphocytes were in a more activated state, and RNA sequencing analyses revealed hyperactivation of several T lymphocyte-associated immune modulatory pathways, attended by significant upregulation of Tfh cell numbers that altogether might explain the observed strong autoreactive processes. Therefore, Anp32b appears to fulfill a role in regulating adequate adaptive immune responses and, hence, may be involved in dysregulation of pathways leading to autoimmune disorders and/or immune deficiencies.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-019-41269-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "The acidic protein rich in leucines Anp32b is an immunomodulator of inflammation in mice", 
    "pagination": "4853", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "21852aef5ca05f909f22802bfdf68105a83efa4b76979506189a88038b9189e7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30890743"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-019-41269-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112850665"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-019-41269-z", 
      "https://app.dimensions.ai/details/publication/pub.1112850665"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78956_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-019-41269-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-41269-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-41269-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-41269-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-41269-z'


 

This table displays all metadata directly associated to this object as RDF triples.

325 TRIPLES      21 PREDICATES      90 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-019-41269-z schema:about anzsrc-for:11
2 anzsrc-for:1107
3 schema:author N721f6633725e45519d9e16e2b3611786
4 schema:citation sg:pub.10.1007/bf01734359
5 sg:pub.10.1038/40159
6 sg:pub.10.1038/cddis.2016.8
7 sg:pub.10.1038/nature16474
8 sg:pub.10.1038/ng0904-925
9 sg:pub.10.1038/sj.cdd.4401825
10 sg:pub.10.1038/sj.onc.1204294
11 sg:pub.10.1080/14734220310017212
12 sg:pub.10.1080/14734220410019020
13 sg:pub.10.1186/s13059-014-0550-8
14 https://app.dimensions.ai/details/publication/pub.1078709041
15 https://app.dimensions.ai/details/publication/pub.1079104928
16 https://doi.org/10.1002/eji.200838619
17 https://doi.org/10.1006/bbrc.2000.3133
18 https://doi.org/10.1006/bbrc.2000.4244
19 https://doi.org/10.1006/dbio.2002.0597
20 https://doi.org/10.1016/0014-5793(96)00010-5
21 https://doi.org/10.1016/j.bbrc.2006.02.026
22 https://doi.org/10.1016/j.bbrc.2012.06.025
23 https://doi.org/10.1016/j.coi.2016.08.003
24 https://doi.org/10.1016/j.febslet.2011.07.020
25 https://doi.org/10.1016/j.jmb.2010.06.005
26 https://doi.org/10.1016/s0006-8993(01)02351-4
27 https://doi.org/10.1016/s0014-5793(00)01218-7
28 https://doi.org/10.1016/s0022-1759(98)00204-x
29 https://doi.org/10.1016/s0092-8674(00)80371-2
30 https://doi.org/10.1016/s0092-8674(01)00196-9
31 https://doi.org/10.1016/s0092-8674(03)00150-8
32 https://doi.org/10.1016/s0167-4781(97)00165-6
33 https://doi.org/10.1021/bi00006a020
34 https://doi.org/10.1038/sj.emboj.7600210
35 https://doi.org/10.1073/pnas.1106211108
36 https://doi.org/10.1073/pnas.89.22.10915
37 https://doi.org/10.1073/pnas.91.21.9670
38 https://doi.org/10.1074/jbc.274.29.20053
39 https://doi.org/10.1074/jbc.m115.664490
40 https://doi.org/10.1074/jbc.m400017200
41 https://doi.org/10.1074/jbc.m510306200
42 https://doi.org/10.1074/jbc.m608849200
43 https://doi.org/10.1084/jem.20030973
44 https://doi.org/10.1091/mbc.7.12.2045
45 https://doi.org/10.1093/bioinformatics/bts635
46 https://doi.org/10.1093/carcin/bgp320
47 https://doi.org/10.1093/nar/22.22.4673
48 https://doi.org/10.1111/j.1460-9568.2005.04555.x
49 https://doi.org/10.1126/science.1064693
50 https://doi.org/10.1126/science.1076807
51 https://doi.org/10.1128/jvi.00383-06
52 https://doi.org/10.1128/jvi.01518-10
53 https://doi.org/10.1128/mcb.01396-07
54 https://doi.org/10.1128/mcb.24.8.3140-3149.2004
55 https://doi.org/10.1159/000064058
56 https://doi.org/10.1210/me.2005-0248
57 https://doi.org/10.1212/nxi.0000000000000272
58 https://doi.org/10.1242/dmm.014449
59 https://doi.org/10.1371/journal.pone.0013597
60 https://doi.org/10.1371/journal.pone.0057820
61 https://doi.org/10.1371/journal.pone.0097233
62 https://doi.org/10.1371/journal.ppat.1003587
63 https://doi.org/10.1538/expanim.15-0062
64 https://doi.org/10.7554/elife.08939
65 schema:datePublished 2019-12
66 schema:datePublishedReg 2019-12-01
67 schema:description ANP32B belongs to a family of evolutionary conserved acidic nuclear phosphoproteins (ANP32A-H). Family members have been described as multifunctional regulatory proteins and proto-oncogenic factors affecting embryonic development, cell proliferation, apoptosis, and gene expression at various levels. Involvement of ANP32B in multiple processes of cellular life is reflected by the previous finding that systemic gene knockout (KO) of Anp32b leads to embryonic lethality in mice. Here, we demonstrate that a conditional KO of Anp32b is well tolerated in adult animals. However, after immune activation splenocytes isolated from Anp32b KO mice showed a strong commitment towards Th17 immune responses. Therefore, we further analyzed the respective animals in vivo using an experimental autoimmune encephalomyelitis (EAE) model. Interestingly, an exacerbated clinical score was observed in the Anp32b KO mice. This was accompanied by the finding that animal-derived T lymphocytes were in a more activated state, and RNA sequencing analyses revealed hyperactivation of several T lymphocyte-associated immune modulatory pathways, attended by significant upregulation of Tfh cell numbers that altogether might explain the observed strong autoreactive processes. Therefore, Anp32b appears to fulfill a role in regulating adequate adaptive immune responses and, hence, may be involved in dysregulation of pathways leading to autoimmune disorders and/or immune deficiencies.
68 schema:genre research_article
69 schema:inLanguage en
70 schema:isAccessibleForFree true
71 schema:isPartOf N7ece00e392d04f72afa388b8aec1c975
72 Ned2aa64d46e545b0b09eb0c42d3e763e
73 sg:journal.1045337
74 schema:name The acidic protein rich in leucines Anp32b is an immunomodulator of inflammation in mice
75 schema:pagination 4853
76 schema:productId N1440aee9de844f95ab3852992fbeb91e
77 N18f7ef48f8174dbd8feefec0a7f28550
78 N3ecb153e47f44e06b3cac347d8feb987
79 N4fce6dd6d9f142bc8c869521a4756043
80 N898d48f8d021447ea073c711cddf19a1
81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112850665
82 https://doi.org/10.1038/s41598-019-41269-z
83 schema:sdDatePublished 2019-04-11T13:19
84 schema:sdLicense https://scigraph.springernature.com/explorer/license/
85 schema:sdPublisher N30a496be8b564775a32b3c9b8f4a7fb1
86 schema:url https://www.nature.com/articles/s41598-019-41269-z
87 sgo:license sg:explorer/license/
88 sgo:sdDataset articles
89 rdf:type schema:ScholarlyArticle
90 N00e36a96e2f644138cadf7adfc5b32c0 schema:affiliation https://www.grid.ac/institutes/grid.418481.0
91 schema:familyName Chemnitz
92 schema:givenName Jan
93 rdf:type schema:Person
94 N101a3681a3eb452eb37bc756b8865b41 schema:affiliation https://www.grid.ac/institutes/grid.412004.3
95 schema:familyName Balabanov
96 schema:givenName Stefan
97 rdf:type schema:Person
98 N1440aee9de844f95ab3852992fbeb91e schema:name readcube_id
99 schema:value 21852aef5ca05f909f22802bfdf68105a83efa4b76979506189a88038b9189e7
100 rdf:type schema:PropertyValue
101 N18f7ef48f8174dbd8feefec0a7f28550 schema:name nlm_unique_id
102 schema:value 101563288
103 rdf:type schema:PropertyValue
104 N29ac67ff806a45518d50373a3593242d rdf:first N8093ac58c3644e17b71d330a2998b87b
105 rdf:rest N65a01492b5cd457f9ef709d6dcf267bb
106 N30a496be8b564775a32b3c9b8f4a7fb1 schema:name Springer Nature - SN SciGraph project
107 rdf:type schema:Organization
108 N3987f80bb5ec45c5bcbcd7d7d96fa276 schema:affiliation https://www.grid.ac/institutes/grid.13648.38
109 schema:familyName Schumacher
110 schema:givenName Udo
111 rdf:type schema:Person
112 N3af945258a7b4b239095d9234eb8717b rdf:first Nafa14183109a4db3897409bb72c7f77a
113 rdf:rest N29ac67ff806a45518d50373a3593242d
114 N3c61f2c2e33b41edafcce531b09fc1ba rdf:first N3987f80bb5ec45c5bcbcd7d7d96fa276
115 rdf:rest Ned973fd59aee40dba6afde7e5dd19211
116 N3ecb153e47f44e06b3cac347d8feb987 schema:name doi
117 schema:value 10.1038/s41598-019-41269-z
118 rdf:type schema:PropertyValue
119 N4c2e1aabc2bb40c0a208adc51e8ecac5 schema:affiliation https://www.grid.ac/institutes/grid.418481.0
120 schema:familyName Grundhoff
121 schema:givenName Adam
122 rdf:type schema:Person
123 N4fce6dd6d9f142bc8c869521a4756043 schema:name dimensions_id
124 schema:value pub.1112850665
125 rdf:type schema:PropertyValue
126 N5d20d4e030284f8f8bc28b670fc360a1 rdf:first Nd0096c2b539146359c6bc8f657dfa019
127 rdf:rest N3c61f2c2e33b41edafcce531b09fc1ba
128 N65a01492b5cd457f9ef709d6dcf267bb rdf:first Ne62ede95eba648e88e7747b83ed5353e
129 rdf:rest rdf:nil
130 N721f6633725e45519d9e16e2b3611786 rdf:first N00e36a96e2f644138cadf7adfc5b32c0
131 rdf:rest Nd21d46306a3648d2b46f69693ec69ede
132 N73c4dfe70f7146e5a99240f720692e1a schema:affiliation https://www.grid.ac/institutes/grid.418481.0
133 schema:familyName Spohn
134 schema:givenName Michael
135 rdf:type schema:Person
136 N7ece00e392d04f72afa388b8aec1c975 schema:volumeNumber 9
137 rdf:type schema:PublicationVolume
138 N8093ac58c3644e17b71d330a2998b87b schema:affiliation https://www.grid.ac/institutes/grid.452463.2
139 schema:familyName Hauber
140 schema:givenName Joachim
141 rdf:type schema:Person
142 N898d48f8d021447ea073c711cddf19a1 schema:name pubmed_id
143 schema:value 30890743
144 rdf:type schema:PropertyValue
145 Nafa14183109a4db3897409bb72c7f77a schema:affiliation https://www.grid.ac/institutes/grid.411668.c
146 schema:familyName Steinkasserer
147 schema:givenName Alexander
148 rdf:type schema:Person
149 Nb83048cafe4a48c9b556a199b09ce54c rdf:first N4c2e1aabc2bb40c0a208adc51e8ecac5
150 rdf:rest N3af945258a7b4b239095d9234eb8717b
151 Nd0096c2b539146359c6bc8f657dfa019 schema:affiliation https://www.grid.ac/institutes/grid.411668.c
152 schema:familyName Stich
153 schema:givenName Lena
154 rdf:type schema:Person
155 Nd21d46306a3648d2b46f69693ec69ede rdf:first Nd6790fd52948456c94177cba65615673
156 rdf:rest N5d20d4e030284f8f8bc28b670fc360a1
157 Nd6790fd52948456c94177cba65615673 schema:affiliation https://www.grid.ac/institutes/grid.418481.0
158 schema:familyName Pieper
159 schema:givenName Dorothea
160 rdf:type schema:Person
161 Ne62ede95eba648e88e7747b83ed5353e schema:affiliation https://www.grid.ac/institutes/grid.411668.c
162 schema:familyName Zinser
163 schema:givenName Elisabeth
164 rdf:type schema:Person
165 Ned2aa64d46e545b0b09eb0c42d3e763e schema:issueNumber 1
166 rdf:type schema:PublicationIssue
167 Ned973fd59aee40dba6afde7e5dd19211 rdf:first N101a3681a3eb452eb37bc756b8865b41
168 rdf:rest Nfb9f9cb6dd8447e5becf78f2982eb8a6
169 Nfb9f9cb6dd8447e5becf78f2982eb8a6 rdf:first N73c4dfe70f7146e5a99240f720692e1a
170 rdf:rest Nb83048cafe4a48c9b556a199b09ce54c
171 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
172 schema:name Medical and Health Sciences
173 rdf:type schema:DefinedTerm
174 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
175 schema:name Immunology
176 rdf:type schema:DefinedTerm
177 sg:journal.1045337 schema:issn 2045-2322
178 schema:name Scientific Reports
179 rdf:type schema:Periodical
180 sg:pub.10.1007/bf01734359 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044065382
181 https://doi.org/10.1007/bf01734359
182 rdf:type schema:CreativeWork
183 sg:pub.10.1038/40159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032260577
184 https://doi.org/10.1038/40159
185 rdf:type schema:CreativeWork
186 sg:pub.10.1038/cddis.2016.8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004246401
187 https://doi.org/10.1038/cddis.2016.8
188 rdf:type schema:CreativeWork
189 sg:pub.10.1038/nature16474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031148592
190 https://doi.org/10.1038/nature16474
191 rdf:type schema:CreativeWork
192 sg:pub.10.1038/ng0904-925 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041181708
193 https://doi.org/10.1038/ng0904-925
194 rdf:type schema:CreativeWork
195 sg:pub.10.1038/sj.cdd.4401825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035627220
196 https://doi.org/10.1038/sj.cdd.4401825
197 rdf:type schema:CreativeWork
198 sg:pub.10.1038/sj.onc.1204294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001572839
199 https://doi.org/10.1038/sj.onc.1204294
200 rdf:type schema:CreativeWork
201 sg:pub.10.1080/14734220310017212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032601961
202 https://doi.org/10.1080/14734220310017212
203 rdf:type schema:CreativeWork
204 sg:pub.10.1080/14734220410019020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041808894
205 https://doi.org/10.1080/14734220410019020
206 rdf:type schema:CreativeWork
207 sg:pub.10.1186/s13059-014-0550-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015222646
208 https://doi.org/10.1186/s13059-014-0550-8
209 rdf:type schema:CreativeWork
210 https://app.dimensions.ai/details/publication/pub.1078709041 schema:CreativeWork
211 https://app.dimensions.ai/details/publication/pub.1079104928 schema:CreativeWork
212 https://doi.org/10.1002/eji.200838619 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039311087
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1006/bbrc.2000.3133 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003627520
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1006/bbrc.2000.4244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007701243
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1006/dbio.2002.0597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014465698
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/0014-5793(96)00010-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036396905
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/j.bbrc.2006.02.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027345333
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/j.bbrc.2012.06.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020946919
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1016/j.coi.2016.08.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007111578
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1016/j.febslet.2011.07.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053060803
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1016/j.jmb.2010.06.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034472890
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1016/s0006-8993(01)02351-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027145823
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1016/s0014-5793(00)01218-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046329716
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1016/s0022-1759(98)00204-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033648033
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1016/s0092-8674(00)80371-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046740254
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1016/s0092-8674(01)00196-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041000766
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1016/s0092-8674(03)00150-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034517449
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1016/s0167-4781(97)00165-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038032988
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1021/bi00006a020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055156849
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1038/sj.emboj.7600210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039762656
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1073/pnas.1106211108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047522538
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1073/pnas.89.22.10915 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010234644
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1073/pnas.91.21.9670 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049153586
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1074/jbc.274.29.20053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005780665
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1074/jbc.m115.664490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000368814
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1074/jbc.m400017200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029518280
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1074/jbc.m510306200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011709900
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1074/jbc.m608849200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007534902
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1084/jem.20030973 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011833589
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1091/mbc.7.12.2045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041832872
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1093/bioinformatics/bts635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053365587
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1093/carcin/bgp320 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028143276
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1093/nar/22.22.4673 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042438223
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1111/j.1460-9568.2005.04555.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050567177
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1126/science.1064693 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062445438
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1126/science.1076807 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062446982
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1128/jvi.00383-06 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011323121
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1128/jvi.01518-10 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051449139
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1128/mcb.01396-07 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047260154
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1128/mcb.24.8.3140-3149.2004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052471185
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1159/000064058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016389711
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1210/me.2005-0248 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064327541
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1212/nxi.0000000000000272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064351891
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1242/dmm.014449 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043771199
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1371/journal.pone.0013597 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047994482
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1371/journal.pone.0057820 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030729810
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1371/journal.pone.0097233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030816533
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1371/journal.ppat.1003587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000396688
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1538/expanim.15-0062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006931807
307 rdf:type schema:CreativeWork
308 https://doi.org/10.7554/elife.08939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036380246
309 rdf:type schema:CreativeWork
310 https://www.grid.ac/institutes/grid.13648.38 schema:alternateName University Medical Center Hamburg-Eppendorf
311 schema:name Center for Experimental Medicine, Department of Anatomy and Experimental Morphology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
312 rdf:type schema:Organization
313 https://www.grid.ac/institutes/grid.411668.c schema:alternateName Universitätsklinikum Erlangen
314 schema:name Department of Immune Modulation, University Hospital Erlangen, Hartmannstrasse 14, 91052, Erlangen, Germany
315 rdf:type schema:Organization
316 https://www.grid.ac/institutes/grid.412004.3 schema:alternateName University Hospital of Zurich
317 schema:name Division of Hematology, University Hospital Zurich, Rämistrasse 100, CH-8091, Zurich, Switzerland
318 rdf:type schema:Organization
319 https://www.grid.ac/institutes/grid.418481.0 schema:alternateName Heinrich-Pette-Institute
320 schema:name Heinrich Pette Institute – Leibniz Institute for Experimental Virology, Martinistrasse 52, 20251, Hamburg, Germany
321 rdf:type schema:Organization
322 https://www.grid.ac/institutes/grid.452463.2 schema:alternateName German Center for Infection Research
323 schema:name German Center for Infection Research (DZIF), Partner site Hamburg, Hamburg, Germany
324 Heinrich Pette Institute – Leibniz Institute for Experimental Virology, Martinistrasse 52, 20251, Hamburg, Germany
325 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...