Ontology type: schema:ScholarlyArticle Open Access: True
2019-12
AUTHORSByunghee Yoo, Veronica Clavijo Jordan, Patrick Sheedy, Ann-Marie Billig, Alana Ross, Pamela Pantazopoulos, Zdravka Medarova
ABSTRACTThe recent past has seen impressive progress in the treatment of various malignancies using immunotherapy. One of the most promising approaches involves immune checkpoint inhibitors. However, the clinical results with these agents have demonstrated variability in the response. Pancreatic cancer, in particular, has proven resistant to initial immunotherapy approaches. Here, we describe an alternative strategy that relies on combining gemcitabine and a novel programmed death-ligand 1 (PD-L1) inhibitor, termed MN-siPDL1. MN-siPDL1 incorporates small interfering RNA against PD-L1 (siPDL1) conjugated to a magnetic nanocarrier (MN). We show that noninvasive magnetic resonance imaging (MRI) could be used to monitor therapeutic response. Combination therapy consisting of gemcitabine and MN-siPDL1 in a syngeneic murine pancreatic cancer model resulted in a significant reduction in tumor growth and an increase in survival. Following optimization, a 90% reduction in tumor volume was achieved 2 weeks after the beginning of treatment. Whereas 100% of the control animals had succumbed to their tumors by week 6 after the beginning of treatment, there was no mortality in the experimental group by week 5, and 67% of the experimental animals survived for 12 weeks. This method could provide therapeutic benefit against an intractable disease for which there are no effective treatments and which is characterized by a mere 1% 5-year survival. More... »
PAGES4712
http://scigraph.springernature.com/pub.10.1038/s41598-019-41251-9
DOIhttp://dx.doi.org/10.1038/s41598-019-41251-9
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1112849854
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30886310
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Massachusetts General Hospital",
"id": "https://www.grid.ac/institutes/grid.32224.35",
"name": [
"MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, 02129, Boston, MA, USA"
],
"type": "Organization"
},
"familyName": "Yoo",
"givenName": "Byunghee",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Massachusetts General Hospital",
"id": "https://www.grid.ac/institutes/grid.32224.35",
"name": [
"MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, 02129, Boston, MA, USA"
],
"type": "Organization"
},
"familyName": "Jordan",
"givenName": "Veronica Clavijo",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Northeastern University",
"id": "https://www.grid.ac/institutes/grid.261112.7",
"name": [
"Department of Health Sciences, CaNCURE Program, Northeastern University, 02115, Boston, MA, USA"
],
"type": "Organization"
},
"familyName": "Sheedy",
"givenName": "Patrick",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Northeastern University",
"id": "https://www.grid.ac/institutes/grid.261112.7",
"name": [
"Department of Health Sciences, CaNCURE Program, Northeastern University, 02115, Boston, MA, USA"
],
"type": "Organization"
},
"familyName": "Billig",
"givenName": "Ann-Marie",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Massachusetts General Hospital",
"id": "https://www.grid.ac/institutes/grid.32224.35",
"name": [
"MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, 02129, Boston, MA, USA"
],
"type": "Organization"
},
"familyName": "Ross",
"givenName": "Alana",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Massachusetts General Hospital",
"id": "https://www.grid.ac/institutes/grid.32224.35",
"name": [
"MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, 02129, Boston, MA, USA"
],
"type": "Organization"
},
"familyName": "Pantazopoulos",
"givenName": "Pamela",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Massachusetts General Hospital",
"id": "https://www.grid.ac/institutes/grid.32224.35",
"name": [
"MGH/MIT/HMS Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, 02129, Boston, MA, USA"
],
"type": "Organization"
},
"familyName": "Medarova",
"givenName": "Zdravka",
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/978-1-4939-3148-4_13",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007857663",
"https://doi.org/10.1007/978-1-4939-3148-4_13"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nm1486",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008398170",
"https://doi.org/10.1038/nm1486"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12885-016-2798-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018095320",
"https://doi.org/10.1186/s12885-016-2798-8"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12885-016-2798-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018095320",
"https://doi.org/10.1186/s12885-016-2798-8"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1011923",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022967950"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/gutjnl-2015-309304",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023687882"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1166/jbn.2014.1795",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025178385"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1166/jbn.2014.1795",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025178385"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/cji.0b013e3181eec14c",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026214675"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/cji.0b013e3181eec14c",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026214675"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/cji.0b013e3181eec14c",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026214675"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-14-1860",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029098996"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-10-2070",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031734681"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ijc.27872",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035811121"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ijc.27872",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035811121"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(16)32455-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046150233"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1200694",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047413837"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.pan.2016.12.010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047679758"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/ddg.13012",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047976976"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s11095-012-0679-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048517667",
"https://doi.org/10.1007/s11095-012-0679-7"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ijc.28499",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050647001"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ijc.28499",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050647001"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/onc.2012.173",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050681272",
"https://doi.org/10.1038/onc.2012.173"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-15-0888",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063215812"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-15-0888",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063215812"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/1756283x13478680",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064076494"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/1756283x13478680",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064076494"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/srep45060",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084132908",
"https://doi.org/10.1038/srep45060"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/srep45060",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084132908",
"https://doi.org/10.1038/srep45060"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1090397240",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/jamaoncol.2017.2411",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1091234688"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/17512433.2017.1389275",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1092133548"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(17)33297-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1099711508"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.eururo.2017.11.023",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1099728182"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2217/fon-2017-0338",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1100451078"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.18632/oncotarget.25085",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1103497672"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1242/dmm.034793",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1104598483"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3747/co.25.3750",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1104888284"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2018.36.4_suppl.349",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1111064418"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-12",
"datePublishedReg": "2019-12-01",
"description": "The recent past has seen impressive progress in the treatment of various malignancies using immunotherapy. One of the most promising approaches involves immune checkpoint inhibitors. However, the clinical results with these agents have demonstrated variability in the response. Pancreatic cancer, in particular, has proven resistant to initial immunotherapy approaches. Here, we describe an alternative strategy that relies on combining gemcitabine and a novel programmed death-ligand 1 (PD-L1) inhibitor, termed MN-siPDL1. MN-siPDL1 incorporates small interfering RNA against PD-L1 (siPDL1) conjugated to a magnetic nanocarrier (MN). We show that noninvasive magnetic resonance imaging (MRI) could be used to monitor therapeutic response. Combination therapy consisting of gemcitabine and MN-siPDL1 in a syngeneic murine pancreatic cancer model resulted in a significant reduction in tumor growth and an increase in survival. Following optimization, a 90% reduction in tumor volume was achieved 2 weeks after the beginning of treatment. Whereas 100% of the control animals had succumbed to their tumors by week 6 after the beginning of treatment, there was no mortality in the experimental group by week 5, and 67% of the experimental animals survived for 12 weeks. This method could provide therapeutic benefit against an intractable disease for which there are no effective treatments and which is characterized by a mere 1% 5-year survival.",
"genre": "research_article",
"id": "sg:pub.10.1038/s41598-019-41251-9",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.7725239",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.3806512",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2481655",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1045337",
"issn": [
"2045-2322"
],
"name": "Scientific Reports",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "9"
}
],
"name": "RNAi-Mediated PD-L1 Inhibition for Pancreatic Cancer Immunotherapy",
"pagination": "4712",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"0b39da4628f5962183a47f95bdda64143c6b9bdee3ec6716d67bab07fcc9d901"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30886310"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101563288"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41598-019-41251-9"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1112849854"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41598-019-41251-9",
"https://app.dimensions.ai/details/publication/pub.1112849854"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T13:59",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130823_00000006.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/s41598-019-41251-9"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-41251-9'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-41251-9'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-41251-9'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-41251-9'
This table displays all metadata directly associated to this object as RDF triples.
207 TRIPLES
21 PREDICATES
59 URIs
21 LITERALS
9 BLANK NODES