DNA polymerase ι is acetylated in response to SN2 alkylating agents View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Justyna McIntyre, Aleksandra Sobolewska, Mikolaj Fedorowicz, Mary P. McLenigan, Matylda Macias, Roger Woodgate, Ewa Sledziewska-Gojska

ABSTRACT

DNA polymerase iota (Polι) belongs to the Y-family of DNA polymerases that are involved in DNA damage tolerance through their role in translesion DNA synthesis. Like all other Y-family polymerases, Polι interacts with proliferating cell nuclear antigen (PCNA), Rev1, ubiquitin and ubiquitinated-PCNA and is also ubiquitinated itself. Here, we report that Polι also interacts with the p300 acetyltransferase and is acetylated. The primary acetylation site is K550, located in the Rev1-interacting region. However, K550 amino acid substitutions have no effect on Polι's ability to interact with Rev1. Interestingly, we find that acetylation of Polι significantly and specifically increases in response to SN2 alkylating agents and to a lower extent to SN1 alkylating and oxidative agents. As we have not observed acetylation of Polι's closest paralogue, DNA polymerase eta (Polη), with which Polι shares many functional similarities, we believe that this modification might exclusively regulate yet to be determined, and separate function(s) of Polι. More... »

PAGES

4789

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-41249-3

DOI

http://dx.doi.org/10.1038/s41598-019-41249-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112854599

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30886224


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