Gut microbiota profile in children affected by atopic dermatitis and evaluation of intestinal persistence of a probiotic mixture View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Sofia Reddel, Federica Del Chierico, Andrea Quagliariello, Simona Giancristoforo, Pamela Vernocchi, Alessandra Russo, Alessandro Fiocchi, Paolo Rossi, Lorenza Putignani, May El Hachem

ABSTRACT

Atopic dermatitis (AD) has been hypothesised to be associated with gut microbiota (GM) composition. We performed a comparative study of the GM profile of 19 AD children and 18 healthy individuals aimed at identifying bacterial biomarkers associated with the disease. The effect of probiotic intake (Bifidobacterium breve plus Lactobacillus salivarius) on the modulation of GM and the probiotic persistence in the GM were also evaluated. Faecal samples were analysed by real-time PCR and 16S rRNA targeted metagenomics. Although the probiotics, chosen for this study, did not shape the entire GM profile, we observed the ability of these species to pass through the gastrointestinal tract and to persist (only B. breve) in the GM. Moreover, the GM of patients compared to CTRLs showed a dysbiotic status characterised by an increase of Faecalibacterium, Oscillospira, Bacteroides, Parabacteroides and Sutterella and a reduction of short-chain fatty acid (SCFA)-producing bacteria (i.e., Bifidobacterium, Blautia, Coprococcus, Eubacterium and Propionibacterium). Taken togheter these results show an alteration in AD microbiota composition with the depletion or absence of some species, opening the way to future probiotic intervention studies. More... »

PAGES

4996

References to SciGraph publications

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  • Journal

    TITLE

    Scientific Reports

    ISSUE

    1

    VOLUME

    9

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-019-41149-6

    DOI

    http://dx.doi.org/10.1038/s41598-019-41149-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112902468

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30899033


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