Ataxia-Telangiectasia Mutated is located in cardiac mitochondria and impacts oxidative phosphorylation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Marguerite Blignaut, Ben Loos, Stanley W. Botchway, Anthony W. Parker, Barbara Huisamen

ABSTRACT

The absence of Ataxia-Telangiectasia mutated protein kinase (ATM) is associated with neurological, metabolic and cardiovascular defects. The protein has been associated with mitochondria and its absence results in mitochondrial dysfunction. Furthermore, it can be activated in the cytosol by mitochondrial oxidative stress and mediates a cellular anti-oxidant response through the pentose phosphate pathway (PPP). However, the precise location and function of ATM within mitochondria and its role in oxidative phosphorylation is still unknown. We show that ATM is found endogenously within cardiac myocyte mitochondria under normoxic conditions and is consistently associated with the inner mitochondrial membrane. Acute ex vivo inhibition of ATM protein kinase significantly decreased mitochondrial electron transfer chain complex I-mediated oxidative phosphorylation rate but did not decrease coupling efficiency or oxygen consumption rate during β-oxidation. Chemical inhibition of ATM in rat cardiomyoblast cells (H9c2) significantly decreased the excited-state autofluorescence lifetime of enzyme-bound reduced NADH and its phosphorylated form, NADPH (NAD(P)H; 2.77 ± 0.26 ns compared to 2.57 ± 0.14 ns in KU60019-treated cells). This suggests an interaction between ATM and the electron transfer chain in the mitochondria, and hence may have an important role in oxidative phosphorylation in terminally differentiated cells such as cardiomyocytes. More... »

PAGES

4782

References to SciGraph publications

  • 2003-03. ATM and related protein kinases: safeguarding genome integrity in NATURE REVIEWS CANCER
  • 2017-12. Aquarius is required for proper CtIP expression and homologous recombination repair in SCIENTIFIC REPORTS
  • 2012-06. Effect of Chronic CPT-1 Inhibition on Myocardial Ischemia-Reperfusion Injury (I/R) in a Model of Diet-Induced Obesity in CARDIOVASCULAR DRUGS AND THERAPY
  • 2005-12. The use of time-resolved fluorescence imaging in the study of protein kinase C localisation in cells in BMC CELL BIOLOGY
  • 2016-05. Quantification of the Metabolic State in Cell-Model of Parkinson’s Disease by Fluorescence Lifetime Imaging Microscopy in SCIENTIFIC REPORTS
  • 2014-12. Separating NADH and NADPH fluorescence in live cells and tissues using FLIM in NATURE COMMUNICATIONS
  • 2013-12. mTOR direct interactions with Rheb-GTPase and raptor: sub-cellular localization using fluorescence lifetime imaging in BMC CELL BIOLOGY
  • 2017-12. In situ click chemistry generation of cyclooxygenase-2 inhibitors in NATURE COMMUNICATIONS
  • 2013-04. The ATM protein kinase: regulating the cellular response to genotoxic stress, and more in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • 2004-01. The mitochondrial calcium uniporter is a highly selective ion channel in NATURE
  • 2018-01. Oxidative stress preconditioning of mouse perivascular myogenic progenitors selects a subpopulation of cells with a distinct survival advantage in vitro and in vivo in CELL DEATH & DISEASE
  • 2015-12. Structure and function of mitochondrial membrane protein complexes in BMC BIOLOGY
  • 2015-02. ATM Protein Kinase Signaling, Type 2 Diabetes and Cardiovascular Disease in CARDIOVASCULAR DRUGS AND THERAPY
  • 2011-10. Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase in NATURE CELL BIOLOGY
  • 2018-12. Protein-bound NAD(P)H Lifetime is Sensitive to Multiple Fates of Glucose Carbon in SCIENTIFIC REPORTS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-019-41108-1

    DOI

    http://dx.doi.org/10.1038/s41598-019-41108-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112849662

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30886180


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