The Post-Synaptic Function of Brca2 View Full Text


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Article Info

DATE

2019-12

AUTHORS

Charles X. Wang, Judit Jimenez-Sainz, Ryan B. Jensen, Alexander V. Mazin

ABSTRACT

Homologous Recombination (HR) is a high-fidelity process with a range of biologic functions from generation of genetic diversity to repair of DNA double-strand breaks (DSBs). In mammalian cells, BRCA2 facilitates the polymerization of RAD51 onto ssDNA to form a presynaptic nucleoprotein filament. This filament can then strand invade a homologous dsDNA to form the displacement loop (D-loop) structure leading to the eventual DSB repair. Here, we have found that RAD51 in stoichiometric excess over ssDNA can cause D-loop disassembly in vitro; furthermore, we show that this RAD51 activity is countered by BRCA2. These results demonstrate that BRCA2 may have a previously unexpected activity: regulation of HR at a post-synaptic stage by modulating RAD51-mediated D-loop dissociation. Our in vitro results suggest a mechanistic underpinning of homeostasis between RAD51 and BRCA2, which is an important factor of HR in mammalian cells. More... »

PAGES

4554

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-41054-y

DOI

http://dx.doi.org/10.1038/s41598-019-41054-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112767354

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30872704


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