Disturbed flow induces a sustained, stochastic NF-κB activation which may support intracranial aneurysm growth in vivo View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Daniel C. Baeriswyl, Ioanna Prionisti, Tom Peach, Grigoris Tsolkas, Kok Yean Chooi, John Vardakis, Sandrine Morel, Mannekomba R. Diagbouga, Philippe Bijlenga, Simon Cuhlmann, Paul Evans, Brenda R. Kwak, Yiannis Ventikos, Rob Krams

ABSTRACT

Intracranial aneurysms are associated with disturbed velocity patterns, and chronic inflammation, but the relevance for these findings are currently unknown. Here, we show that (disturbed) shear stress induced by vortices is a sufficient condition to activate the endothelial NF-kB pathway, possibly through a mechanism of mechanosensor de-activation. We provide evidence for this statement through in-vitro live cell imaging of NF-kB in HUVECs exposed to different flow conditions, stochastic modelling of flow induced NF-kB activation and induction of disturbed flow in mouse carotid arteries. Finally, CFD and immunofluorescence on human intracranial aneurysms showed a correlation similar to the mouse vessels, suggesting that disturbed shear stress may lead to sustained NF-kB activation thereby offering an explanation for the close association between disturbed flow and intracranial aneurysms. More... »

PAGES

4738

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-40959-y

DOI

http://dx.doi.org/10.1038/s41598-019-40959-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112873714

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30894565


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-40959-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-40959-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-40959-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-40959-y'


 

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