Anti-mitochondrial autoantibodies in systemic lupus erythematosus and their association with disease manifestations View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Yann Becker, Renée-Claude Loignon, Anne-Sophie Julien, Geneviève Marcoux, Isabelle Allaeys, Tania Lévesque, Emmanuelle Rollet-Labelle, Hadrien Benk-Fortin, Nathalie Cloutier, Imène Melki, Lihi Eder, Éric Wagner, Martin Pelletier, Hassan El Hajj, Marie-Ève Tremblay, Clémence Belleannée, Marie-Josée Hébert, Mélanie Dieudé, Joyce Rauch, Paul R. Fortin, Eric Boilard

ABSTRACT

Mitochondria are organelles that govern energy supply and control cell death. Mitochondria also express bacterial features, such as the presence of inner membrane cardiolipin and a circular genome rich in hypomethylated CpG motifs. While mitochondrial extrusion by damaged organs or activated cells is thought to trigger innate immunity, it is unclear whether extracellular mitochondria also stimulate an adaptive immune response. We describe the development of novel assays to detect autoantibodies specific to two distinct components of the mitochondrion: the mitochondrial outer membrane and mitochondrial DNA. Antibodies to these two mitochondrial constituents were increased in both human and murine systemic lupus erythematosus (SLE), compared to controls, and were present at higher levels than in patients with antiphospholipid syndrome or primary biliary cirrhosis. In both bi- and multi-variate regression models, antibodies to mitochondrial DNA, but not whole mitochondria, were associated with increased anti-dsDNA antibodies and lupus nephritis. This study describes new and optimized methods for the assessment of anti-mitochondrial antibodies, and demonstrates their presence in both human and murine SLE. These findings suggest that different mitochondrial components are immunogenic in SLE, and support the concept that extracellular mitochondria may provide an important source of circulating autoantigens in SLE. More... »

PAGES

4530

References to SciGraph publications

  • 2009-11. Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps in CELL DEATH & DIFFERENTIATION
  • 1990-11. The mitochondrial chaperonin hsp60 is required for its own assembly in NATURE
  • 1986-10. Mitochondrial antigens and autoantibodies: from anti-M1 to anti-M9 in JOURNAL OF MOLECULAR MEDICINE
  • 2014-07. Mitochondria released by cells undergoing TNF-α-induced necroptosis act as danger signals in CELL DEATH & DISEASE
  • 2009-12. Levels of plasma circulating cell free nuclear and mitochondrial DNA as potential biomarkers for breast tumors in MOLECULAR CANCER
  • 2016-12. Microparticles in the blood of patients with systemic lupus erythematosus (SLE): phenotypic characterization and clinical associations in SCIENTIFIC REPORTS
  • 2009-11. Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells in NATURE PROTOCOLS
  • 2014-01. Mitochondrial form and function in NATURE
  • 2010-03. Circulating mitochondrial DAMPs cause inflammatory responses to injury in NATURE
  • 2011-06. Mitochondria in innate immune responses in NATURE REVIEWS IMMUNOLOGY
  • 2008-09. Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense in NATURE MEDICINE
  • 1997-05. An ancestral mitochondrial DNA resembling a eubacterial genome in miniature in NATURE
  • 2017-05. Mitochondria are the powerhouses of immunity in NATURE IMMUNOLOGY
  • 2016-02. Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease in NATURE MEDICINE
  • 2007-02. Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts in NATURE PROTOCOLS
  • 2010-05. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors in NATURE IMMUNOLOGY
  • 2010-05. Natural IgM Antibodies Against Oxidation-Specific Epitopes in JOURNAL OF CLINICAL IMMUNOLOGY
  • 2003-10. Extracellular mitochondrial DNA and oxidatively damaged DNA in synovial fluid of patients with rheumatoid arthritis in ARTHRITIS RESEARCH & THERAPY
  • 2012-04-25. Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-019-40900-3

    DOI

    http://dx.doi.org/10.1038/s41598-019-40900-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112766937

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30872710


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Laval", 
              "id": "https://www.grid.ac/institutes/grid.23856.3a", 
              "name": [
                "Centre de Recherche du CHU de Qu\u00e9bec \u2013 Universit\u00e9 Laval, D\u00e9partement de microbiologie et immunologie, Facult\u00e9 de M\u00e9decine de l\u2032Universit\u00e9 Laval, Qu\u00e9bec, Qc, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Becker", 
            "givenName": "Yann", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Laval", 
              "id": "https://www.grid.ac/institutes/grid.23856.3a", 
              "name": [
                "Division de Rhumatologie, D\u00e9partement de M\u00e9decine, CHU de Qu\u00e9bec \u2013 Universit\u00e9 Laval, Qu\u00e9bec, Qc, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Loignon", 
            "givenName": "Ren\u00e9e-Claude", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Laval", 
              "id": "https://www.grid.ac/institutes/grid.23856.3a", 
              "name": [
                "D\u00e9partement de math\u00e9matiques et statistique, Universit\u00e9 Laval, Qu\u00e9bec, Qc, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Julien", 
            "givenName": "Anne-Sophie", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Laval", 
              "id": "https://www.grid.ac/institutes/grid.23856.3a", 
              "name": [
                "Centre de Recherche du CHU de Qu\u00e9bec \u2013 Universit\u00e9 Laval, D\u00e9partement de microbiologie et immunologie, Facult\u00e9 de M\u00e9decine de l\u2032Universit\u00e9 Laval, Qu\u00e9bec, Qc, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Marcoux", 
            "givenName": "Genevi\u00e8ve", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Laval", 
              "id": "https://www.grid.ac/institutes/grid.23856.3a", 
              "name": [
                "Centre de Recherche du CHU de Qu\u00e9bec \u2013 Universit\u00e9 Laval, D\u00e9partement de microbiologie et immunologie, Facult\u00e9 de M\u00e9decine de l\u2032Universit\u00e9 Laval, Qu\u00e9bec, Qc, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Allaeys", 
            "givenName": "Isabelle", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Laval", 
              "id": "https://www.grid.ac/institutes/grid.23856.3a", 
              "name": [
                "Centre de Recherche du CHU de Qu\u00e9bec \u2013 Universit\u00e9 Laval, D\u00e9partement de microbiologie et immunologie, Facult\u00e9 de M\u00e9decine de l\u2032Universit\u00e9 Laval, Qu\u00e9bec, Qc, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "L\u00e9vesque", 
            "givenName": "Tania", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Laval", 
              "id": "https://www.grid.ac/institutes/grid.23856.3a", 
              "name": [
                "Centre de Recherche du CHU de Qu\u00e9bec \u2013 Universit\u00e9 Laval, D\u00e9partement de microbiologie et immunologie, Facult\u00e9 de M\u00e9decine de l\u2032Universit\u00e9 Laval, Qu\u00e9bec, Qc, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rollet-Labelle", 
            "givenName": "Emmanuelle", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Laval", 
              "id": "https://www.grid.ac/institutes/grid.23856.3a", 
              "name": [
                "Centre de Recherche du CHU de Qu\u00e9bec \u2013 Universit\u00e9 Laval, D\u00e9partement de microbiologie et immunologie, Facult\u00e9 de M\u00e9decine de l\u2032Universit\u00e9 Laval, Qu\u00e9bec, Qc, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Benk-Fortin", 
            "givenName": "Hadrien", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Laval", 
              "id": "https://www.grid.ac/institutes/grid.23856.3a", 
              "name": [
                "Centre de Recherche du CHU de Qu\u00e9bec \u2013 Universit\u00e9 Laval, D\u00e9partement de microbiologie et immunologie, Facult\u00e9 de M\u00e9decine de l\u2032Universit\u00e9 Laval, Qu\u00e9bec, Qc, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cloutier", 
            "givenName": "Nathalie", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Laval", 
              "id": "https://www.grid.ac/institutes/grid.23856.3a", 
              "name": [
                "Centre de Recherche du CHU de Qu\u00e9bec \u2013 Universit\u00e9 Laval, D\u00e9partement de microbiologie et immunologie, Facult\u00e9 de M\u00e9decine de l\u2032Universit\u00e9 Laval, Qu\u00e9bec, Qc, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Melki", 
            "givenName": "Im\u00e8ne", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Women's College Hospital", 
              "id": "https://www.grid.ac/institutes/grid.417199.3", 
              "name": [
                "Women\u2019s College Hospital and University of Toronto, Toronto, ON, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Eder", 
            "givenName": "Lihi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Laval", 
              "id": "https://www.grid.ac/institutes/grid.23856.3a", 
              "name": [
                "Immunology and Histocompatibility Laboratory, Department of Medical Biology CHU de Qu\u00e9bec - Universit\u00e9 Laval; Department of Microbiology, Infectious Diseases and Immunology, Universit\u00e9 Laval, Qu\u00e9bec, Qc, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wagner", 
            "givenName": "\u00c9ric", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Laval", 
              "id": "https://www.grid.ac/institutes/grid.23856.3a", 
              "name": [
                "Centre de Recherche du CHU de Qu\u00e9bec \u2013 Universit\u00e9 Laval, D\u00e9partement de microbiologie et immunologie, Facult\u00e9 de M\u00e9decine de l\u2032Universit\u00e9 Laval, Qu\u00e9bec, Qc, Canada", 
                "Axe maladies infectieuses et inflammatoires, Centre de recherche du CHU de Qu\u00e9bec \u2013 Universit\u00e9 Laval, Qu\u00e9bec, Qc, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pelletier", 
            "givenName": "Martin", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Laval", 
              "id": "https://www.grid.ac/institutes/grid.23856.3a", 
              "name": [
                "Axe Neurosciences, Centre de Recherche du CHU de Qu\u00e9bec \u2013 Universit\u00e9 Laval, Qu\u00e9bec, Qc, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hajj", 
            "givenName": "Hassan El", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Laval", 
              "id": "https://www.grid.ac/institutes/grid.23856.3a", 
              "name": [
                "Axe Neurosciences, Centre de Recherche du CHU de Qu\u00e9bec \u2013 Universit\u00e9 Laval, Qu\u00e9bec, Qc, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tremblay", 
            "givenName": "Marie-\u00c8ve", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Laval", 
              "id": "https://www.grid.ac/institutes/grid.23856.3a", 
              "name": [
                "Axe Reproduction, Sant\u00e9 de la m\u00e8re et de l\u2019enfant, Centre de recherche du CHU de Qu\u00e9bec \u2013 Universit\u00e9 Laval, Qu\u00e9bec, Qc, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Belleann\u00e9e", 
            "givenName": "Cl\u00e9mence", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Centre de recherche du CHU de Montr\u00e9al, Montr\u00e9al Qu\u00e9bec, Qu\u00e9bec, Qc, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "H\u00e9bert", 
            "givenName": "Marie-Jos\u00e9e", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Centre de recherche du CHU de Montr\u00e9al, Montr\u00e9al Qu\u00e9bec, Qu\u00e9bec, Qc, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Dieud\u00e9", 
            "givenName": "M\u00e9lanie", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "McGill University Health Centre", 
              "id": "https://www.grid.ac/institutes/grid.63984.30", 
              "name": [
                "Division of Rheumatology, Department of Medicine, Research Institute of the McGill University Health Centre, H4A 3J1, Montreal, Qc, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Rauch", 
            "givenName": "Joyce", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Laval", 
              "id": "https://www.grid.ac/institutes/grid.23856.3a", 
              "name": [
                "Division de Rhumatologie, D\u00e9partement de M\u00e9decine, CHU de Qu\u00e9bec \u2013 Universit\u00e9 Laval, Qu\u00e9bec, Qc, Canada", 
                "Axe maladies infectieuses et inflammatoires, Centre de recherche du CHU de Qu\u00e9bec \u2013 Universit\u00e9 Laval, Qu\u00e9bec, Qc, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Fortin", 
            "givenName": "Paul R.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Universit\u00e9 Laval", 
              "id": "https://www.grid.ac/institutes/grid.23856.3a", 
              "name": [
                "Centre de Recherche du CHU de Qu\u00e9bec \u2013 Universit\u00e9 Laval, D\u00e9partement de microbiologie et immunologie, Facult\u00e9 de M\u00e9decine de l\u2032Universit\u00e9 Laval, Qu\u00e9bec, Qc, Canada", 
                "Axe maladies infectieuses et inflammatoires, Centre de recherche du CHU de Qu\u00e9bec \u2013 Universit\u00e9 Laval, Qu\u00e9bec, Qc, Canada"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Boilard", 
            "givenName": "Eric", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.ab.2009.11.017", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000465323"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2014-05-573543", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003499795"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.bbadis.2016.10.020", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003737702"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-pathol-020712-164014", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004252517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0168-8278(91)90903-o", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004302313"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tibs.2011.09.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006323810"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature10992", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009348903", 
              "https://doi.org/10.1038/nature10992"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.freeradbiomed.2012.11.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011865957"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08780", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012383431", 
              "https://doi.org/10.1038/nature08780"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature08780", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012383431", 
              "https://doi.org/10.1038/nature08780"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/trf.13535", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012754099"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e3182a4ea46", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012933948"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/sla.0b013e3182a4ea46", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012933948"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.20564", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013097265"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0076-6879(08)04424-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013186153"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.283.5407.1476", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014149887"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/ajcp/69.6.599", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014880086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10875-010-9396-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015142260", 
              "https://doi.org/10.1007/s10875-010-9396-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10875-010-9396-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015142260", 
              "https://doi.org/10.1007/s10875-010-9396-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hep.25801", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016136968"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01728613", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016489214", 
              "https://doi.org/10.1007/bf01728613"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01728613", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016489214", 
              "https://doi.org/10.1007/bf01728613"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.immuni.2015.02.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016687062"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-0676.1995.tb00687.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018398985"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1600-0676.1995.tb00687.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018398985"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(70)90972-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019907963"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/excr.1996.0003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022021074"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0049767", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022414342"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.1780220304", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023610619"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nri2975", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023733273", 
              "https://doi.org/10.1038/nri2975"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.4027", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023740013", 
              "https://doi.org/10.1038/nm.4027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.1780200308", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023948936"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nm.1855", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024541352", 
              "https://doi.org/10.1038/nm.1855"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1476-4598-8-105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025246487", 
              "https://doi.org/10.1186/1476-4598-8-105"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/348455a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026353654", 
              "https://doi.org/10.1038/348455a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1398-9995.1978.tb01505.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026417868"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/ar787", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026845219", 
              "https://doi.org/10.1186/ar787"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cddis.2014.277", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027184938", 
              "https://doi.org/10.1038/cddis.2014.277"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/09537104.2016.1218455", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027360517"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pmed.1001577", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027614988"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1006/bbrc.1996.0021", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027716824"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2009.151", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027812222", 
              "https://doi.org/10.1038/nprot.2009.151"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2009.151", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027812222", 
              "https://doi.org/10.1038/nprot.2009.151"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1538-7836.2006.01753.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029554696"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1538-7836.2006.01753.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029554696"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.molcel.2012.12.026", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032108146"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hep.1840120222", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032399387"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.30411", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032402292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.1780400928", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032541017"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(75)90055-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033845527"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0891-5849(91)90033-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034450295"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0891-5849(91)90033-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034450295"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0167-5699(05)80045-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034682946"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1248/cpb.43.108", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035242268"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/1529-0131(199907)42:7<1309::aid-anr1>3.0.co;2-f", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036199400"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1863", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036256011", 
              "https://doi.org/10.1038/ni.1863"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.1863", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036256011", 
              "https://doi.org/10.1038/ni.1863"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jaut.2011.02.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038916112"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0124469", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040911481"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/387493a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041368656", 
              "https://doi.org/10.1038/387493a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.39296", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042536015"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/sti.55.4.292", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043391929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/sti.55.4.292", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043391929"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hep.22906", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043933975"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejm197001082820207", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044367198"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci83885", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044432154"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1046/j.1365-2249.2002.01816.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045204508"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jim.2016.02.019", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045419379"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cell.2016.05.034", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045423169"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000346515", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046233044"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2009.96", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046888158", 
              "https://doi.org/10.1038/cdd.2009.96"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/cdd.2009.96", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046888158", 
              "https://doi.org/10.1038/cdd.2009.96"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nprot.2006.478", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048051915", 
              "https://doi.org/10.1038/nprot.2006.478"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/srep36025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049114276", 
              "https://doi.org/10.1038/srep36025"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev-genet-102108-134850", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049257687"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1195491", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051021181"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2249.1990.tb05292.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051319789"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/art.1780251101", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051582030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.20151876", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052500978"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nature12985", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052523108", 
              "https://doi.org/10.1038/nature12985"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.autrev.2008.03.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053465692"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/carcin/13.7.1289", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059450348"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/rheumatology/kew462", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060013018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1126/science.1091334", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062449086"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2015-12-688838", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1064122919"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1055/s-0037-1613606", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1075320094"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076612902", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4049/jimmunol.177.9.6504", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077312035"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078882774", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079848591", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079960033", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1080120820", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081638172", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081714261", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081751161", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082121719", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1082492400", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1083262940", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ta.0000000000001421", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084196788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/ta.0000000000001421", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084196788"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.3704", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084913862", 
              "https://doi.org/10.1038/ni.3704"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ni.3704", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084913862", 
              "https://doi.org/10.1038/ni.3704"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1720553115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100750464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.1720553115", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100750464"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/hep.30145", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105952145"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-12", 
        "datePublishedReg": "2019-12-01", 
        "description": "Mitochondria are organelles that govern energy supply and control cell death. Mitochondria also express bacterial features, such as the presence of inner membrane cardiolipin and a circular genome rich in hypomethylated CpG motifs. While mitochondrial extrusion by damaged organs or activated cells is thought to trigger innate immunity, it is unclear whether extracellular mitochondria also stimulate an adaptive immune response. We describe the development of novel assays to detect autoantibodies specific to two distinct components of the mitochondrion: the mitochondrial outer membrane and mitochondrial DNA. Antibodies to these two mitochondrial constituents were increased in both human and murine systemic lupus erythematosus (SLE), compared to controls, and were present at higher levels than in patients with antiphospholipid syndrome or primary biliary cirrhosis. In both bi- and multi-variate regression models, antibodies to mitochondrial DNA, but not whole mitochondria, were associated with increased anti-dsDNA antibodies and lupus nephritis. This study describes new and optimized methods for the assessment of anti-mitochondrial antibodies, and demonstrates their presence in both human and murine SLE. These findings suggest that different mitochondrial components are immunogenic in SLE, and support the concept that extracellular mitochondria may provide an important source of circulating autoantigens in SLE.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41598-019-40900-3", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "name": "Anti-mitochondrial autoantibodies in systemic lupus erythematosus and their association with disease manifestations", 
        "pagination": "4530", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "cb734b2199342adc9610a4680de8edd41e004493dfee311191824447192cbf62"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30872710"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101563288"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-019-40900-3"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1112766937"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-019-40900-3", 
          "https://app.dimensions.ai/details/publication/pub.1112766937"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T13:19", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78953_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41598-019-40900-3"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-40900-3'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-40900-3'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-40900-3'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-40900-3'


     

    This table displays all metadata directly associated to this object as RDF triples.

    484 TRIPLES      21 PREDICATES      120 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-019-40900-3 schema:about anzsrc-for:11
    2 anzsrc-for:1107
    3 schema:author N46c58f2ee0a3462d8c208a403da6e7f0
    4 schema:citation sg:pub.10.1007/bf01728613
    5 sg:pub.10.1007/s10875-010-9396-3
    6 sg:pub.10.1038/348455a0
    7 sg:pub.10.1038/387493a0
    8 sg:pub.10.1038/cdd.2009.96
    9 sg:pub.10.1038/cddis.2014.277
    10 sg:pub.10.1038/nature08780
    11 sg:pub.10.1038/nature10992
    12 sg:pub.10.1038/nature12985
    13 sg:pub.10.1038/ni.1863
    14 sg:pub.10.1038/ni.3704
    15 sg:pub.10.1038/nm.1855
    16 sg:pub.10.1038/nm.4027
    17 sg:pub.10.1038/nprot.2006.478
    18 sg:pub.10.1038/nprot.2009.151
    19 sg:pub.10.1038/nri2975
    20 sg:pub.10.1038/srep36025
    21 sg:pub.10.1186/1476-4598-8-105
    22 sg:pub.10.1186/ar787
    23 https://app.dimensions.ai/details/publication/pub.1076612902
    24 https://app.dimensions.ai/details/publication/pub.1078882774
    25 https://app.dimensions.ai/details/publication/pub.1079848591
    26 https://app.dimensions.ai/details/publication/pub.1079960033
    27 https://app.dimensions.ai/details/publication/pub.1080120820
    28 https://app.dimensions.ai/details/publication/pub.1081638172
    29 https://app.dimensions.ai/details/publication/pub.1081714261
    30 https://app.dimensions.ai/details/publication/pub.1081751161
    31 https://app.dimensions.ai/details/publication/pub.1082121719
    32 https://app.dimensions.ai/details/publication/pub.1082492400
    33 https://app.dimensions.ai/details/publication/pub.1083262940
    34 https://doi.org/10.1002/1529-0131(199907)42:7<1309::aid-anr1>3.0.co;2-f
    35 https://doi.org/10.1002/art.1780200308
    36 https://doi.org/10.1002/art.1780220304
    37 https://doi.org/10.1002/art.1780251101
    38 https://doi.org/10.1002/art.1780400928
    39 https://doi.org/10.1002/art.20564
    40 https://doi.org/10.1002/art.30411
    41 https://doi.org/10.1002/art.39296
    42 https://doi.org/10.1002/hep.1840120222
    43 https://doi.org/10.1002/hep.22906
    44 https://doi.org/10.1002/hep.25801
    45 https://doi.org/10.1002/hep.30145
    46 https://doi.org/10.1006/bbrc.1996.0021
    47 https://doi.org/10.1006/excr.1996.0003
    48 https://doi.org/10.1016/0168-8278(91)90903-o
    49 https://doi.org/10.1016/0891-5849(91)90033-y
    50 https://doi.org/10.1016/j.ab.2009.11.017
    51 https://doi.org/10.1016/j.autrev.2008.03.006
    52 https://doi.org/10.1016/j.bbadis.2016.10.020
    53 https://doi.org/10.1016/j.cell.2016.05.034
    54 https://doi.org/10.1016/j.freeradbiomed.2012.11.006
    55 https://doi.org/10.1016/j.immuni.2015.02.002
    56 https://doi.org/10.1016/j.jaut.2011.02.001
    57 https://doi.org/10.1016/j.jim.2016.02.019
    58 https://doi.org/10.1016/j.molcel.2012.12.026
    59 https://doi.org/10.1016/j.tibs.2011.09.003
    60 https://doi.org/10.1016/s0076-6879(08)04424-8
    61 https://doi.org/10.1016/s0140-6736(70)90972-4
    62 https://doi.org/10.1016/s0140-6736(75)90055-0
    63 https://doi.org/10.1016/s0167-5699(05)80045-3
    64 https://doi.org/10.1046/j.1365-2249.2002.01816.x
    65 https://doi.org/10.1055/s-0037-1613606
    66 https://doi.org/10.1056/nejm197001082820207
    67 https://doi.org/10.1073/pnas.1720553115
    68 https://doi.org/10.1080/09537104.2016.1218455
    69 https://doi.org/10.1084/jem.20151876
    70 https://doi.org/10.1093/ajcp/69.6.599
    71 https://doi.org/10.1093/carcin/13.7.1289
    72 https://doi.org/10.1093/rheumatology/kew462
    73 https://doi.org/10.1097/sla.0b013e3182a4ea46
    74 https://doi.org/10.1097/ta.0000000000001421
    75 https://doi.org/10.1111/j.1365-2249.1990.tb05292.x
    76 https://doi.org/10.1111/j.1398-9995.1978.tb01505.x
    77 https://doi.org/10.1111/j.1538-7836.2006.01753.x
    78 https://doi.org/10.1111/j.1600-0676.1995.tb00687.x
    79 https://doi.org/10.1111/trf.13535
    80 https://doi.org/10.1126/science.1091334
    81 https://doi.org/10.1126/science.1195491
    82 https://doi.org/10.1126/science.283.5407.1476
    83 https://doi.org/10.1136/sti.55.4.292
    84 https://doi.org/10.1146/annurev-genet-102108-134850
    85 https://doi.org/10.1146/annurev-pathol-020712-164014
    86 https://doi.org/10.1159/000346515
    87 https://doi.org/10.1172/jci83885
    88 https://doi.org/10.1182/blood-2014-05-573543
    89 https://doi.org/10.1182/blood-2015-12-688838
    90 https://doi.org/10.1248/cpb.43.108
    91 https://doi.org/10.1371/journal.pmed.1001577
    92 https://doi.org/10.1371/journal.pone.0049767
    93 https://doi.org/10.1371/journal.pone.0124469
    94 https://doi.org/10.4049/jimmunol.177.9.6504
    95 schema:datePublished 2019-12
    96 schema:datePublishedReg 2019-12-01
    97 schema:description Mitochondria are organelles that govern energy supply and control cell death. Mitochondria also express bacterial features, such as the presence of inner membrane cardiolipin and a circular genome rich in hypomethylated CpG motifs. While mitochondrial extrusion by damaged organs or activated cells is thought to trigger innate immunity, it is unclear whether extracellular mitochondria also stimulate an adaptive immune response. We describe the development of novel assays to detect autoantibodies specific to two distinct components of the mitochondrion: the mitochondrial outer membrane and mitochondrial DNA. Antibodies to these two mitochondrial constituents were increased in both human and murine systemic lupus erythematosus (SLE), compared to controls, and were present at higher levels than in patients with antiphospholipid syndrome or primary biliary cirrhosis. In both bi- and multi-variate regression models, antibodies to mitochondrial DNA, but not whole mitochondria, were associated with increased anti-dsDNA antibodies and lupus nephritis. This study describes new and optimized methods for the assessment of anti-mitochondrial antibodies, and demonstrates their presence in both human and murine SLE. These findings suggest that different mitochondrial components are immunogenic in SLE, and support the concept that extracellular mitochondria may provide an important source of circulating autoantigens in SLE.
    98 schema:genre research_article
    99 schema:inLanguage en
    100 schema:isAccessibleForFree true
    101 schema:isPartOf N477b8b79155b4d8aa1ddc9f17654fc7c
    102 N7d043e2a384c44e6bd6d1d3ab4b5d256
    103 sg:journal.1045337
    104 schema:name Anti-mitochondrial autoantibodies in systemic lupus erythematosus and their association with disease manifestations
    105 schema:pagination 4530
    106 schema:productId N01309166364249fd856012db9efcf904
    107 N5350b54c13014d2b9e4bdab1678edf31
    108 N672f4fd486ec4806a9af8377e264458e
    109 Na5a4051b92fd4191b9a71a19c5f94575
    110 Nf5b02bcf058849f8bedd6442b463a220
    111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112766937
    112 https://doi.org/10.1038/s41598-019-40900-3
    113 schema:sdDatePublished 2019-04-11T13:19
    114 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    115 schema:sdPublisher Nab022c2cc81647b9906dfa1ab05058ab
    116 schema:url https://www.nature.com/articles/s41598-019-40900-3
    117 sgo:license sg:explorer/license/
    118 sgo:sdDataset articles
    119 rdf:type schema:ScholarlyArticle
    120 N01309166364249fd856012db9efcf904 schema:name doi
    121 schema:value 10.1038/s41598-019-40900-3
    122 rdf:type schema:PropertyValue
    123 N093276cb22eb4fadbf1405aa6ccf8a47 rdf:first Neebbbc46b6a946169508637b0b5796ba
    124 rdf:rest Nb15e06dd4f734ee2bf8c935771989b1d
    125 N157edadca2e24c16a27260cecab609db rdf:first Nc9d914393d5d44a5b24dd8063c7b74c0
    126 rdf:rest N093276cb22eb4fadbf1405aa6ccf8a47
    127 N1fb33b4471fd45c9a1fc4e335bf06ef2 schema:affiliation https://www.grid.ac/institutes/grid.23856.3a
    128 schema:familyName Melki
    129 schema:givenName Imène
    130 rdf:type schema:Person
    131 N2324eb983e1847bd996cc54c5b53a054 schema:affiliation N34e5c6af112f4dc791bd21ffb2609d1e
    132 schema:familyName Dieudé
    133 schema:givenName Mélanie
    134 rdf:type schema:Person
    135 N2774163518be409181c521572a54614e rdf:first Nedaececc1a36484691d209b9bf950777
    136 rdf:rest Nf964c153c32040bb8e74db89d3d7c6b0
    137 N27a1e47756244edd814ee1545dd04a30 schema:affiliation https://www.grid.ac/institutes/grid.23856.3a
    138 schema:familyName Wagner
    139 schema:givenName Éric
    140 rdf:type schema:Person
    141 N2816b4555c284ff19c89bc64967640c4 schema:affiliation https://www.grid.ac/institutes/grid.23856.3a
    142 schema:familyName Boilard
    143 schema:givenName Eric
    144 rdf:type schema:Person
    145 N3223744a27f34c6fbc74b1f9d59e99a9 rdf:first Nc02b03c4d0324a8cbff91c79358e7387
    146 rdf:rest Ncd4d269e5aee45d59a6c4da96b312f25
    147 N34e5c6af112f4dc791bd21ffb2609d1e schema:name Centre de recherche du CHU de Montréal, Montréal Québec, Québec, Qc, Canada
    148 rdf:type schema:Organization
    149 N38ffb86280ae499996350bcd3243fae5 rdf:first N5a7829a432c246cc841a9287659cd63d
    150 rdf:rest N6d6c04611bdf4cb6ad9fed9e8f01cafe
    151 N3d1713cd8ce546f5954e22c7dd83095c schema:affiliation https://www.grid.ac/institutes/grid.23856.3a
    152 schema:familyName Marcoux
    153 schema:givenName Geneviève
    154 rdf:type schema:Person
    155 N420ae8adf2294cb9aaafd29ccb6f2477 rdf:first N7bd48f7f02e04f3cb93147c92e1fdcc3
    156 rdf:rest Ne86fb5f91a1c4d22b03b9ef52bbc7832
    157 N425752a54a9d4492a15a7f92ed8a3e09 rdf:first N6687c50b1342414cbf958c96d27734ab
    158 rdf:rest N157edadca2e24c16a27260cecab609db
    159 N427e3254e56d467d83e183c8590b154a schema:affiliation https://www.grid.ac/institutes/grid.23856.3a
    160 schema:familyName Julien
    161 schema:givenName Anne-Sophie
    162 rdf:type schema:Person
    163 N46c58f2ee0a3462d8c208a403da6e7f0 rdf:first Nba5ae3828f224fdba06c8a3eb702fe10
    164 rdf:rest N38ffb86280ae499996350bcd3243fae5
    165 N477b8b79155b4d8aa1ddc9f17654fc7c schema:volumeNumber 9
    166 rdf:type schema:PublicationVolume
    167 N4a0d195cf4174875a56c061cab1f4c9c rdf:first N2816b4555c284ff19c89bc64967640c4
    168 rdf:rest rdf:nil
    169 N5350b54c13014d2b9e4bdab1678edf31 schema:name readcube_id
    170 schema:value cb734b2199342adc9610a4680de8edd41e004493dfee311191824447192cbf62
    171 rdf:type schema:PropertyValue
    172 N5a7829a432c246cc841a9287659cd63d schema:affiliation https://www.grid.ac/institutes/grid.23856.3a
    173 schema:familyName Loignon
    174 schema:givenName Renée-Claude
    175 rdf:type schema:Person
    176 N5d0edeb05c63462f9a04f146c5dd9f4b schema:affiliation https://www.grid.ac/institutes/grid.23856.3a
    177 schema:familyName Pelletier
    178 schema:givenName Martin
    179 rdf:type schema:Person
    180 N63bbbe7413fc41989063253bbd878d72 schema:name Centre de recherche du CHU de Montréal, Montréal Québec, Québec, Qc, Canada
    181 rdf:type schema:Organization
    182 N63e3872c1da546458877998fe2a9b4a7 rdf:first N27a1e47756244edd814ee1545dd04a30
    183 rdf:rest Nd724e4eb138b493c8fb9b7af333edbd4
    184 N6687c50b1342414cbf958c96d27734ab schema:affiliation https://www.grid.ac/institutes/grid.23856.3a
    185 schema:familyName Rollet-Labelle
    186 schema:givenName Emmanuelle
    187 rdf:type schema:Person
    188 N672f4fd486ec4806a9af8377e264458e schema:name pubmed_id
    189 schema:value 30872710
    190 rdf:type schema:PropertyValue
    191 N6d6c04611bdf4cb6ad9fed9e8f01cafe rdf:first N427e3254e56d467d83e183c8590b154a
    192 rdf:rest N8227174e11c64be8a961bca9c77bd4ce
    193 N7bd48f7f02e04f3cb93147c92e1fdcc3 schema:affiliation https://www.grid.ac/institutes/grid.63984.30
    194 schema:familyName Rauch
    195 schema:givenName Joyce
    196 rdf:type schema:Person
    197 N7d043e2a384c44e6bd6d1d3ab4b5d256 schema:issueNumber 1
    198 rdf:type schema:PublicationIssue
    199 N8227174e11c64be8a961bca9c77bd4ce rdf:first N3d1713cd8ce546f5954e22c7dd83095c
    200 rdf:rest N3223744a27f34c6fbc74b1f9d59e99a9
    201 Na28796249d4d4669a689878d6f9abc10 schema:affiliation https://www.grid.ac/institutes/grid.23856.3a
    202 schema:familyName Belleannée
    203 schema:givenName Clémence
    204 rdf:type schema:Person
    205 Na581de565783445fa6490bca1a83f70f schema:affiliation https://www.grid.ac/institutes/grid.23856.3a
    206 schema:familyName Fortin
    207 schema:givenName Paul R.
    208 rdf:type schema:Person
    209 Na59b585ff03043ae951ff5afa731e188 schema:affiliation https://www.grid.ac/institutes/grid.417199.3
    210 schema:familyName Eder
    211 schema:givenName Lihi
    212 rdf:type schema:Person
    213 Na5a4051b92fd4191b9a71a19c5f94575 schema:name dimensions_id
    214 schema:value pub.1112766937
    215 rdf:type schema:PropertyValue
    216 Na8f38bf929974722adf77e94c9bd07f8 schema:affiliation https://www.grid.ac/institutes/grid.23856.3a
    217 schema:familyName Tremblay
    218 schema:givenName Marie-Ève
    219 rdf:type schema:Person
    220 Nab022c2cc81647b9906dfa1ab05058ab schema:name Springer Nature - SN SciGraph project
    221 rdf:type schema:Organization
    222 Nb15e06dd4f734ee2bf8c935771989b1d rdf:first N1fb33b4471fd45c9a1fc4e335bf06ef2
    223 rdf:rest Ncda09cb8a4e44f5eab10c9e4e5f5a60f
    224 Nb87530b0fbeb42c28d76f0529a11492d rdf:first Nffd20c2c381a47758a24223fe00c78ec
    225 rdf:rest Ndb5112cfe6f44c28b82f7756189182f3
    226 Nba5ae3828f224fdba06c8a3eb702fe10 schema:affiliation https://www.grid.ac/institutes/grid.23856.3a
    227 schema:familyName Becker
    228 schema:givenName Yann
    229 rdf:type schema:Person
    230 Nc02b03c4d0324a8cbff91c79358e7387 schema:affiliation https://www.grid.ac/institutes/grid.23856.3a
    231 schema:familyName Allaeys
    232 schema:givenName Isabelle
    233 rdf:type schema:Person
    234 Nc9d914393d5d44a5b24dd8063c7b74c0 schema:affiliation https://www.grid.ac/institutes/grid.23856.3a
    235 schema:familyName Benk-Fortin
    236 schema:givenName Hadrien
    237 rdf:type schema:Person
    238 Ncd4d269e5aee45d59a6c4da96b312f25 rdf:first Nfab3425ec8bf469aba95b218e699e4f2
    239 rdf:rest N425752a54a9d4492a15a7f92ed8a3e09
    240 Ncda09cb8a4e44f5eab10c9e4e5f5a60f rdf:first Na59b585ff03043ae951ff5afa731e188
    241 rdf:rest N63e3872c1da546458877998fe2a9b4a7
    242 Nd724e4eb138b493c8fb9b7af333edbd4 rdf:first N5d0edeb05c63462f9a04f146c5dd9f4b
    243 rdf:rest Nb87530b0fbeb42c28d76f0529a11492d
    244 Ndb5112cfe6f44c28b82f7756189182f3 rdf:first Na8f38bf929974722adf77e94c9bd07f8
    245 rdf:rest Ne7f9f69337fe429f93f57b4f9cdf8a5a
    246 Ne7f9f69337fe429f93f57b4f9cdf8a5a rdf:first Na28796249d4d4669a689878d6f9abc10
    247 rdf:rest N2774163518be409181c521572a54614e
    248 Ne86fb5f91a1c4d22b03b9ef52bbc7832 rdf:first Na581de565783445fa6490bca1a83f70f
    249 rdf:rest N4a0d195cf4174875a56c061cab1f4c9c
    250 Nedaececc1a36484691d209b9bf950777 schema:affiliation N63bbbe7413fc41989063253bbd878d72
    251 schema:familyName Hébert
    252 schema:givenName Marie-Josée
    253 rdf:type schema:Person
    254 Neebbbc46b6a946169508637b0b5796ba schema:affiliation https://www.grid.ac/institutes/grid.23856.3a
    255 schema:familyName Cloutier
    256 schema:givenName Nathalie
    257 rdf:type schema:Person
    258 Nf5b02bcf058849f8bedd6442b463a220 schema:name nlm_unique_id
    259 schema:value 101563288
    260 rdf:type schema:PropertyValue
    261 Nf964c153c32040bb8e74db89d3d7c6b0 rdf:first N2324eb983e1847bd996cc54c5b53a054
    262 rdf:rest N420ae8adf2294cb9aaafd29ccb6f2477
    263 Nfab3425ec8bf469aba95b218e699e4f2 schema:affiliation https://www.grid.ac/institutes/grid.23856.3a
    264 schema:familyName Lévesque
    265 schema:givenName Tania
    266 rdf:type schema:Person
    267 Nffd20c2c381a47758a24223fe00c78ec schema:affiliation https://www.grid.ac/institutes/grid.23856.3a
    268 schema:familyName Hajj
    269 schema:givenName Hassan El
    270 rdf:type schema:Person
    271 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    272 schema:name Medical and Health Sciences
    273 rdf:type schema:DefinedTerm
    274 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    275 schema:name Immunology
    276 rdf:type schema:DefinedTerm
    277 sg:journal.1045337 schema:issn 2045-2322
    278 schema:name Scientific Reports
    279 rdf:type schema:Periodical
    280 sg:pub.10.1007/bf01728613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016489214
    281 https://doi.org/10.1007/bf01728613
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1007/s10875-010-9396-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015142260
    284 https://doi.org/10.1007/s10875-010-9396-3
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1038/348455a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026353654
    287 https://doi.org/10.1038/348455a0
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1038/387493a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041368656
    290 https://doi.org/10.1038/387493a0
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1038/cdd.2009.96 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046888158
    293 https://doi.org/10.1038/cdd.2009.96
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1038/cddis.2014.277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027184938
    296 https://doi.org/10.1038/cddis.2014.277
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1038/nature08780 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012383431
    299 https://doi.org/10.1038/nature08780
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1038/nature10992 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009348903
    302 https://doi.org/10.1038/nature10992
    303 rdf:type schema:CreativeWork
    304 sg:pub.10.1038/nature12985 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052523108
    305 https://doi.org/10.1038/nature12985
    306 rdf:type schema:CreativeWork
    307 sg:pub.10.1038/ni.1863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036256011
    308 https://doi.org/10.1038/ni.1863
    309 rdf:type schema:CreativeWork
    310 sg:pub.10.1038/ni.3704 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084913862
    311 https://doi.org/10.1038/ni.3704
    312 rdf:type schema:CreativeWork
    313 sg:pub.10.1038/nm.1855 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024541352
    314 https://doi.org/10.1038/nm.1855
    315 rdf:type schema:CreativeWork
    316 sg:pub.10.1038/nm.4027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023740013
    317 https://doi.org/10.1038/nm.4027
    318 rdf:type schema:CreativeWork
    319 sg:pub.10.1038/nprot.2006.478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048051915
    320 https://doi.org/10.1038/nprot.2006.478
    321 rdf:type schema:CreativeWork
    322 sg:pub.10.1038/nprot.2009.151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027812222
    323 https://doi.org/10.1038/nprot.2009.151
    324 rdf:type schema:CreativeWork
    325 sg:pub.10.1038/nri2975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023733273
    326 https://doi.org/10.1038/nri2975
    327 rdf:type schema:CreativeWork
    328 sg:pub.10.1038/srep36025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049114276
    329 https://doi.org/10.1038/srep36025
    330 rdf:type schema:CreativeWork
    331 sg:pub.10.1186/1476-4598-8-105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025246487
    332 https://doi.org/10.1186/1476-4598-8-105
    333 rdf:type schema:CreativeWork
    334 sg:pub.10.1186/ar787 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026845219
    335 https://doi.org/10.1186/ar787
    336 rdf:type schema:CreativeWork
    337 https://app.dimensions.ai/details/publication/pub.1076612902 schema:CreativeWork
    338 https://app.dimensions.ai/details/publication/pub.1078882774 schema:CreativeWork
    339 https://app.dimensions.ai/details/publication/pub.1079848591 schema:CreativeWork
    340 https://app.dimensions.ai/details/publication/pub.1079960033 schema:CreativeWork
    341 https://app.dimensions.ai/details/publication/pub.1080120820 schema:CreativeWork
    342 https://app.dimensions.ai/details/publication/pub.1081638172 schema:CreativeWork
    343 https://app.dimensions.ai/details/publication/pub.1081714261 schema:CreativeWork
    344 https://app.dimensions.ai/details/publication/pub.1081751161 schema:CreativeWork
    345 https://app.dimensions.ai/details/publication/pub.1082121719 schema:CreativeWork
    346 https://app.dimensions.ai/details/publication/pub.1082492400 schema:CreativeWork
    347 https://app.dimensions.ai/details/publication/pub.1083262940 schema:CreativeWork
    348 https://doi.org/10.1002/1529-0131(199907)42:7<1309::aid-anr1>3.0.co;2-f schema:sameAs https://app.dimensions.ai/details/publication/pub.1036199400
    349 rdf:type schema:CreativeWork
    350 https://doi.org/10.1002/art.1780200308 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023948936
    351 rdf:type schema:CreativeWork
    352 https://doi.org/10.1002/art.1780220304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023610619
    353 rdf:type schema:CreativeWork
    354 https://doi.org/10.1002/art.1780251101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051582030
    355 rdf:type schema:CreativeWork
    356 https://doi.org/10.1002/art.1780400928 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032541017
    357 rdf:type schema:CreativeWork
    358 https://doi.org/10.1002/art.20564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013097265
    359 rdf:type schema:CreativeWork
    360 https://doi.org/10.1002/art.30411 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032402292
    361 rdf:type schema:CreativeWork
    362 https://doi.org/10.1002/art.39296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042536015
    363 rdf:type schema:CreativeWork
    364 https://doi.org/10.1002/hep.1840120222 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032399387
    365 rdf:type schema:CreativeWork
    366 https://doi.org/10.1002/hep.22906 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043933975
    367 rdf:type schema:CreativeWork
    368 https://doi.org/10.1002/hep.25801 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016136968
    369 rdf:type schema:CreativeWork
    370 https://doi.org/10.1002/hep.30145 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105952145
    371 rdf:type schema:CreativeWork
    372 https://doi.org/10.1006/bbrc.1996.0021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027716824
    373 rdf:type schema:CreativeWork
    374 https://doi.org/10.1006/excr.1996.0003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022021074
    375 rdf:type schema:CreativeWork
    376 https://doi.org/10.1016/0168-8278(91)90903-o schema:sameAs https://app.dimensions.ai/details/publication/pub.1004302313
    377 rdf:type schema:CreativeWork
    378 https://doi.org/10.1016/0891-5849(91)90033-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1034450295
    379 rdf:type schema:CreativeWork
    380 https://doi.org/10.1016/j.ab.2009.11.017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000465323
    381 rdf:type schema:CreativeWork
    382 https://doi.org/10.1016/j.autrev.2008.03.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053465692
    383 rdf:type schema:CreativeWork
    384 https://doi.org/10.1016/j.bbadis.2016.10.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003737702
    385 rdf:type schema:CreativeWork
    386 https://doi.org/10.1016/j.cell.2016.05.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045423169
    387 rdf:type schema:CreativeWork
    388 https://doi.org/10.1016/j.freeradbiomed.2012.11.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011865957
    389 rdf:type schema:CreativeWork
    390 https://doi.org/10.1016/j.immuni.2015.02.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016687062
    391 rdf:type schema:CreativeWork
    392 https://doi.org/10.1016/j.jaut.2011.02.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038916112
    393 rdf:type schema:CreativeWork
    394 https://doi.org/10.1016/j.jim.2016.02.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045419379
    395 rdf:type schema:CreativeWork
    396 https://doi.org/10.1016/j.molcel.2012.12.026 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032108146
    397 rdf:type schema:CreativeWork
    398 https://doi.org/10.1016/j.tibs.2011.09.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006323810
    399 rdf:type schema:CreativeWork
    400 https://doi.org/10.1016/s0076-6879(08)04424-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013186153
    401 rdf:type schema:CreativeWork
    402 https://doi.org/10.1016/s0140-6736(70)90972-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019907963
    403 rdf:type schema:CreativeWork
    404 https://doi.org/10.1016/s0140-6736(75)90055-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033845527
    405 rdf:type schema:CreativeWork
    406 https://doi.org/10.1016/s0167-5699(05)80045-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034682946
    407 rdf:type schema:CreativeWork
    408 https://doi.org/10.1046/j.1365-2249.2002.01816.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1045204508
    409 rdf:type schema:CreativeWork
    410 https://doi.org/10.1055/s-0037-1613606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075320094
    411 rdf:type schema:CreativeWork
    412 https://doi.org/10.1056/nejm197001082820207 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044367198
    413 rdf:type schema:CreativeWork
    414 https://doi.org/10.1073/pnas.1720553115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100750464
    415 rdf:type schema:CreativeWork
    416 https://doi.org/10.1080/09537104.2016.1218455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027360517
    417 rdf:type schema:CreativeWork
    418 https://doi.org/10.1084/jem.20151876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052500978
    419 rdf:type schema:CreativeWork
    420 https://doi.org/10.1093/ajcp/69.6.599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014880086
    421 rdf:type schema:CreativeWork
    422 https://doi.org/10.1093/carcin/13.7.1289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059450348
    423 rdf:type schema:CreativeWork
    424 https://doi.org/10.1093/rheumatology/kew462 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060013018
    425 rdf:type schema:CreativeWork
    426 https://doi.org/10.1097/sla.0b013e3182a4ea46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012933948
    427 rdf:type schema:CreativeWork
    428 https://doi.org/10.1097/ta.0000000000001421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084196788
    429 rdf:type schema:CreativeWork
    430 https://doi.org/10.1111/j.1365-2249.1990.tb05292.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051319789
    431 rdf:type schema:CreativeWork
    432 https://doi.org/10.1111/j.1398-9995.1978.tb01505.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026417868
    433 rdf:type schema:CreativeWork
    434 https://doi.org/10.1111/j.1538-7836.2006.01753.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029554696
    435 rdf:type schema:CreativeWork
    436 https://doi.org/10.1111/j.1600-0676.1995.tb00687.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1018398985
    437 rdf:type schema:CreativeWork
    438 https://doi.org/10.1111/trf.13535 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012754099
    439 rdf:type schema:CreativeWork
    440 https://doi.org/10.1126/science.1091334 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062449086
    441 rdf:type schema:CreativeWork
    442 https://doi.org/10.1126/science.1195491 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051021181
    443 rdf:type schema:CreativeWork
    444 https://doi.org/10.1126/science.283.5407.1476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014149887
    445 rdf:type schema:CreativeWork
    446 https://doi.org/10.1136/sti.55.4.292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043391929
    447 rdf:type schema:CreativeWork
    448 https://doi.org/10.1146/annurev-genet-102108-134850 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049257687
    449 rdf:type schema:CreativeWork
    450 https://doi.org/10.1146/annurev-pathol-020712-164014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004252517
    451 rdf:type schema:CreativeWork
    452 https://doi.org/10.1159/000346515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046233044
    453 rdf:type schema:CreativeWork
    454 https://doi.org/10.1172/jci83885 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044432154
    455 rdf:type schema:CreativeWork
    456 https://doi.org/10.1182/blood-2014-05-573543 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003499795
    457 rdf:type schema:CreativeWork
    458 https://doi.org/10.1182/blood-2015-12-688838 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064122919
    459 rdf:type schema:CreativeWork
    460 https://doi.org/10.1248/cpb.43.108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035242268
    461 rdf:type schema:CreativeWork
    462 https://doi.org/10.1371/journal.pmed.1001577 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027614988
    463 rdf:type schema:CreativeWork
    464 https://doi.org/10.1371/journal.pone.0049767 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022414342
    465 rdf:type schema:CreativeWork
    466 https://doi.org/10.1371/journal.pone.0124469 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040911481
    467 rdf:type schema:CreativeWork
    468 https://doi.org/10.4049/jimmunol.177.9.6504 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077312035
    469 rdf:type schema:CreativeWork
    470 https://www.grid.ac/institutes/grid.23856.3a schema:alternateName Université Laval
    471 schema:name Axe Neurosciences, Centre de Recherche du CHU de Québec – Université Laval, Québec, Qc, Canada
    472 Axe Reproduction, Santé de la mère et de l’enfant, Centre de recherche du CHU de Québec – Université Laval, Québec, Qc, Canada
    473 Axe maladies infectieuses et inflammatoires, Centre de recherche du CHU de Québec – Université Laval, Québec, Qc, Canada
    474 Centre de Recherche du CHU de Québec – Université Laval, Département de microbiologie et immunologie, Faculté de Médecine de l′Université Laval, Québec, Qc, Canada
    475 Division de Rhumatologie, Département de Médecine, CHU de Québec – Université Laval, Québec, Qc, Canada
    476 Département de mathématiques et statistique, Université Laval, Québec, Qc, Canada
    477 Immunology and Histocompatibility Laboratory, Department of Medical Biology CHU de Québec - Université Laval; Department of Microbiology, Infectious Diseases and Immunology, Université Laval, Québec, Qc, Canada
    478 rdf:type schema:Organization
    479 https://www.grid.ac/institutes/grid.417199.3 schema:alternateName Women's College Hospital
    480 schema:name Women’s College Hospital and University of Toronto, Toronto, ON, Canada
    481 rdf:type schema:Organization
    482 https://www.grid.ac/institutes/grid.63984.30 schema:alternateName McGill University Health Centre
    483 schema:name Division of Rheumatology, Department of Medicine, Research Institute of the McGill University Health Centre, H4A 3J1, Montreal, Qc, Canada
    484 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...