Analysis of repetitive element expression in the blood and skin of patients with Parkinson’s disease identifies differential expression of satellite ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Kimberley J. Billingsley, Freddy Lättekivi, Anu Planken, Ene Reimann, Lille Kurvits, Liis Kadastik-Eerme, Kristjan M. Kasterpalu, Vivien J. Bubb, John P. Quinn, Sulev Kõks, Pille Taba

ABSTRACT

Repetitive elements (RE) constitute the majority of the human genome and have a range of functions both structural and regulatory on genomic function and gene expression. RE overexpression has been observed in several neurodegenerative diseases, consistent with the observation of aberrant expression of RE posing a mutagenic threat. Despite reports that associate RE expression with PD no study has comprehensively analysed the role of these elements in the disease. This study presents the first genome-wide analysis of RE expression in PD to date. Analysis of RNA-sequencing data of 12 PD patients and 12 healthy controls identified tissue-specific expression differences and more significantly, differential expression of four satellite elements; two simple satellite III (repName = CATTC_n and _GAATG_n) a high-copy satellite II (HSATII) and a centromeric satellite (ALR_Alpha) in the blood of PD patients. In support of the growing body of recent evidence associating REs with neurodegenerative disease, this study highlights the potential importance of characterization of RE expression in such diseases. More... »

PAGES

4369

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-40869-z

DOI

http://dx.doi.org/10.1038/s41598-019-40869-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112734718

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30867520


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