Ontology type: schema:ScholarlyArticle Open Access: True
2019-12
AUTHORSJutaro Nakamura, Akira Meguro, Genji Ishii, Takahiro Mihara, Masaki Takeuchi, Yuki Mizuki, Kentaro Yuda, Takahiro Yamane, Tatsukata Kawagoe, Masao Ota, Nobuhisa Mizuki
ABSTRACTThe strongest genetic risk factor of Behçet's disease (BD) is HLA-B*51. Our group previously reported that HLA-A*26 is independently associated with the risk of the onset of BD apart from HLA-B*51. Here, we re-evaluated the association between HLA-A*26 and BD in the Japanese population. We also performed a comprehensive literature search and meta-analyzed the extracted published data concerning the relationship between HLA-A*26 and BD to estimate the odds ratio (OR) of HLA-A*26 to BD. In this study, we genotyped 611 Japanese BD patients and 2,955 unrelated ethnically matched healthy controls. Genotyping results showed that the phenotype frequency of HLA-A*26 was higher in BD patients than in controls (OR = 2.12, 95% CI: 1.75-2.56). Furthermore, within the HLA-B*51-negative populations, the phenotype frequency of HLA-A*26 was significantly higher in BD patients than in controls (OR = 3.10, 95% CI: 2.43-3.95). Results obtained from meta-analysis combined with our data showed that the modified OR of HLA-A*26 became 1.80 (95% CI:1.58-2.06), whereas within the HLA-B*51-negative population, the modified OR became 4.02 (95% CI: 2.29-7.05). A subgroup analysis arranged by the geographical regions showed HLA-A*26 is in fact associated with the onset of BD in Northeast Asia (OR = 2.11, 95% CI: 1.75-2.56), but not in the Middle East or in Europe. More... »
PAGES4426
http://scigraph.springernature.com/pub.10.1038/s41598-019-40824-y
DOIhttp://dx.doi.org/10.1038/s41598-019-40824-y
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1112765122
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30872678
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Public Health and Health Services",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Yokohama City University",
"id": "https://www.grid.ac/institutes/grid.268441.d",
"name": [
"Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan",
"Department of Ophthalmology, Heisei Yokohama Hospital, Yokohama, Japan"
],
"type": "Organization"
},
"familyName": "Nakamura",
"givenName": "Jutaro",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Yokohama City University",
"id": "https://www.grid.ac/institutes/grid.268441.d",
"name": [
"Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan"
],
"type": "Organization"
},
"familyName": "Meguro",
"givenName": "Akira",
"type": "Person"
},
{
"affiliation": {
"name": [
"Product Strategy Department, PFU Limited, a Fujitsu Company, Yokohama, Japan"
],
"type": "Organization"
},
"familyName": "Ishii",
"givenName": "Genji",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Yokohama City University",
"id": "https://www.grid.ac/institutes/grid.268441.d",
"name": [
"Department of Anesthesiology and Critical Care Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan"
],
"type": "Organization"
},
"familyName": "Mihara",
"givenName": "Takahiro",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Yokohama City University",
"id": "https://www.grid.ac/institutes/grid.268441.d",
"name": [
"Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan"
],
"type": "Organization"
},
"familyName": "Takeuchi",
"givenName": "Masaki",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Yokohama City University",
"id": "https://www.grid.ac/institutes/grid.268441.d",
"name": [
"Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan"
],
"type": "Organization"
},
"familyName": "Mizuki",
"givenName": "Yuki",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Yokohama City University",
"id": "https://www.grid.ac/institutes/grid.268441.d",
"name": [
"Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan"
],
"type": "Organization"
},
"familyName": "Yuda",
"givenName": "Kentaro",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Yokohama City University",
"id": "https://www.grid.ac/institutes/grid.268441.d",
"name": [
"Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan"
],
"type": "Organization"
},
"familyName": "Yamane",
"givenName": "Takahiro",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Yokohama City University",
"id": "https://www.grid.ac/institutes/grid.268441.d",
"name": [
"Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan"
],
"type": "Organization"
},
"familyName": "Kawagoe",
"givenName": "Tatsukata",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Shinshu University",
"id": "https://www.grid.ac/institutes/grid.263518.b",
"name": [
"Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan",
"Department of Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan"
],
"type": "Organization"
},
"familyName": "Ota",
"givenName": "Masao",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Yokohama City University",
"id": "https://www.grid.ac/institutes/grid.268441.d",
"name": [
"Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Japan"
],
"type": "Organization"
},
"familyName": "Mizuki",
"givenName": "Nobuhisa",
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1111/j.1399-0039.2007.00907.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002527482"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1188021",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002597304"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1188021",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002597304"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1034/j.1399-0039.1999.540308.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003770339"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(00)02491-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004795451"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/gene.2016.36",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005760082",
"https://doi.org/10.1038/gene.2016.36"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1046/j.1365-4362.2003.01893.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005821343"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/art.24642",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005945612"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/art.24642",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005945612"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.181.9.6293",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011132791"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10067-006-0349-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011552991",
"https://doi.org/10.1007/s10067-006-0349-4"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10067-006-0349-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011552991",
"https://doi.org/10.1007/s10067-006-0349-4"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/ard.2009.108571",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014030919"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejm199910213411707",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014703943"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng.705",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015236659",
"https://doi.org/10.1038/ng.705"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng.705",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015236659",
"https://doi.org/10.1038/ng.705"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/ar3292",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015862417",
"https://doi.org/10.1186/ar3292"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/hmg/ddu387",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016828331"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/ar4328",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017289976",
"https://doi.org/10.1186/ar4328"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/ard.50.6.351",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019149469"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1034/j.1399-0039.2002.590207.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019696279"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng.2551",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021208044",
"https://doi.org/10.1038/ng.2551"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.1406575111",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021558513"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/bmj.g7647",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024209218"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1076/opep.9.5.325.10338",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024848884"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1159/000247340",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024908959"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4137/cmamd.s39879",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025396057"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1399-0039.2004.00280.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026258658"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/tan.12852",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030263470"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/ar4569",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030296502",
"https://doi.org/10.1186/ar4569"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1034/j.1399-0039.1999.540605.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036555568"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1034/j.1399-0039.2001.057005457.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037326008"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1399-0039.1997.tb02835.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040198568"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1471-2172-9-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043137968",
"https://doi.org/10.1186/1471-2172-9-1"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0049-0172(98)80001-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046184868"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1034/j.1399-0039.2003.00062.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050710271"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/rheumatology/keq331",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053500577"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1209202",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062464936"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1076959138",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077961721",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1078224296",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1078628221",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1078845213",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079527581",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079593133",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/08820139.2018.1517364",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1107276921"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-12",
"datePublishedReg": "2019-12-01",
"description": "The strongest genetic risk factor of Beh\u00e7et's disease (BD) is HLA-B*51. Our group previously reported that HLA-A*26 is independently associated with the risk of the onset of BD apart from HLA-B*51. Here, we re-evaluated the association between HLA-A*26 and BD in the Japanese population. We also performed a comprehensive literature search and meta-analyzed the extracted published data concerning the relationship between HLA-A*26 and BD to estimate the odds ratio (OR) of HLA-A*26 to BD. In this study, we genotyped 611 Japanese BD patients and 2,955 unrelated ethnically matched healthy controls. Genotyping results showed that the phenotype frequency of HLA-A*26 was higher in BD patients than in controls (OR\u2009=\u20092.12, 95%\u2009CI: 1.75-2.56). Furthermore, within the HLA-B*51-negative populations, the phenotype frequency of HLA-A*26 was significantly higher in BD patients than in controls (OR\u2009=\u20093.10, 95%\u2009CI: 2.43-3.95). Results obtained from meta-analysis combined with our data showed that the modified OR of HLA-A*26 became 1.80 (95%\u2009CI:1.58-2.06), whereas within the HLA-B*51-negative population, the modified OR became 4.02 (95%\u2009CI: 2.29-7.05). A subgroup analysis arranged by the geographical regions showed HLA-A*26 is in fact associated with the onset of BD in Northeast Asia (OR\u2009=\u20092.11, 95%\u2009CI: 1.75-2.56), but not in the Middle East or in Europe.",
"genre": "research_article",
"id": "sg:pub.10.1038/s41598-019-40824-y",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1045337",
"issn": [
"2045-2322"
],
"name": "Scientific Reports",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "9"
}
],
"name": "The association analysis between HLA-A*26 and Beh\u00e7et\u2019s disease",
"pagination": "4426",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"a09856a8ae0515a31b76b68de31a783ec81adaf85fa0c81bf238cfc3ad9638b5"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30872678"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101563288"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41598-019-40824-y"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1112765122"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41598-019-40824-y",
"https://app.dimensions.ai/details/publication/pub.1112765122"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T13:17",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78935_00000001.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/s41598-019-40824-y"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-40824-y'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-40824-y'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-40824-y'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-40824-y'
This table displays all metadata directly associated to this object as RDF triples.
262 TRIPLES
21 PREDICATES
71 URIs
21 LITERALS
9 BLANK NODES