Cholecystokinin induces crowing in chickens View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Tsuyoshi Shimmura, Mai Tamura, Shosei Ohashi, Asuka Sasaki, Takamichi Yamanaka, Nobuhiro Nakao, Kunio Ihara, Shinsaku Okamura, Takashi Yoshimura

ABSTRACT

Animals that communicate using sound are found throughout the animal kingdom. Interestingly, in contrast to human vocal learning, most animals can produce species-specific patterns of vocalization without learning them from their parents. This phenomenon is called innate vocalization. The underlying molecular basis of both vocal learning in humans and innate vocalization in animals remains unknown. The crowing of a rooster is also innately controlled, and the upstream center is thought to be localized in the nucleus intercollicularis (ICo) of the midbrain. Here, we show that the cholecystokinin B receptor (CCKBR) is a regulatory gene involved in inducing crowing in roosters. Crowing is known to be a testosterone (T)-dependent behavior, and it follows that roosters crow but not hens. Similarly, T-administration induces chicks to crow. By using RNA-sequencing to compare gene expression in the ICo between the two comparison groups that either crow or do not crow, we found that CCKBR expression was upregulated in T-containing groups. The expression of CCKBR and its ligand, cholecystokinin (CCK), a neurotransmitter, was observed in the ICo. We also showed that crowing was induced by intracerebroventricular administration of an agonist specific for CCKBR. Our findings therefore suggest that the CCK system induces innate vocalization in roosters. More... »

PAGES

3978

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-40746-9

DOI

http://dx.doi.org/10.1038/s41598-019-40746-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112641580

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30850691


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