Antibacterial activity of ovatodiolide isolated from Anisomeles indica against Helicobacter pylori View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Hsiu-Man Lien, Hui-Yu Wu, Chiu-Lien Hung, Chih-Jung Chen, Chia-Lin Wu, Kuan-Wen Chen, Chao-Lu Huang, Sheau-Jiun Chang, Chia-Chang Chen, Hwai-Jeng Lin, Chih-Ho Lai

ABSTRACT

Helicobacter pylori infection is associated with high incidence of gastric diseases. The extensive therapy of H. pylori infection with antibiotics has increased its resistance rates worldwide. Ovatodiolide, a pure constituent isolated from Anisomeles indica, has been demonstrated to possess bactericidal activity against H. pylori. In this study, ovatodiolide inhibited the growth of both H. pylori reference strain and clinical multidrug-resistant isolates. Docking analysis revealed that ovatodiolide fits into the hydrophobic pocket of a ribosomal protein, RpsB. Furthermore, ovatodiolide inhibited bacterial growth by reducing levels of RpsB, which plays a crucial role in protein translation. Our results demonstrate that ovatodiolide binds to a ribosomal protein and interferes with protein synthesis. This study provides evidence that ovatodiolide has the potential to be developed into a potent therapeutic agent for treating H. pylori infection. More... »

PAGES

4205

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-40735-y

DOI

http://dx.doi.org/10.1038/s41598-019-40735-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112706511

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30862888


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