Similarities, variations, and evolution of cytochrome P450s in Streptomyces versus Mycobacterium View Full Text


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Article Info

DATE

2019-12

AUTHORS

Louisa Moshoeshoe Senate, Martin Phalane Tjatji, Kayla Pillay, Wanping Chen, Ntokozo Minenhle Zondo, Puleng Rosinah Syed, Fanele Cabangile Mnguni, Zinhle Edith Chiliza, Hans Denis Bamal, Rajshekhar Karpoormath, Thandeka Khoza, Samson Sitheni Mashele, Jonathan Michael Blackburn, Jae-Hyuk Yu, David R. Nelson, Khajamohiddin Syed

ABSTRACT

Cytochrome P450 monooxygenases (P450s) found in all domains of life are known for their catalytic versatility and stereo- and regio-specific activity. While the impact of lifestyle on P450 evolution was reported in many eukaryotes, this remains to be addressed in bacteria. In this report, Streptomyces and Mycobacterium, belonging to the phylum Actinobacteria, were studied owing to their contrasting lifestyles and impacts on human. Analyses of all P450s and those predicted to be associated with secondary metabolism have revealed that different lifestyles have affected the evolution of P450s in these bacterial genera. We have found that while species in both genera have essentially the same number of P450s in the genome, Streptomyces P450s are much more diverse than those of Mycobacterium. Moreover, despite both belonging to Actinobacteria, only 21 P450 families were common, and 123 and 56 families were found to be unique to Streptomyces and Mycobacterium, respectively. The presence of a large and diverse number of P450s in Streptomyces secondary metabolism contributes to antibiotic diversity, helping to secure the niche. Conversely, based on the currently available functional data, types of secondary metabolic pathways and associated P450s, mycobacterial P450s seem to play a role in utilization or synthesis of lipids. More... »

PAGES

3962

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-40646-y

DOI

http://dx.doi.org/10.1038/s41598-019-40646-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112641566

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30850694


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curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-40646-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-40646-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-40646-y'


 

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