TACCO, a Database Connecting Transcriptome Alterations, Pathway Alterations and Clinical Outcomes in Cancers View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Po-Hao Chou, Wei-Chao Liao, Kuo-Wang Tsai, Ku-Chung Chen, Jau-Song Yu, Ting-Wen Chen

ABSTRACT

Because of innumerable cancer sequencing projects, abundant transcriptome expression profiles together with survival data are available from the same patients. Although some expression signatures for prognosis or pathologic staging have been identified from these data, systematically discovering such kind of expression signatures remains a challenge. To address this, we developed TACCO (Transcriptome Alterations in CanCer Omnibus), a database for identifying differentially expressed genes and altered pathways in cancer. TACCO also reveals miRNA cooperative regulations and supports construction of models for prognosis. The resulting signatures have great potential for patient stratification and treatment decision-making in future clinical applications. TACCO is freely available at http://tacco.life.nctu.edu.tw/ . More... »

PAGES

3877

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-40629-z

DOI

http://dx.doi.org/10.1038/s41598-019-40629-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112603494

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30846808


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