Human melanoma brain metastases cell line MUG-Mel1, isolated clones and their detailed characterization View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Ellen Heitzer, Arwin Groenewoud, Katharina Meditz, Birgit Lohberger, Bernadette Liegl-Atzwanger, Andreas Prokesch, Karl Kashofer, Diana Behrens, Johannes Haybaeck, Dagmar Kolb-Lenz, Harald Koefeler, Sabrina Riedl, Helmut Schaider, Carina Fischer, B. Ewa Snaar-Jagalska, Danielle de’Jong, Karoly Szuhai, Dagmar Zweytick, Beate Rinner

ABSTRACT

Melanoma is a leading cause of high mortality that frequently spreads to the brain and is associated with deterioration in quality and quantity of life. Treatment opportunities have been restricted until now and new therapy options are urgently required. Our focus was to reveal the potential heterogeneity of melanoma brain metastasis. We succeeded to establish a brain melanoma metastasis cell line, namely MUG-Mel1 and two resulting clones D5 and C8 by morphological variety, differences in lipidome, growth behavior, surface, and stem cell markers. Mutation analysis by next-generation sequencing, copy number profiling, and cytogenetics demonstrated the different genetic profile of MUG-Mel1 and clones. Tumorigenicity was unsuccessfully tested in various mouse systems and finally established in a zebra fish model. As innovative treatment option, with high potential to pass the blood-brain barrier a peptide isolated from lactoferricin was studied in potential toxicity. Brain metastases are a major clinical challenge, therefore the development of relevant in vitro and in vivo models derived from brain melanoma metastases provides valuable information about tumor biology and offers great potential to screen for new innovative therapies. More... »

PAGES

4096

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-40570-1

DOI

http://dx.doi.org/10.1038/s41598-019-40570-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112677955

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30858407


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