Multi-state study of Enterobacteriaceae harboring extended-spectrum beta-lactamase and carbapenemase genes in U.S. drinking water View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-03-08

AUTHORS

Windy D. Tanner, James A. VanDerslice, Ramesh K. Goel, Molly K. Leecaster, Mark A. Fisher, Jeremy Olstadt, Catherine M. Gurley, Anderson G. Morris, Kathryn A. Seely, Leslie Chapman, Michelle Korando, Kalifa-Amira Shabazz, Andrea Stadsholt, Janice VanDeVelde, Ellen Braun-Howland, Christine Minihane, Pamela J. Higgins, Michelle Deras, Othman Jaber, Dee Jette, Adi V. Gundlapalli

ABSTRACT

Community-associated acquisition of extended-spectrum beta-lactamase- (ESBL) and carbapenemase-producing Enterobacteriaceae has significantly increased in recent years, necessitating greater inquiry into potential exposure routes, including food and water sources. In high-income countries, drinking water is often neglected as a possible source of community exposure to antibiotic-resistant organisms. We screened coliform-positive tap water samples (n = 483) from public and private water systems in six states of the United States for blaCTX-M, blaSHV, blaTEM, blaKPC, blaNDM, and blaOXA-48-type genes by multiplex PCR. Positive samples were subcultured to isolate organisms harboring ESBL or carbapenemase genes. Thirty-one samples (6.4%) were positive for blaCTX-M, ESBL-type blaSHV or blaTEM, or blaOXA-48-type carbapenemase genes, including at least one positive sample from each state. ESBL and blaOXA-48-type Enterobacteriaceae isolates included E. coli, Kluyvera, Providencia, Klebsiella, and Citrobacter species. The blaOXA-48-type genes were also found in non-fermenting Gram-negative species, including Shewanella, Pseudomonas and Acinetobacter. Multiple isolates were phenotypically non-susceptible to third-generation cephalosporin or carbapenem antibiotics. These findings suggest that tap water in high income countries could serve as an important source of community exposure to ESBL and carbapenemase genes, and that these genes may be disseminated by non-Enterobacteriaceae that are not detected as part of standard microbiological water quality testing. More... »

PAGES

3938

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-40420-0

DOI

http://dx.doi.org/10.1038/s41598-019-40420-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112641526

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30850706


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16 schema:description Community-associated acquisition of extended-spectrum beta-lactamase- (ESBL) and carbapenemase-producing Enterobacteriaceae has significantly increased in recent years, necessitating greater inquiry into potential exposure routes, including food and water sources. In high-income countries, drinking water is often neglected as a possible source of community exposure to antibiotic-resistant organisms. We screened coliform-positive tap water samples (n = 483) from public and private water systems in six states of the United States for blaCTX-M, blaSHV, blaTEM, blaKPC, blaNDM, and blaOXA-48-type genes by multiplex PCR. Positive samples were subcultured to isolate organisms harboring ESBL or carbapenemase genes. Thirty-one samples (6.4%) were positive for blaCTX-M, ESBL-type blaSHV or blaTEM, or blaOXA-48-type carbapenemase genes, including at least one positive sample from each state. ESBL and blaOXA-48-type Enterobacteriaceae isolates included E. coli, Kluyvera, Providencia, Klebsiella, and Citrobacter species. The blaOXA-48-type genes were also found in non-fermenting Gram-negative species, including Shewanella, Pseudomonas and Acinetobacter. Multiple isolates were phenotypically non-susceptible to third-generation cephalosporin or carbapenem antibiotics. These findings suggest that tap water in high income countries could serve as an important source of community exposure to ESBL and carbapenemase genes, and that these genes may be disseminated by non-Enterobacteriaceae that are not detected as part of standard microbiological water quality testing.
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23 schema:keywords Acinetobacter
24 Citrobacter species
25 Community-associated acquisition
26 ESBL
27 ESBL-type blaSHV
28 Enterobacteriaceae
29 Enterobacteriaceae isolates
30 Gram-negative species
31 Klebsiella
32 Kluyvera
33 PCR
34 Providencia
35 Pseudomonas
36 Shewanella
37 U.S. drinking water
38 United States
39 acquisition
40 antibiotic-resistant organisms
41 antibiotics
42 blaCTX
43 blaKPC
44 blaNDM
45 blaOXA-48-type Enterobacteriaceae isolates
46 blaOXA-48-type carbapenemase genes
47 blaOXA-48-type genes
48 blaSHV
49 blaTEM
50 carbapenem antibiotics
51 carbapenemase genes
52 carbapenemase-producing Enterobacteriaceae
53 cephalosporins
54 coli
55 coliform-positive tap water samples
56 community exposure
57 countries
58 drinking water
59 exposure
60 exposure routes
61 findings
62 food
63 genes
64 greater inquiry
65 high income countries
66 high-income countries
67 important source
68 income countries
69 inquiry
70 isolates
71 microbiological water quality testing
72 multi-state study
73 multiple isolates
74 multiplex PCR
75 non-fermenting Gram-negative species
76 organisms
77 part
78 positive samples
79 possible sources
80 potential exposure routes
81 private water systems
82 quality testing
83 recent years
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88 standard microbiological water quality testing
89 state
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96 water
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