Impaired mitochondrial oxidative phosphorylation capacity in epicardial adipose tissue is associated with decreased concentration of adiponectin and severity of coronary ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Takayuki Nakajima, Takashi Yokota, Yasushige Shingu, Akira Yamada, Yutaka Iba, Kosuke Ujihira, Satoru Wakasa, Tomonori Ooka, Shingo Takada, Ryosuke Shirakawa, Takashi Katayama, Takaaki Furihata, Arata Fukushima, Ryosuke Matsuoka, Hiroshi Nishihara, Flemming Dela, Katsuhiko Nakanishi, Yoshiro Matsui, Shintaro Kinugawa

ABSTRACT

Epicardial adipose tissue (EAT), a source of adipokines, is metabolically active, but the role of EAT mitochondria in coronary artery disease (CAD) has not been established. We investigated the association between EAT mitochondrial respiratory capacity, adiponectin concentration in the EAT, and coronary atherosclerosis. EAT samples were obtained from 25 patients who underwent elective cardiac surgery. Based on the coronary angiographycal findings, the patients were divided into two groups; coronary artery disease (CAD; n = 14) and non-CAD (n = 11) groups. The mitochondrial respiratory capacities including oxidative phosphorylation (OXPHOS) capacity with non-fatty acid (complex I and complex I + II-linked) substrates and fatty acids in the EAT were significantly lowered in CAD patients. The EAT mitochondrial OXPHOS capacities had a close and inverse correlation with the severity of coronary artery stenosis evaluated by the Gensini score. Intriguingly, the protein level of adiponectin, an anti-atherogenic adipokine, in the EAT was significantly reduced in CAD patients, and it was positively correlated with the mitochondrial OXPHOS capacities in the EAT and inversely correlated with the Gensini score. Our study showed that impaired mitochondrial OXPHOS capacity in the EAT was closely linked to decreased concentration of adiponectin in the EAT and severity of coronary atherosclerosis. More... »

PAGES

3535

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-40419-7

DOI

http://dx.doi.org/10.1038/s41598-019-40419-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112544123

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30837669


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Hokkaido University", 
          "id": "https://www.grid.ac/institutes/grid.39158.36", 
          "name": [
            "Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakajima", 
        "givenName": "Takayuki", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hokkaido University", 
          "id": "https://www.grid.ac/institutes/grid.39158.36", 
          "name": [
            "Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yokota", 
        "givenName": "Takashi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hokkaido University", 
          "id": "https://www.grid.ac/institutes/grid.39158.36", 
          "name": [
            "Department of Cardiovascular and Thoracic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shingu", 
        "givenName": "Yasushige", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Teine Keijinkai Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416933.a", 
          "name": [
            "Department of Cardiovascular Surgery, Teine Keijinkai Hospital, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamada", 
        "givenName": "Akira", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Teine Keijinkai Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416933.a", 
          "name": [
            "Department of Cardiovascular Surgery, Teine Keijinkai Hospital, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Iba", 
        "givenName": "Yutaka", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Teine Keijinkai Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416933.a", 
          "name": [
            "Department of Cardiovascular Surgery, Teine Keijinkai Hospital, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ujihira", 
        "givenName": "Kosuke", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hokkaido University", 
          "id": "https://www.grid.ac/institutes/grid.39158.36", 
          "name": [
            "Department of Cardiovascular and Thoracic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wakasa", 
        "givenName": "Satoru", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hokkaido University", 
          "id": "https://www.grid.ac/institutes/grid.39158.36", 
          "name": [
            "Department of Cardiovascular and Thoracic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ooka", 
        "givenName": "Tomonori", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hokkaido University", 
          "id": "https://www.grid.ac/institutes/grid.39158.36", 
          "name": [
            "Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takada", 
        "givenName": "Shingo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hokkaido University", 
          "id": "https://www.grid.ac/institutes/grid.39158.36", 
          "name": [
            "Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shirakawa", 
        "givenName": "Ryosuke", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hokkaido University", 
          "id": "https://www.grid.ac/institutes/grid.39158.36", 
          "name": [
            "Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Katayama", 
        "givenName": "Takashi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hokkaido University", 
          "id": "https://www.grid.ac/institutes/grid.39158.36", 
          "name": [
            "Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Furihata", 
        "givenName": "Takaaki", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hokkaido University", 
          "id": "https://www.grid.ac/institutes/grid.39158.36", 
          "name": [
            "Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fukushima", 
        "givenName": "Arata", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hokkaido University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412167.7", 
          "name": [
            "Division of Clinical Cancer Genomics, Hokkaido University Hospital, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsuoka", 
        "givenName": "Ryosuke", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sapporo National Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415270.5", 
          "name": [
            "Division of Clinical Cancer Genomics, Hokkaido Cancer Center, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nishihara", 
        "givenName": "Hiroshi", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Frederiksberg Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415046.2", 
          "name": [
            "Xlab, Center for Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark", 
            "Department of Geriatrics, Bispebjerg-Frederiksberg University Hospital, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dela", 
        "givenName": "Flemming", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Teine Keijinkai Hospital", 
          "id": "https://www.grid.ac/institutes/grid.416933.a", 
          "name": [
            "Department of Cardiovascular Surgery, Teine Keijinkai Hospital, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakanishi", 
        "givenName": "Katsuhiko", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hokkaido University", 
          "id": "https://www.grid.ac/institutes/grid.39158.36", 
          "name": [
            "Department of Cardiovascular and Thoracic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsui", 
        "givenName": "Yoshiro", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hokkaido University", 
          "id": "https://www.grid.ac/institutes/grid.39158.36", 
          "name": [
            "Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kinugawa", 
        "givenName": "Shintaro", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1152/ajpheart.00701.2003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005408548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cyto.2004.11.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008533700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jacc.2011.01.048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009027501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.cir.0000099542.57313.c5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009639573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ahj.2007.03.019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012440181"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1475-2840-11-106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012916049", 
          "https://doi.org/10.1186/1475-2840-11-106"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circimaging.114.002676", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019985446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circimaging.114.002676", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019985446"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/atvbaha.110.204719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020176730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/atvbaha.110.204719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020176730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/atvbaha.110.204719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020176730"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncpcardio0319", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020440283", 
          "https://doi.org/10.1038/ncpcardio0319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ncpcardio0319", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020440283", 
          "https://doi.org/10.1038/ncpcardio0319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra1011035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021935376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jp273408", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023892855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/eurjhf/hfs172", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032350641"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/jmcc.2001.1378", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034065596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.atherosclerosis.2009.11.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034976541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.00991.2012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036868074"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2337/db05-1421", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040497016"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11604-010-0524-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041343971", 
          "https://doi.org/10.1007/s11604-010-0524-z"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/circulationaha.107.743062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042595204"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.amjcard.2008.08.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046226215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/febs.12096", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047641153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/febs.12096", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047641153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.2009.184754", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048528998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jphysiol.2009.184754", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048528998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9149(83)80105-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051465859"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)66585-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052323239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.carpath.2004.08.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052726915"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1113/jp273049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083811237"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Epicardial adipose tissue (EAT), a source of adipokines, is metabolically active, but the role of EAT mitochondria in coronary artery disease (CAD) has not been established. We investigated the association between EAT mitochondrial respiratory capacity, adiponectin concentration in the EAT, and coronary atherosclerosis. EAT samples were obtained from 25 patients who underwent elective cardiac surgery. Based on the coronary angiographycal findings, the patients were divided into two groups; coronary artery disease (CAD; n\u2009=\u200914) and non-CAD (n\u2009=\u200911) groups. The mitochondrial respiratory capacities including oxidative phosphorylation (OXPHOS) capacity with non-fatty acid (complex I and complex I\u2009+\u2009II-linked) substrates and fatty acids in the EAT were significantly lowered in CAD patients. The EAT mitochondrial OXPHOS capacities had a close and inverse correlation with the severity of coronary artery stenosis evaluated by the Gensini score. Intriguingly, the protein level of adiponectin, an anti-atherogenic adipokine, in the EAT was significantly reduced in CAD patients, and it was positively correlated with the mitochondrial OXPHOS capacities in the EAT and inversely correlated with the Gensini score. Our study showed that impaired mitochondrial OXPHOS capacity in the EAT was closely linked to decreased concentration of adiponectin in the EAT and severity of coronary atherosclerosis.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-019-40419-7", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6147780", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5875820", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6822679", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Impaired mitochondrial oxidative phosphorylation capacity in epicardial adipose tissue is associated with decreased concentration of adiponectin and severity of coronary atherosclerosis", 
    "pagination": "3535", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c1b8e36d39ce633902d5993ad14016e4539f94388aca2edac74c18465833de45"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30837669"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-019-40419-7"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112544123"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-019-40419-7", 
      "https://app.dimensions.ai/details/publication/pub.1112544123"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T11:17", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000354_0000000354/records_11695_00000002.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-019-40419-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-40419-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-40419-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-40419-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-40419-7'


 

This table displays all metadata directly associated to this object as RDF triples.

273 TRIPLES      21 PREDICATES      54 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-019-40419-7 schema:about anzsrc-for:11
2 anzsrc-for:1102
3 schema:author N5de5fc586ce14a8ca2d507b580df798a
4 schema:citation sg:pub.10.1007/s11604-010-0524-z
5 sg:pub.10.1038/ncpcardio0319
6 sg:pub.10.1186/1475-2840-11-106
7 https://doi.org/10.1006/jmcc.2001.1378
8 https://doi.org/10.1016/j.ahj.2007.03.019
9 https://doi.org/10.1016/j.amjcard.2008.08.010
10 https://doi.org/10.1016/j.atherosclerosis.2009.11.020
11 https://doi.org/10.1016/j.carpath.2004.08.005
12 https://doi.org/10.1016/j.cyto.2004.11.002
13 https://doi.org/10.1016/j.jacc.2011.01.048
14 https://doi.org/10.1016/s0002-9149(83)80105-2
15 https://doi.org/10.1016/s0140-6736(05)66585-3
16 https://doi.org/10.1056/nejmra1011035
17 https://doi.org/10.1093/eurjhf/hfs172
18 https://doi.org/10.1111/febs.12096
19 https://doi.org/10.1113/jp273049
20 https://doi.org/10.1113/jp273408
21 https://doi.org/10.1113/jphysiol.2009.184754
22 https://doi.org/10.1152/ajpheart.00701.2003
23 https://doi.org/10.1152/ajpheart.00991.2012
24 https://doi.org/10.1161/01.cir.0000099542.57313.c5
25 https://doi.org/10.1161/atvbaha.110.204719
26 https://doi.org/10.1161/circimaging.114.002676
27 https://doi.org/10.1161/circulationaha.107.743062
28 https://doi.org/10.2337/db05-1421
29 schema:datePublished 2019-12
30 schema:datePublishedReg 2019-12-01
31 schema:description Epicardial adipose tissue (EAT), a source of adipokines, is metabolically active, but the role of EAT mitochondria in coronary artery disease (CAD) has not been established. We investigated the association between EAT mitochondrial respiratory capacity, adiponectin concentration in the EAT, and coronary atherosclerosis. EAT samples were obtained from 25 patients who underwent elective cardiac surgery. Based on the coronary angiographycal findings, the patients were divided into two groups; coronary artery disease (CAD; n = 14) and non-CAD (n = 11) groups. The mitochondrial respiratory capacities including oxidative phosphorylation (OXPHOS) capacity with non-fatty acid (complex I and complex I + II-linked) substrates and fatty acids in the EAT were significantly lowered in CAD patients. The EAT mitochondrial OXPHOS capacities had a close and inverse correlation with the severity of coronary artery stenosis evaluated by the Gensini score. Intriguingly, the protein level of adiponectin, an anti-atherogenic adipokine, in the EAT was significantly reduced in CAD patients, and it was positively correlated with the mitochondrial OXPHOS capacities in the EAT and inversely correlated with the Gensini score. Our study showed that impaired mitochondrial OXPHOS capacity in the EAT was closely linked to decreased concentration of adiponectin in the EAT and severity of coronary atherosclerosis.
32 schema:genre research_article
33 schema:inLanguage en
34 schema:isAccessibleForFree true
35 schema:isPartOf N11456211f1044a1d9fa835388ae94de7
36 Nfccc67c5e1314d76a51cc97eb4d773b3
37 sg:journal.1045337
38 schema:name Impaired mitochondrial oxidative phosphorylation capacity in epicardial adipose tissue is associated with decreased concentration of adiponectin and severity of coronary atherosclerosis
39 schema:pagination 3535
40 schema:productId N2539680b30a3467a99c7061b7a9f1bd2
41 N2c9f3f190a704f52acea5f9f5588e1a8
42 Nb03cc10887e84ff38c052c7d206ff63b
43 Ndb2f8f7e226642edaf1aaf4e30660cf0
44 Nf678387032624006a54b59e89dda8f9d
45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112544123
46 https://doi.org/10.1038/s41598-019-40419-7
47 schema:sdDatePublished 2019-04-11T11:17
48 schema:sdLicense https://scigraph.springernature.com/explorer/license/
49 schema:sdPublisher N71dcf513a69248eeb6d6fa711b0ae1eb
50 schema:url https://www.nature.com/articles/s41598-019-40419-7
51 sgo:license sg:explorer/license/
52 sgo:sdDataset articles
53 rdf:type schema:ScholarlyArticle
54 N06f82aa2e376455d90387044d3bfafc7 schema:affiliation https://www.grid.ac/institutes/grid.39158.36
55 schema:familyName Kinugawa
56 schema:givenName Shintaro
57 rdf:type schema:Person
58 N113a264d4bc64ff6afa9f34457264e3d rdf:first N185e79261e8548278ff922691727b059
59 rdf:rest Na3f6609da83a4f31bee60434276847ea
60 N11456211f1044a1d9fa835388ae94de7 schema:issueNumber 1
61 rdf:type schema:PublicationIssue
62 N178fc94792ca481ca9f5785fd152455c schema:affiliation https://www.grid.ac/institutes/grid.39158.36
63 schema:familyName Wakasa
64 schema:givenName Satoru
65 rdf:type schema:Person
66 N185e79261e8548278ff922691727b059 schema:affiliation https://www.grid.ac/institutes/grid.39158.36
67 schema:familyName Shirakawa
68 schema:givenName Ryosuke
69 rdf:type schema:Person
70 N1cc540d7900b4256a53ffcef3b9d95e3 schema:affiliation https://www.grid.ac/institutes/grid.415270.5
71 schema:familyName Nishihara
72 schema:givenName Hiroshi
73 rdf:type schema:Person
74 N2539680b30a3467a99c7061b7a9f1bd2 schema:name dimensions_id
75 schema:value pub.1112544123
76 rdf:type schema:PropertyValue
77 N2b93ba6a8dbb4ab49a3bf20fe53324e7 rdf:first N88e87e81688d427bb2f560e0e4a65544
78 rdf:rest N894ec1568f0945d2b83e6cbce7e53c41
79 N2c9f3f190a704f52acea5f9f5588e1a8 schema:name doi
80 schema:value 10.1038/s41598-019-40419-7
81 rdf:type schema:PropertyValue
82 N2dca2f7f73924a28852de726e1d0444f schema:affiliation https://www.grid.ac/institutes/grid.39158.36
83 schema:familyName Furihata
84 schema:givenName Takaaki
85 rdf:type schema:Person
86 N303b91b1115e4b6b9f8f9dd25a45f2d5 schema:affiliation https://www.grid.ac/institutes/grid.412167.7
87 schema:familyName Matsuoka
88 schema:givenName Ryosuke
89 rdf:type schema:Person
90 N339089b5f88a4a3a86dcc1cc96c95227 schema:affiliation https://www.grid.ac/institutes/grid.416933.a
91 schema:familyName Nakanishi
92 schema:givenName Katsuhiko
93 rdf:type schema:Person
94 N5b03ab72900d43d689f040e37297bef1 rdf:first N2dca2f7f73924a28852de726e1d0444f
95 rdf:rest Nb66c4c24b6cd4249852cf12c91e66e82
96 N5de5fc586ce14a8ca2d507b580df798a rdf:first N8b00b0f3156747eaa731d4976f3a548b
97 rdf:rest Nfa1c69c495fa462fa62f1708987c1138
98 N61aaecfad5764227804185d3a4244ec3 rdf:first Na7dff5b99bb34175a03c465820163947
99 rdf:rest Ne6e65ef0b9344b54820444a20bbe1330
100 N71dcf513a69248eeb6d6fa711b0ae1eb schema:name Springer Nature - SN SciGraph project
101 rdf:type schema:Organization
102 N720132052bd645b28ceb1149ced73107 schema:affiliation https://www.grid.ac/institutes/grid.39158.36
103 schema:familyName Matsui
104 schema:givenName Yoshiro
105 rdf:type schema:Person
106 N73f39cb893454a94bb301fc4cc5faf63 rdf:first N303b91b1115e4b6b9f8f9dd25a45f2d5
107 rdf:rest Nd2afeda8798c46eaa44c278d7c035043
108 N75f7be6e9f5c498f95b387f1d75f2eb8 rdf:first Nefc7fba06a7e431fb0983d7182e09bcf
109 rdf:rest Nbfb0fb8a335a477eb9c36a3e2dad201c
110 N88e87e81688d427bb2f560e0e4a65544 schema:affiliation https://www.grid.ac/institutes/grid.416933.a
111 schema:familyName Yamada
112 schema:givenName Akira
113 rdf:type schema:Person
114 N894ec1568f0945d2b83e6cbce7e53c41 rdf:first Nb3e3a275790445459ccef8948ac95c28
115 rdf:rest N61aaecfad5764227804185d3a4244ec3
116 N8b00b0f3156747eaa731d4976f3a548b schema:affiliation https://www.grid.ac/institutes/grid.39158.36
117 schema:familyName Nakajima
118 schema:givenName Takayuki
119 rdf:type schema:Person
120 N90372f8a3f3b433e83d2c647a6daf1d0 rdf:first N06f82aa2e376455d90387044d3bfafc7
121 rdf:rest rdf:nil
122 N959c002480ed496eabe9bba4ca2b49dd schema:affiliation https://www.grid.ac/institutes/grid.39158.36
123 schema:familyName Katayama
124 schema:givenName Takashi
125 rdf:type schema:Person
126 N9c45f336238148fda0b05dbc37889776 schema:affiliation https://www.grid.ac/institutes/grid.415046.2
127 schema:familyName Dela
128 schema:givenName Flemming
129 rdf:type schema:Person
130 Na3f6609da83a4f31bee60434276847ea rdf:first N959c002480ed496eabe9bba4ca2b49dd
131 rdf:rest N5b03ab72900d43d689f040e37297bef1
132 Na4f3ac8979f34fa3851ba01b839badfa schema:affiliation https://www.grid.ac/institutes/grid.39158.36
133 schema:familyName Shingu
134 schema:givenName Yasushige
135 rdf:type schema:Person
136 Na7dff5b99bb34175a03c465820163947 schema:affiliation https://www.grid.ac/institutes/grid.416933.a
137 schema:familyName Ujihira
138 schema:givenName Kosuke
139 rdf:type schema:Person
140 Nab4d39a0a0da430783a88274f6360ee6 schema:affiliation https://www.grid.ac/institutes/grid.39158.36
141 schema:familyName Yokota
142 schema:givenName Takashi
143 rdf:type schema:Person
144 Nb03cc10887e84ff38c052c7d206ff63b schema:name pubmed_id
145 schema:value 30837669
146 rdf:type schema:PropertyValue
147 Nb3e3a275790445459ccef8948ac95c28 schema:affiliation https://www.grid.ac/institutes/grid.416933.a
148 schema:familyName Iba
149 schema:givenName Yutaka
150 rdf:type schema:Person
151 Nb66c4c24b6cd4249852cf12c91e66e82 rdf:first Nf734f7b80a99411dba3ef88e4effe00f
152 rdf:rest N73f39cb893454a94bb301fc4cc5faf63
153 Nbfb0fb8a335a477eb9c36a3e2dad201c rdf:first Ne970f21b05bf41b2b0ec509450ed794a
154 rdf:rest N113a264d4bc64ff6afa9f34457264e3d
155 Ncb70e17a3c5f4f6c86104ae9bb70e956 rdf:first N339089b5f88a4a3a86dcc1cc96c95227
156 rdf:rest Nfacb3af03f234b5a9a2fb44104de8721
157 Nd2afeda8798c46eaa44c278d7c035043 rdf:first N1cc540d7900b4256a53ffcef3b9d95e3
158 rdf:rest Ne9ade4d103fd4f828eef0f998249c7af
159 Ndad637be1d834d1d8a9ef471d7b15875 rdf:first Na4f3ac8979f34fa3851ba01b839badfa
160 rdf:rest N2b93ba6a8dbb4ab49a3bf20fe53324e7
161 Ndb2f8f7e226642edaf1aaf4e30660cf0 schema:name nlm_unique_id
162 schema:value 101563288
163 rdf:type schema:PropertyValue
164 Ne6e65ef0b9344b54820444a20bbe1330 rdf:first N178fc94792ca481ca9f5785fd152455c
165 rdf:rest N75f7be6e9f5c498f95b387f1d75f2eb8
166 Ne970f21b05bf41b2b0ec509450ed794a schema:affiliation https://www.grid.ac/institutes/grid.39158.36
167 schema:familyName Takada
168 schema:givenName Shingo
169 rdf:type schema:Person
170 Ne9ade4d103fd4f828eef0f998249c7af rdf:first N9c45f336238148fda0b05dbc37889776
171 rdf:rest Ncb70e17a3c5f4f6c86104ae9bb70e956
172 Nefc7fba06a7e431fb0983d7182e09bcf schema:affiliation https://www.grid.ac/institutes/grid.39158.36
173 schema:familyName Ooka
174 schema:givenName Tomonori
175 rdf:type schema:Person
176 Nf678387032624006a54b59e89dda8f9d schema:name readcube_id
177 schema:value c1b8e36d39ce633902d5993ad14016e4539f94388aca2edac74c18465833de45
178 rdf:type schema:PropertyValue
179 Nf734f7b80a99411dba3ef88e4effe00f schema:affiliation https://www.grid.ac/institutes/grid.39158.36
180 schema:familyName Fukushima
181 schema:givenName Arata
182 rdf:type schema:Person
183 Nfa1c69c495fa462fa62f1708987c1138 rdf:first Nab4d39a0a0da430783a88274f6360ee6
184 rdf:rest Ndad637be1d834d1d8a9ef471d7b15875
185 Nfacb3af03f234b5a9a2fb44104de8721 rdf:first N720132052bd645b28ceb1149ced73107
186 rdf:rest N90372f8a3f3b433e83d2c647a6daf1d0
187 Nfccc67c5e1314d76a51cc97eb4d773b3 schema:volumeNumber 9
188 rdf:type schema:PublicationVolume
189 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
190 schema:name Medical and Health Sciences
191 rdf:type schema:DefinedTerm
192 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
193 schema:name Cardiorespiratory Medicine and Haematology
194 rdf:type schema:DefinedTerm
195 sg:grant.5875820 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-40419-7
196 rdf:type schema:MonetaryGrant
197 sg:grant.6147780 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-40419-7
198 rdf:type schema:MonetaryGrant
199 sg:grant.6822679 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-40419-7
200 rdf:type schema:MonetaryGrant
201 sg:journal.1045337 schema:issn 2045-2322
202 schema:name Scientific Reports
203 rdf:type schema:Periodical
204 sg:pub.10.1007/s11604-010-0524-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1041343971
205 https://doi.org/10.1007/s11604-010-0524-z
206 rdf:type schema:CreativeWork
207 sg:pub.10.1038/ncpcardio0319 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020440283
208 https://doi.org/10.1038/ncpcardio0319
209 rdf:type schema:CreativeWork
210 sg:pub.10.1186/1475-2840-11-106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012916049
211 https://doi.org/10.1186/1475-2840-11-106
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1006/jmcc.2001.1378 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034065596
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/j.ahj.2007.03.019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012440181
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/j.amjcard.2008.08.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046226215
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/j.atherosclerosis.2009.11.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034976541
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/j.carpath.2004.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052726915
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/j.cyto.2004.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008533700
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/j.jacc.2011.01.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009027501
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/s0002-9149(83)80105-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051465859
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/s0140-6736(05)66585-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052323239
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1056/nejmra1011035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021935376
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1093/eurjhf/hfs172 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032350641
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1111/febs.12096 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047641153
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1113/jp273049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083811237
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1113/jp273408 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023892855
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1113/jphysiol.2009.184754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048528998
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1152/ajpheart.00701.2003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005408548
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1152/ajpheart.00991.2012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036868074
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1161/01.cir.0000099542.57313.c5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009639573
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1161/atvbaha.110.204719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020176730
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1161/circimaging.114.002676 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019985446
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1161/circulationaha.107.743062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042595204
254 rdf:type schema:CreativeWork
255 https://doi.org/10.2337/db05-1421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040497016
256 rdf:type schema:CreativeWork
257 https://www.grid.ac/institutes/grid.39158.36 schema:alternateName Hokkaido University
258 schema:name Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan
259 Department of Cardiovascular and Thoracic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan
260 rdf:type schema:Organization
261 https://www.grid.ac/institutes/grid.412167.7 schema:alternateName Hokkaido University Hospital
262 schema:name Division of Clinical Cancer Genomics, Hokkaido University Hospital, Sapporo, Japan
263 rdf:type schema:Organization
264 https://www.grid.ac/institutes/grid.415046.2 schema:alternateName Frederiksberg Hospital
265 schema:name Department of Geriatrics, Bispebjerg-Frederiksberg University Hospital, Copenhagen, Denmark
266 Xlab, Center for Healthy Aging, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
267 rdf:type schema:Organization
268 https://www.grid.ac/institutes/grid.415270.5 schema:alternateName Sapporo National Hospital
269 schema:name Division of Clinical Cancer Genomics, Hokkaido Cancer Center, Sapporo, Japan
270 rdf:type schema:Organization
271 https://www.grid.ac/institutes/grid.416933.a schema:alternateName Teine Keijinkai Hospital
272 schema:name Department of Cardiovascular Surgery, Teine Keijinkai Hospital, Sapporo, Japan
273 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...