Ontology type: schema:ScholarlyArticle Open Access: True
2019-12
AUTHORSKarsten Heusser, Jens Tank, Olaf Holz, Marcus May, Julia Brinkmann, Stefan Engeli, André Diedrich, Theodor Framke, Armin Koch, Anika Großhennig, A. H. Jan Danser, Fred C. G. J. Sweep, Christoph Schindler, Katharina Schwarz, Norbert Krug, Jens Jordan, Jens M. Hohlfeld
ABSTRACTCardiovascular risk rapidly increased following exposure to air pollution. Changes in human autonomic regulation have been implicated based on epidemiological associations between exposure estimates and indirect autonomic nervous system measurements. We conducted a mechanistic study to test the hypothesis that, in healthy older individuals, well-defined experimental exposure to ultrafine carbon particles (UFP) increases sympathetic nervous system activity and more so with added ozone (O3). Eighteen participants (age >50 years, 6 women) were exposed to filtered air (Air), UFP, and UFP + O3 combination for 3 hours during intermittent bicycle ergometer training in a randomized, crossover, double-blind fashion. Two hours following exposure, respiration, electrocardiogram, blood pressure, and muscle sympathetic nerve activity (MSNA) were recorded at supine rest, during deep breathing, and during a Valsalva manoeuvre. Catechols and inflammatory marker levels were measured in venous blood samples. Induced sputum was obtained 3.5 h after exposure. Combined exposure to UFP + O3 but not UFP alone, caused a significant increase in sputum neutrophils and circulating leucocytes. Norepinephrine was modestly increased while the ratio between plasma dihydroxyphenylglycol (DHPG) and norepinephrine levels, a marker for norepinephrine clearance, was reduced with UFP + O3. Resting MSNA was not different (47 ± 12 with Air, 47 ± 14 with UFP, and 45 ± 14 bursts/min with UFP + O3). Indices of parasympathetic heart rate control were unaffected by experimental air pollution. Our study suggests that combined exposure to modest UFP and O3 levels increases peripheral norepinephrine availability through decreased clearance rather than changes in central autonomic activity. Pulmonary inflammatory response may have perturbed pulmonary endothelial norepinephrine clearance. More... »
PAGES3641
http://scigraph.springernature.com/pub.10.1038/s41598-019-40343-w
DOIhttp://dx.doi.org/10.1038/s41598-019-40343-w
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1112577543
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30842540
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Cardiorespiratory Medicine and Haematology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "German Aerospace Center",
"id": "https://www.grid.ac/institutes/grid.7551.6",
"name": [
"Institute of Aerospace Medicine, German Aerospace Center (DLR), 51147, Cologne, Germany"
],
"type": "Organization"
},
"familyName": "Heusser",
"givenName": "Karsten",
"type": "Person"
},
{
"affiliation": {
"alternateName": "German Aerospace Center",
"id": "https://www.grid.ac/institutes/grid.7551.6",
"name": [
"Institute of Aerospace Medicine, German Aerospace Center (DLR), 51147, Cologne, Germany"
],
"type": "Organization"
},
"familyName": "Tank",
"givenName": "Jens",
"type": "Person"
},
{
"affiliation": {
"alternateName": "German Center for Lung Research",
"id": "https://www.grid.ac/institutes/grid.452624.3",
"name": [
"Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), 30625, Hannover, Germany",
"Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, 30625, Hannover, Germany"
],
"type": "Organization"
},
"familyName": "Holz",
"givenName": "Olaf",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hannover Medical School",
"id": "https://www.grid.ac/institutes/grid.10423.34",
"name": [
"MHH CRC Core Facility & Centre for Pharmacology and Toxicology, Hannover Medical School, 30625, Hannover, Germany"
],
"type": "Organization"
},
"familyName": "May",
"givenName": "Marcus",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Kaufm\u00e4nnische Krankenkasse",
"id": "https://www.grid.ac/institutes/grid.492147.d",
"name": [
"Institute for Clinical Pharmacology, Hannover Medical School, 30625, Hannover, Germany",
"Kaufm\u00e4nnische Krankenkasse - KKH, Karl-Wiechert-Allee 61, 30625, Hannover, Germany"
],
"type": "Organization"
},
"familyName": "Brinkmann",
"givenName": "Julia",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hannover Medical School",
"id": "https://www.grid.ac/institutes/grid.10423.34",
"name": [
"Institute for Clinical Pharmacology, Hannover Medical School, 30625, Hannover, Germany"
],
"type": "Organization"
},
"familyName": "Engeli",
"givenName": "Stefan",
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Medicine, Division of Clinical Pharmacology, Autonomic Dysfunction Center, Vanderbilt University School of Medicine, 37232, Nashville, TN, USA"
],
"type": "Organization"
},
"familyName": "Diedrich",
"givenName": "Andr\u00e9",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hannover Medical School",
"id": "https://www.grid.ac/institutes/grid.10423.34",
"name": [
"Institute of Biostatistics, Hannover Medical School, 30625, Hannover, Germany"
],
"type": "Organization"
},
"familyName": "Framke",
"givenName": "Theodor",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hannover Medical School",
"id": "https://www.grid.ac/institutes/grid.10423.34",
"name": [
"Institute of Biostatistics, Hannover Medical School, 30625, Hannover, Germany"
],
"type": "Organization"
},
"familyName": "Koch",
"givenName": "Armin",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hannover Medical School",
"id": "https://www.grid.ac/institutes/grid.10423.34",
"name": [
"Institute of Biostatistics, Hannover Medical School, 30625, Hannover, Germany"
],
"type": "Organization"
},
"familyName": "Gro\u00dfhennig",
"givenName": "Anika",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Erasmus University Medical Center",
"id": "https://www.grid.ac/institutes/grid.5645.2",
"name": [
"Division of Vascular Medicine and Pharmacology, Department of Internal Medicine, Erasmus Medical Center, 3015 GE, Rotterdam, The Netherlands"
],
"type": "Organization"
},
"familyName": "Danser",
"givenName": "A. H. Jan",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Radboud University Nijmegen Medical Centre",
"id": "https://www.grid.ac/institutes/grid.10417.33",
"name": [
"Department of Laboratory Medicine, Radboud University Medical Centre, 6500 HB, Nijmegen, The Netherlands"
],
"type": "Organization"
},
"familyName": "Sweep",
"givenName": "Fred C. G. J.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hannover Medical School",
"id": "https://www.grid.ac/institutes/grid.10423.34",
"name": [
"MHH CRC Core Facility & Centre for Pharmacology and Toxicology, Hannover Medical School, 30625, Hannover, Germany"
],
"type": "Organization"
},
"familyName": "Schindler",
"givenName": "Christoph",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Fraunhofer Institute for Toxicology and Experimental Medicine",
"id": "https://www.grid.ac/institutes/grid.418009.4",
"name": [
"Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), 30625, Hannover, Germany"
],
"type": "Organization"
},
"familyName": "Schwarz",
"givenName": "Katharina",
"type": "Person"
},
{
"affiliation": {
"alternateName": "German Center for Lung Research",
"id": "https://www.grid.ac/institutes/grid.452624.3",
"name": [
"Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), 30625, Hannover, Germany",
"Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, 30625, Hannover, Germany"
],
"type": "Organization"
},
"familyName": "Krug",
"givenName": "Norbert",
"type": "Person"
},
{
"affiliation": {
"alternateName": "German Aerospace Center",
"id": "https://www.grid.ac/institutes/grid.7551.6",
"name": [
"Institute of Aerospace Medicine, German Aerospace Center (DLR), 51147, Cologne, Germany"
],
"type": "Organization"
},
"familyName": "Jordan",
"givenName": "Jens",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hannover Medical School",
"id": "https://www.grid.ac/institutes/grid.10423.34",
"name": [
"Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM), 30625, Hannover, Germany",
"Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research, 30625, Hannover, Germany",
"Department of Respiratory Medicine, Hannover Medical School, 30625, Hannover, Germany"
],
"type": "Organization"
},
"familyName": "Hohlfeld",
"givenName": "Jens M.",
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1164/rccm.200309-1325pp",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000855014"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1124/pr.108.000869",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003126168"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/15287399409531838",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006245906"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/08958370490439650",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006691963"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1289/ehp.1002237",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006992737"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/oem.2007.035253",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007034292"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/oem.2007.035253",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007034292"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s40360-015-0021-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008616284",
"https://doi.org/10.1186/s40360-015-0021-1"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.cir.0000108927.80044.7f",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008857249"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jc.2002-020533",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009050044"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1365-2125.1979.tb05903.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009271324"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1164/ajrccm.159.3.9806098",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009945473"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0735-1097(01)01616-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011463248"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/hc3401.095038",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011533111"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1108/eb006513",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012210121"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.envres.2016.06.014",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012407554"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbagen.2016.07.015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012577492"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/oxfordjournals.aje.a009934",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012832483"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1183/09031936.03.00402403",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014103704"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/hypertensionaha.109.130237",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014324553"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/hypertensionaha.109.130237",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014324553"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/08958370801903800",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017351407"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/jcp.0000000000000611",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017711337"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/jcp.0000000000000611",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017711337"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.cir.0000130847.18666.39",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019229974"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0018737",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019702534"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00004872-199816060-00017",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020424279"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00004872-199816060-00017",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020424279"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00004872-199816060-00017",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020424279"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/08958370500515913",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021700424"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1164/rccm.200611-1627oc",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022758405"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.cir.103.23.2810",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028461067"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/rmed.2001.1265",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030215734"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00168693",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030778870",
"https://doi.org/10.1007/bf00168693"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00168693",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030778870",
"https://doi.org/10.1007/bf00168693"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/aje/kwi143",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032461434"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/aje/kwi143",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032461434"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejm200002243420803",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034424049"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12989-014-0039-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034942856",
"https://doi.org/10.1186/s12989-014-0039-3"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/s12989-014-0039-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034942856",
"https://doi.org/10.1186/s12989-014-0039-3"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.cir.101.11.1267",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035362117"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jchromb.2010.06.022",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036274073"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/08940630.1989.10466554",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039687027"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jacc.2006.04.073",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041826121"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/08958370490439597",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043351085"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0163-7258(01)00144-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043505208"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/atvbaha.108.166967",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045410639"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/atvbaha.108.166967",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045410639"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/jama.292.19.2372",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047131676"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1373/clinchem.2003.023135",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047177242"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/08958370490439470",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050081074"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1164/ajrccm/148.5.1363",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050178475"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.cir.0000013838.94747.64",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051113700"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.jom.0000229781.27181.7d",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051340385"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.jom.0000229781.27181.7d",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051340385"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s007020050121",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053142047",
"https://doi.org/10.1007/s007020050121"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1253/circj.72.144",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053694667"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1089/0894268041457147",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059201296"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/circresaha.116.309279",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063343857"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/circresaha.116.309279",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063343857"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2105/ajph.91.9.1346",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1068878331"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3390/ijms18020243",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1074212953"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1152/ajplung.1992.262.3.l360",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1076955808"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079428008",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1152/jappl.1993.74.5.2345",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1082762441"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1152/ajpregu.1999.276.1.r243",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083374119"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/circulationaha.116.026796",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1091246080"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/circulationaha.116.026796",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1091246080"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-12",
"datePublishedReg": "2019-12-01",
"description": "Cardiovascular risk rapidly increased following exposure to air pollution. Changes in human autonomic regulation have been implicated based on epidemiological associations between exposure estimates and indirect autonomic nervous system measurements. We conducted a mechanistic study to test the hypothesis that, in healthy older individuals, well-defined experimental exposure to ultrafine carbon particles (UFP) increases sympathetic nervous system activity and more so with added ozone (O3). Eighteen participants (age >50 years, 6 women) were exposed to filtered air (Air), UFP, and UFP\u2009+\u2009O3 combination for 3\u2009hours during intermittent bicycle ergometer training in a randomized, crossover, double-blind fashion. Two hours following exposure, respiration, electrocardiogram, blood pressure, and muscle sympathetic nerve activity (MSNA) were recorded at supine rest, during deep breathing, and during a Valsalva manoeuvre. Catechols and inflammatory marker levels were measured in venous blood samples. Induced sputum was obtained 3.5\u2009h after exposure. Combined exposure to UFP\u2009+\u2009O3 but not UFP alone, caused a significant increase in sputum neutrophils and circulating leucocytes. Norepinephrine was modestly increased while the ratio between plasma dihydroxyphenylglycol (DHPG) and norepinephrine levels, a marker for norepinephrine clearance, was reduced with UFP\u2009+\u2009O3. Resting MSNA was not different (47\u2009\u00b1\u200912 with Air, 47\u2009\u00b1\u200914 with UFP, and 45\u2009\u00b1\u200914 bursts/min with UFP\u2009+\u2009O3). Indices of parasympathetic heart rate control were unaffected by experimental air pollution. Our study suggests that combined exposure to modest UFP and O3 levels increases peripheral norepinephrine availability through decreased clearance rather than changes in central autonomic activity. Pulmonary inflammatory response may have perturbed pulmonary endothelial norepinephrine clearance.",
"genre": "research_article",
"id": "sg:pub.10.1038/s41598-019-40343-w",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.2436900",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1045337",
"issn": [
"2045-2322"
],
"name": "Scientific Reports",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "9"
}
],
"name": "Ultrafine particles and ozone perturb norepinephrine clearance rather than centrally generated sympathetic activity in humans",
"pagination": "3641",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"9feb711c7423f2fb2e813a9a49b1c733378b1f07e0f647a60a5bb2d10747ca88"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30842540"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101563288"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41598-019-40343-w"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1112577543"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41598-019-40343-w",
"https://app.dimensions.ai/details/publication/pub.1112577543"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T11:22",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000354_0000000354/records_11734_00000002.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/s41598-019-40343-w"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-40343-w'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-40343-w'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-40343-w'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-40343-w'
This table displays all metadata directly associated to this object as RDF triples.
363 TRIPLES
21 PREDICATES
85 URIs
21 LITERALS
9 BLANK NODES