Ontology type: schema:ScholarlyArticle Open Access: True
2019-12
AUTHORSKristin Möbius, Sina Kazemi, Peter Güntert, Andreas Jakob, Alexander Heckel, Johanna Becker-Baldus, Clemens Glaubitz
ABSTRACTEscherichia coli diacylglycerol kinase (DGK) is an integral membrane protein, which catalyses the ATP-dependent phosphorylation of diacylglycerol (DAG) to phosphatic acid (PA). It is a unique trimeric enzyme, which does not share sequence homology with typical kinases. It exhibits a notable complexity in structure and function despite of its small size. Here, chemical shift assignment of wild-type DGK within lipid bilayers was carried out based on 3D MAS NMR, utilizing manual and automatic analysis protocols. Upon nucleotide binding, extensive chemical shift perturbations could be observed. These data provide evidence for a symmetric DGK trimer with all of its three active sites concurrently occupied. Additionally, we could detect that the nucleotide substrate induces a substantial conformational change, most likely directing DGK into its catalytic active form. Furthermore, functionally relevant interprotomer interactions are identified by DNP-enhanced MAS NMR in combination with site-directed mutagenesis and functional assays. More... »
PAGES3995
http://scigraph.springernature.com/pub.10.1038/s41598-019-40264-8
DOIhttp://dx.doi.org/10.1038/s41598-019-40264-8
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30850624
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