Interleukin-33 serum levels in postmenopausal women with osteoporosis View Full Text


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Article Info

DATE

2019-12

AUTHORS

Lia Ginaldi, Massimo De Martinis, Salvatore Saitta, Maria Maddalena Sirufo, Carmen Mannucci, Marco Casciaro, Fedra Ciccarelli, Sebastiano Gangemi

ABSTRACT

There are many cytokines involved in the pathogenesis of osteoporosis. So far IL-33 involvement in osteoporotic patients has not yet been studied. IL-33 is a pro-inflammatory cytokine which mediates several immune functions; its involvement in a wide range of diseases, such as atopic dermatitis, asthma, and rheumatoid arthritis, is now emerging. In view of the crucial role of this cytokine in inflammation and bone remodeling, we measured IL-33 levels in the serum of postmenopausal women with osteoporosis. In 50 postmenopausal osteoporotic patients and 28 healthy postmenopausal control women, serum IL-33 levels were measured by enzyme linked immunosorbent assay. In both patients and controls the bone mineral density (BMD) was measured by double-energy X-ray absorptiometry (DXA). Vitamin D, calcium, alkaline phosphatase (ALP), parathyroid hormone (PTH) serum levels, as well as bone turnover markers, such as C-terminal telopeptide of type 1 collagen (CTX) and N-terminal propeptide of type 1 procollagen (P1NP) were also evaluated. In postmenopausal osteoporotic women IL-33 levels were significantly lower compared to healthy controls (3.53 ± 2.45 vs. 13.72 ± 5.39 pg/ml; P = 0.009) and positively correlated respectively with serum PTH (rho = 0.314; P = 0.026) and P1NP (rho = 0.373; P = 0.011) levels, while a statistically significant inverse correlation was observed between serum IL-33 and CTX levels (rho = -0.455; P = 0.002). Our results thus suggest that IL-33 represents an important bone-protecting cytokine which may be of therapeutic benefit in treating bone resorption. More... »

PAGES

3786

References to SciGraph publications

  • 2015-12. Increased levels of interleukin 31 (IL-31) in osteoporosis in BMC IMMUNOLOGY
  • 2015-12. PTH receptor-1 signalling—mechanistic insights and therapeutic prospects in NATURE REVIEWS ENDOCRINOLOGY
  • 2010-11. Interleukin-33 stimulates formation of functional osteoclasts from human CD14+ monocytes in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2016-11. Interleukin-33 in health and disease in NATURE REVIEWS IMMUNOLOGY
  • 2011-12. Role of IL-33 in inflammation and disease in JOURNAL OF INFLAMMATION
  • 2015-02. Two-faced immunology—from osteogenesis to bone resorption in NATURE REVIEWS RHEUMATOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-019-40212-6

    DOI

    http://dx.doi.org/10.1038/s41598-019-40212-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112602749

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30846811


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    41 schema:description There are many cytokines involved in the pathogenesis of osteoporosis. So far IL-33 involvement in osteoporotic patients has not yet been studied. IL-33 is a pro-inflammatory cytokine which mediates several immune functions; its involvement in a wide range of diseases, such as atopic dermatitis, asthma, and rheumatoid arthritis, is now emerging. In view of the crucial role of this cytokine in inflammation and bone remodeling, we measured IL-33 levels in the serum of postmenopausal women with osteoporosis. In 50 postmenopausal osteoporotic patients and 28 healthy postmenopausal control women, serum IL-33 levels were measured by enzyme linked immunosorbent assay. In both patients and controls the bone mineral density (BMD) was measured by double-energy X-ray absorptiometry (DXA). Vitamin D, calcium, alkaline phosphatase (ALP), parathyroid hormone (PTH) serum levels, as well as bone turnover markers, such as C-terminal telopeptide of type 1 collagen (CTX) and N-terminal propeptide of type 1 procollagen (P1NP) were also evaluated. In postmenopausal osteoporotic women IL-33 levels were significantly lower compared to healthy controls (3.53 ± 2.45 vs. 13.72 ± 5.39 pg/ml; P = 0.009) and positively correlated respectively with serum PTH (rho = 0.314; P = 0.026) and P1NP (rho = 0.373; P = 0.011) levels, while a statistically significant inverse correlation was observed between serum IL-33 and CTX levels (rho = -0.455; P = 0.002). Our results thus suggest that IL-33 represents an important bone-protecting cytokine which may be of therapeutic benefit in treating bone resorption.
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