Autoreactivity profiles of influenza hemagglutinin broadly neutralizing antibodies View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Goran Bajic, Cees E. van der Poel, Masayuki Kuraoka, Aaron G. Schmidt, Michael C. Carroll, Garnett Kelsoe, Stephen C. Harrison

ABSTRACT

Epitope-focused approaches for selective clonal induction of broadly neutralizing antibodies (bnAbs) inform most current vaccine strategies for influenza virus and other rapidly evolving pathogens. The two conserved epitopes on the influenza hemagglutinin (HA) - the "stem" and the receptor-binding site (RBS) on the "head" - are the focus of the current "universal" influenza vaccine development efforts. Because stem-directed serum bnAbs are much less abundant than head-directed ones, we hypothesized that the HA stem bnAbs may be autoreactive and thus eliminated through the mechanisms of self-tolerance. We compared autoreactivity profiles of a set of stem and head-directed bnAbs. Most of the stem bnAbs we examined bound autoantigens; several showed staining of HEp-2 cells. A smaller proportion of the head-directed bnAbs were polyreactive. Gene usage did not correlate with autoreactivity. We suggest that complex foreign antigens may often have surface patches resembling some host epitope; our results indicate that HA stem epitopes resemble a host epitope more frequently than does the RBS. More... »

PAGES

3492

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-40175-8

DOI

http://dx.doi.org/10.1038/s41598-019-40175-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112544074

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30837606


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