The genetic vulnerability to cisplatin ototoxicity: a systematic review View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Evangelia Tserga, Tara Nandwani, Niklas K. Edvall, Jan Bulla, Poulam Patel, Barbara Canlon, Christopher R. Cederroth, David M. Baguley

ABSTRACT

Ototoxicity is one of the major side-effects of platinum-based chemotherapy, in particular cisplatin (cis-diammine dichloroplatinum II). To our knowledge, no systematic review has previously provided a quantitative summary estimate of the impact of genetics upon the risk of developing hearing loss. We searched Embase, Medline, ASSIA, Pubmed, Scopus, and Web of Science, for studies documenting the genetic risk of ototoxicity in patients with cancer treated with cisplatin. Titles/abstracts and full texts were reviewed for inclusion. Meta-analytic estimates of risk (Odds Ratio) from the pooled data were calculated for studies that have been repeated twice or more. The search identified 3891 papers, of which 30 were included. The majority were retrospective (44%), ranging from n = 39 to n = 317, some including only patients younger than 25 years of age (33%), and some on both genders (80%). The most common cancers involved were osteosarcoma (53%), neuroblastoma (37%), prostate (17%) and reproductive (10%). Most studies performed genotyping, though only 5 studies performed genome-wide association studies. Nineteen single-nucleotide polymorphisms (SNPs) from 15 genes were repeated more than twice. Meta-analysis of group data indicated that rs1872328 on ACYP2, which plays a role in calcium homeostasis, increases the risk of ototoxicity by 4.61 (95% CI: 3.04-7.02; N = 696, p < 0.0001) as well as LRP2 rs4668123 shows a cumulated Odds Ratio of 3.53 (95% CI: 1.48-8.45; N = 118, p = 0.0059), which could not be evidenced in individual studies. Despite the evidence of heterogeneity across studies, these meta-analytic results from 30 studies are consistent with a view of a genetic predisposition to platinum-based chemotherapy mediated ototoxicity. These new findings are informative and encourage the genetic screening of cancer patients in order to identify patients with greater vulnerability of developing hearing loss, a condition having a potentially large impact on quality of life. More studies are needed, with larger sample size, in order to identify additional markers of ototoxic risk associated with platinum-based chemotherapy and investigate polygenic risks, where multiple markers may exacerbate the side-effects. More... »

PAGES

3455

References to SciGraph publications

  • 2008-02. Megalin genetic polymorphisms and individual sensitivity to the ototoxic effect of cisplatin in THE PHARMACOGENOMICS JOURNAL
  • 2007-10. Ototoxicity in KIDNEY INTERNATIONAL
  • 2009-10. Common variations in ERCC2 are associated with response to cisplatin chemotherapy and clinical outcome in osteosarcoma patients in THE PHARMACOGENOMICS JOURNAL
  • 2009-12. Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy in NATURE GENETICS
  • 2017-12. Promoter region variation in NFE2L2 influences susceptibility to ototoxicity in patients exposed to high cumulative doses of cisplatin in THE PHARMACOGENOMICS JOURNAL
  • 2017-12. Cisplatin is retained in the cochlea indefinitely following chemotherapy in NATURE COMMUNICATIONS
  • 2003-10. Cisplatin: mode of cytotoxic action and molecular basis of resistance in ONCOGENE
  • 2015-03. Common variants in ACYP2 influence susceptibility to cisplatin-induced hearing loss in NATURE GENETICS
  • 2018-11. Megalin mediates plasma membrane to mitochondria cross-talk and regulates mitochondrial metabolism in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2017-08. Differential effects of thiopurine methyltransferase (TPMT) and multidrug resistance-associated protein gene 4 (MRP4) on mercaptopurine toxicity in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2013-08. Replication of TPMT and ABCC3 Genetic Variants Highly Associated With Cisplatin‐Induced Hearing Loss in Children in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2011-04. Ototoxic Effects of Irradiation in INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY
  • 2005-04. Cellular processing of platinum anticancer drugs in NATURE REVIEWS DRUG DISCOVERY
  • 2000-12. Mitochondrial defects and hearing loss in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2007-12. Association between long-term neuro-toxicities in testicular cancer survivors and polymorphisms in glutathione-s-transferase-P1 and -M1, a retrospective cross sectional study in JOURNAL OF TRANSLATIONAL MEDICINE
  • 2013-08. The Role of Inherited TPMT and COMT Genetic Variation in Cisplatin‐Induced Ototoxicity in Children With Cancer in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-019-40138-z

    DOI

    http://dx.doi.org/10.1038/s41598-019-40138-z

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112544065

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30837596


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Karolinska Institute", 
              "id": "https://www.grid.ac/institutes/grid.4714.6", 
              "name": [
                "Experimental Audiology, Biomedicum, Karolinska Institutet, Solnav\u00e4gen 9, 171 65, Stockholm, Sweden"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tserga", 
            "givenName": "Evangelia", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Nottingham", 
              "id": "https://www.grid.ac/institutes/grid.4563.4", 
              "name": [
                "School of Medicine, University of Nottingham, Nottingham, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nandwani", 
            "givenName": "Tara", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Karolinska Institute", 
              "id": "https://www.grid.ac/institutes/grid.4714.6", 
              "name": [
                "Experimental Audiology, Biomedicum, Karolinska Institutet, Solnav\u00e4gen 9, 171 65, Stockholm, Sweden"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Edvall", 
            "givenName": "Niklas K.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Regensburg", 
              "id": "https://www.grid.ac/institutes/grid.7727.5", 
              "name": [
                "Department of Mathematics, University of Bergen, Bergen, Norway", 
                "Department of Psychiatry and Psychotherapy, University Regensburg, Universit\u00e4tsstra\u00dfe 84, 93053, Regensburg, Germany"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Bulla", 
            "givenName": "Jan", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Nottingham", 
              "id": "https://www.grid.ac/institutes/grid.4563.4", 
              "name": [
                "Division of Oncology, School of Medicine, University of Nottingham, Nottingham, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Patel", 
            "givenName": "Poulam", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Karolinska Institute", 
              "id": "https://www.grid.ac/institutes/grid.4714.6", 
              "name": [
                "Experimental Audiology, Biomedicum, Karolinska Institutet, Solnav\u00e4gen 9, 171 65, Stockholm, Sweden"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Canlon", 
            "givenName": "Barbara", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Karolinska Institute", 
              "id": "https://www.grid.ac/institutes/grid.4714.6", 
              "name": [
                "Experimental Audiology, Biomedicum, Karolinska Institutet, Solnav\u00e4gen 9, 171 65, Stockholm, Sweden"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cederroth", 
            "givenName": "Christopher R.", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Nottingham", 
              "id": "https://www.grid.ac/institutes/grid.4563.4", 
              "name": [
                "Otology and Hearing Group, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, UK", 
                "NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Baguley", 
            "givenName": "David M.", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1186/1479-5876-5-70", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000297806", 
              "https://doi.org/10.1186/1479-5876-5-70"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mph.0b013e3182707fc5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001035699"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mph.0b013e3182707fc5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001035699"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0115869", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001146552"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cam4.516", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003786492"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1365-2125.2012.04379.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006051922"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.1691-15.2015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008311483"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1523/jneurosci.1691-15.2015", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008311483"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2006.08.9599", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008689821"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3217", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009543967", 
              "https://doi.org/10.1038/ng.3217"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.15252/emmm.201606230", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009651921"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.2041-210x.2012.00250.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010223384"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/pgs.14.112", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010702565"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ar.22578", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010780754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/tpj.2016.52", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010791550", 
              "https://doi.org/10.1038/tpj.2016.52"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0130827", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011999393"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pbc.24366", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012513187"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1081/sac-200040691", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012921681"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2016.66.8822", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014307137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2016.66.8822", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014307137"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.478", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014622763", 
              "https://doi.org/10.1038/ng.478"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.478", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014622763", 
              "https://doi.org/10.1038/ng.478"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2016.68.2476", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014692766"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001813-200009000-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015934433"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00001813-200009000-00007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015934433"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuroscience.2005.10.044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017282639"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.toxlet.2009.12.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018695581"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.lungcan.2012.03.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019261082"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.7668", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019895980"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/clpt.2013.80", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020692663", 
              "https://doi.org/10.1038/clpt.2013.80"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.ki.5002434", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021811936", 
              "https://doi.org/10.1038/sj.ki.5002434"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.0807219105", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022261877"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4067/s0716-97602011000100012", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022876906"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12070-011-0142-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023290826", 
              "https://doi.org/10.1007/s12070-011-0142-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1215/15228517-2008-089", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023790052"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/cncr.29779", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025101559"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/pl00000673", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027217061", 
              "https://doi.org/10.1007/pl00000673"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/pgs.14.182", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027756384"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.mlg.0000185596.20207.d2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028991836"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.mlg.0000185596.20207.d2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028991836"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/01.mlg.0000185596.20207.d2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028991836"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/jom.0b013e31825902ce", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030036079"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/jom.0b013e31825902ce", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030036079"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.heares.2005.03.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035427613"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.heares.2005.03.023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035427613"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1206933", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035533524", 
              "https://doi.org/10.1038/sj.onc.1206933"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.onc.1206933", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035533524", 
              "https://doi.org/10.1038/sj.onc.1206933"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3233/dma-2010-0693", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039185419"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.gene.2016.08.029", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040076490"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.taap.2004.09.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040476496"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1620/tjem.219.177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041138674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1620/tjem.219.177", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041138674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.tpj.6500455", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041492612", 
              "https://doi.org/10.1038/sj.tpj.6500455"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ijc.1369", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044665733"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1691", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044896419", 
              "https://doi.org/10.1038/nrd1691"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd1691", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044896419", 
              "https://doi.org/10.1038/nrd1691"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-04-1581", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045159664"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1373/clinchem.2004.037788", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045562259"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/pbc.24138", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046685615"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1124/mol.106.022244", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046817310"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/clpt.2013.121", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1048403098", 
              "https://doi.org/10.1038/clpt.2013.121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/dju044", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049886151"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.heares.2009.07.008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050157671"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ijporl.2016.09.001", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052063397"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/tpj.2009.19", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052063828", 
              "https://doi.org/10.1038/tpj.2009.19"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0000000000000212", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060340401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0000000000000212", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060340401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0000000000000212", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1060340401"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-16-2809", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063225723"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.4149/212_140820n391", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1072260048"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1074272989", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075304698", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1080143519", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2016.71.5292", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083403135"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.neuro.2017.02.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083821781"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/lio2.65", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084014094"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pone.0175711", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084829321"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1001/jamaoncol.2017.0502", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085079667"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/neuonc/nox076", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085258310"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0000000000000281", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085320615"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0000000000000281", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085320615"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/fpc.0000000000000281", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085320615"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2174/1871525715666170529091921", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085763821"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-017-3361-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086043284", 
              "https://doi.org/10.1007/s00280-017-3361-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-017-3361-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086043284", 
              "https://doi.org/10.1007/s00280-017-3361-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(17)31073-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090580938"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2017.75.2212", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092156305"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fncel.2017.00338", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092402826"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41467-017-01837-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092714943", 
              "https://doi.org/10.1038/s41467-017-01837-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2217/pgs-2017-0125", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1093040041"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0140-6736(17)33097-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1093097121"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/14992027.2017.1417644", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099931470"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/14992027.2017.1417644", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1099931470"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3389/fnagi.2017.00447", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100346297"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/1078-0432.ccr-17-2810", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100559736"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1091581818761128", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101755082"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1177/1091581818761128", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1101755082"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.24796", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103623107"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00018-018-2847-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1104495994", 
              "https://doi.org/10.1007/s00018-018-2847-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.18632/oncotarget.25767", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1105754024"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-12", 
        "datePublishedReg": "2019-12-01", 
        "description": "Ototoxicity is one of the major side-effects of platinum-based chemotherapy, in particular cisplatin (cis-diammine dichloroplatinum II). To our knowledge, no systematic review has previously provided a quantitative summary estimate of the impact of genetics upon the risk of developing hearing loss. We searched Embase, Medline, ASSIA, Pubmed, Scopus, and Web of Science, for studies documenting the genetic risk of ototoxicity in patients with cancer treated with cisplatin. Titles/abstracts and full texts were reviewed for inclusion. Meta-analytic estimates of risk (Odds Ratio) from the pooled data were calculated for studies that have been repeated twice or more. The search identified 3891 papers, of which 30 were included. The majority were retrospective (44%), ranging from n\u2009=\u200939 to n\u2009=\u2009317, some including only patients younger than 25 years of age (33%), and some on both genders (80%). The most common cancers involved were osteosarcoma (53%), neuroblastoma (37%), prostate (17%) and reproductive (10%). Most studies performed genotyping, though only 5 studies performed genome-wide association studies. Nineteen single-nucleotide polymorphisms (SNPs) from 15 genes were repeated more than twice. Meta-analysis of group data indicated that rs1872328 on ACYP2, which plays a role in calcium homeostasis, increases the risk of ototoxicity by 4.61 (95% CI: 3.04-7.02; N\u2009=\u2009696, p\u2009<\u20090.0001) as well as LRP2 rs4668123 shows a cumulated Odds Ratio of 3.53 (95% CI: 1.48-8.45; N\u2009=\u2009118, p\u2009=\u20090.0059), which could not be evidenced in individual studies. Despite the evidence of heterogeneity across studies, these meta-analytic results from 30 studies are consistent with a view of a genetic predisposition to platinum-based chemotherapy mediated ototoxicity. These new findings are informative and encourage the genetic screening of cancer patients in order to identify patients with greater vulnerability of developing hearing loss, a condition having a potentially large impact on quality of life. More studies are needed, with larger sample size, in order to identify additional markers of ototoxic risk associated with platinum-based chemotherapy and\u00a0investigate polygenic risks, where multiple markers may exacerbate the side-effects.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/s41598-019-40138-z", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1045337", 
            "issn": [
              "2045-2322"
            ], 
            "name": "Scientific Reports", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "1", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "9"
          }
        ], 
        "name": "The genetic vulnerability to cisplatin ototoxicity: a systematic review", 
        "pagination": "3455", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "9dfb6d08e98dd5c48eb86724e08c6ddaf00a187ef676947871bb9637cf855e84"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30837596"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "101563288"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/s41598-019-40138-z"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1112544065"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/s41598-019-40138-z", 
          "https://app.dimensions.ai/details/publication/pub.1112544065"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T11:19", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000354_0000000354/records_11710_00000002.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://www.nature.com/articles/s41598-019-40138-z"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-40138-z'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-40138-z'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-40138-z'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-40138-z'


     

    This table displays all metadata directly associated to this object as RDF triples.

    375 TRIPLES      21 PREDICATES      110 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/s41598-019-40138-z schema:about anzsrc-for:11
    2 anzsrc-for:1112
    3 schema:author N4e09715cb66144cdb41f3a3fbc68fedc
    4 schema:citation sg:pub.10.1007/pl00000673
    5 sg:pub.10.1007/s00018-018-2847-3
    6 sg:pub.10.1007/s00280-017-3361-2
    7 sg:pub.10.1007/s12070-011-0142-9
    8 sg:pub.10.1038/clpt.2013.121
    9 sg:pub.10.1038/clpt.2013.80
    10 sg:pub.10.1038/ng.3217
    11 sg:pub.10.1038/ng.478
    12 sg:pub.10.1038/nrd1691
    13 sg:pub.10.1038/s41467-017-01837-1
    14 sg:pub.10.1038/sj.ki.5002434
    15 sg:pub.10.1038/sj.onc.1206933
    16 sg:pub.10.1038/sj.tpj.6500455
    17 sg:pub.10.1038/tpj.2009.19
    18 sg:pub.10.1038/tpj.2016.52
    19 sg:pub.10.1186/1479-5876-5-70
    20 https://app.dimensions.ai/details/publication/pub.1074272989
    21 https://app.dimensions.ai/details/publication/pub.1075304698
    22 https://app.dimensions.ai/details/publication/pub.1080143519
    23 https://doi.org/10.1001/jamaoncol.2017.0502
    24 https://doi.org/10.1002/ar.22578
    25 https://doi.org/10.1002/cam4.516
    26 https://doi.org/10.1002/cncr.29779
    27 https://doi.org/10.1002/ijc.1369
    28 https://doi.org/10.1002/lio2.65
    29 https://doi.org/10.1002/pbc.24138
    30 https://doi.org/10.1002/pbc.24366
    31 https://doi.org/10.1016/j.gene.2016.08.029
    32 https://doi.org/10.1016/j.heares.2005.03.023
    33 https://doi.org/10.1016/j.heares.2009.07.008
    34 https://doi.org/10.1016/j.ijporl.2016.09.001
    35 https://doi.org/10.1016/j.lungcan.2012.03.023
    36 https://doi.org/10.1016/j.neuro.2017.02.007
    37 https://doi.org/10.1016/j.neuroscience.2005.10.044
    38 https://doi.org/10.1016/j.taap.2004.09.008
    39 https://doi.org/10.1016/j.toxlet.2009.12.003
    40 https://doi.org/10.1016/s0140-6736(17)31073-5
    41 https://doi.org/10.1016/s0140-6736(17)33097-0
    42 https://doi.org/10.1073/pnas.0807219105
    43 https://doi.org/10.1080/14992027.2017.1417644
    44 https://doi.org/10.1081/sac-200040691
    45 https://doi.org/10.1093/jnci/dju044
    46 https://doi.org/10.1093/neuonc/nox076
    47 https://doi.org/10.1097/00001813-200009000-00007
    48 https://doi.org/10.1097/01.mlg.0000185596.20207.d2
    49 https://doi.org/10.1097/fpc.0000000000000212
    50 https://doi.org/10.1097/fpc.0000000000000281
    51 https://doi.org/10.1097/jom.0b013e31825902ce
    52 https://doi.org/10.1097/mph.0b013e3182707fc5
    53 https://doi.org/10.1111/j.1365-2125.2012.04379.x
    54 https://doi.org/10.1111/j.2041-210x.2012.00250.x
    55 https://doi.org/10.1124/mol.106.022244
    56 https://doi.org/10.1158/0008-5472.can-04-1581
    57 https://doi.org/10.1158/1078-0432.ccr-16-2809
    58 https://doi.org/10.1158/1078-0432.ccr-17-2810
    59 https://doi.org/10.1177/1091581818761128
    60 https://doi.org/10.1200/jco.2006.08.9599
    61 https://doi.org/10.1200/jco.2016.66.8822
    62 https://doi.org/10.1200/jco.2016.68.2476
    63 https://doi.org/10.1200/jco.2016.71.5292
    64 https://doi.org/10.1200/jco.2017.75.2212
    65 https://doi.org/10.1215/15228517-2008-089
    66 https://doi.org/10.1371/journal.pone.0115869
    67 https://doi.org/10.1371/journal.pone.0130827
    68 https://doi.org/10.1371/journal.pone.0175711
    69 https://doi.org/10.1373/clinchem.2004.037788
    70 https://doi.org/10.1523/jneurosci.1691-15.2015
    71 https://doi.org/10.15252/emmm.201606230
    72 https://doi.org/10.1620/tjem.219.177
    73 https://doi.org/10.18632/oncotarget.24796
    74 https://doi.org/10.18632/oncotarget.25767
    75 https://doi.org/10.18632/oncotarget.7668
    76 https://doi.org/10.2174/1871525715666170529091921
    77 https://doi.org/10.2217/pgs-2017-0125
    78 https://doi.org/10.2217/pgs.14.112
    79 https://doi.org/10.2217/pgs.14.182
    80 https://doi.org/10.3233/dma-2010-0693
    81 https://doi.org/10.3389/fnagi.2017.00447
    82 https://doi.org/10.3389/fncel.2017.00338
    83 https://doi.org/10.4067/s0716-97602011000100012
    84 https://doi.org/10.4149/212_140820n391
    85 schema:datePublished 2019-12
    86 schema:datePublishedReg 2019-12-01
    87 schema:description Ototoxicity is one of the major side-effects of platinum-based chemotherapy, in particular cisplatin (cis-diammine dichloroplatinum II). To our knowledge, no systematic review has previously provided a quantitative summary estimate of the impact of genetics upon the risk of developing hearing loss. We searched Embase, Medline, ASSIA, Pubmed, Scopus, and Web of Science, for studies documenting the genetic risk of ototoxicity in patients with cancer treated with cisplatin. Titles/abstracts and full texts were reviewed for inclusion. Meta-analytic estimates of risk (Odds Ratio) from the pooled data were calculated for studies that have been repeated twice or more. The search identified 3891 papers, of which 30 were included. The majority were retrospective (44%), ranging from n = 39 to n = 317, some including only patients younger than 25 years of age (33%), and some on both genders (80%). The most common cancers involved were osteosarcoma (53%), neuroblastoma (37%), prostate (17%) and reproductive (10%). Most studies performed genotyping, though only 5 studies performed genome-wide association studies. Nineteen single-nucleotide polymorphisms (SNPs) from 15 genes were repeated more than twice. Meta-analysis of group data indicated that rs1872328 on ACYP2, which plays a role in calcium homeostasis, increases the risk of ototoxicity by 4.61 (95% CI: 3.04-7.02; N = 696, p < 0.0001) as well as LRP2 rs4668123 shows a cumulated Odds Ratio of 3.53 (95% CI: 1.48-8.45; N = 118, p = 0.0059), which could not be evidenced in individual studies. Despite the evidence of heterogeneity across studies, these meta-analytic results from 30 studies are consistent with a view of a genetic predisposition to platinum-based chemotherapy mediated ototoxicity. These new findings are informative and encourage the genetic screening of cancer patients in order to identify patients with greater vulnerability of developing hearing loss, a condition having a potentially large impact on quality of life. More studies are needed, with larger sample size, in order to identify additional markers of ototoxic risk associated with platinum-based chemotherapy and investigate polygenic risks, where multiple markers may exacerbate the side-effects.
    88 schema:genre research_article
    89 schema:inLanguage en
    90 schema:isAccessibleForFree true
    91 schema:isPartOf N0bd656389d7c4b61a3f647ab368063a3
    92 N1d454af6b5184fceba9b3991ec8c0d64
    93 sg:journal.1045337
    94 schema:name The genetic vulnerability to cisplatin ototoxicity: a systematic review
    95 schema:pagination 3455
    96 schema:productId N02bec6d0d4204ad289df1ed0ee3fbe8a
    97 N3c2c629cc57b4be2a894c1120d3b66b9
    98 N9628ca9fe5a148cebec8358aeb37446b
    99 N99cc8f4311af4c15a29f1c28912a11f0
    100 Nf17e92c86d2f4327939e1b0ab153702c
    101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112544065
    102 https://doi.org/10.1038/s41598-019-40138-z
    103 schema:sdDatePublished 2019-04-11T11:19
    104 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    105 schema:sdPublisher N3e7397d0250942b399b9a87eddf8ee76
    106 schema:url https://www.nature.com/articles/s41598-019-40138-z
    107 sgo:license sg:explorer/license/
    108 sgo:sdDataset articles
    109 rdf:type schema:ScholarlyArticle
    110 N02bec6d0d4204ad289df1ed0ee3fbe8a schema:name readcube_id
    111 schema:value 9dfb6d08e98dd5c48eb86724e08c6ddaf00a187ef676947871bb9637cf855e84
    112 rdf:type schema:PropertyValue
    113 N0bd656389d7c4b61a3f647ab368063a3 schema:volumeNumber 9
    114 rdf:type schema:PublicationVolume
    115 N0c4b98f2ceda4f929c3922cb45ced17f rdf:first N411a08c0b73644ed832e762f08eb755b
    116 rdf:rest N3816e7bb2c434d639ab34106c7a5fe69
    117 N1d454af6b5184fceba9b3991ec8c0d64 schema:issueNumber 1
    118 rdf:type schema:PublicationIssue
    119 N3816e7bb2c434d639ab34106c7a5fe69 rdf:first Na8af099ee29c4f10999b0f507f1943a0
    120 rdf:rest N54b089acdd0845a4a01679763faf497e
    121 N3c2c629cc57b4be2a894c1120d3b66b9 schema:name pubmed_id
    122 schema:value 30837596
    123 rdf:type schema:PropertyValue
    124 N3e7397d0250942b399b9a87eddf8ee76 schema:name Springer Nature - SN SciGraph project
    125 rdf:type schema:Organization
    126 N411a08c0b73644ed832e762f08eb755b schema:affiliation https://www.grid.ac/institutes/grid.4714.6
    127 schema:familyName Canlon
    128 schema:givenName Barbara
    129 rdf:type schema:Person
    130 N4e09715cb66144cdb41f3a3fbc68fedc rdf:first Nfb61238e73c1462b941d1140d15ba0d0
    131 rdf:rest Nb86c98d99fc64fc18a515a48ccc0dad1
    132 N50c85fa6b67143f49c5b1245f6fb34dd schema:affiliation https://www.grid.ac/institutes/grid.7727.5
    133 schema:familyName Bulla
    134 schema:givenName Jan
    135 rdf:type schema:Person
    136 N54b089acdd0845a4a01679763faf497e rdf:first Ncecfa48bcc0e4917859849b59687a89e
    137 rdf:rest rdf:nil
    138 N9212cd117f2b4fbf8f2f0e1807a705fe schema:affiliation https://www.grid.ac/institutes/grid.4563.4
    139 schema:familyName Patel
    140 schema:givenName Poulam
    141 rdf:type schema:Person
    142 N9628ca9fe5a148cebec8358aeb37446b schema:name doi
    143 schema:value 10.1038/s41598-019-40138-z
    144 rdf:type schema:PropertyValue
    145 N99cc8f4311af4c15a29f1c28912a11f0 schema:name nlm_unique_id
    146 schema:value 101563288
    147 rdf:type schema:PropertyValue
    148 N9ca1cd002d834757b64745dc46a51320 rdf:first N9212cd117f2b4fbf8f2f0e1807a705fe
    149 rdf:rest N0c4b98f2ceda4f929c3922cb45ced17f
    150 Na8af099ee29c4f10999b0f507f1943a0 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
    151 schema:familyName Cederroth
    152 schema:givenName Christopher R.
    153 rdf:type schema:Person
    154 Nb86c98d99fc64fc18a515a48ccc0dad1 rdf:first Nca51037e803144dea69fc979e8a819ca
    155 rdf:rest Nc96ce0decdc64ea2a86c3c6588dfac25
    156 Nbd388b37e59b4924b9823f17b7403d4f rdf:first N50c85fa6b67143f49c5b1245f6fb34dd
    157 rdf:rest N9ca1cd002d834757b64745dc46a51320
    158 Nc96ce0decdc64ea2a86c3c6588dfac25 rdf:first Nfc993ad9e07f4368b2905bea58fbd4dd
    159 rdf:rest Nbd388b37e59b4924b9823f17b7403d4f
    160 Nca51037e803144dea69fc979e8a819ca schema:affiliation https://www.grid.ac/institutes/grid.4563.4
    161 schema:familyName Nandwani
    162 schema:givenName Tara
    163 rdf:type schema:Person
    164 Ncecfa48bcc0e4917859849b59687a89e schema:affiliation https://www.grid.ac/institutes/grid.4563.4
    165 schema:familyName Baguley
    166 schema:givenName David M.
    167 rdf:type schema:Person
    168 Nf17e92c86d2f4327939e1b0ab153702c schema:name dimensions_id
    169 schema:value pub.1112544065
    170 rdf:type schema:PropertyValue
    171 Nfb61238e73c1462b941d1140d15ba0d0 schema:affiliation https://www.grid.ac/institutes/grid.4714.6
    172 schema:familyName Tserga
    173 schema:givenName Evangelia
    174 rdf:type schema:Person
    175 Nfc993ad9e07f4368b2905bea58fbd4dd schema:affiliation https://www.grid.ac/institutes/grid.4714.6
    176 schema:familyName Edvall
    177 schema:givenName Niklas K.
    178 rdf:type schema:Person
    179 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    180 schema:name Medical and Health Sciences
    181 rdf:type schema:DefinedTerm
    182 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    183 schema:name Oncology and Carcinogenesis
    184 rdf:type schema:DefinedTerm
    185 sg:journal.1045337 schema:issn 2045-2322
    186 schema:name Scientific Reports
    187 rdf:type schema:Periodical
    188 sg:pub.10.1007/pl00000673 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027217061
    189 https://doi.org/10.1007/pl00000673
    190 rdf:type schema:CreativeWork
    191 sg:pub.10.1007/s00018-018-2847-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104495994
    192 https://doi.org/10.1007/s00018-018-2847-3
    193 rdf:type schema:CreativeWork
    194 sg:pub.10.1007/s00280-017-3361-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086043284
    195 https://doi.org/10.1007/s00280-017-3361-2
    196 rdf:type schema:CreativeWork
    197 sg:pub.10.1007/s12070-011-0142-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023290826
    198 https://doi.org/10.1007/s12070-011-0142-9
    199 rdf:type schema:CreativeWork
    200 sg:pub.10.1038/clpt.2013.121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048403098
    201 https://doi.org/10.1038/clpt.2013.121
    202 rdf:type schema:CreativeWork
    203 sg:pub.10.1038/clpt.2013.80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020692663
    204 https://doi.org/10.1038/clpt.2013.80
    205 rdf:type schema:CreativeWork
    206 sg:pub.10.1038/ng.3217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009543967
    207 https://doi.org/10.1038/ng.3217
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1038/ng.478 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014622763
    210 https://doi.org/10.1038/ng.478
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1038/nrd1691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044896419
    213 https://doi.org/10.1038/nrd1691
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1038/s41467-017-01837-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092714943
    216 https://doi.org/10.1038/s41467-017-01837-1
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1038/sj.ki.5002434 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021811936
    219 https://doi.org/10.1038/sj.ki.5002434
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1038/sj.onc.1206933 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035533524
    222 https://doi.org/10.1038/sj.onc.1206933
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1038/sj.tpj.6500455 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041492612
    225 https://doi.org/10.1038/sj.tpj.6500455
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1038/tpj.2009.19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052063828
    228 https://doi.org/10.1038/tpj.2009.19
    229 rdf:type schema:CreativeWork
    230 sg:pub.10.1038/tpj.2016.52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010791550
    231 https://doi.org/10.1038/tpj.2016.52
    232 rdf:type schema:CreativeWork
    233 sg:pub.10.1186/1479-5876-5-70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000297806
    234 https://doi.org/10.1186/1479-5876-5-70
    235 rdf:type schema:CreativeWork
    236 https://app.dimensions.ai/details/publication/pub.1074272989 schema:CreativeWork
    237 https://app.dimensions.ai/details/publication/pub.1075304698 schema:CreativeWork
    238 https://app.dimensions.ai/details/publication/pub.1080143519 schema:CreativeWork
    239 https://doi.org/10.1001/jamaoncol.2017.0502 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085079667
    240 rdf:type schema:CreativeWork
    241 https://doi.org/10.1002/ar.22578 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010780754
    242 rdf:type schema:CreativeWork
    243 https://doi.org/10.1002/cam4.516 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003786492
    244 rdf:type schema:CreativeWork
    245 https://doi.org/10.1002/cncr.29779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025101559
    246 rdf:type schema:CreativeWork
    247 https://doi.org/10.1002/ijc.1369 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044665733
    248 rdf:type schema:CreativeWork
    249 https://doi.org/10.1002/lio2.65 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084014094
    250 rdf:type schema:CreativeWork
    251 https://doi.org/10.1002/pbc.24138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046685615
    252 rdf:type schema:CreativeWork
    253 https://doi.org/10.1002/pbc.24366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012513187
    254 rdf:type schema:CreativeWork
    255 https://doi.org/10.1016/j.gene.2016.08.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040076490
    256 rdf:type schema:CreativeWork
    257 https://doi.org/10.1016/j.heares.2005.03.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035427613
    258 rdf:type schema:CreativeWork
    259 https://doi.org/10.1016/j.heares.2009.07.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050157671
    260 rdf:type schema:CreativeWork
    261 https://doi.org/10.1016/j.ijporl.2016.09.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052063397
    262 rdf:type schema:CreativeWork
    263 https://doi.org/10.1016/j.lungcan.2012.03.023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019261082
    264 rdf:type schema:CreativeWork
    265 https://doi.org/10.1016/j.neuro.2017.02.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083821781
    266 rdf:type schema:CreativeWork
    267 https://doi.org/10.1016/j.neuroscience.2005.10.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017282639
    268 rdf:type schema:CreativeWork
    269 https://doi.org/10.1016/j.taap.2004.09.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040476496
    270 rdf:type schema:CreativeWork
    271 https://doi.org/10.1016/j.toxlet.2009.12.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018695581
    272 rdf:type schema:CreativeWork
    273 https://doi.org/10.1016/s0140-6736(17)31073-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090580938
    274 rdf:type schema:CreativeWork
    275 https://doi.org/10.1016/s0140-6736(17)33097-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093097121
    276 rdf:type schema:CreativeWork
    277 https://doi.org/10.1073/pnas.0807219105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022261877
    278 rdf:type schema:CreativeWork
    279 https://doi.org/10.1080/14992027.2017.1417644 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099931470
    280 rdf:type schema:CreativeWork
    281 https://doi.org/10.1081/sac-200040691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012921681
    282 rdf:type schema:CreativeWork
    283 https://doi.org/10.1093/jnci/dju044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049886151
    284 rdf:type schema:CreativeWork
    285 https://doi.org/10.1093/neuonc/nox076 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085258310
    286 rdf:type schema:CreativeWork
    287 https://doi.org/10.1097/00001813-200009000-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015934433
    288 rdf:type schema:CreativeWork
    289 https://doi.org/10.1097/01.mlg.0000185596.20207.d2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028991836
    290 rdf:type schema:CreativeWork
    291 https://doi.org/10.1097/fpc.0000000000000212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060340401
    292 rdf:type schema:CreativeWork
    293 https://doi.org/10.1097/fpc.0000000000000281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085320615
    294 rdf:type schema:CreativeWork
    295 https://doi.org/10.1097/jom.0b013e31825902ce schema:sameAs https://app.dimensions.ai/details/publication/pub.1030036079
    296 rdf:type schema:CreativeWork
    297 https://doi.org/10.1097/mph.0b013e3182707fc5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001035699
    298 rdf:type schema:CreativeWork
    299 https://doi.org/10.1111/j.1365-2125.2012.04379.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006051922
    300 rdf:type schema:CreativeWork
    301 https://doi.org/10.1111/j.2041-210x.2012.00250.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010223384
    302 rdf:type schema:CreativeWork
    303 https://doi.org/10.1124/mol.106.022244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046817310
    304 rdf:type schema:CreativeWork
    305 https://doi.org/10.1158/0008-5472.can-04-1581 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045159664
    306 rdf:type schema:CreativeWork
    307 https://doi.org/10.1158/1078-0432.ccr-16-2809 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063225723
    308 rdf:type schema:CreativeWork
    309 https://doi.org/10.1158/1078-0432.ccr-17-2810 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100559736
    310 rdf:type schema:CreativeWork
    311 https://doi.org/10.1177/1091581818761128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101755082
    312 rdf:type schema:CreativeWork
    313 https://doi.org/10.1200/jco.2006.08.9599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008689821
    314 rdf:type schema:CreativeWork
    315 https://doi.org/10.1200/jco.2016.66.8822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014307137
    316 rdf:type schema:CreativeWork
    317 https://doi.org/10.1200/jco.2016.68.2476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014692766
    318 rdf:type schema:CreativeWork
    319 https://doi.org/10.1200/jco.2016.71.5292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083403135
    320 rdf:type schema:CreativeWork
    321 https://doi.org/10.1200/jco.2017.75.2212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092156305
    322 rdf:type schema:CreativeWork
    323 https://doi.org/10.1215/15228517-2008-089 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023790052
    324 rdf:type schema:CreativeWork
    325 https://doi.org/10.1371/journal.pone.0115869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001146552
    326 rdf:type schema:CreativeWork
    327 https://doi.org/10.1371/journal.pone.0130827 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011999393
    328 rdf:type schema:CreativeWork
    329 https://doi.org/10.1371/journal.pone.0175711 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084829321
    330 rdf:type schema:CreativeWork
    331 https://doi.org/10.1373/clinchem.2004.037788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045562259
    332 rdf:type schema:CreativeWork
    333 https://doi.org/10.1523/jneurosci.1691-15.2015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008311483
    334 rdf:type schema:CreativeWork
    335 https://doi.org/10.15252/emmm.201606230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009651921
    336 rdf:type schema:CreativeWork
    337 https://doi.org/10.1620/tjem.219.177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041138674
    338 rdf:type schema:CreativeWork
    339 https://doi.org/10.18632/oncotarget.24796 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103623107
    340 rdf:type schema:CreativeWork
    341 https://doi.org/10.18632/oncotarget.25767 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105754024
    342 rdf:type schema:CreativeWork
    343 https://doi.org/10.18632/oncotarget.7668 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019895980
    344 rdf:type schema:CreativeWork
    345 https://doi.org/10.2174/1871525715666170529091921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085763821
    346 rdf:type schema:CreativeWork
    347 https://doi.org/10.2217/pgs-2017-0125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1093040041
    348 rdf:type schema:CreativeWork
    349 https://doi.org/10.2217/pgs.14.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010702565
    350 rdf:type schema:CreativeWork
    351 https://doi.org/10.2217/pgs.14.182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027756384
    352 rdf:type schema:CreativeWork
    353 https://doi.org/10.3233/dma-2010-0693 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039185419
    354 rdf:type schema:CreativeWork
    355 https://doi.org/10.3389/fnagi.2017.00447 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100346297
    356 rdf:type schema:CreativeWork
    357 https://doi.org/10.3389/fncel.2017.00338 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092402826
    358 rdf:type schema:CreativeWork
    359 https://doi.org/10.4067/s0716-97602011000100012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022876906
    360 rdf:type schema:CreativeWork
    361 https://doi.org/10.4149/212_140820n391 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072260048
    362 rdf:type schema:CreativeWork
    363 https://www.grid.ac/institutes/grid.4563.4 schema:alternateName University of Nottingham
    364 schema:name Division of Oncology, School of Medicine, University of Nottingham, Nottingham, UK
    365 NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK
    366 Otology and Hearing Group, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, UK
    367 School of Medicine, University of Nottingham, Nottingham, UK
    368 rdf:type schema:Organization
    369 https://www.grid.ac/institutes/grid.4714.6 schema:alternateName Karolinska Institute
    370 schema:name Experimental Audiology, Biomedicum, Karolinska Institutet, Solnavägen 9, 171 65, Stockholm, Sweden
    371 rdf:type schema:Organization
    372 https://www.grid.ac/institutes/grid.7727.5 schema:alternateName University of Regensburg
    373 schema:name Department of Mathematics, University of Bergen, Bergen, Norway
    374 Department of Psychiatry and Psychotherapy, University Regensburg, Universitätsstraße 84, 93053, Regensburg, Germany
    375 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...