Unravelling paralogous gene expression dynamics during three-spined stickleback embryogenesis View Full Text


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Article Info

DATE

2019-03-06

AUTHORS

Elisavet Kaitetzidou, Ioanna Katsiadaki, Jacques Lagnel, Efthimia Antonopoulou, Elena Sarropoulou

ABSTRACT

Development requires the implementation of a plethora of molecular mechanisms, involving a large set of genes to ensure proper cell differentiation, morphogenesis of tissues and organs as well as the growth of the organism. Genome duplication and resulting paralogs are considered to provide the raw genetic materials important for new adaptation opportunities and boosting evolutionary innovation. The present study investigated paralogous genes, involved in three-spined stickleback (Gasterosteus aculeatus) development. Therefore, the transcriptomes of five early stages comprising developmental leaps were explored. Obtained expression profiles reflected the embryo's needs at different stages. Early stages, such as the morula stage comprised transcripts mainly involved in energy requirements while later stages were mostly associated with GO terms relevant to organ development and morphogenesis. The generated transcriptome profiles were further explored for differential expression of known and new paralogous genes. Special attention was given to hox genes, with hoxa13a being of particular interest and to pigmentation genes where itgb1, involved in the melanophore development, displayed a complementary expression pattern throughout studied stages. Knowledge obtained by untangling specific paralogous gene functions during development might not only significantly contribute to the understanding of teleost ontogenesis but might also shed light on paralogous gene evolution. More... »

PAGES

3752

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-019-40127-2

    DOI

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    DIMENSIONS

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    38 schema:description Development requires the implementation of a plethora of molecular mechanisms, involving a large set of genes to ensure proper cell differentiation, morphogenesis of tissues and organs as well as the growth of the organism. Genome duplication and resulting paralogs are considered to provide the raw genetic materials important for new adaptation opportunities and boosting evolutionary innovation. The present study investigated paralogous genes, involved in three-spined stickleback (Gasterosteus aculeatus) development. Therefore, the transcriptomes of five early stages comprising developmental leaps were explored. Obtained expression profiles reflected the embryo's needs at different stages. Early stages, such as the morula stage comprised transcripts mainly involved in energy requirements while later stages were mostly associated with GO terms relevant to organ development and morphogenesis. The generated transcriptome profiles were further explored for differential expression of known and new paralogous genes. Special attention was given to hox genes, with hoxa13a being of particular interest and to pigmentation genes where itgb1, involved in the melanophore development, displayed a complementary expression pattern throughout studied stages. Knowledge obtained by untangling specific paralogous gene functions during development might not only significantly contribute to the understanding of teleost ontogenesis but might also shed light on paralogous gene evolution.
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    46 Hox genes
    47 ITGB1
    48 adaptation opportunities
    49 attention
    50 cell differentiation
    51 complementary expression patterns
    52 development
    53 developmental leap
    54 different stages
    55 differential expression
    56 differentiation
    57 duplication
    58 dynamics
    59 early stages
    60 embryo needs
    61 embryogenesis
    62 energy requirements
    63 evolution
    64 evolutionary innovation
    65 expression
    66 expression dynamics
    67 expression patterns
    68 expression profiles
    69 function
    70 gene evolution
    71 gene expression dynamics
    72 gene function
    73 generated transcriptome profiles
    74 genes
    75 genetic material
    76 genome duplication
    77 growth
    78 implementation
    79 innovation
    80 interest
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    82 large set
    83 later stages
    84 leap
    85 light
    86 materials
    87 mechanism
    88 melanophore development
    89 molecular mechanisms
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    92 morula stage
    93 need
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    95 new paralogous genes
    96 ontogenesis
    97 opportunities
    98 organisms
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    100 paralogous gene evolution
    101 paralogous gene expression dynamics
    102 paralogous gene functions
    103 paralogous genes
    104 paralogs
    105 particular interest
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    108 plethora
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    112 raw genetic material
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