Impact of laterality and mucinous histology on relapse-free and overall survival in a registry-based colon cancer series View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Francesca Negri, Annamaria De Giorgi, Annalisa Gilli, Cinzia Azzoni, Lorena Bottarelli, Letizia Gnetti, Matteo Goldoni, Laura Manotti, Paolo Sgargi, Maria Michiara, Francesco Leonardi, Guido Rindi, Stefano Cascinu, Enrico Maria Silini

ABSTRACT

Recent data suggest that tumor laterality and mucinous histology may be clinically relevant. We investigated how both variables impact on the prognosis and the response to therapies in a large population-based cohort of cancer patients. Incidence data, clinical and pathological features, and outcome were systematically collected from the Tumor Registry of Parma over the years 2004-2009. Survival data were modeled by multivariable analysis. 1358 patients affected by stage I-IV colon cancer were considered; 661 (49%) had right-sided and 697 (51%) left-sided tumors. 144 (11%) had mucinous (MAC) and 1214 (89%) non-mucinous (NMAC) histology. MACs and NMACs of the right colon showed no difference in stage distribution, whereas left colon MACs were more frequently in an advanced stage (stage IV) (p = 0.008). Stage IV right colon tumors had a poorer overall survival than stage IV left-sided colon cancers (75th percentile 20 vs 34 months, p < 0.001). At relapse, MACs were less responsive to systemic therapy and had worse survival compared with NMACs regardless of tumor side (7.1 vs 13.1 months, p = 0.018). Right-sided colon cancers had poorer survival compared to left-sided tumors; the effect was mainly attributable to NMACs. At relapse, MACs had unfavorable prognosis regardless of the primary tumor-side. More... »

PAGES

3668

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-40096-6

DOI

http://dx.doi.org/10.1038/s41598-019-40096-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112571497

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30842570


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