Synchrony and asynchrony between an epigenetic clock and developmental timing View Full Text


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Article Info

DATE

2019-12

AUTHORS

Akina Hoshino, Steve Horvath, Akshayalakshmi Sridhar, Alex Chitsazan, Thomas A. Reh

ABSTRACT

Epigenetic changes have been used to estimate chronological age across the lifespan, and some studies suggest that epigenetic "aging" clocks may already operate in developing tissue. To better understand the relationship between developmental stage and epigenetic age, we utilized the highly regular sequence of development found in the mammalian neural retina and a well-established epigenetic aging clock based on DNA methylation. Our results demonstrate that the epigenetic age of fetal retina is highly correlated with chronological age. We further establish that epigenetic aging progresses normally in vitro, suggesting that epigenetic aging is a property of individual tissues. This correlation is also retained in stem cell-derived retinal organoids, but is accelerated in individuals with Down syndrome, a progeroid-like condition. Overall, our results suggest that epigenetic aging begins as early as a few weeks post-conception, in fetal tissues, and the mechanisms underlying the phenomenon of epigenetic aging might be studied in developing organs. More... »

PAGES

3770

References to SciGraph publications

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  • Journal

    TITLE

    Scientific Reports

    ISSUE

    1

    VOLUME

    9

    From Grant

  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-019-39919-3

    DOI

    http://dx.doi.org/10.1038/s41598-019-39919-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112576925

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30842553


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    JSON-LD is a popular format for linked data which is fully compatible with JSON.

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    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39919-3'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39919-3'

    RDF/XML is a standard XML format for linked data.

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