Ontology type: schema:ScholarlyArticle Open Access: True
2019-12
AUTHORSAnne-Louise Gannon, Laura O’Hara, J. Ian Mason, Diane Rebourcet, Sarah Smith, Adriana Traveres, Carlos Jose Alcaide-Corral, Hanne Frederiksen, Anne Jørgensen, Laura Milne, Rod T. Mitchell, Lee B. Smith
ABSTRACTThe hypothalamic-pituitary-adrenal (HPA) axis regulates responses to internal and external stressors. Many patients diagnosed with conditions such as depression or anxiety also have hyperactivity of the HPA axis. Hyper-stimulation of the HPA axis results in sustained elevated levels of glucocorticoids which impair neuronal function and can ultimately result in a psychiatric disorder. Studies investigating Glucocorticoid Receptor (GR/NR3C1) in the brain have primarily focused on the forebrain, however in recent years, the hindbrain has become a region of interest for research into the development of anxiety and depression, though the role of GR signalling in the hindbrain remains poorly characterised. To determine the role of glucocorticoid signalling in the hindbrain we have developed a novel mouse model that specifically ablates hindbrain GR to ascertain its role in behaviour, HPA-axis regulation and adrenal structure. Our study highlights that ablation of GR in the hindbrain results in excessive barbering, obsessive compulsive digging and lack of cage exploration. These mice also develop kyphosis, elevated circulating corticosterone and severe adrenal cortex disruption. Together, this data demonstrates a role for hindbrain GR signalling in regulating stress-related behaviour and identifies a novel mouse model to allow further investigation into the pathways impacting stress and anxiety. More... »
PAGES3250
http://scigraph.springernature.com/pub.10.1038/s41598-019-39867-y
DOIhttp://dx.doi.org/10.1038/s41598-019-39867-y
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1112475546
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30824750
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1109",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Neurosciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University of Newcastle Australia",
"id": "https://www.grid.ac/institutes/grid.266842.c",
"name": [
"MRC Centre for Reproductive Health, University of Edinburgh, The Queen\u2019s Medical Research Institute, 47 Little France Crescent, EH16 4TJ, Edinburgh, UK",
"School of Environmental and Life Sciences, Faculty of Science, University of Newcastle, 2308, Callaghan, NSW, Australia"
],
"type": "Organization"
},
"familyName": "Gannon",
"givenName": "Anne-Louise",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Edinburgh",
"id": "https://www.grid.ac/institutes/grid.4305.2",
"name": [
"MRC Centre for Reproductive Health, University of Edinburgh, The Queen\u2019s Medical Research Institute, 47 Little France Crescent, EH16 4TJ, Edinburgh, UK",
"Centre for Discovery Brain Sciences, Hugh Robson Building, George Square, EH8 9XD, Edinburgh, UK"
],
"type": "Organization"
},
"familyName": "O\u2019Hara",
"givenName": "Laura",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Edinburgh",
"id": "https://www.grid.ac/institutes/grid.4305.2",
"name": [
"MRC Centre for Reproductive Health, University of Edinburgh, The Queen\u2019s Medical Research Institute, 47 Little France Crescent, EH16 4TJ, Edinburgh, UK"
],
"type": "Organization"
},
"familyName": "Mason",
"givenName": "J. Ian",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Newcastle Australia",
"id": "https://www.grid.ac/institutes/grid.266842.c",
"name": [
"MRC Centre for Reproductive Health, University of Edinburgh, The Queen\u2019s Medical Research Institute, 47 Little France Crescent, EH16 4TJ, Edinburgh, UK",
"School of Environmental and Life Sciences, Faculty of Science, University of Newcastle, 2308, Callaghan, NSW, Australia"
],
"type": "Organization"
},
"familyName": "Rebourcet",
"givenName": "Diane",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Edinburgh",
"id": "https://www.grid.ac/institutes/grid.4305.2",
"name": [
"MRC Centre for Reproductive Health, University of Edinburgh, The Queen\u2019s Medical Research Institute, 47 Little France Crescent, EH16 4TJ, Edinburgh, UK"
],
"type": "Organization"
},
"familyName": "Smith",
"givenName": "Sarah",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Edinburgh",
"id": "https://www.grid.ac/institutes/grid.4305.2",
"name": [
"Edinburgh Preclinical Imaging, College of Medicine and Veterinary Medicine, University of Edinburgh, EH16 4TJ, Edinburgh, UK"
],
"type": "Organization"
},
"familyName": "Traveres",
"givenName": "Adriana",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Edinburgh",
"id": "https://www.grid.ac/institutes/grid.4305.2",
"name": [
"Edinburgh Preclinical Imaging, College of Medicine and Veterinary Medicine, University of Edinburgh, EH16 4TJ, Edinburgh, UK"
],
"type": "Organization"
},
"familyName": "Alcaide-Corral",
"givenName": "Carlos Jose",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Rigshospitalet",
"id": "https://www.grid.ac/institutes/grid.475435.4",
"name": [
"Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark",
"International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, Denmark"
],
"type": "Organization"
},
"familyName": "Frederiksen",
"givenName": "Hanne",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Rigshospitalet",
"id": "https://www.grid.ac/institutes/grid.475435.4",
"name": [
"Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark",
"International Centre for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, Denmark"
],
"type": "Organization"
},
"familyName": "J\u00f8rgensen",
"givenName": "Anne",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Edinburgh",
"id": "https://www.grid.ac/institutes/grid.4305.2",
"name": [
"MRC Centre for Reproductive Health, University of Edinburgh, The Queen\u2019s Medical Research Institute, 47 Little France Crescent, EH16 4TJ, Edinburgh, UK"
],
"type": "Organization"
},
"familyName": "Milne",
"givenName": "Laura",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Edinburgh",
"id": "https://www.grid.ac/institutes/grid.4305.2",
"name": [
"MRC Centre for Reproductive Health, University of Edinburgh, The Queen\u2019s Medical Research Institute, 47 Little France Crescent, EH16 4TJ, Edinburgh, UK"
],
"type": "Organization"
},
"familyName": "Mitchell",
"givenName": "Rod T.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Newcastle Australia",
"id": "https://www.grid.ac/institutes/grid.266842.c",
"name": [
"MRC Centre for Reproductive Health, University of Edinburgh, The Queen\u2019s Medical Research Institute, 47 Little France Crescent, EH16 4TJ, Edinburgh, UK",
"School of Environmental and Life Sciences, Faculty of Science, University of Newcastle, 2308, Callaghan, NSW, Australia"
],
"type": "Organization"
},
"familyName": "Smith",
"givenName": "Lee B.",
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/j.ynstr.2014.10.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001020790"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1756-0500-5-16",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001524710",
"https://doi.org/10.1186/1756-0500-5-16"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1152/ajpendo.00070.2006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002288187"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.psyneuen.2010.03.007",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006124251"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrn2647",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006137598",
"https://doi.org/10.1038/nrn2647"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrn2647",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006137598",
"https://doi.org/10.1038/nrn2647"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1016/s0893-133x(00)00159-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008542408",
"https://doi.org/10.1016/s0893-133x(00)00159-7"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbr.2009.12.041",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010069947"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/12207",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011815823",
"https://doi.org/10.1038/12207"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/12207",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011815823",
"https://doi.org/10.1038/12207"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.metabol.2005.01.008",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013177354"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0009-2797(00)00244-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013933269"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.5772/27498",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020844532"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pgen.1000980",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021064886"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1096/fj.09-138347",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021335764"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1046/j.1471-4159.1998.71062231.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021374985"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archpsyc.1991.01810320017003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025640163"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.beproc.2005.09.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026132201"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0084541",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028148629"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.applanim.2004.07.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030673252"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s12035-008-8024-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030797702",
"https://doi.org/10.1007/s12035-008-8024-1"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0308114100",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031809577"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1530/jme-15-0079",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031810928"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.neubiorev.2005.03.020",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037379590"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1460-9568.2006.05121.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038495093"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0301-0511(01)00092-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038500828"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0742-8413(99)00065-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038579732"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0165-0327(99)00132-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039850692"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jocn.2006.08.005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046793400"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.95.24.14476",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047026685"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbadis.2011.02.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048162021"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0031-9384(93)90084-s",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051445146"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0031-9384(93)90084-s",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051445146"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0079-6123(08)81011-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051724744"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1476-5381.2010.00872.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051886203"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1523/jneurosci.0522-10.2010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052545432"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jb/mvp142",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059746181"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jb/mvp142",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059746181"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/en.2006-1100",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064248273"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/en.2010-0928",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064250722"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/endo.138.9.5395",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064281897"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/jc.2005-0582",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064288440"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4103/0972-6748.98407",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1072241475"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1081437189",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cca.2017.03.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084064032"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-12",
"datePublishedReg": "2019-12-01",
"description": "The hypothalamic-pituitary-adrenal (HPA) axis regulates responses to internal and external stressors. Many patients diagnosed with conditions such as depression or anxiety also have hyperactivity of the HPA axis. Hyper-stimulation of the HPA axis results in sustained elevated levels of glucocorticoids which impair neuronal function and can ultimately result in a psychiatric disorder. Studies investigating Glucocorticoid Receptor (GR/NR3C1) in the brain have primarily focused on the forebrain, however in recent years, the hindbrain has become a region of interest for research into the development of anxiety and depression, though the role of GR signalling in the hindbrain remains poorly characterised. To determine the role of glucocorticoid signalling in the hindbrain we have developed a novel mouse model that specifically ablates hindbrain GR to ascertain its role in behaviour, HPA-axis regulation and adrenal structure. Our study highlights that ablation of GR in the hindbrain results in excessive barbering, obsessive compulsive digging and lack of cage exploration. These mice also develop kyphosis, elevated circulating corticosterone and severe adrenal cortex disruption. Together, this data demonstrates a role for hindbrain GR signalling in regulating stress-related behaviour and identifies a novel mouse model to allow further investigation into the pathways impacting stress and anxiety.",
"genre": "research_article",
"id": "sg:pub.10.1038/s41598-019-39867-y",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.4849893",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1045337",
"issn": [
"2045-2322"
],
"name": "Scientific Reports",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "9"
}
],
"name": "Ablation of glucocorticoid receptor in the hindbrain of the mouse provides a novel model to investigate stress disorders",
"pagination": "3250",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"f47207deb5a907048327780b12fac9e5ef4a591cbbd0eaea3cfd884b1d50e225"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30824750"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101563288"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41598-019-39867-y"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1112475546"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41598-019-39867-y",
"https://app.dimensions.ai/details/publication/pub.1112475546"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T11:17",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000354_0000000354/records_11692_00000002.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/s41598-019-39867-y"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39867-y'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39867-y'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39867-y'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39867-y'
This table displays all metadata directly associated to this object as RDF triples.
272 TRIPLES
21 PREDICATES
70 URIs
21 LITERALS
9 BLANK NODES