A transcriptome-wide analysis deciphers distinct roles of G1 cyclins in temporal organization of the yeast cell cycle View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Lotte Teufel, Katja Tummler, Max Flöttmann, Andreas Herrmann, Naama Barkai, Edda Klipp

ABSTRACT

Oscillating gene expression is crucial for correct timing and progression through cell cycle. In Saccharomyces cerevisiae, G1 cyclins Cln1-3 are essential drivers of the cell cycle and have an important role for temporal fine-tuning. We measured time-resolved transcriptome-wide gene expression for wild type and cyclin single and double knockouts over cell cycle with and without osmotic stress. Clustering of expression profiles, peak time detection of oscillating genes, integration with transcription factor network dynamics, and assignment to cell cycle phases allowed us to quantify the effect of genetic or stress perturbations on the duration of cell cycle phases. Cln1 and Cln2 showed functional differences, especially affecting later phases. Deletion of Cln3 led to a delay of START followed by normal progression through later phases. Our data and network analysis suggest mutual effects of cyclins with the transcriptional regulators SBF and MBF. More... »

PAGES

3343

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-019-39850-7

    DOI

    http://dx.doi.org/10.1038/s41598-019-39850-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112507020

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30833602


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