Differences in monocyte: lymphocyte ratio and Tuberculosis disease progression in genetically distinct populations of macaques View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Laura Sibley, Karen Gooch, Alice Wareham, Susan Gray, Andrew Chancellor, Stuart Dowall, Simon Bate, Anthony Marriott, Mike Dennis, Andrew D. White, Philip D. Marsh, Helen Fletcher, Sally Sharpe

ABSTRACT

Monocyte:lymphocyte ratio (M:L) has been identified as a risk factor in development of TB disease in children and those undergoing treatment for HIV in co-infected individuals. Retrospective analysis was performed using M:L data collected from TB modelling studies performed in Rhesus macaques of Indian genotype (RM), cynomolgus macaque of Chinese genotype (CCM) and cynomolgus macaque of Mauritian genotype (MCM), which found that the more susceptible populations (RM and MCM) had higher M:L ratios than the least susceptible population (CCM). Following Mycobacterium tuberculosis exposure, significant increases in M:L ratio were observed in susceptible RM and MCM within 12 weeks of TB infection, whereas M:L in CCM remained stable, suggesting that changes in M:L ratio may also act as a biomarker of TB disease progression. The frequency of PPD-specific interferon gamma (IFNγ) secreting cells (SFU) were compared, with the more susceptible macaque populations showing an association between M:L and IFNγ SFU frequency. Investigation of the genes associated with monocyte-derived antigen presenting cells revealed differences between RM and CCM, highlighting differences in their monocyte populations, as well as overall M:L ratio. Differences in M:L ratio between macaque populations could be used to explore immunological mechanisms in susceptible populations that would complement human population studies. More... »

PAGES

3340

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-39819-6

DOI

http://dx.doi.org/10.1038/s41598-019-39819-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112505590

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30833652


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