Fibroblast origin shapes tissue homeostasis, epidermal differentiation, and drug uptake View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Christian Hausmann, Christian Zoschke, Christopher Wolff, Maxim E. Darvin, Michaela Sochorová, Andrej Kováčik, Barbara Wanjiku, Fabian Schumacher, Julia Tigges, Burkhard Kleuser, Jürgen Lademann, Ellen Fritsche, Kateřina Vávrová, Nan Ma, Monika Schäfer-Korting

ABSTRACT

Preclinical studies frequently lack predictive value for human conditions. Human cell-based disease models that reflect patient heterogeneity may reduce the high failure rates of preclinical research. Herein, we investigated the impact of primary cell age and body region on skin homeostasis, epidermal differentiation, and drug uptake. Fibroblasts derived from the breast skin of female 20- to 30-year-olds or 60- to 70-year-olds and fibroblasts from juvenile foreskin (<10 years old) were compared in cell monolayers and in reconstructed human skin (RHS). RHS containing aged fibroblasts differed from its juvenile and adult counterparts, especially in terms of the dermal extracellular matrix composition and interleukin-6 levels. The site from which the fibroblasts were derived appeared to alter fibroblast-keratinocyte crosstalk by affecting, among other things, the levels of granulocyte-macrophage colony-stimulating factor. Consequently, the epidermal expression of filaggrin and e-cadherin was increased in RHS containing breast skin fibroblasts, as were lipid levels in the stratum corneum. In conclusion, the region of the body from which fibroblasts are derived appears to affect the epidermal differentiation of RHS, while the age of the fibroblast donors determines the expression of proteins involved in wound healing. Emulating patient heterogeneity in preclinical studies might improve the treatment of age-related skin conditions. More... »

PAGES

2913

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-39770-6

DOI

http://dx.doi.org/10.1038/s41598-019-39770-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112387830

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30814627


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Freie Universit\u00e4t Berlin", 
          "id": "https://www.grid.ac/institutes/grid.14095.39", 
          "name": [
            "Institute of Pharmacy (Pharmacology & Toxicology), Freie Universit\u00e4t Berlin, K\u00f6nigin-Luise-Str. 2 + 4, 14195, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hausmann", 
        "givenName": "Christian", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Freie Universit\u00e4t Berlin", 
          "id": "https://www.grid.ac/institutes/grid.14095.39", 
          "name": [
            "Institute of Pharmacy (Pharmacology & Toxicology), Freie Universit\u00e4t Berlin, K\u00f6nigin-Luise-Str. 2 + 4, 14195, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zoschke", 
        "givenName": "Christian", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Freie Universit\u00e4t Berlin", 
          "id": "https://www.grid.ac/institutes/grid.14095.39", 
          "name": [
            "Institute of Pharmacy (Pharmacology & Toxicology), Freie Universit\u00e4t Berlin, K\u00f6nigin-Luise-Str. 2 + 4, 14195, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wolff", 
        "givenName": "Christopher", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charit\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Charit\u00e9platz 1, 10117, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Darvin", 
        "givenName": "Maxim E.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charles University", 
          "id": "https://www.grid.ac/institutes/grid.4491.8", 
          "name": [
            "Faculty of Pharmacy in Hradec Kr\u00e1lov\u00e9, Charles University, Akademika Heyrovsk\u00e9ho 1203, 50005, Hradec Kr\u00e1lov\u00e9, Czech Republic"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sochorov\u00e1", 
        "givenName": "Michaela", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charles University", 
          "id": "https://www.grid.ac/institutes/grid.4491.8", 
          "name": [
            "Faculty of Pharmacy in Hradec Kr\u00e1lov\u00e9, Charles University, Akademika Heyrovsk\u00e9ho 1203, 50005, Hradec Kr\u00e1lov\u00e9, Czech Republic"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kov\u00e1\u010dik", 
        "givenName": "Andrej", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Freie Universit\u00e4t Berlin", 
          "id": "https://www.grid.ac/institutes/grid.14095.39", 
          "name": [
            "Institute of Pharmacy (Pharmacology & Toxicology), Freie Universit\u00e4t Berlin, K\u00f6nigin-Luise-Str. 2 + 4, 14195, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wanjiku", 
        "givenName": "Barbara", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Duisburg-Essen", 
          "id": "https://www.grid.ac/institutes/grid.5718.b", 
          "name": [
            "Institute of Nutritional Science, Department of Nutritional Toxicology, University of Potsdam, Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany", 
            "Department of Molecular Biology, University of Duisburg-Essen, Hufelandstr. 55, 45122, Essen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schumacher", 
        "givenName": "Fabian", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "IUF - Leibniz Research Institute for Environmental Medicine, Auf\u2019m Hennekamp 50, 40225, D\u00fcsseldorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tigges", 
        "givenName": "Julia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Potsdam", 
          "id": "https://www.grid.ac/institutes/grid.11348.3f", 
          "name": [
            "Institute of Nutritional Science, Department of Nutritional Toxicology, University of Potsdam, Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kleuser", 
        "givenName": "Burkhard", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charit\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.6363.0", 
          "name": [
            "Charit\u00e9 - Universit\u00e4tsmedizin Berlin, Charit\u00e9platz 1, 10117, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lademann", 
        "givenName": "J\u00fcrgen", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "IUF - Leibniz Research Institute for Environmental Medicine, Auf\u2019m Hennekamp 50, 40225, D\u00fcsseldorf, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fritsche", 
        "givenName": "Ellen", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Charles University", 
          "id": "https://www.grid.ac/institutes/grid.4491.8", 
          "name": [
            "Faculty of Pharmacy in Hradec Kr\u00e1lov\u00e9, Charles University, Akademika Heyrovsk\u00e9ho 1203, 50005, Hradec Kr\u00e1lov\u00e9, Czech Republic"
          ], 
          "type": "Organization"
        }, 
        "familyName": "V\u00e1vrov\u00e1", 
        "givenName": "Kate\u0159ina", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Helmholtz-Zentrum Geesthacht Centre for Materials and Coastal Research", 
          "id": "https://www.grid.ac/institutes/grid.24999.3f", 
          "name": [
            "Institute of Biomaterial Science, Helmholtz-Zentrum Geesthacht, Kantstra\u00dfe 55, 14513, Teltow, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ma", 
        "givenName": "Nan", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Freie Universit\u00e4t Berlin", 
          "id": "https://www.grid.ac/institutes/grid.14095.39", 
          "name": [
            "Institute of Pharmacy (Pharmacology & Toxicology), Freie Universit\u00e4t Berlin, K\u00f6nigin-Luise-Str. 2 + 4, 14195, Berlin, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sch\u00e4fer-Korting", 
        "givenName": "Monika", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nrm3758", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000491787", 
          "https://doi.org/10.1038/nrm3758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1535370214538916", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004112366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1535370214538916", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004112366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4161/derm.23872", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005632346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1046/j.0022-202x.2001.01544.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006066759", 
          "https://doi.org/10.1046/j.0022-202x.2001.01544.x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000348876", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008517953"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejpb.2012.11.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009379913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13075-016-1156-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011246971", 
          "https://doi.org/10.1186/s13075-016-1156-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13075-016-1156-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011246971", 
          "https://doi.org/10.1186/s13075-016-1156-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01062121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011948276", 
          "https://doi.org/10.1007/bf01062121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.01005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012460341"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1015570104121", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012653457", 
          "https://doi.org/10.1023/a:1015570104121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1006945108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012722261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.yexmp.2011.04.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016798307"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/exd.12866", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017387223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/ics.12068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017728604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jdermsci.2015.09.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018299346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.3002847", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019233067"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2133.2002.04871.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020910201"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004030100212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020929802", 
          "https://doi.org/10.1007/s004030100212"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pgen.0020119", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020998590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.semarthrit.2015.11.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024929254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2133.2008.08974.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025178950"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c6ra16565f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025436888"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-5122(94)90126-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026230545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-5122(94)90126-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026230545"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0625.2011.01305.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029567141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/jid.2015.120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029592823", 
          "https://doi.org/10.1038/jid.2015.120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst0350695", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032125028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1042/bst0350695", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032125028"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jconrel.2016.04.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032732499"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.smim.2014.01.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032899034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1016233107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032924168"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.3153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035887518", 
          "https://doi.org/10.1038/ni.3153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni.3153", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035887518", 
          "https://doi.org/10.1038/ni.3153"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jaci.2013.02.029", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040470238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/geront/gnw003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041043226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.89.11.5068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041210863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2013.05.039", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041626640"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.162488599", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042993090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/acs.orglett.5b02816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043974609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/1523-1747.ep12280259", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045042851", 
          "https://doi.org/10.1111/1523-1747.ep12280259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/13697137.2013.808563", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046173928"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd.2016.89", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048496416", 
          "https://doi.org/10.1038/nrd.2016.89"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd.2016.89", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048496416", 
          "https://doi.org/10.1038/nrd.2016.89"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-pathol-012414-040418", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048677889"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/jcs.01635", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050722081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40265-015-0377-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051943227", 
          "https://doi.org/10.1007/s40265-015-0377-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40265-015-0377-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051943227", 
          "https://doi.org/10.1007/s40265-015-0377-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jid.2015.11.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053017524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrd.2016.85", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053249719", 
          "https://doi.org/10.1038/nrd.2016.85"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/wound.2011.0356", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059327837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/wound.2014.0540", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059327939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074365870", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077656046", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078405756", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/17435390.2017.1292371", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083686454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/exd.13329", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084212530"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41598-017-01238-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085058007", 
          "https://doi.org/10.1038/s41598-017-01238-w"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/acel.12592", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085086657"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-12", 
    "datePublishedReg": "2019-12-01", 
    "description": "Preclinical studies frequently lack predictive value for human conditions. Human cell-based disease models that reflect patient heterogeneity may reduce the high failure rates of preclinical research. Herein, we investigated the impact of primary cell age and body region on skin homeostasis, epidermal differentiation, and drug uptake. Fibroblasts derived from the breast skin of female 20- to 30-year-olds or 60- to 70-year-olds and fibroblasts from juvenile foreskin (<10 years old) were compared in cell monolayers and in reconstructed human skin (RHS). RHS containing aged fibroblasts differed from its juvenile and adult counterparts, especially in terms of the dermal extracellular matrix composition and interleukin-6 levels. The site from which the fibroblasts were derived appeared to alter fibroblast-keratinocyte crosstalk by affecting, among other things, the levels of granulocyte-macrophage colony-stimulating factor. Consequently, the epidermal expression of filaggrin and e-cadherin was increased in RHS containing breast skin fibroblasts, as were lipid levels in the stratum corneum. In conclusion, the region of the body from which fibroblasts are derived appears to affect the epidermal differentiation of RHS, while the age of the fibroblast donors determines the expression of proteins involved in wound healing. Emulating patient heterogeneity in preclinical studies might improve the treatment of age-related skin conditions.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/s41598-019-39770-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6891585", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4828293", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1045337", 
        "issn": [
          "2045-2322"
        ], 
        "name": "Scientific Reports", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "9"
      }
    ], 
    "name": "Fibroblast origin shapes tissue homeostasis, epidermal differentiation, and drug uptake", 
    "pagination": "2913", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "03563f14c8a47801fcd9a19d3f0385f6c721513702803ea024781438b1f81d58"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30814627"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "101563288"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/s41598-019-39770-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112387830"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/s41598-019-39770-6", 
      "https://app.dimensions.ai/details/publication/pub.1112387830"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:50", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000350_0000000350/records_77583_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://www.nature.com/articles/s41598-019-39770-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39770-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39770-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39770-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39770-6'


 

This table displays all metadata directly associated to this object as RDF triples.

344 TRIPLES      21 PREDICATES      82 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/s41598-019-39770-6 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N4cf69b46b0004a1989ccb4ff0f5ebfcb
4 schema:citation sg:pub.10.1007/bf01062121
5 sg:pub.10.1007/s004030100212
6 sg:pub.10.1007/s40265-015-0377-y
7 sg:pub.10.1023/a:1015570104121
8 sg:pub.10.1038/jid.2015.120
9 sg:pub.10.1038/ni.3153
10 sg:pub.10.1038/nrd.2016.85
11 sg:pub.10.1038/nrd.2016.89
12 sg:pub.10.1038/nrm3758
13 sg:pub.10.1038/s41598-017-01238-w
14 sg:pub.10.1046/j.0022-202x.2001.01544.x
15 sg:pub.10.1111/1523-1747.ep12280259
16 sg:pub.10.1186/s13075-016-1156-1
17 https://app.dimensions.ai/details/publication/pub.1074365870
18 https://app.dimensions.ai/details/publication/pub.1077656046
19 https://app.dimensions.ai/details/publication/pub.1078405756
20 https://doi.org/10.1016/0378-5122(94)90126-0
21 https://doi.org/10.1016/j.cell.2013.05.039
22 https://doi.org/10.1016/j.ejpb.2012.11.008
23 https://doi.org/10.1016/j.jaci.2013.02.029
24 https://doi.org/10.1016/j.jconrel.2016.04.037
25 https://doi.org/10.1016/j.jdermsci.2015.09.002
26 https://doi.org/10.1016/j.jid.2015.11.007
27 https://doi.org/10.1016/j.semarthrit.2015.11.007
28 https://doi.org/10.1016/j.smim.2014.01.008
29 https://doi.org/10.1016/j.yexmp.2011.04.007
30 https://doi.org/10.1021/acs.orglett.5b02816
31 https://doi.org/10.1039/c6ra16565f
32 https://doi.org/10.1042/bst0350695
33 https://doi.org/10.1046/j.1365-2133.2002.04871.x
34 https://doi.org/10.1073/pnas.1006945108
35 https://doi.org/10.1073/pnas.1016233107
36 https://doi.org/10.1073/pnas.162488599
37 https://doi.org/10.1073/pnas.89.11.5068
38 https://doi.org/10.1080/17435390.2017.1292371
39 https://doi.org/10.1089/wound.2011.0356
40 https://doi.org/10.1089/wound.2014.0540
41 https://doi.org/10.1093/geront/gnw003
42 https://doi.org/10.1111/acel.12592
43 https://doi.org/10.1111/exd.12866
44 https://doi.org/10.1111/exd.13329
45 https://doi.org/10.1111/ics.12068
46 https://doi.org/10.1111/j.1365-2133.2008.08974.x
47 https://doi.org/10.1111/j.1600-0625.2011.01305.x
48 https://doi.org/10.1126/scitranslmed.3002847
49 https://doi.org/10.1146/annurev-pathol-012414-040418
50 https://doi.org/10.1159/000348876
51 https://doi.org/10.1177/1535370214538916
52 https://doi.org/10.1242/jcs.01005
53 https://doi.org/10.1242/jcs.01635
54 https://doi.org/10.1371/journal.pgen.0020119
55 https://doi.org/10.3109/13697137.2013.808563
56 https://doi.org/10.4161/derm.23872
57 schema:datePublished 2019-12
58 schema:datePublishedReg 2019-12-01
59 schema:description Preclinical studies frequently lack predictive value for human conditions. Human cell-based disease models that reflect patient heterogeneity may reduce the high failure rates of preclinical research. Herein, we investigated the impact of primary cell age and body region on skin homeostasis, epidermal differentiation, and drug uptake. Fibroblasts derived from the breast skin of female 20- to 30-year-olds or 60- to 70-year-olds and fibroblasts from juvenile foreskin (<10 years old) were compared in cell monolayers and in reconstructed human skin (RHS). RHS containing aged fibroblasts differed from its juvenile and adult counterparts, especially in terms of the dermal extracellular matrix composition and interleukin-6 levels. The site from which the fibroblasts were derived appeared to alter fibroblast-keratinocyte crosstalk by affecting, among other things, the levels of granulocyte-macrophage colony-stimulating factor. Consequently, the epidermal expression of filaggrin and e-cadherin was increased in RHS containing breast skin fibroblasts, as were lipid levels in the stratum corneum. In conclusion, the region of the body from which fibroblasts are derived appears to affect the epidermal differentiation of RHS, while the age of the fibroblast donors determines the expression of proteins involved in wound healing. Emulating patient heterogeneity in preclinical studies might improve the treatment of age-related skin conditions.
60 schema:genre research_article
61 schema:inLanguage en
62 schema:isAccessibleForFree true
63 schema:isPartOf N8c6d442afefb4b50a9c5d1fcec060432
64 Na0f47e493fb74bf697dbe4c232351fd7
65 sg:journal.1045337
66 schema:name Fibroblast origin shapes tissue homeostasis, epidermal differentiation, and drug uptake
67 schema:pagination 2913
68 schema:productId N084cbe7afc9646d4a1fa9fd03887040c
69 N138ec965f1524574ac2524f8fd993ce9
70 N264980f9cb9749348377b86b1b7f0c69
71 N62b0dd0d1eec4efbba3c76f995244198
72 Ncb8d4570a3b845a8a579ece188d3c8db
73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112387830
74 https://doi.org/10.1038/s41598-019-39770-6
75 schema:sdDatePublished 2019-04-11T10:50
76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
77 schema:sdPublisher Ndb9b857f224d46f2a2185a9c7e267d19
78 schema:url https://www.nature.com/articles/s41598-019-39770-6
79 sgo:license sg:explorer/license/
80 sgo:sdDataset articles
81 rdf:type schema:ScholarlyArticle
82 N084cbe7afc9646d4a1fa9fd03887040c schema:name nlm_unique_id
83 schema:value 101563288
84 rdf:type schema:PropertyValue
85 N0c13f94606f24b42af225ea386e0b06b schema:affiliation https://www.grid.ac/institutes/grid.4491.8
86 schema:familyName Sochorová
87 schema:givenName Michaela
88 rdf:type schema:Person
89 N0e979726ce8a4d47875929e0ba124535 rdf:first Nff6bd1f22abc4bc98d588b5c72906165
90 rdf:rest Nb1f279c8d71b41d1854f936c0f4d4ab4
91 N0eb743268e924719ac077f88dafef22d schema:affiliation https://www.grid.ac/institutes/grid.14095.39
92 schema:familyName Hausmann
93 schema:givenName Christian
94 rdf:type schema:Person
95 N1032f58bd54747dab86cf2cfc9279f4b schema:affiliation https://www.grid.ac/institutes/grid.14095.39
96 schema:familyName Wolff
97 schema:givenName Christopher
98 rdf:type schema:Person
99 N138ec965f1524574ac2524f8fd993ce9 schema:name readcube_id
100 schema:value 03563f14c8a47801fcd9a19d3f0385f6c721513702803ea024781438b1f81d58
101 rdf:type schema:PropertyValue
102 N2279601181144edc894c3f4e0f2e3af2 rdf:first Nb31ead7f100a4febac6f4d340ef588d0
103 rdf:rest Nd2298a5c74d94fac9cf6d540f92284bf
104 N264980f9cb9749348377b86b1b7f0c69 schema:name doi
105 schema:value 10.1038/s41598-019-39770-6
106 rdf:type schema:PropertyValue
107 N44178d6af7e84329906223c44aa3dbe3 schema:affiliation https://www.grid.ac/institutes/grid.6363.0
108 schema:familyName Lademann
109 schema:givenName Jürgen
110 rdf:type schema:Person
111 N45802d395fdd4c17ac52623f5350c512 rdf:first N0c13f94606f24b42af225ea386e0b06b
112 rdf:rest Naeea2baffeee47d38c5b388223da05b5
113 N4cf69b46b0004a1989ccb4ff0f5ebfcb rdf:first N0eb743268e924719ac077f88dafef22d
114 rdf:rest Nc1a960939ec84bed8002d5884ffe5ff1
115 N62b0dd0d1eec4efbba3c76f995244198 schema:name dimensions_id
116 schema:value pub.1112387830
117 rdf:type schema:PropertyValue
118 N66955903b1644f5f92cb6d98aa6c504e rdf:first N68fd90aa05bc49eeaec6a05ee8546df8
119 rdf:rest rdf:nil
120 N68fd90aa05bc49eeaec6a05ee8546df8 schema:affiliation https://www.grid.ac/institutes/grid.14095.39
121 schema:familyName Schäfer-Korting
122 schema:givenName Monika
123 rdf:type schema:Person
124 N74beca1cf2da419987356308bc0fb2e3 rdf:first N97ab18e339484d4c8e76ae5d548dd37f
125 rdf:rest N66955903b1644f5f92cb6d98aa6c504e
126 N764b0d0223f04a1fbb2a394d6db5e34b rdf:first N44178d6af7e84329906223c44aa3dbe3
127 rdf:rest N2279601181144edc894c3f4e0f2e3af2
128 N7cc786632da848638679e98738bad0dc schema:affiliation https://www.grid.ac/institutes/grid.14095.39
129 schema:familyName Wanjiku
130 schema:givenName Barbara
131 rdf:type schema:Person
132 N7cef05ba2f8a45e2be6e355d1ebe943c rdf:first Nd44fc9d433fe42d39c35c87a6443dada
133 rdf:rest N45802d395fdd4c17ac52623f5350c512
134 N8c6d442afefb4b50a9c5d1fcec060432 schema:volumeNumber 9
135 rdf:type schema:PublicationVolume
136 N925ab58a03f54bf0bceac6c6f978b856 schema:affiliation https://www.grid.ac/institutes/grid.11348.3f
137 schema:familyName Kleuser
138 schema:givenName Burkhard
139 rdf:type schema:Person
140 N93e3befbfdaa4149bca6b306cc070b41 rdf:first N7cc786632da848638679e98738bad0dc
141 rdf:rest Ndee1f81cf89c481bb9082c7e855426ef
142 N97ab18e339484d4c8e76ae5d548dd37f schema:affiliation https://www.grid.ac/institutes/grid.24999.3f
143 schema:familyName Ma
144 schema:givenName Nan
145 rdf:type schema:Person
146 N9ab52f84aad942be9f6129653a07273b schema:name IUF - Leibniz Research Institute for Environmental Medicine, Auf’m Hennekamp 50, 40225, Düsseldorf, Germany
147 rdf:type schema:Organization
148 Na0f47e493fb74bf697dbe4c232351fd7 schema:issueNumber 1
149 rdf:type schema:PublicationIssue
150 Na940ea2570be4183b8e819e511b10922 rdf:first N1032f58bd54747dab86cf2cfc9279f4b
151 rdf:rest N7cef05ba2f8a45e2be6e355d1ebe943c
152 Naeea2baffeee47d38c5b388223da05b5 rdf:first Ncb8284b59aaf4fbc8090bc07fe3d5380
153 rdf:rest N93e3befbfdaa4149bca6b306cc070b41
154 Nb1f279c8d71b41d1854f936c0f4d4ab4 rdf:first N925ab58a03f54bf0bceac6c6f978b856
155 rdf:rest N764b0d0223f04a1fbb2a394d6db5e34b
156 Nb31ead7f100a4febac6f4d340ef588d0 schema:affiliation N9ab52f84aad942be9f6129653a07273b
157 schema:familyName Fritsche
158 schema:givenName Ellen
159 rdf:type schema:Person
160 Nbd1e5b4086dc46769bb898508e78814e schema:name IUF - Leibniz Research Institute for Environmental Medicine, Auf’m Hennekamp 50, 40225, Düsseldorf, Germany
161 rdf:type schema:Organization
162 Nc1a960939ec84bed8002d5884ffe5ff1 rdf:first Nfc62edf0911a4722a9ad6e301e849981
163 rdf:rest Na940ea2570be4183b8e819e511b10922
164 Ncb8284b59aaf4fbc8090bc07fe3d5380 schema:affiliation https://www.grid.ac/institutes/grid.4491.8
165 schema:familyName Kováčik
166 schema:givenName Andrej
167 rdf:type schema:Person
168 Ncb8d4570a3b845a8a579ece188d3c8db schema:name pubmed_id
169 schema:value 30814627
170 rdf:type schema:PropertyValue
171 Nd2298a5c74d94fac9cf6d540f92284bf rdf:first Nd6eb32e3fcf34ed995eb8b5430f16125
172 rdf:rest N74beca1cf2da419987356308bc0fb2e3
173 Nd44fc9d433fe42d39c35c87a6443dada schema:affiliation https://www.grid.ac/institutes/grid.6363.0
174 schema:familyName Darvin
175 schema:givenName Maxim E.
176 rdf:type schema:Person
177 Nd6eb32e3fcf34ed995eb8b5430f16125 schema:affiliation https://www.grid.ac/institutes/grid.4491.8
178 schema:familyName Vávrová
179 schema:givenName Kateřina
180 rdf:type schema:Person
181 Nd742679b827a4738902482b4f04fa3ac schema:affiliation https://www.grid.ac/institutes/grid.5718.b
182 schema:familyName Schumacher
183 schema:givenName Fabian
184 rdf:type schema:Person
185 Ndb9b857f224d46f2a2185a9c7e267d19 schema:name Springer Nature - SN SciGraph project
186 rdf:type schema:Organization
187 Ndee1f81cf89c481bb9082c7e855426ef rdf:first Nd742679b827a4738902482b4f04fa3ac
188 rdf:rest N0e979726ce8a4d47875929e0ba124535
189 Nfc62edf0911a4722a9ad6e301e849981 schema:affiliation https://www.grid.ac/institutes/grid.14095.39
190 schema:familyName Zoschke
191 schema:givenName Christian
192 rdf:type schema:Person
193 Nff6bd1f22abc4bc98d588b5c72906165 schema:affiliation Nbd1e5b4086dc46769bb898508e78814e
194 schema:familyName Tigges
195 schema:givenName Julia
196 rdf:type schema:Person
197 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
198 schema:name Medical and Health Sciences
199 rdf:type schema:DefinedTerm
200 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
201 schema:name Clinical Sciences
202 rdf:type schema:DefinedTerm
203 sg:grant.4828293 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-39770-6
204 rdf:type schema:MonetaryGrant
205 sg:grant.6891585 http://pending.schema.org/fundedItem sg:pub.10.1038/s41598-019-39770-6
206 rdf:type schema:MonetaryGrant
207 sg:journal.1045337 schema:issn 2045-2322
208 schema:name Scientific Reports
209 rdf:type schema:Periodical
210 sg:pub.10.1007/bf01062121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011948276
211 https://doi.org/10.1007/bf01062121
212 rdf:type schema:CreativeWork
213 sg:pub.10.1007/s004030100212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020929802
214 https://doi.org/10.1007/s004030100212
215 rdf:type schema:CreativeWork
216 sg:pub.10.1007/s40265-015-0377-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1051943227
217 https://doi.org/10.1007/s40265-015-0377-y
218 rdf:type schema:CreativeWork
219 sg:pub.10.1023/a:1015570104121 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012653457
220 https://doi.org/10.1023/a:1015570104121
221 rdf:type schema:CreativeWork
222 sg:pub.10.1038/jid.2015.120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029592823
223 https://doi.org/10.1038/jid.2015.120
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/ni.3153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035887518
226 https://doi.org/10.1038/ni.3153
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/nrd.2016.85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053249719
229 https://doi.org/10.1038/nrd.2016.85
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/nrd.2016.89 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048496416
232 https://doi.org/10.1038/nrd.2016.89
233 rdf:type schema:CreativeWork
234 sg:pub.10.1038/nrm3758 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000491787
235 https://doi.org/10.1038/nrm3758
236 rdf:type schema:CreativeWork
237 sg:pub.10.1038/s41598-017-01238-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1085058007
238 https://doi.org/10.1038/s41598-017-01238-w
239 rdf:type schema:CreativeWork
240 sg:pub.10.1046/j.0022-202x.2001.01544.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1006066759
241 https://doi.org/10.1046/j.0022-202x.2001.01544.x
242 rdf:type schema:CreativeWork
243 sg:pub.10.1111/1523-1747.ep12280259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045042851
244 https://doi.org/10.1111/1523-1747.ep12280259
245 rdf:type schema:CreativeWork
246 sg:pub.10.1186/s13075-016-1156-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011246971
247 https://doi.org/10.1186/s13075-016-1156-1
248 rdf:type schema:CreativeWork
249 https://app.dimensions.ai/details/publication/pub.1074365870 schema:CreativeWork
250 https://app.dimensions.ai/details/publication/pub.1077656046 schema:CreativeWork
251 https://app.dimensions.ai/details/publication/pub.1078405756 schema:CreativeWork
252 https://doi.org/10.1016/0378-5122(94)90126-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026230545
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1016/j.cell.2013.05.039 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041626640
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1016/j.ejpb.2012.11.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009379913
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1016/j.jaci.2013.02.029 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040470238
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1016/j.jconrel.2016.04.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032732499
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1016/j.jdermsci.2015.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018299346
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1016/j.jid.2015.11.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053017524
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1016/j.semarthrit.2015.11.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024929254
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1016/j.smim.2014.01.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032899034
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1016/j.yexmp.2011.04.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016798307
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1021/acs.orglett.5b02816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043974609
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1039/c6ra16565f schema:sameAs https://app.dimensions.ai/details/publication/pub.1025436888
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1042/bst0350695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032125028
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1046/j.1365-2133.2002.04871.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020910201
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1073/pnas.1006945108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012722261
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1073/pnas.1016233107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032924168
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1073/pnas.162488599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042993090
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1073/pnas.89.11.5068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041210863
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1080/17435390.2017.1292371 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083686454
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1089/wound.2011.0356 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059327837
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1089/wound.2014.0540 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059327939
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1093/geront/gnw003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041043226
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1111/acel.12592 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085086657
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1111/exd.12866 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017387223
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1111/exd.13329 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084212530
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1111/ics.12068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017728604
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1111/j.1365-2133.2008.08974.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1025178950
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1111/j.1600-0625.2011.01305.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029567141
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1126/scitranslmed.3002847 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019233067
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1146/annurev-pathol-012414-040418 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048677889
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1159/000348876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008517953
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1177/1535370214538916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004112366
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1242/jcs.01005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012460341
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1242/jcs.01635 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050722081
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1371/journal.pgen.0020119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020998590
321 rdf:type schema:CreativeWork
322 https://doi.org/10.3109/13697137.2013.808563 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046173928
323 rdf:type schema:CreativeWork
324 https://doi.org/10.4161/derm.23872 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005632346
325 rdf:type schema:CreativeWork
326 https://www.grid.ac/institutes/grid.11348.3f schema:alternateName University of Potsdam
327 schema:name Institute of Nutritional Science, Department of Nutritional Toxicology, University of Potsdam, Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany
328 rdf:type schema:Organization
329 https://www.grid.ac/institutes/grid.14095.39 schema:alternateName Freie Universität Berlin
330 schema:name Institute of Pharmacy (Pharmacology & Toxicology), Freie Universität Berlin, Königin-Luise-Str. 2 + 4, 14195, Berlin, Germany
331 rdf:type schema:Organization
332 https://www.grid.ac/institutes/grid.24999.3f schema:alternateName Helmholtz-Zentrum Geesthacht Centre for Materials and Coastal Research
333 schema:name Institute of Biomaterial Science, Helmholtz-Zentrum Geesthacht, Kantstraße 55, 14513, Teltow, Germany
334 rdf:type schema:Organization
335 https://www.grid.ac/institutes/grid.4491.8 schema:alternateName Charles University
336 schema:name Faculty of Pharmacy in Hradec Králové, Charles University, Akademika Heyrovského 1203, 50005, Hradec Králové, Czech Republic
337 rdf:type schema:Organization
338 https://www.grid.ac/institutes/grid.5718.b schema:alternateName University of Duisburg-Essen
339 schema:name Department of Molecular Biology, University of Duisburg-Essen, Hufelandstr. 55, 45122, Essen, Germany
340 Institute of Nutritional Science, Department of Nutritional Toxicology, University of Potsdam, Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany
341 rdf:type schema:Organization
342 https://www.grid.ac/institutes/grid.6363.0 schema:alternateName Charité
343 schema:name Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany
344 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...