Fibroblast origin shapes tissue homeostasis, epidermal differentiation, and drug uptake View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-12

AUTHORS

Christian Hausmann, Christian Zoschke, Christopher Wolff, Maxim E. Darvin, Michaela Sochorová, Andrej Kováčik, Barbara Wanjiku, Fabian Schumacher, Julia Tigges, Burkhard Kleuser, Jürgen Lademann, Ellen Fritsche, Kateřina Vávrová, Nan Ma, Monika Schäfer-Korting

ABSTRACT

Preclinical studies frequently lack predictive value for human conditions. Human cell-based disease models that reflect patient heterogeneity may reduce the high failure rates of preclinical research. Herein, we investigated the impact of primary cell age and body region on skin homeostasis, epidermal differentiation, and drug uptake. Fibroblasts derived from the breast skin of female 20- to 30-year-olds or 60- to 70-year-olds and fibroblasts from juvenile foreskin (<10 years old) were compared in cell monolayers and in reconstructed human skin (RHS). RHS containing aged fibroblasts differed from its juvenile and adult counterparts, especially in terms of the dermal extracellular matrix composition and interleukin-6 levels. The site from which the fibroblasts were derived appeared to alter fibroblast-keratinocyte crosstalk by affecting, among other things, the levels of granulocyte-macrophage colony-stimulating factor. Consequently, the epidermal expression of filaggrin and e-cadherin was increased in RHS containing breast skin fibroblasts, as were lipid levels in the stratum corneum. In conclusion, the region of the body from which fibroblasts are derived appears to affect the epidermal differentiation of RHS, while the age of the fibroblast donors determines the expression of proteins involved in wound healing. Emulating patient heterogeneity in preclinical studies might improve the treatment of age-related skin conditions. More... »

PAGES

2913

References to SciGraph publications

  • 2001-11. Modulation of Skin Collagen Metabolism in Aged and Photoaged Human Skin In Vivo in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2016-12. Rheumatoid synovial fibroblasts differentiate into distinct subsets in the presence of cytokines and cartilage in ARTHRITIS RESEARCH & THERAPY
  • 1989-09. Age-Related Mechanical Properties of Human Skin: An In Vivo Study in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2015-05. IL-6 as a keystone cytokine in health and disease in NATURE IMMUNOLOGY
  • 2015-04. An Update on Pharmacological, Pharmacokinetic Properties and Drug–Drug Interactions of Rotigotine Transdermal System in Parkinson’s Disease and Restless Legs Syndrome in DRUGS
  • 2017-12. Two-photon autofluorescence lifetime imaging of human skin papillary dermis in vivo: assessment of blood capillaries and structural proteins localization in SCIENTIFIC REPORTS
  • 2001-04. Determination of stratum corneum lipid profile by tape stripping in combination with high-performance thin-layer chromatography in ARCHIVES OF DERMATOLOGICAL RESEARCH
  • 1989-12. The effect of aging on percutaneous absorption in man in JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
  • 2002-04. Hospitalisations caused by adverse drug reactions (ADR): a meta-analysis of observational studies in INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
  • 2016-09. Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease in NATURE REVIEWS DRUG DISCOVERY
  • 2016-06. Trends in clinical success rates in NATURE REVIEWS DRUG DISCOVERY
  • 2015-08. Characterization of Skin Aging–Associated Secreted Proteins (SAASP) Produced by Dermal Fibroblasts Isolated from Intrinsically Aged Human Skin in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2014-03. Molecular mechanisms of epithelial–mesenchymal transition in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/s41598-019-39770-6

    DOI

    http://dx.doi.org/10.1038/s41598-019-39770-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1112387830

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30814627


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