Ontology type: schema:ScholarlyArticle Open Access: True
2019-12
AUTHORSDavid Devos, Caroline Moreau, Maeva Kyheng, Guillaume Garçon, Anne Sophie Rolland, Hélène Blasco, Patrick Gelé, T. Timothée Lenglet, C. Veyrat-Durebex, Philippe Corcia, Mary Dutheil, Peter Bede, Andreas Jeromin, Patrick Oeckl, Markus Otto, Vincent Meninger, Véronique Danel-Brunaud, Jean-christophe Devedjian, James A. Duce, Pierre François Pradat
ABSTRACTAccurate patient stratification into prognostic categories and targeting Amyotrophic Lateral Sclerosis (ALS)-associated pathways may pave the way for promising trials. We evaluated blood-based prognostic indicators using an array of pathological markers. Plasma samples were collected as part of a large, phase III clinical trial (Mitotarget/TRO19622) at months 1, 6, 12 and 18. The ALSFRS-r score was used as a proxy of disease progression to assess the predictive value of candidate biological indicators. First, established clinical predictors were evaluated in all 512 patients. Subsequently, pathologic markers, such as proxies of neuronal integrity (Neurofilament light chain and phosphorylated heavy chain), DNA oxidation (8-oxo-2'-desoxyguanosine), lipid peroxidation (4-hydroxy-2-nonenal, isoprostane), inflammation (interleukin-6) and iron status (ferritin, hepcidin, transferrin) were assessed in a subset of 109 patients that represented the whole cohort. Markers of neuronal integrity, DNA and lipid oxidation, as well as iron status at baseline are accurate predictors of disability at 18-month follow-up. The composite scores of these markers in association with established clinical predictors enable the accurate forecasting of functional decline. The identified four biomarkers are all closely associated with 'ferroptosis', a recently discovered form of programmed cell death with promising therapeutic targets. The predictive potential of these pathophysiology-based indicators may offer superior patient stratification for future trials, individualised patient care and resource allocation. More... »
PAGES2918
http://scigraph.springernature.com/pub.10.1038/s41598-019-39739-5
DOIhttp://dx.doi.org/10.1038/s41598-019-39739-5
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1112394096
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30814647
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Lille 1 University",
"id": "https://www.grid.ac/institutes/grid.4461.7",
"name": [
"Department of Neurology, ALS Center, Lille University, INSERM UMRS_1171, University Hospital Center, LICEND COEN Center, Lille, France",
"Department of Medical Pharmacology, Lille University, INSERM UMRS_1171, University Hospital Center, LICEND COEN Center, Lille, France"
],
"type": "Organization"
},
"familyName": "Devos",
"givenName": "David",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Lille 1 University",
"id": "https://www.grid.ac/institutes/grid.4461.7",
"name": [
"Department of Neurology, ALS Center, Lille University, INSERM UMRS_1171, University Hospital Center, LICEND COEN Center, Lille, France"
],
"type": "Organization"
},
"familyName": "Moreau",
"givenName": "Caroline",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Lille 1 University",
"id": "https://www.grid.ac/institutes/grid.4461.7",
"name": [
"Department of Biostatistics, Lille University, University Hospital Center, Lille, France"
],
"type": "Organization"
},
"familyName": "Kyheng",
"givenName": "Maeva",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Centre Hospitalier Regional et Universitaire de Lille",
"id": "https://www.grid.ac/institutes/grid.410463.4",
"name": [
"Univ. Lille, CHU Lille, Institut Pasteur de Lille, EA4483 IMPECS-IMPact de l\u2019Environnement Chimique sur la Sant\u00e9 humaine, Lille, France"
],
"type": "Organization"
},
"familyName": "Gar\u00e7on",
"givenName": "Guillaume",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Lille 1 University",
"id": "https://www.grid.ac/institutes/grid.4461.7",
"name": [
"Department of Medical Pharmacology, Lille University, INSERM UMRS_1171, University Hospital Center, LICEND COEN Center, Lille, France"
],
"type": "Organization"
},
"familyName": "Rolland",
"givenName": "Anne Sophie",
"type": "Person"
},
{
"affiliation": {
"name": [
"Universit\u00e9 Fran\u00e7ois-Rabelais, Inserm U930, Laboratoire de Biochimie, CHRU de Tours, France"
],
"type": "Organization"
},
"familyName": "Blasco",
"givenName": "H\u00e9l\u00e8ne",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Lille 1 University",
"id": "https://www.grid.ac/institutes/grid.4461.7",
"name": [
"CRB/CIC1403, Universit\u00e9 de LILLE, Lille, France"
],
"type": "Organization"
},
"familyName": "Gel\u00e9",
"givenName": "Patrick",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Piti\u00e9-Salp\u00eatri\u00e8re Hospital",
"id": "https://www.grid.ac/institutes/grid.411439.a",
"name": [
"APHP, Department of Neurophysiology, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, Paris, France"
],
"type": "Organization"
},
"familyName": "Lenglet",
"givenName": "T. Timoth\u00e9e",
"type": "Person"
},
{
"affiliation": {
"name": [
"Universit\u00e9 Fran\u00e7ois-Rabelais, Inserm U930, Laboratoire de Biochimie, CHRU de Tours, France"
],
"type": "Organization"
},
"familyName": "Veyrat-Durebex",
"givenName": "C.",
"type": "Person"
},
{
"affiliation": {
"name": [
"Centre Constitutif SLA, Tours-F\u00e9d\u00e9ration des centres SLA Tours-Limoges, LITORALS, Tours, France"
],
"type": "Organization"
},
"familyName": "Corcia",
"givenName": "Philippe",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Lille 1 University",
"id": "https://www.grid.ac/institutes/grid.4461.7",
"name": [
"Department of Medical Pharmacology, Lille University, INSERM UMRS_1171, University Hospital Center, LICEND COEN Center, Lille, France"
],
"type": "Organization"
},
"familyName": "Dutheil",
"givenName": "Mary",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Trinity College Dublin",
"id": "https://www.grid.ac/institutes/grid.8217.c",
"name": [
"Biomedical Imaging Laboratory, CNRS, INSERM, Sorbonne University, Paris, France",
"Computational Neuroimaging Group, Academic Unit of Neurology, Trinity College Dublin, Dublin, Ireland"
],
"type": "Organization"
},
"familyName": "Bede",
"givenName": "Peter",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Quanterix (United States)",
"id": "https://www.grid.ac/institutes/grid.470381.9",
"name": [
"Quanterix, Lexington, Massachusetts, USA"
],
"type": "Organization"
},
"familyName": "Jeromin",
"givenName": "Andreas",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University Hospital Ulm",
"id": "https://www.grid.ac/institutes/grid.410712.1",
"name": [
"Department of Neurology, Ulm University Hospital, Oberer Eselsberg 45, 89081 Ulm, Ulm, Germany"
],
"type": "Organization"
},
"familyName": "Oeckl",
"givenName": "Patrick",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University Hospital Ulm",
"id": "https://www.grid.ac/institutes/grid.410712.1",
"name": [
"Department of Neurology, Ulm University Hospital, Oberer Eselsberg 45, 89081 Ulm, Ulm, Germany"
],
"type": "Organization"
},
"familyName": "Otto",
"givenName": "Markus",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Piti\u00e9-Salp\u00eatri\u00e8re Hospital",
"id": "https://www.grid.ac/institutes/grid.411439.a",
"name": [
"APHP, Department of Neurology, Paris ALS Center, Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Paris, France"
],
"type": "Organization"
},
"familyName": "Meninger",
"givenName": "Vincent",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Lille 1 University",
"id": "https://www.grid.ac/institutes/grid.4461.7",
"name": [
"Department of Neurology, ALS Center, Lille University, INSERM UMRS_1171, University Hospital Center, LICEND COEN Center, Lille, France"
],
"type": "Organization"
},
"familyName": "Danel-Brunaud",
"givenName": "V\u00e9ronique",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Lille 1 University",
"id": "https://www.grid.ac/institutes/grid.4461.7",
"name": [
"Department of Medical Pharmacology, Lille University, INSERM UMRS_1171, University Hospital Center, LICEND COEN Center, Lille, France"
],
"type": "Organization"
},
"familyName": "Devedjian",
"givenName": "Jean-christophe",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Leeds",
"id": "https://www.grid.ac/institutes/grid.9909.9",
"name": [
"ALBORADA Drug Discovery Institute, University of Cambridge, Cambridge Biomedical Campus, Hills Road, CB2 0AH, Cambridge, UK",
"School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, West Yorkshire, United Kingdom"
],
"type": "Organization"
},
"familyName": "Duce",
"givenName": "James A.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Altnagelvin Area Hospital",
"id": "https://www.grid.ac/institutes/grid.413639.a",
"name": [
"Biomedical Imaging Laboratory, CNRS, INSERM, Sorbonne University, Paris, France",
"APHP, Department of Neurology, Paris ALS Center, Piti\u00e9 Salp\u00eatri\u00e8re Hospital, Paris, France",
"Northern Ireland Centre for Stratified Medicine, Biomedical Sciences Research Institute Ulster University, C-TRIC, Altnagelvin Hospital, Derry/Londonderry, United Kingdom"
],
"type": "Organization"
},
"familyName": "Pradat",
"givenName": "Pierre Fran\u00e7ois",
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1371/journal.pone.0045034",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000210676"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.0000000000001642",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001708055"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.0000000000001642",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001708055"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1017/cjn.2016.284",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004155566"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/jamaneurol.2013.4646",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008186648"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.nbd.2016.05.011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012045176"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1155/2014/485723",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017172577"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0022-510x(99)00210-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017812516"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/17482960801933942",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018041952"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/10715762.2013.794265",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019783562"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/ene.12754",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019798412"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2169/internalmedicine.51.7465",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024747497"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/ene.12344",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025682934"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m115.680090",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053387069"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/01.wnl.0000188907.97339.76",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064347686"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/01.wnl.0000188907.97339.76",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064347686"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/01.wnl.0000188907.97339.76",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064347686"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.62.10.1758",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064381759"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.62.10.1758",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064381759"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.62.10.1758",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064381759"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/21678421.2017.1281962",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083715351"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/jamaneurol.2016.5398",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084005979"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.0000000000004029",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1085466496"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.0000000000004029",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1085466496"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.0000000000004029",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1085466496"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.0000000000004029",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1085466496"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41598-017-09097-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1091260105",
"https://doi.org/10.1038/s41598-017-09097-1"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41598-017-09097-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1091260105",
"https://doi.org/10.1038/s41598-017-09097-1"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2017.09.021",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1092117016"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.0000000000004761",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1099758786"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.0000000000004761",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1099758786"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1212/wnl.0000000000004761",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1099758786"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1089/ars.2017.7493",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1100141971"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1474-4422(18)30089-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1101773044"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1474-4422(18)30089-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1101773044"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1474-4422(18)30089-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1101773044"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s1474-4422(18)30089-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1101773044"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-12",
"datePublishedReg": "2019-12-01",
"description": "Accurate patient stratification into prognostic categories and targeting Amyotrophic Lateral Sclerosis (ALS)-associated pathways may pave the way for promising trials. We evaluated blood-based prognostic indicators using an array of pathological markers. Plasma samples were collected as part of a large, phase III clinical trial (Mitotarget/TRO19622) at months 1, 6, 12 and 18. The ALSFRS-r score was used as a proxy of disease progression to assess the predictive value of candidate biological indicators. First, established clinical predictors were evaluated in all 512 patients. Subsequently, pathologic markers, such as proxies of neuronal integrity (Neurofilament light chain and phosphorylated heavy chain), DNA oxidation (8-oxo-2'-desoxyguanosine), lipid peroxidation (4-hydroxy-2-nonenal, isoprostane), inflammation (interleukin-6) and iron status (ferritin, hepcidin, transferrin) were assessed in a subset of 109 patients that represented the whole cohort. Markers of neuronal integrity, DNA and lipid oxidation, as well as iron status at baseline are accurate predictors of disability at 18-month follow-up. The composite scores of these markers in association with established clinical predictors enable the accurate forecasting of functional decline. The identified four biomarkers are all closely associated with 'ferroptosis', a recently discovered form of programmed cell death with promising therapeutic targets. The predictive potential of these pathophysiology-based indicators may offer superior patient stratification for future trials, individualised patient care and resource allocation.",
"genre": "research_article",
"id": "sg:pub.10.1038/s41598-019-39739-5",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isPartOf": [
{
"id": "sg:journal.1045337",
"issn": [
"2045-2322"
],
"name": "Scientific Reports",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "9"
}
],
"name": "A ferroptosis\u2013based panel of prognostic biomarkers for Amyotrophic Lateral Sclerosis",
"pagination": "2918",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"96eaa2d1607cdeb43eb1b6779e2a9604cb0494ee17025d498b8add72858f3b04"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30814647"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101563288"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41598-019-39739-5"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1112394096"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41598-019-39739-5",
"https://app.dimensions.ai/details/publication/pub.1112394096"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T11:01",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000352_0000000352/records_60342_00000004.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/s41598-019-39739-5"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39739-5'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39739-5'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39739-5'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39739-5'
This table displays all metadata directly associated to this object as RDF triples.
286 TRIPLES
21 PREDICATES
52 URIs
21 LITERALS
9 BLANK NODES