Ontology type: schema:ScholarlyArticle Open Access: True
2019-12
AUTHORSSaleh Omairi, Kwan-Leong Hau, Henry Collins-Hooper, Charlotte Scott, Sakthivel Vaiyapuri, Silvia Torelli, Federica Montanaro, Antonios Matsakas, Ketan Patel
ABSTRACTThe dystrophin-glycoprotein complex (DGC) links the muscle cytoskeleton to the extracellular matrix and is responsible for force transduction and protects the muscle fibres from contraction induced damage. Mutations in components of the DGC are responsible for muscular dystrophies and congenital myopathies. Expression of DGC components have been shown to be altered in many myopathies. In contrast we have very little evidence of whether adaptive changes in muscle impact on DGC expression. In this study we investigated connection between muscle fibre phenotype and the DGC. Our study reveals that the levels of DGC proteins at the sarcolemma differ in highly glycolytic muscle compared to wild-type and that these changes can be normalised by the super-imposition of an oxidative metabolic programme. Importantly we show that the metabolic properties of the muscle do not impact on the total amount of DGC components at the protein level. Our work shows that the metabolic property of a muscle fibre is a key factor in regulating the expression of DGC proteins at the sarcolemma. More... »
PAGES2770
http://scigraph.springernature.com/pub.10.1038/s41598-019-39532-4
DOIhttp://dx.doi.org/10.1038/s41598-019-39532-4
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1112393185
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30808964
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biochemistry and Cell Biology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "University of Wasit",
"id": "https://www.grid.ac/institutes/grid.449814.4",
"name": [
"School of Biological Sciences, University of Reading, Reading, UK",
"College of Medicine, Wasit University, Kut, Iraq"
],
"type": "Organization"
},
"familyName": "Omairi",
"givenName": "Saleh",
"type": "Person"
},
{
"affiliation": {
"alternateName": "National Institute for Health Research",
"id": "https://www.grid.ac/institutes/grid.451056.3",
"name": [
"UCL Great Ormond Street Institute of Child Health, Developmental Neurosciences, Programme, London, UK",
"NIHR Great Ormond Street Hospital Biomedical Research Centre, 30 Guilford Street, WC1N 1EH, London, UK"
],
"type": "Organization"
},
"familyName": "Hau",
"givenName": "Kwan-Leong",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Reading",
"id": "https://www.grid.ac/institutes/grid.9435.b",
"name": [
"School of Biological Sciences, University of Reading, Reading, UK"
],
"type": "Organization"
},
"familyName": "Collins-Hooper",
"givenName": "Henry",
"type": "Person"
},
{
"affiliation": {
"alternateName": "National Institute for Health Research",
"id": "https://www.grid.ac/institutes/grid.451056.3",
"name": [
"UCL Great Ormond Street Institute of Child Health, Developmental Neurosciences, Programme, London, UK",
"NIHR Great Ormond Street Hospital Biomedical Research Centre, 30 Guilford Street, WC1N 1EH, London, UK"
],
"type": "Organization"
},
"familyName": "Scott",
"givenName": "Charlotte",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Reading",
"id": "https://www.grid.ac/institutes/grid.9435.b",
"name": [
"School of Pharmacy, University of Reading, Reading, UK"
],
"type": "Organization"
},
"familyName": "Vaiyapuri",
"givenName": "Sakthivel",
"type": "Person"
},
{
"affiliation": {
"alternateName": "National Institute for Health Research",
"id": "https://www.grid.ac/institutes/grid.451056.3",
"name": [
"UCL Great Ormond Street Institute of Child Health, Developmental Neurosciences, Programme, London, UK",
"NIHR Great Ormond Street Hospital Biomedical Research Centre, 30 Guilford Street, WC1N 1EH, London, UK"
],
"type": "Organization"
},
"familyName": "Torelli",
"givenName": "Silvia",
"type": "Person"
},
{
"affiliation": {
"alternateName": "National Institute for Health Research",
"id": "https://www.grid.ac/institutes/grid.451056.3",
"name": [
"UCL Great Ormond Street Institute of Child Health, Developmental Neurosciences, Programme, London, UK",
"NIHR Great Ormond Street Hospital Biomedical Research Centre, 30 Guilford Street, WC1N 1EH, London, UK"
],
"type": "Organization"
},
"familyName": "Montanaro",
"givenName": "Federica",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Hull York Medical School",
"id": "https://www.grid.ac/institutes/grid.413631.2",
"name": [
"Molecular Physiology Laboratory, Centre for Atherothrombotic & Metabolic Disease, Hull York Medical School, Hull, UK"
],
"type": "Organization"
},
"familyName": "Matsakas",
"givenName": "Antonios",
"type": "Person"
},
{
"affiliation": {
"alternateName": "University of Reading",
"id": "https://www.grid.ac/institutes/grid.9435.b",
"name": [
"School of Biological Sciences, University of Reading, Reading, UK"
],
"type": "Organization"
},
"familyName": "Patel",
"givenName": "Ketan",
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.3390/cosmetics3030028",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001976576"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cphy.c140048",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002065479"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.80.12.3850",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002976970"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/aja.1002020109",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004002681"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00433399",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004218254",
"https://doi.org/10.1007/bf00433399"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1365-2990.2012.01250.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005050585"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0012-1606(82)90122-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011950253"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1365-2990.2009.01056.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013132846"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1365-2990.2009.01056.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013132846"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1155/2011/210797",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014030827"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.271.50.32321",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014385611"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7554/elife.16940",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016734562"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/00071660310001598346",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018894856"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cmet.2011.01.019",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019725387"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1038/mt.2011.248",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020350142"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/mus.22094",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021587742"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/brain/awr291",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023122710"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.tem.2015.05.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024810700"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0014-5793(96)00056-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025305412"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/387083a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027453384",
"https://doi.org/10.1038/387083a0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1432-0436.1984.tb00279.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028028372"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0092-8674(88)90463-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028969643"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.stem.2016.09.010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032184509"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.stem.2016.09.010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032184509"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/2044-5040-1-30",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032592667",
"https://doi.org/10.1186/2044-5040-1-30"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1440-1681.2004.04026.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033099213"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(11)60756-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036777140"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.semcdb.2016.09.013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037475389"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1083/jcb.108.5.1873",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042821592"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m704146200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043416805"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci116661",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043671460"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0006-291x(85)90436-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046860598"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1748-1716.1980.tb06515.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047306418"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1006939",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047476807"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ncl.2014.04.005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048064745"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1469-7580.2012.01503.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048302577"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/nen.0b013e3181aa31c2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048875851"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00139514",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049554193",
"https://doi.org/10.1007/bf00139514"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00139514",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049554193",
"https://doi.org/10.1007/bf00139514"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m110.125401",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050000903"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0604893104",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051205176"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0021-9290(84)90103-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051938103"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0073224",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052333172"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.14670/hh-24.611",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1077864312"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079188871",
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s13311-018-00687-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1109799039",
"https://doi.org/10.1007/s13311-018-00687-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s13311-018-00687-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1109799039",
"https://doi.org/10.1007/s13311-018-00687-z"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-12",
"datePublishedReg": "2019-12-01",
"description": "The dystrophin-glycoprotein complex (DGC) links the muscle cytoskeleton to the extracellular matrix and is responsible for force transduction and protects the muscle fibres from contraction induced damage. Mutations in components of the DGC are responsible for muscular dystrophies and congenital myopathies. Expression of DGC components have been shown to be altered in many myopathies. In contrast we have very little evidence of whether adaptive changes in muscle impact on DGC expression. In this study we investigated connection between muscle fibre phenotype and the DGC. Our study reveals that the levels of DGC proteins at the sarcolemma differ in highly glycolytic muscle compared to wild-type and that these changes can be normalised by the super-imposition of an oxidative metabolic programme. Importantly we show that the metabolic properties of the muscle do not impact on the total amount of DGC components at the protein level. Our work shows that the metabolic property of a muscle fibre is a key factor in regulating the expression of DGC proteins at the sarcolemma.",
"genre": "research_article",
"id": "sg:pub.10.1038/s41598-019-39532-4",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.2767097",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1045337",
"issn": [
"2045-2322"
],
"name": "Scientific Reports",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "9"
}
],
"name": "Regulation of the dystrophin-associated glycoprotein complex composition by the metabolic properties of muscle fibres",
"pagination": "2770",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"81525785462b542da2c0bb441e64a5a2011bdefc7dbcd8393ba20e4117c0a3d3"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30808964"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101563288"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41598-019-39532-4"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1112393185"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41598-019-39532-4",
"https://app.dimensions.ai/details/publication/pub.1112393185"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T10:49",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000350_0000000350/records_77561_00000001.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/s41598-019-39532-4"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39532-4'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39532-4'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39532-4'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39532-4'
This table displays all metadata directly associated to this object as RDF triples.
262 TRIPLES
21 PREDICATES
72 URIs
21 LITERALS
9 BLANK NODES