Metabolites related to purine catabolism and risk of type 2 diabetes incidence; modifying effects of the TCF7L2-rs7903146 polymorphism View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-02-27

AUTHORS

Christopher Papandreou, Jun Li, Liming Liang, Mònica Bulló, Yan Zheng, Miguel Ruiz-Canela, Edward Yu, Marta Guasch-Ferré, Cristina Razquin, Clary Clish, Dolores Corella, Ramon Estruch, Emilio Ros, Montserrat Fitó, Fernando Arós, Lluís Serra-Majem, Nuria Rosique, Miguel A. Martínez-González, Frank B. Hu, Jordi Salas-Salvadó

ABSTRACT

Studies examining associations between purine metabolites and type 2 diabetes (T2D) are limited. We prospectively examined associations between plasma levels of purine metabolites with T2D risk and the modifying effects of transcription factor-7-like-2 (TCF7L2) rs7903146 polymorphism on these associations. This is a case-cohort design study within the PREDIMED study, with 251 incident T2D cases and a random sample of 694 participants (641 non-cases and 53 overlapping cases) without T2D at baseline (median follow-up: 3.8 years). Metabolites were semi-quantitatively profiled with LC-MS/MS. Cox regression analysis revealed that high plasma allantoin levels, including allantoin-to-uric acid ratio and high xanthine-to-hypoxanthine ratio were inversely and positively associated with T2D risk, respectively, independently of classical risk factors. Elevated plasma xanthine and inosine levels were associated with a higher T2D risk in homozygous carriers of the TCF7L2-rs7903146 T-allele. The potential mechanisms linking the aforementioned purine metabolites and T2D risk must be also further investigated. More... »

PAGES

2892

Journal

TITLE

Scientific Reports

ISSUE

1

VOLUME

9

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/s41598-019-39441-6

DOI

http://dx.doi.org/10.1038/s41598-019-39441-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112388260

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30814579


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