Ontology type: schema:ScholarlyArticle Open Access: True
2019-12
AUTHORSAbdullah R. Ahmed, Raymond J. Owens, Christopher D. Stubbs, Anthony W. Parker, Richard Hitchman, Rahul B. Yadav, Maud Dumoux, Chris Hawes, Stanley W. Botchway
ABSTRACTKnowledge of protein signalling pathways in the working cell is seen as a primary route to identifying and developing targeted medicines. In recent years there has been a growing awareness of the importance of the mTOR pathway, making it an attractive target for therapeutic intervention in several diseases. Within this pathway we have focused on S6 kinase 1 (S6K1), the downstream phosphorylation substrate of mTORC1, and specifically identify its juxtaposition with mTORC1. When S6K1 is co-expressed with raptor we show that S6K1 is translocated from the nucleus to the cytoplasm. By developing a novel biosensor we demonstrate in real-time, that phosphorylation and de-phosphorylation of S6K1 occurs mainly in the cytoplasm of living cells. Furthermore, we show that the scaffold protein raptor, that typically recruits mTOR substrates, is not always involved in S6K1 phosphorylation. Overall, we demonstrate how FRET-FLIM imaging technology can be used to show localisation of S6K1 phosphorylation in living cells and hence a key site of action of inhibitors targeting mTOR phosphorylation. More... »
PAGES3408
http://scigraph.springernature.com/pub.10.1038/s41598-019-39410-z
DOIhttp://dx.doi.org/10.1038/s41598-019-39410-z
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1112509971
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30833605
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biochemistry and Cell Biology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Rutherford Appleton Laboratory",
"id": "https://www.grid.ac/institutes/grid.76978.37",
"name": [
"Central Laser Facility, Research Complex at Harwell, STFC Rutherford Appleton Laboratory, Harwell Campus, OX11 0FA, Didcot, UK"
],
"type": "Organization"
},
"familyName": "Ahmed",
"givenName": "Abdullah R.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wellcome Centre for Human Genetics",
"id": "https://www.grid.ac/institutes/grid.270683.8",
"name": [
"Protein Production UK, Research Complex at Harwell, Rutherford Appleton Laboratory, Harwell Campus, OX11 0FA, Didcot, UK",
"The Wellcome Centre for Human Genetics, Roosevelt Drive, OX3 7BN, Oxford, UK"
],
"type": "Organization"
},
"familyName": "Owens",
"givenName": "Raymond J.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Rutherford Appleton Laboratory",
"id": "https://www.grid.ac/institutes/grid.76978.37",
"name": [
"Central Laser Facility, Research Complex at Harwell, STFC Rutherford Appleton Laboratory, Harwell Campus, OX11 0FA, Didcot, UK"
],
"type": "Organization"
},
"familyName": "Stubbs",
"givenName": "Christopher D.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Rutherford Appleton Laboratory",
"id": "https://www.grid.ac/institutes/grid.76978.37",
"name": [
"Central Laser Facility, Research Complex at Harwell, STFC Rutherford Appleton Laboratory, Harwell Campus, OX11 0FA, Didcot, UK"
],
"type": "Organization"
},
"familyName": "Parker",
"givenName": "Anthony W.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Evotec (United Kingdom)",
"id": "https://www.grid.ac/institutes/grid.448222.a",
"name": [
"Evotec (UK) Ltd, 114 Innovation Drive, Milton Park, OX14 4RZ, Abingdon, Oxfordshire, UK"
],
"type": "Organization"
},
"familyName": "Hitchman",
"givenName": "Richard",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Evotec (United Kingdom)",
"id": "https://www.grid.ac/institutes/grid.448222.a",
"name": [
"Evotec (UK) Ltd, 114 Innovation Drive, Milton Park, OX14 4RZ, Abingdon, Oxfordshire, UK"
],
"type": "Organization"
},
"familyName": "Yadav",
"givenName": "Rahul B.",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Rutherford Appleton Laboratory",
"id": "https://www.grid.ac/institutes/grid.76978.37",
"name": [
"Diamond Light Source, Harwell Campus, OX11 0DE, Didcot, UK",
"Protein Production UK, Research Complex at Harwell, Rutherford Appleton Laboratory, Harwell Campus, OX11 0FA, Didcot, UK"
],
"type": "Organization"
},
"familyName": "Dumoux",
"givenName": "Maud",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Oxford Brookes University",
"id": "https://www.grid.ac/institutes/grid.7628.b",
"name": [
"Oxford Brookes University, Headington Campus, OX3 0BP, Oxford, UK"
],
"type": "Organization"
},
"familyName": "Hawes",
"givenName": "Chris",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Rutherford Appleton Laboratory",
"id": "https://www.grid.ac/institutes/grid.76978.37",
"name": [
"Central Laser Facility, Research Complex at Harwell, STFC Rutherford Appleton Laboratory, Harwell Campus, OX11 0FA, Didcot, UK"
],
"type": "Organization"
},
"familyName": "Botchway",
"givenName": "Stanley W.",
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/s00726-011-0965-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001145414",
"https://doi.org/10.1007/s00726-011-0965-4"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00726-011-0965-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001145414",
"https://doi.org/10.1007/s00726-011-0965-4"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m809207200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001572928"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.1419425111",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002206214"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0092-8674(02)00833-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002278073"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0076-6879(07)38021-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002728577"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m110.120295",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004798142"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.celrep.2015.02.031",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005463114"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.celrep.2015.02.031",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005463114"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.celrep.2015.02.031",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005463114"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.celrep.2015.02.031",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005463114"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m112.402461",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006063563"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.res.0000071748.48338.25",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006432004"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.res.0000071748.48338.25",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006432004"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/08977190802556986",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007411924"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m702376200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007845363"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrneurol.2016.81",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007914063",
"https://doi.org/10.1038/nrneurol.2016.81"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m202625200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008276441"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7554/elife.19960",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008494701"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7554/elife.19960",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008494701"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.bbrc.2003.07.018",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009673982"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/1471-2121-14-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011470842",
"https://doi.org/10.1186/1471-2121-14-3"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1742-4658.2008.06372.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014172799"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s13238-016-0346-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014495552",
"https://doi.org/10.1007/s13238-016-0346-6"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s13238-016-0346-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014495552",
"https://doi.org/10.1007/s13238-016-0346-6"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1523/jneurosci.2781-15.2015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014586867"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nbt.3770",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015721243",
"https://doi.org/10.1038/nbt.3770"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jsb.2010.02.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016062263"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m512218200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019179675"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/onc.2011.165",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021138290",
"https://doi.org/10.1038/onc.2011.165"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m308573200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021350101"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.lfs.2015.03.001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021477268"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2012.03.017",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022080500"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m603566200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022459152"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1095/biolreprod.112.105080",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023685989"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0960-9822(02)00762-5",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023895411"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1128/mcb.01225-13",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024263017"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1105/tpc.105.035931",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024288986"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nmeth.1855",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024460461",
"https://doi.org/10.1038/nmeth.1855"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/bj20110892",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024734461"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/bj20110892",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024734461"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0960-9822(03)00329-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025832168"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0960-9822(03)00329-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025832168"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/978-1-4939-1420-3_6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026421556",
"https://doi.org/10.1007/978-1-4939-1420-3_6"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.molcel.2013.12.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027190428"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m413995200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027852234"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.molcel.2016.03.011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028926467"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.molcel.2016.03.011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028926467"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.c500125200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031311508"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m610736200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031389749"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.aaa3870",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033430910"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.celrep.2012.11.020",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035686819"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.c200665200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038492195"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m702636200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040823579"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1157535",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042086566"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/pmic.200600849",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043577773"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jviromet.2004.07.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046537383"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/bst20130037",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046974505"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/bst20130037",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046974505"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/onc.2009.401",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047043356",
"https://doi.org/10.1038/onc.2009.401"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.011511898",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047920394"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1101/gad.1110003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048217925"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.c500169200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048533396"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1242/jcs.051011",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049581720"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.celrep.2016.09.020",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050896868"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.molcel.2007.08.010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051548301"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.molcel.2007.03.003",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052856492"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m116.761205",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1058215747"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7124/bc.00083b",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1073608812"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/j.1460-2075.1994.tb06418.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1082677760"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.celrep.2017.01.023",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083699270"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.celrep.2017.01.023",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083699270"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature21380",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083734574",
"https://doi.org/10.1038/nature21380"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature21380",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083734574",
"https://doi.org/10.1038/nature21380"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/wsbm.1379",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1083739545"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2017.02.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084064453"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2017.02.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084064453"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-12",
"datePublishedReg": "2019-12-01",
"description": "Knowledge of protein signalling pathways in the working cell is seen as a primary route to identifying and developing targeted medicines. In recent years there has been a growing awareness of the importance of the mTOR pathway, making it an attractive target for therapeutic intervention in several diseases. Within this pathway we have focused on S6 kinase 1 (S6K1), the downstream phosphorylation substrate of mTORC1, and specifically identify its juxtaposition with mTORC1. When S6K1 is co-expressed with raptor we show that S6K1 is translocated from the nucleus to the cytoplasm. By developing a novel biosensor we demonstrate in real-time, that phosphorylation and de-phosphorylation of S6K1 occurs mainly in the cytoplasm of living cells. Furthermore, we show that the scaffold protein raptor, that typically recruits mTOR substrates, is not always involved in S6K1 phosphorylation. Overall, we demonstrate how FRET-FLIM imaging technology can be used to show localisation of S6K1 phosphorylation in living cells and hence a key site of action of inhibitors targeting mTOR phosphorylation.",
"genre": "research_article",
"id": "sg:pub.10.1038/s41598-019-39410-z",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.3866052",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1045337",
"issn": [
"2045-2322"
],
"name": "Scientific Reports",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "9"
}
],
"name": "Direct imaging of the recruitment and phosphorylation of S6K1 in the mTORC1 pathway in living cells",
"pagination": "3408",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"a31eee48405dee626cb5e56e50da733fcadc231b5d09b5f46642e2f739d8fe2f"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30833605"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"101563288"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/s41598-019-39410-z"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1112509971"
]
}
],
"sameAs": [
"https://doi.org/10.1038/s41598-019-39410-z",
"https://app.dimensions.ai/details/publication/pub.1112509971"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T11:21",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000354_0000000354/records_11724_00000002.jsonl",
"type": "ScholarlyArticle",
"url": "https://www.nature.com/articles/s41598-019-39410-z"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39410-z'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39410-z'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39410-z'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/s41598-019-39410-z'
This table displays all metadata directly associated to this object as RDF triples.
328 TRIPLES
21 PREDICATES
92 URIs
21 LITERALS
9 BLANK NODES